Association between indoxyl sulfate and bone histomorphometry in pre-dialysis chronic kidney disease patients

Introduction: Experimental studies have suggested that indoxyl sulfate (IS), a protein-bound uremic toxin, may be involved in the development of renal osteodystrophy. Objective: evaluate the association between IS levels and biochemical parameters related to mineral metabolism and bone histomorphometry in a cohort of pre-dialysis chronic kidney disease (CKD) patients. Methods: This is a post-hoc analysis of an observational study evaluating the association between coronary calcification and bone biopsy findings in 49 patients (age: 52 ± 10 years; 67% male; estimated glomerular filtration rate: 36 ± 17 ml/min). Serum levels of IS were measured. Results: Patients at CKD stages 2 and 3 presented remarkably low bone formation rate. Patients at CKD stages 4 and 5 presented significantly higher osteoid volume, osteoblast and osteoclast surface, bone fibrosis volume and bone formation rate and a lower mineralization lag time than CKD stage 2 and 3 patients. We observed a positive association between IS levels on one hand and the bone formation rate, osteoid volume, osteoblast surface and bone fibrosis volume on the other. Multivariate regression models confirmed that the associations between IS levels and osteoblast surface and bone fibrosis volume were both independent of demographic and biochemical characteristics of the study population. A similar trend was observed for the bone formation rate. Conclusion: Our findings demonstrated that IS is positively associated with bone formation rate in pre-dialysis CKD patients.

They Do Things Differently There. Essays on Cultural History

This collection of Finnish essays in cultural history will be revelatory for anglophone readers. Pioneering in the study of cultural history as early as the nineteenth century, by the 1930s Finnish scholars already deployed the broad conception of 'culture' as embracing 'everyday life' that is usually thought of as emerging in the work of Raymond Williams decades later. These essays emanate from the Department of Cultural History, established at the University of Turku in 1972, and its partner department at the University of Lapland. The collection signals new genealogies of cultural historiography in general, and in its distinctively Finnish inflections.

Kertomuksia lapsille hengelliseltä alalta

Päiväys: Kuopiossa 5.12.1882 A. G. Borg. - Takakannessa: Näitä kertomuksia löytyy tilattawina Kuopiossa tuomiorovasti Borg'in luona.

Revue d'histoire contemporaine (Paris)

Périodicité : Bimensuel ; Hebdomadaire

Revue d'histoire contemporaine / dir. A. Bouvard, R. Berthault

1888/04/01 (A1,N1)-1891/05/02 (A4).

7-6-20, Hôtel de Ville [de Paris, hommage aux artisans de la victoire, présence de MM. Clémenceau, Poincaré, Foch, etc.] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 59585

7-6-20, Hôtel de Ville [de Paris, hommage aux artisans de la victoire, présence de MM. Clémenceau, Poincaré, Foch, etc.] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 59586

7-6-20, Hôtel de Ville [de Paris], arrivée de M. Poincaré : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 59594

7-6-20, Hôtel de Ville [de Paris], départ de M. Poincaré : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 59597

23/6/20, cérémonie [commémorative de l'échec allemand de 1916] au cimetière de Verdun : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 59827

23/6/20, cérémonie au cimetière de Verdun [en tête de cortège MM. Pétain, Poincaré, Lefèvre et Maginot] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 59828

23/6/20, cérémonie au cimetière de Verdun [MM. Maginot, Poincaré, Pétain] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 59830

23/6/20, les officiels dans Verdun [MM. Pétain, Poincaré, Lefèvre et Maginot] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 59831

Verdun, 23/6/20, cérémonie commémorative [de l'échec allemand de 1916], M. Lefèvre pose la 1ère pierre du monument aux morts de Verdun : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 59833

28/6/20, monument Stendhal [jardins du Luxembourg], discours de Maurice Donnay [en présence de MM. Barrès et Poincaré] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 59879