Eighth Report of the Iowa Library Commission for the Biannual Period July 1, 1914 to June 30, 1916

1914-1916 Iowa Library Commission Report made to the Governor of Iowa.

Ninth Report of the Iowa Library Commission for the Biennial Period July 1, 1916 to June 30, 1918

1916-1918 Iowa Library Commission Report made to the Governor of Iowa.

1920 Report of the Iowa Library Commission Made to the Governor of Iowa for the Biennial Period July 1, 1918 to June 30, 1920

1918-1920 Iowa Library Commission Report made to the Governor of Iowa.

Eleventh Report of the Iowa Library Commission for the Biennial Period July 1, 1920 to June 30, 1922

1920-1922 Iowa Library Commission Report made to the Governor of Iowa.

Twelfth Report of the Iowa Library Commission to the Governor of Iowa for the Biennial Period July 1, 1922 to June 30, 1924

1922-1924 Iowa Library Commission Report made to the Governor of Iowa.

Thirteenth Report of the Iowa Library Commission Made to the Governor of Iowa for the Biennial Period July 1, 1924 to June 30, 1926

1924-1926 Iowa Library Commission Report made to the Governor of Iowa.

Fourteenth Report of the Iowa Library Commission Made to the Governor of Iowa for the Biennial Period July 1, 2926 to June 30, 1928

1926-1928 Iowa Library Commission Report made to the Governor of Iowa.

Fifteenth Report of the Iowa Library Commission Made to the Governor of Iowa for the Biennial Period July 1, 1928 to June 30, 1930 1928-1930

1928-1930 Iowa Library Commission Report made to the Governor of Iowa.

Sixteenth Report of the Iowa Library Commission Made to the Governor of Iowa for the Biennial Period July 1, 1930 to June 30, 1932

1930-1932 Iowa Library Commission Report made to the Governor of Iowa.

Seventeenth Report of the Iowa Library Commission Made to the Governor of Iowa for the Biennial Period July 1, 1932 to June 30, 1934

1932-1934 Iowa Library Commission Report made to the Governor of Iowa.

Eighteenth Report of the Iowa Library Commission Made to the Governor of Iowa for the Biannual Period July 1,1934 to June 30, 1936

1934-1936 Iowa Library Commission Report made to the Governor of Iowa.

Nineteenth Report of the Iowa Library Commission Made to the Governor of Iowa for the Biennial Period July 1,1936 to June 30, 1938

1936-1938 Iowa Library Commission Report made to the Governor of Iowa.

Hypocretin/orexin in addiction: a mediator of stress-induced reinstatement of cocaine-seeking behaviour

The importance of the lateral hypothalamus in the pursuit of reward has long been recognized. However, the hypothalamic neuronal network involved in the regulation of reward still remains partially unknown. Hypocretins (aka orexins) are neuropeptides synthesized by a few thousand neurons restricted to the lateral hypothalamus and the perifornical area. Compelling evidence indicates that hypocretin neurons receive inputs from sensory and limbic systems and drive hyper-arousal possibly through modulation of stress responses. Major advances have been made in the elucidation of the hypocretin involvement in the regulation of arousal, stress, motivation, and reward seeking, without clearly defining the role of hypocretins in addictionrelated behaviors. We have recently gathered substantial evidence that points to a previously unidentified role for hypocretin-1 in driving relapse for cocaine seeking through activation of brain stress pathways. Meanwhile, several authors published concordant observations rather suggesting a direct activation of the mesolimbic dopamine system. In particular, hypocretin-1 has been shown to be critically involved in cocaine sensitization through the recruitment of NMDA receptors in the ventral tegmental area. Overall, on can conclude from recent findings that activation of hypocretin/orexin neurons plays a critical role in the development of the addiction process, either by contributing to brain sensitization (which is thought to lead to the unmanageable desire for drug intake) or by modulating the brain reward system that, in coordination with brain stress systems, leads to a vulnerable state that may facilitate relapse for drug seeking behavior.

Sex differences in hospital readmission among colorectal cancer patients.

Background: While several studies have analysed sex and socioeconomic differences in cancer incidence and mortality, sex differences in oncological health care have been seldom considered. Objective: To investigate sex based inequalities in hospital readmission among patients diagnosed with colorectal cancer. Design: Prospective cohort study. Setting: Hospital Universitary in L¿Hospitalet (Barcelona, Spain). Participants: Four hundred and three patients diagnosed with colorectal between January 1996 and December 1998 were actively followed up until 2002. Main outcome measurements and methods: Hospital readmission times related to colorectal cancer after surgical procedure. Cox proportional model with random effect (frailty) was used to estimate hazard rate ratios and 95% confidence intervals of readmission time for covariates analysed. Results: Crude hazard rate ratio of hospital readmission in men was 1.61 (95% CI 1.21 to 2.15). When other significant determinants of readmission were controlled for (including Dukes¿s stage, mortality, and Charlson¿s index) a significant risk of readmission was still present for men (hazard rate ratio: 1.52, 95% CI 1.17 to 1.96). Conclusions: In the case of colorectal cancer, women are less likely than men to be readmitted to the hospital, even after controlling for tumour characteristics, mortality, and comorbidity. New studies should investigate the role of other non-clinical variable such as differences in help seeking behaviours or structural or personal sex bias in the attention given to patients.

Monday Morning Eye Opener, January 11, 2016

Weekly Newsletter from the Northwest District Office for libraries containing programs, activities, classes for the upcoming week.