Activin A inhibits Pax-6 expression and perturbs cell differentiation in the developing spinal cord in vitro.

We have developed an in vitro model of the isolated chicken neural plate. Here we demonstrate that even in the absence of notochord, the neural plate rapidly develops a typical dorsoventral patterning. This observation suggests that the ventral cell types are specified or at least predetermined prior to notochord formation and that permissive conditions are sufficient for differentiation of ventral structures. Treatment of the neural plate with activin A extinguishes Pax-6 gene expression, whereas the dorsal markers Pax-3 and Pax-7 are still expressed. The absence of Pax-6 transcripts can be correlated with an impeded differentiation of the motor neurons, whereas the floor plate seems to be enlarged. We propose that the region-specific expression of Pax-6 in the spinal cord is under the control of activin-like molecules.

Implementation of non-local boundary layer schemes in the Regional Atmospheric Modeling System and its impact on simulated mesoscale circulations

This paper proposes the implementation of different non-local Planetary Boundary Layer schemes within the Regional Atmospheric Modeling System (RAMS) model. The two selected PBL parameterizations are the Medium-Range Forecast (MRF) PBL and its updated version, known as the Yonsei University (YSU) PBL. YSU is a first-order scheme that uses non-local eddy diffusivity coefficients to compute turbulent fluxes. It is based on the MRF, and improves it with an explicit treatment of the entrainment. With the aim of evaluating the RAMS results for these PBL parameterizations, a series of numerical simulations have been performed and contrasted with the results obtained using the Mellor and Yamada (MY) scheme, also widely used, and the standard PBL scheme in the RAMS model. The numerical study carried out here is focused on mesoscale circulation events during the summer, as these meteorological situations dominate this season of the year in the Western Mediterranean coast. In addition, the sensitivity of these PBL parameterizations to the initial soil moisture content is also evaluated. The results show a warmer and moister PBL for the YSU scheme compared to both MRF and MY. The model presents as well a tendency to overestimate the observed temperature and to underestimate the observed humidity, considering all PBL schemes and a low initial soil moisture content. In addition, the bias between the model and the observations is significantly reduced moistening the initial soil moisture of the corresponding run. Thus, varying this parameter has a positive effect and improves the simulated results in relation to the observations. However, there is still a significant overestimation of the wind speed over flatter terrain, independently of the PBL scheme and the initial soil moisture used, even though a different degree of accuracy is reproduced by RAMS taking into account the different sensitivity tests.

Benchmarking analogue models of brittle thrust wedges

We performed a quantitative comparison of brittle thrust wedge experiments to evaluate the variability among analogue models and to appraise the reproducibility and limits of model interpretation. Fifteen analogue modeling laboratories participated in this benchmark initiative. Each laboratory received a shipment of the same type of quartz and corundum sand and all laboratories adhered to a stringent model building protocol and used the same type of foil to cover base and sidewalls of the sandbox. Sieve structure, sifting height, filling rate, and details on off-scraping of excess sand followed prescribed procedures. Our analogue benchmark shows that even for simple plane-strain experiments with prescribed stringent model construction techniques, quantitative model results show variability, most notably for surface slope, thrust spacing and number of forward and backthrusts. One of the sources of the variability in model results is related to slight variations in how sand is deposited in the sandbox. Small changes in sifting height, sifting rate, and scraping will result in slightly heterogeneous material bulk densities, which will affect the mechanical properties of the sand, and will result in lateral and vertical differences in peak and boundary friction angles, as well as cohesion values once the model is constructed. Initial variations in basal friction are inferred to play the most important role in causing model variability. Our comparison shows that the human factor plays a decisive role, and even when one modeler repeats the same experiment, quantitative model results still show variability. Our observations highlight the limits of up-scaling quantitative analogue model results to nature or for making comparisons with numerical models. The frictional behavior of sand is highly sensitive to small variations in material state or experimental set-up, and hence, it will remain difficult to scale quantitative results such as number of thrusts, thrust spacing, and pop-up width from model to nature.

Annotated record of the detailed examination of Mn deposits in a core from R/V Hakuho Maru Cruise KH-74-4 station

A sediment core obtained from the northeastern Philippine Sea Basin was analyzed for 232Th, 230Th, 226Ra and 210Pb. Three sheets of Ferro-manganese oxide in a matrix of red clay were included in the 73 m core. Although the concentration of 232Th of land origin is normal as compared with that of the usual red clay or of the sediment obtained at the neighboring station, the concentration of radiogenic 230Th is extremely low and does not decrease with increasing depth. The radioactivity of rather soluble 226Ra at the station is not less than that of 230Th in the surface sediment, showing a tendency different from that observed in usual cores. Some enrichment in the comparatively short-lived 210Pb activity relative to 226Ra activity was found in the top sediment and in the first ferro-manganese sheet at the station. If the excess 210Pb in the ferro-manganese sheet is not due to contamination of the surface sediment, lead should migrate through the sheet. These facts suggest that the core has not been accumulating during the past few hundred thousand years or more.

Design of the program-controlled semiconductor and printed circuit board test console /

"October 21, 1963"

Emulation of disc file processor /

"June, 1971."

Experimental results for logical filtering of digitized pictures /

"*This work was supported in part by the U.S. Atomic Energy Commission under Contract No. AT911-1)-1018."

Performance characteristics of fast logic for ILLIAC III : Basic NAND and NOR circuits.

Mode of access: Internet.

Cable driver and termiator design.

Mode of access: Internet.

Chang ge you xi /

Shi shu wei Riben Shantian Yuanyilang, Gaoqiao Zhongcilang er ren yuan zhu ... yi yi wo guo zhi ge ci.

Zenmon hōgoshū : kōho tenchū /

Mode of access: Internet.

[Kairo /

On double leaves, oriental style.