TRIBUNAL ARBITRAL DE CARLOS EDUARDO NARANJO FLÓREZ Y MANUEL GUILLERMO ESTRADA FLÓREZ VS. EDWIN FERNANDO NUÑEZ SÁNCHEZ

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Legitimidad del régimen de estampillas departamentales en Colombia

Análisis de la dinámica legitimadora de la Corte Constitucional en el tributo de estampillas, considerado desde la jurisdicción departamental, en el Estado colombiano.

Entre la tradición y el cambio: Evolución tecnológica de la caficultura costarricense. Mario Samper, Carlos Naranjo y Paul Sfez

Introducción Entre la Tradición y el Cambio: Evolución tecnológica de la caficultura costarricense, está orientado a satisfacer las necesidades diversas de un círculo amplio de lectores, desde el estudioso de la historia agraria que pretende obtener una síntesis interpretativa del desarrollo cafetalero costarricense hasta los diferentes sectores productivos involucrados con las faenas diarias de la caficultura. Esta característica divulgativa al gran público pone en manifiesto uno de los objetivos del quehacer universitario, devolver a los protagonistas que han construido la historia nacional las experiencias y conocimientos sobre la actividad productiva…

“El cadáver de la vieja historia política todavía insepulto. Crítica de la obra de Joaquín Vargas Coto ‘Crónicas de la época y vida de don Ricardo’"

IntroducciónLa Editorial Costa Rica nos entraga, en un voluminoso tomo de más de cuatrocientas páginas, una crónica bibliográfica. Se trata de una serie de escritos realizados por Joaquín Vargas Coto, periodista nacional, y ordenados por sus hijos en particular la Lic. Alicia Vargas de Fournier, quienes le darían el carácter de lobro de valor histórico. La obra del periodista se proyectó con el consentimiento de don Ricardo para dejarnos algo así como un testamento político en la forma de esta crónicas.

LAS CONDICIONES SOCIO-ECONOMICAS Y ESPACIALES DE LA PRODUCCION LECHERA EN COTO BRUS PACIFICO SUR

Este trabajo ofrece una visión de las condiciones regionales y los factores más importantes que han afectado el desarrollo de la producción lechera de Coto Brus. El área ofrece algunas ventajas para su producción, sin embargo, la orientación de las inversiones y la valoración de las condiciones socio-económicas no permitieron la obtención de los índices esperados.     SUMMARY This article offers a vision of general regional conditions and emphasizes the most important factors that have affected the development of the milk production in the Coto Brus region of Costa Rica. This area offers some advantages; nevertheless, the orientations of investments and the evaluation of the social economical conditions did not permit the obtention of expected indexes in the milk production.   RESUME Ce travail présente les conditions régionales et les facteurs les plus importants qui ont permis le développement du secteur laitier en Coto Brus, au Pacifique Sud. Bien que cette zone offre certains avantages pour cette activité, les investissements portent sur d’autres secteurs. Ceci, ajouté á que les conditions socio-économique n’ont pas permis d’atteindre les résultats espérés.

Mapa de amenazas naturales potenciales: Hoja Coto Brus

Mapa de ubicación de amenazas naturales, con el objetivo de apoyar el proceso de prevención contra desastres naturales en el nivel local.

Saúde da criança: caso clínico [problemas com o coto umbilical]

Vídeo produzido com o GoAnimate! que apresenta a visita da agente de saúde à Antonieta, que há cinco dias deu a luz a Leonardo. Após análise da caderneta de saúde da criança, a agente confirma a aplicação da vacinação adequada e a anotação correta dos índices antropométricos. A mãe ainda refere que seu filho apresentou odor pútrido no cordão umbilical, aumento da temperatura corporal e choro constante.

Antioxidant And Antiproliferative Activities Of Methanolic Extract From A Neglected Agricultural Product: Corn Cobs.

Neglected agricultural products (NAPs) are defined as discarded material in agricultural production. Corn cobs are a major waste of agriculture maize. Here, a methanolic extract from corn cobs (MEC) was obtained. MEC contains phenolic compounds, protein, carbohydrates (1.4:0.001:0.001). We evaluated the in vitro and in vivo antioxidant potential of MEC. Furthermore, its antiproliferative property against tumor cells was assessed through MTT assays and proteins related to apoptosis in tumor cells were examined by western blot. MEC showed no hydroxyl radical scavenger capacity, but it showed antioxidant activity in Total Antioxidant Capacity and DPPH scavenger ability assays. MEC showed higher Reducing Power than ascorbic acid and exhibited high Superoxide Scavenging activity. In tumor cell culture, MEC increased catalase, metallothionein and superoxide dismutase expression in accordance with the antioxidant tests. In vivo antioxidant test, MEC restored SOD and CAT, decreased malondialdehyde activities and showed high Trolox Equivalent Antioxidant Capacity in animals treated with CCl4. Furthermore, MEC decreased HeLa cells viability by apoptosis due an increase of Bax/Bcl-2 ratio, caspase 3 active. Protein kinase C expression increased was also detected in treated tumor cells. Thus, our findings pointed out the biotechnological potential of corn cobs as a source of molecules with pharmacological activity.

Crosstalk Between Kinases, Phosphatases And Mirnas In Cancer.

Reversible phosphorylation of proteins, performed by kinases and phosphatases, is the major post translational protein modification in eukaryotic cells. This intracellular event represents a critical regulatory mechanism of several signaling pathways and can be related to a vast array of diseases, including cancer. Cancer research has produced increasing evidence that kinase and phosphatase activity can be compromised by mutations and also by miRNA silencing, performed by small non-coding and endogenously produced RNA molecules that lead to translational repression. miRNAs are believed to target about one-third of human mRNAs while a single miRNA may target about 200 transcripts simultaneously. Regulation of the phosphorylation balance by miRNAs has been a topic of intense research over the last years, spanning topics going as far as cancer aggressiveness and chemotherapy resistance. By addressing recent studies that have shown miRNA expression patterns as phenotypic signatures of cancers and how miRNA influence cellular processes such as apoptosis, cell cycle control, angiogenesis, inflammation and DNA repair, we discuss how kinases, phosphatases and miRNAs cooperatively act in cancer biology.

A New Goniothalamin N-acylated Aza-derivative Strongly Downregulates Mediators Of Signaling Transduction Associated With Pancreatic Cancer Aggressiveness.

In this study, a novel concise series of molecules based on the structure of goniothalamin (1) was synthesized and evaluated against a highly metastatic human pancreatic cancer cell line (Panc-1). Among them, derivative 8 displayed a low IC50 value (2.7 μM) and its concentration for decreasing colony formation was 20-fold lower than goniothalamin (1). Both compounds reduced the levels of the receptor tyrosine kinase (AXL) and cyclin D1 which are known to be overexpressed in pancreatic cancer cells. Importantly, despite the fact that goniothalamin (1) and derivative 8 caused pancreatic cancer cell cycle arrest and cell death, only derivative 8 was able to downregulate pro-survival and proliferation pathways mediated by mitogen activated protein kinase ERK1/2. Another interesting finding was that Panc-1 cells treated with derivative 8 displayed a strong decrease in the transcription factor (c-Myc), hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) protein levels. Notably, the molecular effects caused by derivative 8 might not be related to ROS generation, since no significant production of ROS was observed in low concentrations of this compound (from 1.5 up to 3 μM). Therefore, the downregulation of important mediators of pancreatic cancer aggressiveness by derivative 8 reveals its great potential for the development of new chemotherapeutic agents for pancreatic cancer treatment.

Nausea, Vomiting And Quality Of Life Of Patients With Cancer Undergoing Antineoplastic Treatment: An Evaluation By Pharmacists.

This study aims to evaluate the frequency and severity of nausea and vomiting using two different instruments and relate them to quality of life (QOL) in patients with cancer receiving antineoplastic treatment. Severity of chemotherapy-induced nausea and vomiting (CINV) was measured by Common Terminology Criteria for Adverse Events (CTCAE) and a numerical scale. QOL was assessed using the Functional Assessment of Cancer Therapy-General questionnaire. Of the 50 patients studied, 60.0% reported nausea (40.0% CTCAE grade 1; 66.7% moderate intensity on numerical scale) and 30.0% reported vomiting (46.7% CTCAE grades 1 and 2, each; 66.7% moderate intensity on numerical scale). CINV did not influence overall QOL. The frequency of CINV was high. There was no association between nausea/vomiting and overall QOL.

Intracerebral Granulocytic Sarcoma In Recurrence Of Chronic Myeloid Leukemia.

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Nasal Potential Difference In Cystic Fibrosis Considering Severe Cftr Mutations.

The gold standard for diagnosing cystic fibrosis (CF) is a sweat chloride value above 60 mEq/L. However, this historical and important tool has limitations; other techniques should be studied, including the nasal potential difference (NPD) test. CFTR gene sequencing can identify CFTR mutations, but this method is time-consuming and too expensive to be used in all CF centers. The present study compared CF patients with two classes I-III CFTR mutations (10 patients) (G1), CF patients with classes IV-VI CFTR mutations (five patients) (G2), and 21 healthy subjects (G3). The CF patients and healthy subjects also underwent the NPD test. A statistical analysis was performed using the Mann-Whitney, Kruskal-Wallis, χ(2), and Fisher's exact tests, α = 0.05. No differences were observed between the CF patients and healthy controls for the PDMax, Δamiloride, and Δchloride + free + amiloride markers from the NPD test. For the finger value, a difference between G2 and G3 was described. The Wilschanski index values were different between G1 and G3. In conclusion, our data showed that NPD is useful for CF diagnosis when classes I-III CFTR mutations are screened. However, if classes IV-VI are considered, the NPD test showed an overlap in values with healthy subjects.

Low Molecular Weight Protein Tyrosine Phosphatase (lmwptp) Upregulation Mediates Malignant Potential In Colorectal Cancer.

Phosphatases have long been regarded as tumor suppressors, however there is emerging evidence for a tumor initiating role for some phosphatases in several forms of cancer. Low Molecular Weight Protein Tyrosine Phosphatase (LMWPTP; acid phosphatase 1 [ACP1]) is an 18 kDa enzyme that influences the phosphorylation of signaling pathway mediators involved in cancer and is thus postulated to be a tumor-promoting enzyme, but neither unequivocal clinical evidence nor convincing mechanistic actions for a role of LMWPTP have been identified. In the present study, we show that LMWPTP expression is not only significantly increased in colorectal cancer (CRC), but also follows a step-wise increase in different levels of dysplasia. Chemical inhibition of LMWPTP significantly reduces CRC growth. Furthermore, downregulation of LMWPTP in CRC leads to a reduced migration ability in both 2D- and 3D-migration assays, and sensitizes tumor cells to the chemotherapeutic agent 5-FU. In conclusion, this study shows that LMWPTP is not only overexpressed in colorectal cancer, but it is correlated with the malignant potential of this cancer, suggesting that this phosphatase may act as a predictive biomaker of CRC stage and represents a rational novel target in the treatment of this disease.