Retrospective evaluation of the effects of administration of tetrastarch (hydroxyethyl starch 130/0.4) on plasma creatinine concentration in dogs (2010-2013): 201 dogs

OBJECTIVE To determine changes in creatinine concentrations following the administration of 6% tetrastarch (hydroxyethyl starch [HES] 130/0.4) compared to crystalloids (CRYSs) in critically ill dogs. DESIGN Retrospective case series (2010-2013). SETTING University teaching hospital. ANIMALS Two hundred and one dogs admitted to the intensive care unit with initial plasma creatinine concentrations not exceeding laboratory reference intervals (52-117 μmol/L [0.6-1.3 mg/dL]) and receiving either CRYSs alone (CRYS group, n = 115) or HES with or without CRYSs (HES group, n = 86) for at least 24 hours. INTERVENTIONS None. MEASUREMENTS AND MAIN RESULTS Creatinine concentrations at admission to the intensive care unit (T0), and 2-13 days (T1) and 2-12 weeks (T2) after initiation of fluid therapy were analyzed. Creatinine concentrations were analyzed as absolute values and as the maximum percentage change from T0 to T1 (T1max%) and from T0 to T2 (T2max%), respectively. Creatinine concentrations were available for 192 dogs during T1 and 37 dogs during T2. The median cumulative dose of HES was 86 mL/kg (range, 12-336 mL/kg). No difference was detected between the groups for age, gender, body weight, and length of hospitalization. Outcome was significantly different between the HES (66% survived) and the CRYS (87% survived) groups (P = 0.014). No significant difference was detected between groups for creatinine concentrations at T0, T1, T2, T1max%, or T2max%. No significant difference was detected between the groups for T1max% creatinine in dogs subclassified as having systemic inflammatory response syndrome or sepsis. CONCLUSIONS HES administration in this canine population did not result in increased creatinine concentrations compared to administration of CRYSs. Further studies are needed to establish the safety of HES in critically ill dogs.

A report from the National Hispanic Conference on Law Enforcement and Criminal Justice, July 28-30, 1980, Washington, D.C.

Item 968-H-1

Odometer tampering violations analysis: manual for administration of state odometer enforcement programs. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Better administration of capital grants could reduce unnecessary expenditures on mass transit projects. Report by the Comptroller General of the United States.

Mode of access: Internet.

State administration of bilingual education-- sí o no? : A report /

"Written by Ramona L. Godoy."

Affirmative action in Salt Lake's criminal justice agencies : a report /

Includes bibliographical references.

Medical Advisory Committee report and recommendations on the administration of the OASI disability freeze provision : preservation of rights of individuals with extended total disability, Social security amendments of l954.

"July 1955."

Rules and regulations governing the administration of the Federal water power act with text of the act and of amendments of March 3, 1921, and June 23, 1930.

Mode of access: Internet.

Revision of title 28, United States Code.

Mode of access: Internet.

Historical sketh of the naval administration of the government of American Samoa, April 17, 1900-July 1, 1951.

Mode of access: Internet.

Communist political propaganda and use of United States mails : hearing before the Subcommittee to Investigate the Administration of the Internal Security Act and Other Internal Security Laws of the Committee on the Judiciary, United States Senate.

Includes tables.

Uneconomical practices in the administration of employment service and unemployment compensation programs, Bureau of Employment Security, Department of Labor /

Mode of access: Internet.

Report of the Honorable James P. McGranery, Attorney General of the United States, to the Judicial Conference of the United States.

"September 22, 1952."