Social neuroendocrinology of competition

The relationship between testosterone concentrations and aggressive behaviour in studies of people has produced very inconsistent findings. However, one consistent fmding that has emerged is that competitive and aggressive interactions potentiate testosterone release in both human and non-human species. It has been argued that socially-induced alterations in testosterone concentrations may function to influence ongoing and/or future social behaviour. Nonetheless, few studies have empirically tested this hypothesis. The current series of experiments was designed to address the extent to which competitioninduced fluctuations in testosterone concentrations were associated with ongoing and/or subsequent social behaviour. In Study 1, men (n = 38) provided saliva samples prior to, and at the conclusion of, the Point Subtraction Aggression Paradigm (PSAP). Although baseline testosterone concentrations were not related to aggressive behaviour, there was a positive correlation between change in testosterone and aggressive behaviour such that men who were most aggressive on the PSAP demonstrated the largest increase in testosterone concentrations. Furthermore, a rise in testosterone during the PSAP predicted willingness to choose a subsequent competitive task. In Study 2, men and women provided saliva samples prior to and after competing against a same-sex opponent on the Number Tracing Task (NTT). The outcome of the competition was rigged such that half of the individuals won most of the races, while the other half lost most of the races, thus experimentally creating a winner and loser in the laboratory. Following the competitive interaction, men and women played the PSAP with their same-sex partner. Results indicated that men selected the aggressive response (but not reward or protection responses), more frequently than women. For men assigned to the loss condition, an increase in testosterone concentrations in response to the NTT predicted subsequent aggressive behaviour. For men assigned to the win condition, an increase in testosterone concentrations in response to the NTT predicted subsequent aggressive behaviour, but only among those men who scored high on trait dominance. Change in testosterone and trait dominance did not predict aggressive behaviour in women. In Study 3, men provided saliva samples prior to, during, and at the end of the PSAP. They were randomly assigned to one of four experimental conditions that differed in the extent to which they were provoked and whether they received reward for behaving aggressively (i.e., stealing points). Results indicated that baseline testosterone concentrations did not correlate with aggression in any of the experimental conditions. Consistent with Study 1, there was a positive correlation between change in testosterone and aggressive behaviour among men who were provoked, but did not receive reward for aggression (i.e., reactive condition). Men who were provoked but did not receive reward for aggression enjoyed the task the most and were more likely to choose the competitive versus non-competitive task relative to men assigned to the other experimental conditions. Also, individual differences in aggressive behaviour among these men were positively correlated with the extent to which they enjoyed the task. Together, these studies indicate that testosterone dynamics within the context of competition influence subsequent competitive and aggressive behaviours in humans and that testosterone may be a marker of the intrinsically rewarding nature of costly aggressive behaviour.

Niagara-Welland Power Company Limited fonds, 1833, 1852, 1904-1906, 1909, n.d.

The Welland Power and Supply Canal Company Limited, established in 1893 and incorporated in 1894 with a capital stock of $500,000. The aim of the company was to harness the natural water supply of the Niagara and Welland Rivers. In 1898 the Canadian Electrical News published a report by Henry Symons, QC outlining the main project of the company. This project involves the construction of a canal from the Welland River to the brow of the mountain at Thorold, a distance of 8 miles; the construction at Thorold of a power house, and from Thorold to Lake Ontario, a raceway by which to carry water into the lake. The estimate for the machinery to generate 100,000 horse power is £125,000; for transmission line to Toronto at a voltage of 10,000….The total estimate therefore amounts to £2,452,162, or roughly speaking, $12,000,000. Source: Canadian Electrical News, August 1898, p. 172. In 1899 the company officers petitioned the federal government desiring a name change to the Niagara-Welland Power Company Limited. Officers of the company were Harry Symons, President; Charles A. Hesson, Vice-President; and M.R. O’Loughlin, James B. Sheehan, James S. Haydon, Frederick K. Foster, directors; John S. Campbell, secretary-treasurer. The company’s head offices were located in St. Catharines, with a New York (City) office on Broad Street. In 1905 and 1909 the company petitioned the federal government for additional time to construct its works, which was granted. The company had until May 16, 1915 to complete construction. John S. Campbell (1860-1950) was a graduate of the University of Toronto and Osgoode Hall. During his university years John began his military career first in "K" Company, Queens Own rifles and then later as Commanding Officer of the 19th Lincoln Regiment, from 1906 to 1910. Upon his return to St. Catharines John Campbell served as secretary in the St. Catharines Garrison Club, a social club for military men begun in 1899. After being called to the Bar, he became a partner in the firm of Campbell and McCarron and was appointed to the bench in 1916, serving until retirement in 1934. Judge Campbell served as an alderman for several terms and was the mayor of St. Catharines in 1908 and 1909. He also served as the first chairman of the St. Catharines Public Utilities in 1914. John S. Campbell was married to Elizabeth Oille, daughter of Jerome B. and Charlotte (St. John) Oille. The family home "Cruachan" was located at 32 Church St.

Manuscript of James Cummings- August 28, 1860

Transcript (spelling and grammar retained): Chippawa [Chippewa] 28th August 1860 My Dear Sir I duly received your very kind letter of the 24th [June] asking me to communicate such facts of general interest connected with my career during the War with the United States. I have no objection to afford you such information as came under my own observation; nevertheless I do so, with the understanding, I have no desire to be my own trumpeter. With respect to your circular wherein you state you have been for several years collecting materials for a History of the late War between the United States & Great Britain, for which you are now gathering further materials to add to your collection, concerning the Second War for Independence. I am rather at a loss to know, what is meant by the second war; If you allude to the petty Rebellion, it could not be called a War, Those that caused the outbreak were very soon put down, by the Loyal people of the Province without the aid of Regular Troops being satisfied with the Independence they enjoyed. With respect to the several questions names in your circular: To the 1st I would say, this locality is made memorable by the battle of Chippawa [Chippewa] which took place about a mile above the village on the ground I pointed out to you, when I had the pleasure of seeing you a few days ago, with Mr Porter of the Niagara Falls, of which I believe you took sketches at the time. 2nd I have no historical documents of any value; so many years having gone past, the most of my old papers have either been lost or destroyed, I however came across two letters, one dated Queenston 9th July 1812 from Lt. Col. Nicholl Quarter Master General of Militia, the other from Lt. Col Myers Deputy Quarter Master General of the Regular Army date Fort George 23rd same month, directed to me in the hand writing of each of those officers as Deputy Quarter Master General of Militia, which letters I shall be obliged you would return at as early a day possible, as I wish to place them with tome others in the case, I have had made to hold the cocked hat & feather I wore during that eventful period, which I am sorry I did not exhibit when you was at my house; with reference to it I now enclose a letter from Lt. Col. Clark, residing at Port Dalhousie he was Captain & Adjutant of Militia in the War of 1812__ I send the letter in proof of the cock’d hat it is a lengthy one, but you may find time to turn over it, as I shall also place it in the hat case__ 3rd Where are [but] [for] traditionary [sic] witnesses residing in this vicinity – Col Clark above named Mr Merritt of St. Catharines, & Mr Kerby of Brantford are the only ones I now recollect, who could offord [sic] you any statistical information. 4th I have no pictorial sketches of any Military Movements or fortifications. As regards my own career, which you appear [ ? ] of knowing__ I was first a Lieutenant in a volunteer flank company stationed on the river side opposite [Navy] Island not far from the battle ground of Chippawa [Chippewa], I got promotion as Lieutenant of Cavalry before I got my Cavalry dress completed in three days more, I was called by General Brock to Fort George, was appointed Deputy Quarter Master General of Militia with the rank of Captain s the accompanying letters will show. I was at the battle of Stony Creek, several skirmishes at the Cross Roads, when the American army [ ? ] Fort George, at the taking of Col. Boerstler at the Beaver Dam, & had the honor of receiving Colonel Chapens sword at the surrender, who commanded a company of volunteer Horse Men was at the taking of 15 regulars & two officers at Fort Schlosser—was with Col. Bishop at the taking of Black Rock, near him when he fell, three men of the 8th Reg. more killed in the Boat I was in – I was at Chippawa battle, and the last, not the least in Lundy’s lane battle, which the Americans call the battle of Bridge [Waters]. I had forgot; there was another small affair at Corks Mill where I was. I could write a little history of events, but have not the time to do so. If what I have stated will be of any service for the purpose you require I shall feel happy. The history of the late War was published at Toronto in the Anglo American Magazine. Did you ever see it, I have the Books, there were however several errors which came under my notice, which I could have corrected. If my time would permit I could give you a more detailed statement of events. I trust however you may succeed with your publication , and I shall be most happy to hear from you at all times—I related many little occurances verbally to you when here, which I thought not necessary to repeat again as you would have a perfect recollection of them. Be pleased to return the letters for the purpose I require them. I am My Dear Sir Your respectful friend James Cummings

Photograph - Unidentified Male in Uniform

A photograph of a male in uniform standing in front of a horse. In background are tents and trees.

General regulations and orders, 1804

Bound with: The manual and platoon exercises, &c., &c. (51 p.) and: General orders and observations on the movement and field exercise of infantry (16 p.) Inscribed on front paste-down: L. Colonel Brock. Also inscribed: Maj. Genl T.A. Smith late of the 1st. Rifle Regt. Bookplate of Robert B. Taylor, Norfolk. On front flyleaf: lengthy, two-page transcription in ink, headed /Copy/Circular/ dated "Horse Guards, 25th May '07" and signed: "Harry Calvert Adjt. General.

General regulations and orders, 1804

Bound with: The manual and platoon exercises, &c., &c. (51 p.) and: General orders and observations on the movement and field exercise of infantry (16 p.) Inscribed on front paste-down: L. Colonel Brock. Also inscribed: Maj. Genl T.A. Smith late of the 1st. Rifle Regt. Bookplate of Robert B. Taylor, Norfolk. On front flyleaf: lengthy, two-page transcription in ink, headed /Copy/Circular/ dated "Horse Guards, 25th May '07" and signed: "Harry Calvert Adjt. General.

Photograph - Colin Campbell and Helen Stanley Smith with Judge Campbell, 1910.

A photograph of Colin Campbell and Helen Stanley Smith sitting in a horse buggy in front of the Campbell home. Judge Campbell is saddled on a horse behind the buggy. There are two other unidentified females sitting on the porch of the Campbell home on Church Street.

Dorothy Rungeling fonds, 1887-2013, n.d.

Dorothy Rungeling was born in 1911 and raised in Fenwick, Ontario, by her adopted mother, Ethelwyn Wetherald. After graduating high school, she attended Fort Erie business College. She worked briefly in Toronto and then Hamilton, but eventually took a job with Brown Brothers’ Nursery in Pelham to be closer to home. Dorothy pursued many interests, learning to play the violin, saxophone and clarinet. She met her husband Charles at a local dance where she was playing. In 1939, they opened an automobile and farm machinery business in Welland. In their spare time, they were active in skeet and trap shooting, for which Dorothy won many trophies. In the early 1940s, Dorothy developed a passion for horses, training and showing them in addition to teaching riding at the Welland Riding Club, as well as judging at horse shows. By the late 1940s her interest in horses was waning, but she soon after discovered and pursued a new interest: flying. She joined the Welland Flying Club, obtained a flying licence, and in 1949 purchased her first plane. She proceeded to obtain a Commercial Pilot Licence in 1951, an Instructor’s Licence in 1953, and a Senior Commercial Licence in 1954. She participated in many air races in the 1950s, including the All Women’s International Air Races, the Women’s Transcontinental Air Races, and the Canadian Governor-General’s Cup Air Race. Some of the most notable races were the 1954 International Air Race, where Dorothy met with President Batista of Cuba, and the Governor-General’s Cup Air Race, where she won 1st place in 1953 and 1956 (and was the only woman competing). In 1958, she was also the first Canadian woman to solo pilot a helicopter. That same year she obtained her Airline Transport Licence. She also wrote several articles on aviation, contributing to publications such as Canadian Aviation and Air Facts, a U.S. aviation magazine. In addition to these articles, Dorothy authored several books about her life, as well as a selection of poems and articles by Ethelwyn Wetherald. As planes became more expensive, Dorothy spent less time flying, instead pursuing an interest in sailing. She and her husband bought a sailboat and became members of the Niagara-on-the-Lake Sailing Club. In 2003, Dorothy was awarded the Order of Canada for her accomplishments. She also wrote a regular column for the Voice of Pelham in 2012-2013, called A Century in Pelham. Dorothy celebrated her 100th birthday in 2011, and remains an active member of the community.

Horsemanship Notes

Notes or an essay from Dorothy Rungeling's time in horsemanship classes in the 1940s. The notes/essay is three pages in length and is focused on the "head and neck" of a horse. She mentions the "schooling" of a horse, much like people. The horse must be taught the way to use his head and neck in the judging ring. She focuses on the horses use of it's neck and head for balance much like we use our arms, for example, "Did you ever try walking the rails on a railroad track or try walking on any narrow board? You would automatically put your arms out if you felt unbalanced. Your arms would be your balancer and the horse's head and neck are his".

The Rapids, Niagara

The description of the image reads "No. 115 - The Rapids, Niagara - From the Terrapin Tower". On the reverse it reads "The Rapids, Niagara, From the Terrapin Tower (taken instantaneously). From this commanding point of view the rapids are seen to great perfection - the Tower standing just on the edge of the Horse-shoe Fall. Some idea of the rapidity with which these waters hurry onward to the mighty abyss may be formed from the fact that the river descends nearly fifty-one feet in a distance of three-quarters of a mile. Gathering force as they approach nearer the edge of the Falls, they dash and foam amid the rocks which speck their surface, and with torturous writhes dash onward with a fury grand and beautiful in the extreme. Whole flocks of water-fowl have often been seen going to destruction among these rapids. Pleased with being carried by the stream, they have indulged in the pleasure till the rapidity of the current has rendered it impossible for them to rise and thus have they been carried down and washed over the Fall. At one time during the months of September and October, sufficient quantities of dead water-fowl have been found every morning below the Fall to afford ample subsistence for the garrison at the fort. The bodies of bears, deer, and other animals have also been found."

Receipt to Samuel Woodruff from Wynn Hubbuck

Receipt to Samuel Woodruff from Wynn Hubbuck for horse and buggy, Nov. 1, 1845.

Warrant that a complaint was presented to Edmund Riselay, Justice of the Peace in Bertie by Henry Nelles, Justice of the Peace in Niagara against William Wintermute and Benjamin Wright of Bertie by Joseph Lindeberry of Clinton

Warrant (1 page, handwritten copy) that a complaint was presented to Edmund Riselay, Justice of the Peace in Bertie by Henry Nelles, Justice of the Peace in Niagara against William Wintermute and Benjamin Wright of Bertie by Joseph Lindeberry of Clinton regarding the suspicion of Wintermute and Wright stealing wheat from the Lindeberry barn. Benjamin Wright seemed the guiltier of the two and therefore it is requested that he be brought before a Justice of the Peace to be examined. This document is stained, but this does not affect the text, April 4, 1837.

Letter to H.H. Collier of Houston, Texas from J. M. Long and delivered by Captain Daniels

Letter to H.H. Collier of Houston, Texas from J. M. Long and delivered by Captain Daniels. This is a friendly letter in which he mentions that General Edward Burleson has gone on an Indian campaign. Also mentioned are the Indian raid in Austin, the stealing of horses and candidates for the election. He also talks about a ball in Austin. This is actually quite a poetic letter in his description of how Austin used to be and what Austin has become (3 pages, handwritten), Aug. 26, 1842.

Thérapie par les cellules souches mésenchymateuses dans la guérison tendineuse chez le cheval

Les tendinites sont des lésions communes chez le cheval athlète, ayant un impact financier et sportif considérable. Les cellules souches mésenchymateuses (CSMs) de moelle osseuse (MO) sont empiriquement utilisées en clinique pour améliorer la guérison des affections myoarthrosquelettiques. Cependant, il est nécessaire de standardiser les protocoles d’isolement des CSMs équines et d’analyser leurs effets sur la guérison tendineuse pour ajuster leur dose. Les objectifs de cette étude étaient de comparer 3 méthodes d’isolement des CSMs équines et d’établir un modèle de guérison tendineuse minimal invasif pour analyser l’effet des CSMs sur cette guérison. Des CSMs de MO du sternum de juments étaient isolées par 3 protocoles couramment utilisés (adhérence au pétri (Classique) et 2 méthodes par gradient de densité (Percoll et Ficoll)). La viabilité des cellules après isolement, le rendement d’isolement, le nombre de CSMs obtenues après 14 jours de culture et leurs caractéristiques fonctionnelles (renouvellement et différentiation) étaient comparés entre les 3 protocoles. Les résultats suggéraient que le Percoll était le meilleur protocole en termes de rendement et de capacité de renouvellement des cellules. La différence n’était pas significative pour leur viabilité et leur capacité de différentiation. Un modèle de guérison tendineuse, consistant en une ténectomie du tendon extenseur latéral du doigt fut ensuite développé. Cependant, la grande variabilité interindividuelle de qualité de guérison dans le groupe pilote implique une ré-évaluation du modèle. Des études futures, avec des CSMs isolées par le Percoll dans de nouveaux modèles de guérison tendineuse devraient permettre de déterminer la dose adéquate de CSMs.

Caractérisation de l’ADNc et de l’ADN génomique codant l’intégrine plaquettaire αIIb‐β3 chez un cheval atteint de Thrombasthénie de Glanzmann

La thrombasthénie de Glanzmann (TG) est une maladie caractérisée par un défaut d’agrégation plaquettaire. C’est une maladie génétique autosomale récessive causée par une anomalie du récepteur plaquettaire pour le fibrinogène. Ce récepteur est une intégrine localisée à la surface plasmatique qui est formée par un complexe composé des sous‐unités αIIb et β3. Nous avons identifié un cheval démontrant les caractéristiques clinicopathologiques de la TG. Des études par cytométrie de flux ont révélé une déficience au niveau de la portion αIIb du récepteur. Ces résultats suggèrent une ou plusieurs mutations au niveau du gène codant pour cette portion αIIb du récepteur. L’objectif de notre étude était de caractériser l’ADNc et l’ADN génomique codant pour les gènes ITGA2B et ITGB3 codant respectivement pour les deux sous‐unités αIIb et β3 chez un cheval atteint de la TG. L’ADNc a été synthétisé par RT‐PCR en utilisant l’ARN total récolté à partir des plaquettes. L’ADN génomique a été extrait à partir des globules blancs. Des amorces spécifiques ont été utilisées pour l’amplification par PCR d’ITGA2B et d’ITGB3. Les séquences d’ADNc et d’ADN génomique de notre patient ont été caractérisées par séquençage et comparées par l’analyse BLAST (GenBank). Une substitution d’une guanine par une cytosine a été mise en évidence au niveau de l’exon 2 d’ITGA2B amenant à la substitution d’une arginine (Arg72) par une proline (Pro72). Ce changement d’acide aminé pourrait résulter en une conformation structurelle anormale qui amènerait à une sous‐unité αIIb inactive. L’analyse de l’ADN génomique a démontré que ce cheval était homozygote pour cette mutation. Le séquençage de l’ADN génomique des parents et de la grand‐mère du patient a démontré que ces individus étaient hétérozygotes pour cette mutation. Le séquençage d’ITGB3 n’a démontré aucune anomalie.