Efeito do treinamento físico na qualidade de vida, capacidade funcional e fatores de risco cardiovascular nos portadores de doença renal crônica em tratamento conservador

Pós-graduação em Fisiopatologia em Clínica Médica - FMB

Cor triatriatum sinister e hipertensão arterial pulmonar secundária em cão

This paper describes the occurrence of cor triatriatum sinister, a rare cardiac malformation in dogs, associated with pulmonary edema and pulmonary hypertension in a 5-year-old Poodle female with history of acute dyspnea and cyanosis. The animal presented acute respiratory failure, heart failure with low cardiac output, progressing to acute tubular necrosis and death. The diagnosis was made posmortem due to the clinical instability of the dog. This malformation was diagnosed by the subdivision of the left atrium into two compartments separated by an abnormal fibromuscular membrane, absence of structural abnormalities of the mitral valve and thickening of pulmonary artery tunica media associated with renal tubular degeneration. The occurrence of cor triatriatum in dogs is most common in the right atrium, defined as cor triatriatum dexter. Additionally, pulmonary arterial hypertension associated with this malformation is described only in humans with this heart defect.

Agregação de fatores de risco cardiovascular e ocorrência de hipertensão arterial em adultos sedentários

OBJETIVO: Analisar em uma grande amostra de adultos sedentários a possível associação entre hipertensão arterial e baixa aptidão cardiorrespiratória, obesidade geral e central. MÉTODOS: A amostra foi composta por 1.092 adultos sedentários brasileiros (429 homens e 633 mulheres). Pressão arterial foi acessada e hipertensão arterial diagnosticada. Três fatores de risco cardiovascular foram considerados: obesidade geral (índice de massa corporal), obesidade abdominal (circunferência de cintura) e baixa aptidão cardiorrespiratória (teste submáximo em cicloergômetro). RESULTADOS: A taxa de hipertensão arterial foi de 9,3% (IC95% = 7,6 - 11,2). Houve associação entre mais alta prevalência de hipertensão arterial e diagnóstico de obesidade (p = 0,001), valores elevados de circunferência de cintura (p = 0,001) e baixo VO2máx (p = 0,013). Independentemente de idade e sexo, indivíduos sedentários com simultaneamente baixo consumo máximo de oxigênio e obesidade geral (RP = 5,21 [IC95% = 8,94 - 3,03]; p = 0,001) ou abdominal (RP = 4,05 [IC95% = 2,22 - 7,40]; p = 0,001) apresentaram maior probabilidade de ser hipertenso que os sedentários com nenhum fator de risco. CONCLUSÃO: Adultos sedentários, independentemente de sexo e idade, a presença de baixa aptidão cardiorrespiratória está associada à hipertensão arterial apenas quando também há obesidade geral ou abdominal, indicando que a interação destas variáveis tem relevante peso na gênese da doença.

Hipertensão arterial e cuidados com a saúde: concepções de homens e mulheres

Pós-graduação em Psicologia do Desenvolvimento e Aprendizagem - FC

Função cognitiva e qualidade de vida de pacientes com doença renal crônica nos estadios III e IV

Pós-graduação em Saúde Coletiva - FMB

Relação entre toxicidade urêmica, anemia e perda auditiva neurossensorial em indivíduos com doença renal crônica: um estudo prospectivo

Pós-graduação em Bases Gerais da Cirurgia - FMB

Efeito da aldosterona e da espironolactona na hipertrofia ventricular esquerda em pacientes com doença renal crônica em hemodiálise

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Entendendo a pressão arterial

Este trabalho teve o objetivo elaborar e produzir uma cartilha informativa com noções fisiológicas básicas envolvidas no controle da pressão arterial, bem como a descrição da hipertensão e prevenção destinadas a alunos a partir do Ensino Médio, pois além da hipertensão arterial ser uma doença crônica que se caracteriza pela elevação da pressão arterial sistêmica persistente e compor um dos fatores de risco cardiovasculares mais importantes e comuns, apresentando altos índices de morbidade e mortalidade em todos os grupos populacionais, o conceito de pressão arterial e a importância da manutenção dos níveis pressóricos normais devem ser difundidos, a fim de auxiliar no autocuidado com a saúde. Para a formulação adequada da cartilha realizou - se um estudo prévio com 60 alunos de Ensino Médio de uma escola municipal de Botucatu, e através de um questionário avaliamos quantitativamente e qualitativamente por análise de conteúdo: vocabulário, conceitos, interesse sobre pressão arterial e temas interligados. Os dados gerados na análise de conteúdo propiciaram a formulação da cartilha

Análise de dez anos de utilização de serviços de saúde por uma coorte de pacientes diagnosticados com hipertensão arterial, no CSE - Botucatu, em 1995

The arterial hypertension is a chronic disease, which can be controlled by changing the way of life, as well as by drug treatment, which demand specific Health Care sequence. The lack of adherence to sequence/treatment is one of the main obstacles the disease control. Characterize and analyze the profile of Health Care usage by a 192 patient cohort diagnosed with arterial hypertension in 1995, between the period of 2001 – 2005 and 2006 – 2010. It is a longitudinal study, retrospective and descriptive developed on School Health Center(SHC) which belongs to School of Medicine Botucatu –UNESP, in continuity of the previous research which has analyzed the sequence of the referred sample between the period of 1995 – 1999. The database was obtained from the patients records by using structured adapted forms appointed in the previous study phase. In the case there were transfers to other Health Care facilities, the database was obtained by the records either, while the patients attended the CSE. The database was analyzed by means of descriptive statistics. Predominated the patients in the age from 50 – 69 (47,9%), whites (93,2%), female (56,7%) with low level of education (72,7%). In the period of 2001 - 2005, 76 (39,5%) of the patients remained under sequence, and that 44 (22,9%) belonged to adherence group (GAD), 17 belonged to abandonment/adherent group (GAB/GAD) and 15 to the abandonment group (GAB), groups which were already identified by the study which has analyzed the period of 1995 – 1999. At the end of the third period of the sample sequence (2006 – 2010), 60 (31,2%) of the patients kept under medical sequence. The cohort’s mortality rate in the period reached 15,1% and 21,9% were transferred to other Municipal Health Care facilities. We conclude that the Health Care service usage by the 192 sample’s integrants kept the same model already identified in the previous analysis... (Complete abstract click electronic access below)

Pressão arterial em cães: uma revisão

The evaluation of blood pressure is an essential tool for veterinarian clinical practice and for monitoring anesthetized patients or patients in intensive care, because of its usefulness in diagnostics, treatment and monitoring of several diseases. Apart from the pathological factor, the blood pressure also suffers the influence of different variables, such as age, breed, gender, temperament (anxiety and stress especially during the treatment, “white coat syndrome”), disease state, physical activity and, with lower intensity, animal’s diet. One of the main indications of the evaluation of blood pressure is the observation of clinical changes resulting from hypertension in animals, which one is characterized by lesions in the nervous and cardiovascular systems, kidneys and eyes. Not least important, the evaluation of blood pressure is also essential in hypotensive states, which represent an imminent risk of death. The techniques used in measuring blood pressure correspond to invasive forms (direct) or non invasive (indirect), whose correlation has been the subject of study and improvement within the small animal clinic. Thus, the purpose of this review is emphasize the importance of measuring blood pressure within the veterinary clinic routine, studying the influence of variables associated or not with elevated blood pressure, comparing the different methods used to obtain the blood pressure

Efeitos da redução da concentração de sódio na solução de hemodiálise e no conteúdo de sódio da dieta sobre a resposta inflamatória de pacientes com doença renal crônica

Pós-graduação em Fisiopatologia em Clínica Médica - FMB

Rastreamento e detecção precose de doença aterosclerítica em pacientes com HIV positivo

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Avalição ecocardiográfica do ventrículo direito e da pressão arterial pulmonar em portadoresde hipertireoidismo

Pós-graduação em Fisiopatologia em Clínica Médica - FMB

Efeitos de drogas antiplaquetárias na doença periodontal

The association between platelets, angiogenesis and progression or repair of periodontal disease has been little explored and, consequently, the results are inconclusive. The pathogenic bacteria present in the periodontal pocket release endotoxins that affect the endothelial integrity and are able to induce the production of chemical mediators derived from plasma proteins and blood clotting while altering platelet function. There is great interest in the modulation of platelet activity in vascular disorders, especially cardiovascular diseases. For this reason, antiplatelet drugs, that are commonly used in the prevention of thromboembolic diseases, such as myocardial infarction, ischemic stroke and peripheral arterial disease, have been used. Aspirin is the only non-steroidal antiinflammatory agent with antiplatelet activity. In the periodontium, instead of only reduces levels of inflammatory cytokines, also significantly affects bleeding on probing, suggesting a dose-dependent modulation of periodontitis. In contrast, clopidogrel and ticlopidine are thienopyridine drugs with no known antiinflammatory action, suggesting that this benefit is related to an antiinflammatory effect indirectly correlated to their antiplatelet activity already established. In the literature there is limited information about the effect of these drugs on periodontium and periodontal disease development. Antiplatelet drugs hypothetically can change both the pathogenesis of periodontitis and subsequent periodontal tissue repair by blocking the secretion of chemical mediators which in general are important in modulating inflammation and tissue repair.

Participação do óxido nítrico na fisiopatologia da doença renal crônica

Nitric oxide (NO) is a free radical gas, inorganic, which has seven electrons of nitrogen and oxygen eight, possessing an unpaired electron. This radical is produced from L-arginine by a reaction mediated by the enzyme NO synthase. NO it is about a radical of who acts abundant on a variety of biological processes, particularly when produced by endothelial cells plays a significant role in cardiovascular control, as a modulator of peripheral vascular resistance and platelet aggregation. This free radical has also a neurotransmitter and mediator of the immune system. NO kidney function has been considered in many physiological functions such as: (a) regulation of hemodynamics and glomerular function tubuloglomerular, (b) participation in pressure natriuresis (c) maintaining medullar perfusion (d) inhibiting sodium reabsorption tubular, and (e) acting as a modulator of the activity of the sympathetic nervous system. Given these functions, the occurrence of its deficiency is associated with chronic kidney disease (CKD) in vasoconstriction and consequently glomerular hypertension, high blood pressure (HBP), proteinuria and progression of renal dysfunction. This work has the scope to describe the role of NO in renal physiology and pathophysiology of CKD.