Review of the C-nat(n,gamma) cross section and criticality calculations of the graphite moderated reactor BR1

A review of the experimental data for natC(n,c) and 12C(n,c) was made to identify the origin of the natC capture cross sections included in evaluated data libraries and to clarify differences observed in neutronic calculations for graphite moderated reactors using different libraries. The performance of the JEFF-3.1.2 and ENDF/B-VII.1 libraries was verified by comparing results of criticality calculations with experimental results obtained for the BR1 reactor. This reactor is an air-cooled reactor with graphite as moderator and is located at the Belgian Nuclear Research Centre SCK-CEN in Mol (Belgium). The results of this study confirm conclusions drawn from neutronic calculations of the High Temperature Engineering Test Reactor (HTTR) in Japan. Furthermore, both BR1 and HTTR calculations support the capture cross section of 12C at thermal energy which is recommended by Firestone and Révay. Additional criticality calculations were carried out in order to illustrate that the natC thermal capture cross section is important for systems with a large amount of graphite. The present study shows that only the evaluation carried out for JENDL-4.0 reflects the current status of the experimental data.

Advanced Control for Very Fast DC-DC Converters Based on Hysteresis of the C-out Current

The bandwidth achievable by using voltage mode control or current mode control in switch-mode power supply is limited by the switching frequency. Fast transient response requires high switching frequency, although lower switching frequencies could be more suitable for higher efficiency. This paper proposes the use of hysteretic control of the output capacitor $(C_{out})$ current to improve the dynamic response of the buck converter. An external voltage loop is required to accurately regulate the output voltage. The design of the hysteretic loop and the voltage loop are presented. Besides, it is presented a non-invasive current sensor that allows measuring the current in the capacitor. This strategy has been applied for DVS (dynamic voltage scaling) on a 5 MHz buck converter. Experimental results validate the proposed control technique and show fast transient response from 1.5 V to 2.5 V in 2 $mu{rm s}$.

L. C. Sylla [Material gráfico]

Resumen: Descripción: retrato de busto de Sylla basado en una escultura

Estudio del crecimiento de gallinas ponedoras de 18 hasta 60 semanas de edad criadas en jaulas enriquecidas sometidas a diferentes intensidades de iluminación. 1. Curva de crecimiento

El objetivo del estudio fue comparar el peso corporal adulto de gallinas ponedoras alojadas en jaulas enriquecidas y sometidas a diferentes intensidades de iluminación de acuerdo con el esquema factorial 2x3: iluminación del pasillo (lateral y central) versus iluminación del piso (bajo, intermedio y alto) , evaluado en el periodo de 18 hasta 60 se manas de edad de acuerdo con el modelo no lineal de Gompertz. Las gallinas fueron alojadas en dos baterías de 3 pisos, con dos filas por piso y cinco jaulas por fila (25 aves/jaula), con un total de 1.500 gallinas. Dichas jaulas cumplen la Directiva CE 199 9/74. Se pesaron 10 gallinas de cada jaula, identificadas con anillas de color diferente, a la edad de 18, 20, 24, 28, 32, 36, 44, 52 y 60 semanas. Para el ajuste de los parámetros B y C del modelo de Gompertz se utilizó el peso medio de las pollitas hasta la 17 a semana edad, pues tuvimos como objetivo mantener dichos parámetros B y C de la curva de Gompertz para todos los tratamientos, ya que el fin del estudio fue evaluar la influencia de la intensidad luminosa en el peso adulto de las gallinas, es decir, el crecimiento después del punto de inflexión de la curva.

C. Marius [Material gráfico]

Resumen: Descripción: retrato de busto de C. Mario basado en una escultura

Evidence for a recommended dietary allowance for vitamin C from pharmacokinetics: A comment and analysis

The current recommended dietary allowance (RDA) for vitamin C, as proposed by the Food and Nutrition Board/National Research Council in 1980 and reconfirmed in 1989, is 60 mg daily for nonsmoking adult males. Levine et al. [Levine, M., Conry-Cantilena, C., Wang, Y., Welch, R. W., Washko, P. W., et al. (1996) Proc. Natl. Acad. Sci. USA 93, 3704–3709], based on a study of vitamin C pharmacokinetics in seven healthy men, have now proposed that the RDA should be increased to 200 mg daily. I have examined, in brief, the experimental and conceptual bases for this new recommendation and its implications for public health and nutrition policy and programs. Using, for illustrative purposes only, data extracted from each of two recent dietary surveys of noninstitutionalized adult males living in households in the Netherlands and the United States, it is predicted that the prevalence of intakes inadequate to meet the individual’s own requirement would be about 96% or 84%, respectively, if the criteria of adequacy used for derivation of the 200 mg RDA are accepted. Depending upon the particular average requirement value for ascorbic acid that might be derived from their data, the proposal by Levine et al. would mean a desirable increase in mean intakes in these two populations by as much about 2- to 3-fold. Hence, before an action of this kind is to be recommended, an answer must be sought to the question whether current experimental data including the criteria selected (saturation kinetics) are adequate to establish a new set of requirements for vitamin C, which then carry such profound policy implications. This will require critical assessment of all of the available evidence emerging from laboratory, clinical, and epidemiological studies to determine whether it provides a sufficient rationale for accepting criteria of vitamin C adequacy such as those proposed by Levine et al. and the requirement estimates so derived.

Direitos fundamentais e o depositário infiel : evolução jurisprudencial / Eduardo Biacchi Gomes e Paulo C. Coen. --

Inclui bibliografia.

Regulation of sorting and post-Golgi trafficking of rhodopsin by its C-terminal sequence QVS(A)PA

Several mutations that cause severe forms of the human disease autosomal dominant retinitis pigmentosa cluster in the C-terminal region of rhodopsin. Recent studies have implicated the C-terminal domain of rhodopsin in its trafficking on specialized post-Golgi membranes to the rod outer segment of the photoreceptor cell. Here we used synthetic peptides as competitive inhibitors of rhodopsin trafficking in the frog retinal cell-free system to delineate the potential regulatory sequence within the C terminus of rhodopsin and model the effects of severe retinitis pigmentosa alleles on rhodopsin sorting. The rhodopsin C-terminal sequence QVS(A)PA is highly conserved among different species. Peptides that correspond to the C terminus of bovine (amino acids 324–348) and frog (amino acids 330–354) rhodopsin inhibited post-Golgi trafficking by 50% and 60%, respectively, and arrested newly synthesized rhodopsin in the trans-Golgi network. Peptides corresponding to the cytoplasmic loops of rhodopsin and other control peptides had no effect. When three naturally occurring mutations: Q344ter (lacking the last five amino acids QVAPA), V345M, and P347S were introduced into the frog C-terminal peptide, the inhibitory activity of the peptides was no longer detectable. These observations suggest that the amino acids QVS(A)PA comprise a signal that is recognized by specific factors in the trans-Golgi network. A lack of recognition of this sequence, because of mutations in the last five amino acids causing autosomal dominant retinitis pigmentosa, most likely results in abnormal post-Golgi membrane formation and in an aberrant subcellular localization of rhodopsin.

Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance.

Determinants of the recommended dietary allowance (RDA) for vitamin C include the relationship between vitamin C dose and steady-state plasma concentration, bioavailability, urinary excretion, cell concentration, and potential adverse effects. Because current data are inadequate, an in-hospital depletion-repletion study was conducted. Seven healthy volunteers were hospitalized for 4-6 months and consumed a diet containing <5 mg of vitamin C daily. Steady-state plasma and tissue concentrations were determined at seven daily doses of vitamin C from 30 to 2500 mg. Vitamin C steady-state plasma concentrations as a function of dose displayed sigmoid kinetics. The steep portion of the curve occurred between the 30- and 100-mg daily dose, the current RDA of 60 mg daily was on the lower third of the curve, the first dose beyond the sigmoid portion of the curve was 200 mg daily, and complete plasma saturation occurred at 1000 mg daily. Neutrophils, monocytes, and lymphocytes saturated at 100 mg daily and contained concentrations at least 14-fold higher than plasma. Bioavailability was complete for 200 mg of vitamin C as a single dose. No vitamin C was excreted in urine of six of seven volunteers until the 100-mg dose. At single doses of 500 mg and higher, bioavailability declined and the absorbed amount was excreted. Oxalate and urate excretion were elevated at 1000 mg of vitamin C daily compared to lower doses. Based on these data and Institute of Medicine criteria, the current RDA of 60 mg daily should be increased to 200 mg daily, which can be obtained from fruits and vegetables. Safe doses of vitamin C are less than 1000 mg daily, and vitamin C daily doses above 400 mg have no evident value.

Washington, D.C., 1884 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Topographical map of the District of Columbia and a portion of Virginia, compiled under the direction of Major G.J. Lydecker, Corps of Engineers, Engineer Commissioner D.C., by Captain F.V. Greene, Corps of Engineers ; drawn by W.T.O. Bruff. It was published in 1884. Scale [1:15,840]. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Maryland State Plane Coordinate System Meters NAD83 (Fipszone 1900). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, railroads, drainage, selected public buildings, selected private residences and names of landowners, built-up areas, parks, and more. Relief shown by contours. Depths shown by soundings. Includes source materials note. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.