The current status of anticoagulant resistance in rats and mice in the UK

Introduction: Resistance to anticoagulants in Norway rats (Rattus norvegicus) and house mice (Mus domesticus) has been studied in the UK since the early 1960s. In no other country in the world is our understanding of resistance phenomena so extensive and profound. Almost every aspect of resistance in the key rodent target species has been examined in laboratory and field trials and results obtained by independent researchers have been published. It is the principal purpose of this document to present a short synopsis of this information. More recently, however, the development of genetical techniques has provided a definitive means of detection of resistant genotypes among pest rodent populations. Preliminary information from a number of such surveys will also be presented. Resistance in Norway rats: A total of nine different anticoagulant resistance mutations (single nucleotide polymorphisms or SNPs) are found among Norway rats in the UK. In no other country worldwide are present so many different forms of Norway rat resistance. Among these nine SNPs, five are known to confer on rats that carry them a significant degree of resistance to anticoagulant rodenticides. These mutations are: L128Q, Y139S, L120Q, Y139C and Y139F. The latter three mutations confer, to varying degrees, practical resistance to bromadiolone and difenacoum, the two second-generation anticoagulants in predominant use in the UK. It is the recommendation of RRAG that bromadiolone and difenacoum should not be used against rats carrying the L120Q, Y139C and Y139F mutations because this will promote the spread of resistance and jeopardise the long-term efficacy of anticoagulants. Brodifacoum, flocoumafen and difethialone are effective against these three genotypes but cannot presently be used because of the regulatory restriction that they can only be applied against rats that are living and feeding predominantly indoors. Our understanding of the geographical distribution of Norway rat resistance in incomplete but is rapidly increasing. In particular, the mapping of the focus of L120Q Norway rat resistance in central-southern England by DNA sequencing is well advanced. We now know that rats carrying this resistance mutation are present across a large part of the counties of Hampshire, Berkshire and Wiltshire, and the resistance spreads into Avon, Oxfordshire and Surrey. It is also found, perhaps as outlier foci, in south-west Scotland and East Sussex. L120Q is currently the most severe form of anticoagulant resistance found in Norway rats and is prevalent over a considerable part of central-southern England. A second form of advanced Norway rat resistance is conferred by the Y139C mutation. This is noteworthy because it occurs in at least four different foci that are widely geographically dispersed, namely in Dumfries and Galloway, Gloucestershire, Yorkshire and Norfolk. Once again, bromadiolone and difenacoum are not recommended for use against rats carrying this genotype and a concern of RRAG is that continued applications of resisted active substances may result in Y139C becoming more or less ubiquitous across much of the UK. Another type of advanced resistance, the Y139F mutation, is present in Kent and Sussex. This means that Norway rats, carrying some degree of resistance to bromadiolone and difenacoum, are now found from the south coast of Kent, west into the city of Bristol, to Yorkshire in the north-east and to the south-west of Scotland. This difficult situation can only deteriorate further where these three genotypes exist and resisted anticoagulants are predominantly used against them. Resistance in house mice: House mouse is not so well understood but the presence in the UK of two resistant genotypes, L128S and Y139C, is confirmed. House mice are naturally tolerant to anticoagulants and such is the nature of this tolerance, and the presence of genetical resistance, that house mice resistant to the first-generation anticoagulants are considered to be widespread in the UK. Consequently, baits containing warfarin, sodium warfarin, chlorophacinone and coumatetralyl are not approved for use against mice. This regulatory position is endorsed by RRAG. Baits containing brodifacoum, flocoumafen and difethialone are effective against house mice and may be applied in practice because house mouse infestations are predominantly indoors. There are some reports of resistance among mice in some areas to the second-generation anticoagulant bromadiolone, while difenacoum remains largely efficacious. Alternatives to anticoagulants: The use of habitat manipulation, that is the removal of harbourage, denial of the availability of food and the prevention of ingress to structures, is an essential component of sustainable rodent pest management. All are of importance in the management of resistant rodents and have the advantage of not selecting for resistant genotypes. The use of these techniques may be particularly valuable in preventing the build-up of rat infestations. However, none can be used to remove any sizeable extant rat infestation and for practical reasons their use against house mice is problematic. Few alternative chemical interventions are available in the European Union because of the removal from the market of zinc phosphide, calciferol and bromethalin. Our virtual complete reliance on the use of anticoagulants for the chemical control of rodents in the UK, and more widely in the EU, calls for improved schemes for resistance management. Of course, these might involve the use of alternatives to anticoagulant rodenticides. Also important is an increasing knowledge of the distribution of resistance mutations in rats and mice and the use of only fully effective anticoagulants against them.

Advances in understanding mineral dust and boundary layer processes over the Sahara from Fennec aircraft observations

The Fennec climate program aims to improve understanding of the Saharan climate system through a synergy of observations and modelling. We present a description of the Fennec airborne observations during 2011 and 2012 over the remote Sahara (Mauritania and Mali) and the advances in the understanding of mineral dust and boundary layer processes they have provided. Aircraft instrumentation aboard the UK FAAM BAe146 and French SAFIRE Falcon 20 is described, with specific focus on instrumentation specially developed and relevant to Saharan meteorology and dust. Flight locations, aims and associated meteorology are described. Examples and applications of aircraft measurements from the Fennec flights are presented, highlighting new scientific results delivered using a synergy of different instruments and aircraft. These include: (1) the first airborne measurement of dust particles sized up to 300 microns and associated dust fluxes in the Saharan atmospheric boundary layer (SABL), (2) dust uplift from the breakdown of the nocturnal low-level jet before becoming visible in SEVIRI satellite imagery, (3) vertical profiles of the unique vertical structure of turbulent fluxes in the SABL, (4) in-situ observations of processes in SABL clouds showing dust acting as CCN and IN at −15 °C, (5) dual-aircraft observations of the SABL dynamics, thermodynamics and composition in the Saharan heat low region (SHL), (6) airborne observations of a dust storm associated with a cold-pool (haboob) issued from deep convection over the Atlas, (7) the first airborne chemical composition measurements of dust in the SHL region with differing composition, sources (determined using Lagrangian backward trajectory calculations) and absorption properties between 2011 and 2012, (8) coincident ozone and dust surface area measurements suggest coarser particles provide a route for ozone depletion, (9) discrepancies between airborne coarse mode size distributions and AERONET sunphotometer retrievals under light dust loadings. These results provide insights into boundary layer and dust processes in the SHL region – a region of substantial global climatic importance.

Discontinuous Galerkin methods for the p-biharmonic equation from a discrete variational perspective

We study discontinuous Galerkin approximations of the p-biharmonic equation for p∈(1,∞) from a variational perspective. We propose a discrete variational formulation of the problem based on an appropriate definition of a finite element Hessian and study convergence of the method (without rates) using a semicontinuity argument. We also present numerical experiments aimed at testing the robustness of the method.

Deiro Collection Finding Aid

The Deiro Collection at the City University of New York Graduate Center's Mina Rees Library is an archival collection of materials related to the professional and personal lives of Guido Deiro (1886-1950), Pietro Deiro Sr. (1888-1954) and Pietro “Lee” Deiro Jr. (1913-1999). Immigrating from Italy to the United States in the early 1900's, the Deiro brothers Guido and Pietro, made enduring contributions to the popularization of the Piano Accordion in the 20th Century. As masters of the instrument, the Deiro's achieved headliner status on the vaudeville theatre circuit. Both composed, arranged and recorded an impressive repertoire of accordion music. Pietro Deiro Publications produced a catalogue of over 10,000 pieces of sheet music and instructional materials for the Piano Accordion. The Deiro Collection documents not only a singular segment of American musical history but also a unique aspect of the Italian-American experience in 20th Century America.

En retorisk analys av Fahrenheit 9/11 ur ett dokumentärhistoriskt perspektiv

The history of rhetorics in documentary film is a long one. The French brothers Louise and Auguste Lumiére were among the first persons who produced a documentary and their work has had a big impression in the history of documentary during the 1900 century. John Grierson has been called “the father” of documentary film. He produced films in the English speaking part of the world and he is the founder of the concept “documentary film”. Propaganda filming has a big part in the history of documentary film. Most frequently it appeard in Germany before and during the secound WW II, but propaganda films has been produced in Great Britain and USA as well as in other parts of the world. Rhetorics are of current interest today. It effects the news, papers, magazines, books and movies. The purpose with this essay is to investigate the rhetorics in Michael Moores controversial documentary of September 11th, Fahrenheit 9/11. The main question is: what rhetorical tools does Michael Moore use in order to communicate his politcal message in Fahrenheit 9/11? The rhetorical analysis includes exordium, narratio, propsitio, argumentatio and conclusio as well as ethos, logos and pathos. In order to conduct the analysis I have used Kurt Johannesson’s book Retorik eller konsten att övertyga, Maria Karlberg and Brigitte Mral’s book Heder och påverkan. Att analysera modern retorik. And at last a chapter by Brigitte Mral named Retorikanalys in the book Metoder i kommunikationeverenskap, by Mats Ekström and Larsåke Larsson. For the background about the history of documentary film I have used Barsam M. Richard, Nonfiction Film A Critical History and Bjørn Sørenssen’s book Å fange virkeligheten –Dokumentarfilmens århundre.The analysis shows that Moore uses different rhetorical tools in order to point out that George W Bush is the wrong man for the role as the president of United States of America. Some of the most effective tools that Moores uses are his own voice, pictures who awakes emotions, recordings and sharp arguments. His way of using ethos, logos and pathos is very clear. The disposal can also be distinct discern, however there are some exceptions towards the classical rhetoric. One example is that Moore doesn´t describe the arrangement of the movie in exordium.

Provning av ackumulatorsystem för solvärmeanläggningar

Inom projektet provades 10 konfigurationer av samma ackumulatortank. Tankarna utsattes under kontrollerade förhållanden för en 6-dagars testcykel. Under testet tillfördes varje tank värme från en (simulerad) solfångare och, i den mån det behövdes, tillsatsvärme från elpatronen. Väderförhållanden under de sex dagarna var två fina, en växlande, två dåliga och ytterligare en växlande dag i nämnd följd. De flesta systemkonfigurationer klarade sig under de soliga dagarna utan energitillskott från elpatronen och förmådde dessutom att lagra värnlen så att även tappningar på följande dag med "växlande" väder kunde ske utan el-tillskott. De molniga dagarna behövde alla systemkonfigurationer el-tillskott. Solvärmesystemens täckningsgrad varierade mellan 36,5 % för det sämsta systemet till 70, 3 % för det bästa. En ackumulatortank med två seriekopplade tappvarmvattenvärmeväxIare (en i botten för förvärmning och en i tankens övre del för slutvärmning) ger betydligt bättre resultat än en tank med bara en enda sådan värmeväxlare. Tankens volym var i de utförda provningarna 750 liter, solfångarstorleken 10 m2 och lasten 13 kWh per dag. För dessa förutsättningar ger en yttre solvärmeväxlare inga mätbara fördelar gentemot en tillräcklig stor inbyggd värmeväxlare. De gjorda försöken visar, att alla tankkonfigurationerna visar dålig skiktning. Ett fortsatt arbete bör göras för att minska omblandningen i tanken vid både inladdning och uttag av värme.

Villasystem för solvärme

Del 1:Innehållsförteckning och korta sammanfattningarDEL 2:Verksamhetsberättelsen för perioden maj 1992 till april 1993 beskriver de arbeten som har gjorts av villasolvärmegruppen på SERC efter den inledande studie (SERC/UCFB-91/0039), där villasolvärmesystem kartlades. Följande arbeten beskrivs:- Utveckling av lågflödessystem och internationella kontakter- Uppbyggnad av värmelaboratorium på SERC- Praktiska test av värmelagringsenheten- Praktiska test av nya systemkomponenter i solvärmekretsen- Datasimulering inkluderande nyutvecklade systemkomponenterI verksamhetsplanen beskrivs huvudmålet för de arbeten som ska utföras under trårsperioden 93 - 96. Mera detaljerat beskrivs de arbeten som ska utföras under budgetåret 1993/94:- Beräkningsprogram för nogrannare dimensionering av finrörsvärmeväxlare- Konstruktion av maskiner för värmeväxlartillverkning- Utveckling av värmeväxlare för tappvarmvatten- Simuleringsberäkningar för hela systemet med PRESIM/TRNSYS.DEL 3:Del 3 innehåller en redovisning av mätresultat för den undersökta kombitanken. Temperaturförloppen på olika höjd i tankens har studerats vid uppvärmning genom solvärmeväxlaren och nedkylning genom tappning av varmvatten. Resultaten diskuteras kvalitativt och redovisas kvantitativt i form av diagram. Mätresultaten på två prototyper av den på SERC utvecklade finrörsvärmeväxlaren redovisas och diskuteras i jämförelse till traditionell värmeväxlare. De erhållna mätresultaten används som ingångsvärden för simuleringsberäkningar med PRESIM/TRNSYS. Problemen med de i PRESIM/TRNSYS befintliga modellerna diskuteras. De utförda modellberäkningarna tillåter en uppskattning av möjliga förbättringar i form av höjd årsverkningsgrad för ett svenskt villasolvärmesystem med kombitank. I del 3 redovisas dessutom de mätningar som har utförts på otika pumpar vilka skulle kunna användas i solfångarkretsen. Sex olika pumpar analyseras och diskuteras. Del 3 har följande rubriker:- Beskrivning av den undersökta lagringstanken- Mätningar på tappvarmvattenväxlare- Mätningar på solvärmeväxlare (kamflänsrör och finrörsvärmeväxlare)- Simuleringsberäkningar- PumpmätningarDEL 4:Del 4 innehåller publicerade rapporter under 1992 och 93 samt patentansökan för SERC?s finrörsvärmeväxlare: - NORTH SUN 1992, Solar Energy at High Latitudes, June 24-26 1992 Trondheim, Norway. Domestic solar heating system - a systematic study i progress Patentansökan på finrorsvärmeväxlare till Patent- och Registreringsverket från 93 01 23. ISES SOLAR WORLD CONGRESS, 23-27 augusti 1993, Budapest, HUNGARY Criteria for cost efficient small scale solar hot water installations.DEL 5:Del 5 hänvisar till rapporterna från IEA Task-1 4 mötena om solfångarsystem i- Hameln, Tyskland, augusti 1992 och- Rom, Italien, januari 1993.I rapporterna beskrivs aktiviteten inom den internationella arbetsgruppen speciellt med hänsyn på utveckling av villasolvärmesystem. I Rom presenterades principlösningen för den på SERC utvecklade finrörsvärmeväxlare. De har publicerats separat som nr 42 och 46 i SERCs rapportserie.

The Björling 'Opera' : A children's Nursery Academy and an Italian Conservatory in Miniature

The aim in this chapter is to develop a deeper understanding about the informal Björling 'School' in Sweden. Contextually the example is related to the micro history of opera education contributing to the macro perspective illuminating a provincial example of the concept of domestic opera schooling. The specific focus was on Karl David Björling (1873-1926), the teaching parent of the Swedish tenor Jussi Björling (1911-1960) and his brothers Gösta and Olle.   The Björling family model of opera schooling belongs to the classical canon of domestic home education which was common during the epoch. The phenomenon is also within the field of opera singing an important reference to the historical context of the Nordic opera history of vocal education.   The uniqueness concerning the Björling School seems to be the rigorous and exceptionally early training. David Björling’s pedagogy was rooted in earlier German theories of musical upbringing. It's clear from his results that he was familiar with the neo-humanistic ideal on which reformed music education was based. Of a specific interest is the term Gesang als Unterricht as a concept for developing childrens musical and memorising capacities.   Conceptually the roots of the Björling model are in the eighteenth-century Romantic view of prodigies and their abilities. The extensive touring is connected to the promotion of wonder-children, and David Björling’s educational style to the conservative Master-pupil tradition.   David Björling's vocal ideal was a part of the contemporary debate about “The decadence of the singing art”, and seems to have its roots in an older Italian tradition. There are recurring similarities between his educational methods and the didactic principles of the Lamperti School: Enjoying a revival around the late 1800s and early 1900s, it has been called the natural or the national school. Nevertheless, through authentic experiences and gramophone recordings the Italian tenor Enrico Caruso became David Björling’s pedagogical role model.

Análise em tempo real de comportamento explosivo em preços no Brasil

O objetivo deste trabalho é determinar a existência de comportamento explosivo em preços no mercado brasileiro e identificar quando essas explosões ocorreram. Para tanto, foi utilizada uma nova metodologia recursiva de testes de raiz unitária, que identifica início e fim de explosões de preços em tempo real. Foram escolhidos os índices de mercado (Bovespa ajustado pelo dólar e pelo dividend yield do mercado) e a série de preços IGP-DI (taxa de inflação mensal e acumulada em 12 meses) por apresentarem evidências de comportamento explosivo ao longo do tempo. Os resultados obtidos apontaram a existência de comportamentos explosivos nas séries do Ibovespa ajustado pelo dólar nos anos de 1997, 2006 e 2008 (período anterior à quebra do Banco Lehman Brothers) e na taxa de inflação acumulada em 12 meses nas décadas de 80 e 90, previamente ao Plano Real.

Transmissão assimétrica de um choque de liquidez bancário para o crédito no Brasil: evidências sobre impacto às empresas durante a crise financeira de 2008/2009

Esta dissertação estuda o impacto do choque de liquidez no sistema financeiro nacional (SFN) sobre o crédito às empresas após a quebra do Lehman Brothers, em setembro/2008. O choque ocorreu de forma diferenciada aos players do mercado nacional, de modo que algumas instituições financeiras passaram por forte restrição de recursos, ao passo que outras receberam um volume acentuado de depósitos. Para expurgar possíveis efeitos de demanda por crédito, utiliza-se a abordagem de efeitos fixos por atividade econômica, de modo que os coeficientes estimados reflitam a oferta de crédito dos bancos. Os resultados obtidos corroboram, em diferentes graus, as hipóteses delineadas, com destaque para dois pontos: (i) a elasticidade do crédito empresarial aos depósitos é diferente entre os grupos de bancos que têm aumento ou diminuição desta forma de funding, fato consistente com os modelos que preveem que os agentes tendem a manter mais liquidez em um contexto de incerteza sistêmica; (ii) com a escassez de recursos externos e do mercado de capitais nacional após a quebra do Lehman Brothers, as grandes empresas tiveram que recorrer ao segmento bancário, e na disputa pelos recursos oriundos desta fonte levaram vantagem comparativa em relação às pequenas e médias empresas.