Impaired brainstem and thalamic high-frequency oscillatory EEG activity in migraine between attacks

INTRODUCTION: We investigated whether interictal thalamic dysfunction in migraine without aura (MO) patients is a primary determinant or the expression of its functional disconnection from proximal or distal areas along the somatosensory pathway. METHODS: Twenty MO patients and twenty healthy volunteers (HVs) underwent an electroencephalographic (EEG) recording during electrical stimulation of the median nerve at the wrist. We used the functional source separation algorithm to extract four functionally constrained nodes (brainstem, thalamus, primary sensory radial, and primary sensory motor tangential parietal sources) along the somatosensory pathway. Two digital filters (1-400 Hz and 450-750 Hz) were applied in order to extract low- (LFO) and high- frequency (HFO) oscillatory activity from the broadband signal. RESULTS: Compared to HVs, patients presented significantly lower brainstem (BS) and thalamic (Th) HFO activation bilaterally. No difference between the two cortical HFO as well as in LFO peak activations between the two groups was seen. The age of onset of the headache was positively correlated with HFO power in the right brainstem and thalamus. CONCLUSIONS: This study provides evidence for complex dysfunction of brainstem and thalamocortical networks under the control of genetic factors that might act by modulating the severity of migraine phenotype.

The Betsy South Beach

The Betsy - South Beach is a distinguished landmark hotel providing an elegant, personalized boutique experience in the heart of South Beach. The Betsy’s relaxed tropical interiors and 61 welcoming, beachside retreats create an aura that is passionately low-key. Exquisite amenities, incredible ocean views, world-class cuisine, and more.

The Betsy South Beach

The Betsy - South Beach is a distinguished landmark hotel providing an elegant, personalized boutique experience in the heart of South Beach. The Betsy’s relaxed tropical interiors and 61 welcoming, beachside retreats create an aura that is passionately low-key. Exquisite amenities, incredible ocean views, world-class cuisine, and more.

The Betsy South Beach

The Betsy - South Beach is a distinguished landmark hotel providing an elegant, personalized boutique experience in the heart of South Beach. The Betsy’s relaxed tropical interiors and 61 welcoming, beachside retreats create an aura that is passionately low-key. Exquisite amenities, incredible ocean views, world-class cuisine, and more.

Radiocarbon dates of peatland initiation across the northern high latitudes

A compilation of basal dates of peatland initiation across the northern high latitudes, associated metadata including location, age, raw and calibrated radiocarbon ages, and associated references. Includes previously published datasets from sources below as well as 365 new data points.

Imaginários da morte: poética das imagens em cemitérios brasileiros

The thesis presented is committed to a poetic reading that results in the creation of meaning and images of the death from the various cultural practices and symbolic representations exposed in urban cemeteries in some Brazilian cities, aiming to give visibility to new understandings about the imaginary of the in the contemporary scene. Death, therefore, will be seen as a imagining condition of anthroposwhen starts itself from the prerogative of the human consciousness of death (MORIN, 1970), in other words, this awareness that man has he will die and that triggers reflections about their existence allows the emergence of a number of practices such as: mourning, funeral rituals and the creation of several impregnated representations of human emotions emerged from the death facing the man and present, in a more evident form in cemeterial spaces. For this, it focuses on the conflictuous dimension that man establishes with death, because the cultural practices and symbolic representations observed in the research field are the result of this conflict and allow the expansion of the senses about this issue, to the extent that these are coated with a fantastic aura, mystical, secret, spooky, fearful, religious, building a complex imagination. The general plan of this study is to discuss and create, from a phenomenology of imagination and materials / dynamics imagination, as well as along the lines treated by Gaston Bachelard, images of death, from a field experience in cemeteries in Brazil. For this, it is assumed, to observe the cultural practices and symbolic representations in these spaces, a posture able to make the experience into the search field a moment of symbolic exchanges and creation. Thus, it was used observation, conversations with visitors and employees of the cemeteries and the capture of photographic records. The data produced as a fragment of a conversation, a tearful outburst about the loss of a relative, a melancholic epitaph, a flower on the grave or a cry captured by photography were seen as detonators of meanings and a poetic of the imagination.

Imaginários da morte: poética das imagens em cemitérios brasileiros

The thesis presented is committed to a poetic reading that results in the creation of meaning and images of the death from the various cultural practices and symbolic representations exposed in urban cemeteries in some Brazilian cities, aiming to give visibility to new understandings about the imaginary of the in the contemporary scene. Death, therefore, will be seen as a imagining condition of anthroposwhen starts itself from the prerogative of the human consciousness of death (MORIN, 1970), in other words, this awareness that man has he will die and that triggers reflections about their existence allows the emergence of a number of practices such as: mourning, funeral rituals and the creation of several impregnated representations of human emotions emerged from the death facing the man and present, in a more evident form in cemeterial spaces. For this, it focuses on the conflictuous dimension that man establishes with death, because the cultural practices and symbolic representations observed in the research field are the result of this conflict and allow the expansion of the senses about this issue, to the extent that these are coated with a fantastic aura, mystical, secret, spooky, fearful, religious, building a complex imagination. The general plan of this study is to discuss and create, from a phenomenology of imagination and materials / dynamics imagination, as well as along the lines treated by Gaston Bachelard, images of death, from a field experience in cemeteries in Brazil. For this, it is assumed, to observe the cultural practices and symbolic representations in these spaces, a posture able to make the experience into the search field a moment of symbolic exchanges and creation. Thus, it was used observation, conversations with visitors and employees of the cemeteries and the capture of photographic records. The data produced as a fragment of a conversation, a tearful outburst about the loss of a relative, a melancholic epitaph, a flower on the grave or a cry captured by photography were seen as detonators of meanings and a poetic of the imagination.

Hand somatosensory sub-cortical sources arehypoactive in migraine interictally: a functionalsource separation analysis

Background: Recent morpho-functional evidences pointed out that abnormalities in the thalamus could play a major role in the expression of migraine neurophysiological and clinical correlates. Whether this phenomenon is primary or secondary to its functional disconnection from the brain stem remains to be determined.Aim: We used a Functional Source Separation algorithmof EEG signal to extract the activity of the different neuronal pools recruited at different latencies along the somatosensory pathway in interictal migraine without aura(MO) patients. Method: Twenty MO patients and 20 healthy volunteers(HV) underwent EEG recording. Four ad-hoc functional constraints, two sub-cortical (FS14 at brain stem andFS16 at thalamic level) and two cortical (FS20 radial andFS22 tangential parietal sources), were used to extract the activity of successive stages of somatosensory information processing in response to the separate left and right median nerve electric stimulation. A band-pass digital filter (450–750 Hz) was applied offline in order to extract high-frequency oscillatory (HFO) activity from the broadband EEG signal. Results: In both stimulated sides, significant reduced subcortical brain stem (FS14) and thalamic (FS16) HFO activations characterized MO patients when compared with HV. No difference emerged in the two cortical HFO activations between two groups. Conclusion: Present results are the first neurophysiological evidence supporting the hypothesis that a functional disconnection of the thalamus from the subcortical monoaminergicsystem may underline the interictal cortical abnormal information processing in migraine. Further studiesare needed to investigate the precise directional connectivity across the entire primary subcortical and cortical somatosensory pathway in interictal MO.

Nowhere Landscape, for Clarinets, Trombones, Percussion, Violins, and Electronics and “The Map and the Territory: Documenting David Dunn’s Sky Drift”

1. nowhere landscape, for clarinets, trombones, percussion, violins, and electronics

nowhere landscape is an eighty-minute work for nine performers, composed of acoustic and electronic sounds. Its fifteen movements invoke a variety of listening strategies, using slow change, stasis, layering, coincidence, and silence to draw attention to the sonic effects of the environment—inside the concert hall as well as the world outside of it. The work incorporates a unique stage set-up: the audience sits in close proximity to the instruments, facing in one of four different directions, while the musicians play from a number of constantly-shifting locations, including in front of, next to, and behind the audience.

Much of nowhere landscape’s material is derived from a collection of field recordings

made by the composer during a road trip from Springfield, MA to Douglas, WY along US- 20, a cross-country route made effectively obsolete by the completion of I-90 in the mid- 20th century. In an homage to artist Ed Ruscha’s 1963 book Twentysix Gasoline Stations, the composer made twenty-six recordings at gas stations along US-20. Many of the movements of nowhere landscape examine the musical potential of these captured soundscapes: familiar and anonymous, yet filled with poignancy and poetic possibility.

2. “The Map and the Territory: Documenting David Dunn’s Sky Drift”

In 1977, David Dunn recruited twenty-six musicians to play his work Sky Drift in the

Anza-Borrego Desert in Southern California. This outdoor performance was documented with photos and recorded with four stationary microphones to tape. A year later, Dunn presented the work in New York City as a “performance/documentation,” playing back the audio recording and projecting slides. In this paper I examine the consequences of this kind of act: what does it mean for a recording of an outdoor work to be shared at an indoor concert event? Can such a complex and interactive experience be successfully flattened into some kind of re-playable documentation? What can a recording capture and what must it exclude?

This paper engages with these questions as they relate to David Dunn’s Sky Drift and to similar works by Karlheinz Stockhausen and John Luther Adams. These case-studies demonstrate different solutions to the difficulty of documenting outdoor performances. Because this music is often heard from a variety of equally-valid perspectives—and because any single microphone only captures sound from one of these perspectives—the physical set-up of these kind of pieces complicate what it means to even “hear the music” at all. To this end, I discuss issues around the “work itself” and “aura” as well as “transparency” and “liveness” in recorded sound, bringing in thoughts and ideas from Walter Benjamin, Howard Becker, Joshua Glasgow, and others. In addition, the artist Robert Irwin and the composer Barry Truax have written about the conceptual distinctions between “the work” and “not- the-work”; these distinctions are complicated by documentation and recording. Without the context, the being-there, the music is stripped of much of its ability to communicate meaning.

L’espace comme matériau : l’architecture moderne et le complexe du Bauhaus à Dessau

Pour respecter les droits d’auteur, la version électronique de ce mémoire a été dépouillée de certains documents visuels. La version intégrale du mémoire a été déposée à la Division de la gestion des documents et des archives.

Conception, synthèse et activité anticancéreuse d’analogues basés sur la molécule FTY720 (Gilenya)

FTY720 (aussi connu sous le nom de Fingolimod ou Gilenya) agit sur les récepteurs sphingosine-1-phosphate (S1P) et induit la suppression du système immunitaire (immunosuppression). Cette molécule est reconnue pour avoir une activité contre plusieurs cellules cancéreuses. Cette activité est indépendante de l’action sur les récepteurs S1P et on attribue plutôt la mort (apoptose) des cellules cancéreuse à la capacité que possède la molécule à réduire le transport des nutriments dans la cellule. Toutefois, malgré ses nombreux avantages, FTY720 ne peut pas être utilisé afin de traiter des humains puisque l’activation secondaire des récepteurs S1P1 et S1P3 mènent à une diminution du rythme cardiaque (bradycardie) chez les patients. Notre groupe s’est donc concentré sur la synthèse d’analogues qui potentiellement n’activeraient pas le récepteur S1P tout en gardant une activité biologique contre plusieurs cellules cancéreuses. Malgré le fait que nos analogues agissent également sur la diminution du transport des nutriments dans les cellules, nous ne connaissons pas le mécanisme d’action par lequel ceux-ci agissent. Au passage, le projet de recherche ci-présenté nous aura par ailleurs permis de développer une grande variété de sondes photo-actives dans l’espoir d’isoler une ou plusieurs protéines qui seraient impliquées dans le mécanisme d’action.

Women, Drug use and Imprisonment. Intersectional Approach

Research on women prisoners and drug use is scarce in our context and needs theoretical tools to understand their life paths. In this article, I introduce an intersectional perspective on the experiences of women in prison, with particular focus on drug use. To illustrate this, I draw on the life story of one of the women interviewed in prison, in order to explore the axes of inequality in the lives of women in prison. These are usually presented as accumulated and articulated in complex and diverse ways. The theoretical tool of intersectionality allows us to gain an understanding of the phenomenon of women prisoners who have used drugs. This includes both the structural constraints in which they were embedded and the decisions they made, considering the circumstances of disadvantage in which they were immersed. This is a perspective which has already been intuitively present since the dawn of feminist criminology in the English-speaking world and can now be developed further due to new contributions in this field of gender studies.

The Neolithic of El Niño cave (Ayna, Albacete) in the Sierra del Segura context

Since its excavation in the summer of 1973, El Niño cave has been considered a key site to understand the process of production economy and pottery technology introduction in South-eastern Iberian Peninsula, and especially to approach how such process could have affected people already settled in the Segura mountains. However, data from El Niño cave was very fragmentary, due to the lack of a broad study of Neolithic occupations of the site. In this paper, we present the analysis of pottery, lithic industry and faunal remains, as well as the existing dates from the site´s Holocene levels. The review of different evidence from the site allows suggesting that El Niño cave would have probably acted as a hunting and shepherding station, being a logistical site of larger places. However, limitations due to the fact that we are dealing with a 40- year-old excavation, prevent specifying how the process of Neolithic introduction in the Segura Mountains occurred.

The management of bone tools from the Bronze Age site of El Portalón of Cueva Mayor, Sierra de Atapuerca, Burgos

In this paper we analyze the set of Bronze Age bone tools recovered at the archaeological site of El Portalón of Cueva Mayor in the Sierra de Atapuerca (Burgos). The Bronze Age cultural period is the best represented in the cavity and its study has forced us to unify the different excavation and stratigraphical criteria undertaken from the earliest archaeological excavations developed by J.M. Apellániz during the 70s until the excavations of the current research team (EIA) since 2000. We propose here for the first time a relationship between the initial system of “beds” used by Apellániz and our recent sedimentary sequence that recognizes eleven stratigraphic levels radiometrically dated from the late Upper Pleistocene to the Middle Age. Within the bone industry assemblage we recognize a large variety of utensils and ornamental elements, with native and allochthonous features, that make evident a regional as well as long distance relationships of these populations of the interior of the Iberian Peninsula during the recent Prehistory.

Apariencia y juego. La teoría de la imitación de Walter Benjamin

El presente trabajo analiza la teoría de la imitación desarrollada por Walter Benjamin en el célebre ensayo sobre la obra de arte. Se pretende abordar el ensayo como una nueva muestra de la “investigación sobre el origen” ya empleada en sus obras anteriores, lo cual nos permitirá esclarecer el papel privilegiado que Benjamin asigna a la “mimesis” como el “origen” que revela la ley unitaria de toda la época. El ensayo, por tanto, supera el reducido ámbito de la estética en el que ha sido tradicionalmente enmarcado y apunta a una reflexión más amplia sobre las contradicciones internas de la modernidad, respecto de la cual la mimesis señala a la vez el problema y una posible vía de salida.