Festschrift zur Hundertjahrfeier des Vereins 1806 - 1906 : Geschichte der Chewra Kadischa, Israeltischer Verein für Krankenpflege, Bestattungswesen und religiöse Belehrung in München

von H. Ehrentreu

Vom ersten bis zum zweiten Tempel : Geschichte der israelitischen Cultus-Gemeinde in Wien (1820 - 1860)

von G. Wolf

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Using a genome-wide association and replication study in up to 100,000 individuals, we identified 35 common variant loci associated with QT interval that collectively explain ∼8-10% of QT-interval variation and highlight the importance of calcium regulation in myocardial repolarization. Rare variant analysis of 6 new QT interval-associated loci in 298 unrelated probands with LQTS identified coding variants not found in controls but of uncertain causality and therefore requiring validation. Several newly identified loci encode proteins that physically interact with other recognized repolarization proteins. Our integration of common variant association, expression and orthogonal protein-protein interaction screens provides new insights into cardiac electrophysiology and identifies new candidate genes for ventricular arrhythmias, LQTS and SCD.

TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei.

The metabolic network of a cell represents the catabolic and anabolic reactions that interconvert small molecules (metabolites) through the activity of enzymes, transporters and non-catalyzed chemical reactions. Our understanding of individual metabolic networks is increasing as we learn more about the enzymes that are active in particular cells under particular conditions and as technologies advance to allow detailed measurements of the cellular metabolome. Metabolic network databases are of increasing importance in allowing us to contextualise data sets emerging from transcriptomic, proteomic and metabolomic experiments. Here we present a dynamic database, TrypanoCyc (http://www.metexplore.fr/trypanocyc/), which describes the generic and condition-specific metabolic network of Trypanosoma brucei, a parasitic protozoan responsible for human and animal African trypanosomiasis. In addition to enabling navigation through the BioCyc-based TrypanoCyc interface, we have also implemented a network-based representation of the information through MetExplore, yielding a novel environment in which to visualise the metabolism of this important parasite.

Dr. B. Kellermann, Kritische Beiträge zur Entstehungsgeschichte des Christentums [Rezension]

Eugen Wolbe

B. S. Straus [Illustration] : (Porträt)

Scan von Monochrom-Mikroform

Adolf von Sonnenthal : zur Erinnerung an sein Künstler-Jubiläum am 31. Mai 1906

B. Samuel

B'Reiges-Tanz [Musikdruck] : (jüdische Volksmelodie)

Arno Nadel