Recueil de pièces relatives à la Papauté et aux républiques de Venise, Gênes et Lucques ; conclaves du XVII° siècle, etc. (1513-1658, et 1303-1400).

Contient : Rome (1513-1658). — Pièces diverses, relatives aux affaires de Rome, 1513-1527 (f. 1) ; « Lettre du Roy au cardinal de Rambouillet, sur le sujet de la liberté du comte Gaiasse », 1571 ; « Commentarius caussarum belli a Paulo IIII, Pont. Max., in Italia suscepti anno 1556 », pièce anciennement paginée 509-528 ; Manifeste en faveur de Marc-Antoine Colonna, 1572 ; Minutes de lettres de Charles IX, à l'occasion de la maladie de Pie V, 1572 ; « Relatione dell'illustrissimo seignore Giovanni Dolfino, cavalliere e procuratore di Santo-Marco, ritornato d'ambasciatore à Roma l'anno 1598 » ; « Discours de l'Estat de l'Esglise et court de Rome », 1604, par J. Bosc ; Pièces relatives à divers conclaves ; Relations de la mort et éloges de Clément VIII (f. 173), — et du cardinal Baronius (f. 174) ; Pièces relatives à l'élection de Grégoire XV, 1621 ; « Relation des affaires de la cour de Rome..., faite par le sr de Brèves », 1623 ; Pièces relatives à l'élection d'Urbain VIII, 1623 ; Relation de la cour de Rome, 1624 ; Pièces relatives à l'élection d'Innocent X, 1644 ; « Mémoire, fait durant la maladie du pape Innocent X, des noms des cardinaux, de leurs aages et qualitez », 1655 ; Pièces relatives à l'élection d'Alexandre VII, 1655 ; « Relatione del clarissimo Mgr Bernardo Navagiero, che fu poi cardinale, ritornando da Roma ambasciatore à papa Paolo quarto, l'anno 1558 » ; « Il sussesso della morte di signori Carafi, con la declaratione et il modo che morirono » ; Mémoire sur la Cour pontificale au temps de Paul V, vers 1615 (f. 457) ; Venise (XVIe siècle-1627). — « Discours de l'évesque de Rodez [Georges d'Armagnac], ambassadeur pour le Roy à Venise... » (f. 291) ; « Mémoire pour... faire sçavoir les payemens ordonnez à la seigneurie de Venise et au duc de Florence, sur les prests par eux faicts au Roy », 1573 (f. 293), — et autres pièces concernant Venise et principalement les relations de Venise avec la France (f. 294) ; Pièces relatives aux différends entre les papes Clément VIII et Paul V et les Vénitiens, 1600-1607 ; « Relation de Venize, de l'année 1627 » ; Gênes (1575-1629). — « Relazione di Genova », 1575, mémoire très détaillé (f. 367) ; « Relatione della cità et dominio Genovese », 1580 ; Autre relation, adressée à Charles IX ; « Instruction baillée à Monsieur de Sabran, envoyé... vers le duc et la seigneurie de Gênes », 1629 (f. 440) ; Lucques . — « Mémoire de l'Estat de Lucques, depuis 1303 jusques en 1400... » (f. 446)

« Documens, instrumens, escriptures et enseignemens du droit que le roy nostre sire, comme comte de Provence et Forcalquier et terres adjacentes, a ès pais et seigneuries de Lombardie, Piemont, Nyce et autres lieux cy après speciffiez et declairez, tirez des archifz et chambre des comptes dud. seigneur, à Aix aud. Provence ».

Contient : 1 Liste des « villes, places et chasteaulx » qui composent la viguerie de Nice », liste dressée pour « meulx (sic) et plus clerement entendre la usurpation que faict monseigneur le duc de Savoye ». Vers 1464 ; 2 Procuration donnée par la ville d'Alexandrie, en Lombardie, à « Jacobum de Peter, Odonem Carmellum, Octonem Langanegram et Jacobum Viciatum » pour traiter avec Robert « de Landrio », fondé de pouvoir de Charles, roi de Sicile. 22 mai 1270. En latin ; 3 Acte, en latin, par lequel les habitants et les consuls d'Alexandrie déclarent se soumettre sous certaines conditions à Charles, roi de Sicile et comte de Provence, et le reconnaissent comme leur seigneur. 22 mai 1270 ; 4 Vidimus de la charte par laquelle l'empereur Othon IV accorde à la commune d'Alexandrie la juridiction civile et criminelle sur lad. ville et quelques autres lieux. 1210. Le vidimus est daté du 22 août 1270. En latin ; 5 Autre copie de l'acte analysé sous le n° 3. Il est ici correctement daté du 22 mai, jour de la fête de l'Ascension. En latin ; 6 Acte par lequel les habitants et les consuls d'Alexandrie renouvellent avec ROBERT, roi de Jérusalem et de Sicile, dont le pouvoir relatif audit acte le termine, la soumission faite à Charles, son prédécesseur. S. d ; 7 Conventions, en latin, entre le susdit roi Robert, et Thomas, marquis de Saluces. 18 mars 1342 ; 8 Actes, en latin, du don fait à Charles II, roi de Jérusalem et de Sicile, par Manfred, marquis de Saluces et de Montferrat, du lieu de « Feyani », avec ses dépendances. 6 mai et 26 juin 1307 ; 9 « Reductio castri Draonerii, in marchionatu Saluciarum, ad manus... regis Roberti Sicilie, Provincie comitis, cum promissione de prestando homagium et sacramentum fidelitatis ipsi regi et comiti ». 7 août 1313. Copie faite sur l'ordre donné par « Philippus de Sanguieto, comes Altimontis, comitatuum Provincie et Forcalquerii senescallus », en 1346, le 24 juillet. En latin ; 10 Mise en garde dudit château, « villas, valles et fortalicias Drayonerii » entre les mains de « Basteto de Podio, militi, homini ligio domini dalphini Viennensis », jusqu'à ce que Thomas, marquis de Saluces, se soit présenté devant le susdit roi Robert. 18 mars 1342. En latin ; 11 Actes de foi et hommage faits à Charles II, roi de Sicile, par différents vassaux du comté de Piémont. 1309. En latin ; 12 Autre pièce relative à la mise en garde du « castrum... Draonerii ». 12 juillet 1343, « regnante... domina Johanna, Jerhusalem et Sicilie regina ». En latin ; 13 Actes, en latin, par lesquels PHILIPPE, comte DE SAVOIE, reconnaît tenir de Robert, roi de Jérusalem et de Sicile, « terram Savilhani ». 31 juillet-6 septembre 1320. Philippe de Valois, neveu de Robert, figure dans ces actes ; 14 Acte, en latin, de foi et hommage fait à Charles, comte de Provence, tanquam « domino Albe, Claraschi, Cunei, Saviliani, Montis Regalis », par « Manuel, comes de Blandoaco ». 23 avril 1260 ; 15 Acte par lequel il est déclaré que Manfred et Théodore de Saluces tiennent de Robert, roi de Jérusalem et de Sicile, le château de « Mollabruna ». 3 mars 1340. En latin ; 16 Transaction entre Robert « de Landrio » et Philippe, son fils, d'une part, et les marquis de Cena, passée le 30 septembre 1270 et ratifiée le 30 janvier 1271. En latin ; 17 Acte par lequel Robert, roi de Jérusalem et de Sicile, renouvelle l'alliance conclue par son père, Charles II, avec les habitants d'Asti. 1306-1310. En latin ; 18 Traité d'alliance entre Charles d'Anjou, comte de Provence, et les habitants de Milan et de quelques autres villes, conclu en 1264 et confirmé le 28 juin 1273. En latin ; 19 « Promissio facta per illos de Turre Mediolani comiti Provincie, de adjuvando et deffendendo ipsum cum valitoribus eorum perpetuo ». 23 janvier 1265 (n. s.). En latin ; 20 Prise de possession au nom de Jeanne, reine de Jérusalem et de Sicile, comtesse de Provence, du château de Pinha, au comté de Vintimille. Acte daté du 18 janvier 1379. En latin ; 21 « Instrumentum protestacionis facte per dominum regem Renatum Sicilie, Provincie comitem, contra ducem Sabaudie, quod eidem regi... non currat prescriptio pro terra Nicie et aliis que tenet injuste ipse dux Sabaudie ». 29 novembre 1464. En latin ; 22 Traité conclu entre Charles, roi de Sicile, et la ville de Plaisance. 8 mai 1271. En latin ; 23 « Procuratorium comunis et civitatis Albe et Claraschi ad conveniendum cum rege Sicilie, Provincie comite ». 14 septembre 1259. En latin ; 24 Confirmation par les habitants d'Albe du traité conclu par leurs procureurs avec Charles d'Anjou, comte de Provence et de Forcalquier. 8 octobre 1259. En latin ; 25 Confirmation par les habitants d'Albe et de Clarasche de l'abandon qui avait été fait par leurs procureurs à Charles d'Anjou, comte de Provence, de toute leur juridiction et de tous leurs revenus. 23 février 1260 et 10 décembre 1259. En latin ; 26 « Convenciones civitatis Albe cum comite Provincie,... Carolo secundo, Jerhusalem et Sicilie rege ». 28 septembre 1303. En latin ; 27 « Procuratorium loci Claraschi ad componendum... cum rege Sicilie Carolo », Andegavensi et « Provincie comite ». 24 août 1264. En latin ; 28 « Instrumentum... procurationis Albe ad dandum et tradendum domino comiti Provincie civitatem Albe et Claraschi ». 30 août 1259. En latin ; 29 « Instrumentum donacionis Cunei, facte in favorem » Caroli, « regis Sicilie, comitis Provincie ». 10 juillet 1258. En latin ; 30 « Instrumentum donacionis Montis Regalis, facta (sic) per Universitatem et comune ejusdem loci comiti Provincie ». 21 mars 1305. Exemplaire de 1337. En latin ; 31 Autre copie de la pièce analysée sous le n° 8. On y voit le même personnage appelé « Gaufredus » et « Manfredus », et on y trouve la forme « Foxani » au lieu de « Fayani » ou « Feyani ». En latin

Synthetic approaches to syn-diol containing biologically active compounds /

The deoxy derivative of pancratistatin 1.10 was prepared in good yield through the use of a [4+2] Diels-Alder cycloaddition and Bischler-Napieralski cyclization approach. The Bischler-Napieralski cyclization was shown to yield two additional side products 2.9, 2.10, however, under slightly modified hydrolysis conditions, the tetracyclic product 2.11 was obtained exclusively in greater than 84% yield. Initial screening of the di-hydroxylatgd derivative, and the other complementary pair analogue 1.10' previously prepared in our laboratories gave interesting results. Both of these compounds were shown to exhibit cytostatic activity; the mono-alcohol was marginally active while the di-hydroxylated analogue proved to be more potent although one to two magnitudes less potent than pancratistatin itself Human tumour cell line assay results indicated that the di-hydroxylated derivative exhibited selective cytotoxic inhibition in the following cell lines: non-small cell lung cancer line NCI-H226 (ED50 - 0.65 ^g/mL), leukemia cell lines CCRF-CEM (ED30 = 0.55 Hg/mL) and HL-60(TB) (ED50 = 0.89^ig/mL). Our results demonstrated that the pharmacophore is not a mono-alcohol, and that the minimum pharmacophore contains the hydroxyl group at the C4 position in addition to either, or both, of the hydroxyl groups present at C2 and C3.' The minimum pharmacophore has been narrowed to only three possibilities which are current synthetic targets in several research groups. The controlled Grignard addition to the tartaric acid derived bis-Weinreb amide 1.25 afforded a direct entry to a host of 1,4-diflferentiated tartaric acid derived intermediates (2.12-2.18). This potentially usefiil methodology was demonstrated through the efficient synthesis of the naturally occurring lactone 2.23, which bears the inherent syn-dio\ subunit. Based on this result, a similar approach to the synthesis of syn-dio\ bearing natural products looks very promising? A direct 2,3-diol desymmetrization method using TIPS-triflate was shown to be effective on the selective differentiation of Z,-methyl tartrate (and diisopropyl tartrate). The mono-silyl-protected intermediates 2.31 also proved to be useful when they were selectively differentiated at the 1,4-carboxyl position (2.35, 2.36) through the use of a borohydride reducing agent. Furthermore, the mono-silyl-protected derivative underwent periodate cleavage affording two synthetically useful a,P-unsaturated esters 2.43, 2.44, with one of esters being obtained via a silyl-migration method.''

Menstrual status and thermoregulatory responses of active adolescents during exercise in a cold environment

This study examined the interactions between the reproductive status and the thermoregulatory responses during exercise in the cold in girls involved in competitive sports. Four girls with established menstrual cycles comprised the eumenorrheic menarcheal group (EM) and 5 non-menstruating girls comprised the pre-menarcheal group (PM). During the first visit maximal oxygen consumption, height, weight and percent body fat (%BF) were measured. The second visit involved: a determination of metabolic rate in thermoneutrality (21°C) involving 10-min rest and 20-min cycling (30% of VCL max), and a cold stress test (5°C, 40% humidity, <0.3 m/s air velocity) involving 20-min rest and 40-min cycling (30% of VCL max.). Subjects in the EM group were tested twice in the chamber during the follicular and luteal phases. Pre-menarcheal subjects were found to have significantly (p<0.05) lower core temperatures during the final stages of cold exposure. Overall, body fat was not significantly correlated with core temperature in the cold, however there was a significant surface-to-mass ratio difference between the groups. While in the follicular phase, EM girls had a higher core temperature during cold exposure. Therefore, reproductive hormonal status seems to be an important factor in terms of cold tolerance in females during adolescence.

Immunohistochemical study of laterodorsal tegmental neurons active during 22kHz vocalization /

An ascending cholinergic projection, which originates in the laterodorsal tegmental nucleus (LDT), was implicated in the initiation of ultrasonic vocalization. The goal of this study was to histochemically examine the activity the LDT following ultrasonic calls induced by two methods. It was hypothesized that cholinergic LDT cells would be more active during air puffinduced vocalization than carbachol-induced one. Choline acetyltransferase (ChAT), and cFos protein were visualized histochemically as markers of cholinergic calls and cellular activity, respectively. Results indicated that animals vocalizing after carbachol, but not after air puff, had a significantly higher number of Fos labeled nuclei within the LDT than non vocalizing controls. A significantly higher number of doublelabeled neurons were discovered in the LDT of vocalizing animals (in both groups) as compared to control conditions. Thus, there were significantly more active cholinergic cells in the LDT of vocalizing than non-vocalizing rats for both methods of call induction.

A dimensional analysis of the benzylic hydroxylase active site in mortierella isabellina

The spatial limits of the active site in the benzylic hydroxylase enzyme of the fungus Mortierella isabellina were investigated. Several molecular probes were used in incubation experiments to determine the acceptability of each compound by this enzyme. The yields of benzylic alcohols provided information on the acceptability of the particular compound into the active site, and the enantiomeric excess values provided information on the "fit" of acceptable substrates. Measurements of the molecular models were made using Cambridge Scientific Computing Inc. CSC Chem 3D Plus modeling program. i The dimensional limits of the aromatic binding pocket of the benzylic hydroxylase were tested using suitably substituted ethyl benzenes. Both the depth (para substituted substrates) and width (ortho and meta substituted substrates) of this region were investigated, with results demonstrating absolute spatial limits in both directions in the plane of the aromatic ring of 7.3 Angstroms for the depth and 7.1 Angstroms for the width. A minimum requirement for the height of this region has also been established at 6.2 Angstroms. The region containing the active oxygen species was also investigated, using a series of alkylphenylmethanes and fused ring systems in indan, 1,2,3,4-tetrahydronaphthalene and benzocycloheptene substrates. A maximum distance of 6.9 Angstroms (including the 1.5 Angstroms from the phenyl substituent to the active center of the heme prosthetic group of the enzyme) has been established extending directly in ii front of the aromatic binding pocket. The other dimensions in this region of the benzylic hydroxylase active site will require further investigation to establish maximum allowable values. An explanation of the stereochemical distributions in the obtained products has also been put forth that correlates well with the experimental observations.

Active living in municipal parks and recreation : a case study

If quality of life is an important recreation outcome, then municipal parks and recreation management's efforts have to change because:· Over one-third of all the little kids in schools will be diabetic in their lifetime if the trends we are looking at continue. The average loss of life is about 15 years, and there is an average reduction in quality oflife by about 20 years (Jackson, 2007). This thesis is about municipal parks and recreation, an agency that controls and limits physical activity opportunity. It is also about active living; from an ecological perspective, a multi-disciplinary approach to incorporate physical activity into more 111 people's daily lives. In particular, this thesis examines one case --'. the Donutville Case - . with the intent of providing an explanation of how municipal parks and recreation can advance its management efforts to improve health outcomes of people suffering from daily physical activity deficits. More specifically, how can the tension between external and internal environments to municipal parks and recreation be better balanced to affect the change needed? Given that changing the current social reality is through making decisions, decision-making functions connected with systems theory helps identify how recreation authorities can more effectively influence environmental physical activity determinants. , Sallis et al.' (2006) ·social ecological model provides the a priori focus on active living decision-making. An integrated analogous emerging logic model is developed and presented as an efficacious strategy for how municipal parks and recreation decisionmakers can affect change. Keywords: physical activity, benefits outcomes, healthy livable community, quality of life, systems thinking, social ecological model, deci~ion-making, logic modeling, municipal parks and recreation, active living.

Active isolated stretching : an investigation of the mechanical mechanisms

The Active Isolated Stretching (AIS) technique proposes that by contracting a muscle (agonist) the opposite muscle (antagonist) will relax through reciprocal inhibition and lengthen without increasing muscle tension (Mattes, 2000). The clinical effectiveness of AIS has been reported but its mechanism of action has not been investigated at the tissue level. Proposed mechanisms for increased range of motion (ROM) include mechanical or neural changes, or an increased stretch tolerance. The purpose of the study was to investigate changes in mechanical properties, i.e. stiffness, of skeletal muscle in response to acute and long-term AIS stretching for the hamstring muscle group. Recreationally active university-aged students (female n=8, male n=2) classified as having tight hamstrings, by a knee extension test, volunteered for the study. All stretch procedures were performed on the right leg, with the left leg serving as a control. Each subject was assessed twice: at an initial session and after completing a 6-week AIS hamstring stretch training program. For both test sessions active knee extension (ROM) to a position of "light irritation", passive resisted torque and stiffness were determined before and after completion of the AIS technique (2x10 reps). Data were collected using a Biodex System 3 Pro (Biodex Medical Systems, NY, USA) isokinetic dynamometer. Surface electromyography (EMG) was used to monitor vastus lateralis (VL) and hamstring muscle activity during the stretching movements. Between test sessions, 2x10 reps of the AIS bent knee hamstring stretch were performed daily for 6-weeks.

Adult Participants’ Experiences of a Sport Program Implementing the Easy-Play Model: Implications for an Active Lifestyle

The Easy-Play Model is a useful framework for facilitating sport among a diverse group of participants of different ages and ability levels. The model’s focus on de-emphasizing competitiveness in an effort to establish an optimally competitive environment has facilitated positive play experiences. This study investigated the experiences of players who have been a part of a weekly soccer program implementing the Easy-Play Model. In-depth interviews of 8 participants provided insight concerning the benefits and weaknesses of the approach and the notable experiences of the players. Results provided data confirming the model’s effectiveness in facilitating positive social interactions, safe play experiences where injury is generally a negligible concern, and productive opportunities to be physically active through sport. This study of the Easy-Play Model sets the foundation for future research which should further add to our understanding of productive ways to engage people in physical activity through sport.

Developing Physical Activity Habit in Schools for Active Lifestyle Among Children and Adolescents

This study sought to identify and suggest ways to develop physical activity habits in school-aged children and adolescents that could help them continue healthy active practices throughout their lifespan. A systematic review of the literature identified 4 key factors that may influence school-based physical activity habit formation—motivation, enjoyment, commitment, and sustainment—and how each may be achieved in schools. The research paper begins by exploring the definitions and meaning of a habit, how it is developed, and its effect on a healthy active lifestyle. The study proposes a framework comprising 3 major components (i.e., programs, teachers, students) and offers practical strategies that support and nurture the development of students’ physical activity habits in schools. The study concludes by making recommendations for further study.

Can a Manipulated Mind Alter Matter? : The Effects of Verbal Feedback on Self-Efficacy, Exercise Intention, and Exercise Behaviour among Low-Active College-Aged Women

Self-efficacy (SE), a person’s confidence in the ability to perform a task, is an important predictor of the adoption and maintenance of physical activity. The present study examined the effects of SE manipulated through verbal persuasion on exercise intentions and behaviour during a 4-week follow-up period and investigated the role of social physique anxiety (SPA) as a moderator. Female college infrequent exercisers (n = 66) were randomly assigned into one of three groups (high-efficacy [HE], low-efficacy [LE], or control) and asked to complete several questionnaires at baseline. The HE and LE groups were provided with positive and negative exercise adherence feedback, respectively. The HE group reported higher SE from pre- to post-feedback. Both the HE and LE groups reported increases in exercise behaviour at the 4-week follow-up. Pre- to post-feedback changes in SE, exercise intention, and exercise behaviour did not depend on level of SPA reported.

Understanding Network Governance: A Case Study Exploration of Active Canada 20/20

Consistent with the governance shift towards network forms of governance, a number of new social movements have formed in response to the declining levels of physical activity in the Western world. One such movement is Active Canada 20/20: A Physical Activity Strategy and Change Agenda for Canada. Network governance is employed as the theoretical framework for this case study exploration of Active Canada 20/20 and the political landscape surrounding its development and implementation. Semi-structured interviews were conducted in addition to document/policy analysis and direct observations. Analysis of the data resulted in three overarching themes – the defining characteristics of network governance, the political landscape, and intersectoral linkages – that interconnect multifariously based the nature of the Canadian federal government and its relationship with the voluntary sector for physical activity. Despite progress in driving Active Canada 20/20 forward, entrenched dynamics of power need to be navigated within the political landscape surrounding network governance.