The one hundred and fiftieth anniversary of the granting of the charter of the town of Plymouth, New Hampshire, July 15, 1763, July 13-14-15, 1913;

Plates printed on both sides.

Investigation and report of property values, together with the status and control of stocks and bonds of carriers subject to the act to regulate commerce. Hearings before the Committee on Interstate and Foreign Commerce of the House of Representatives, on the bill H.R. 12811, as to the details, methods, practicability, and costs of the investigation proposed. February 15 and 16, 1912.

William C. Adamson, Chairman.

Life and letters of Brooke Foss Westcott, D.D., D.C.L., sometime bishop of Durham;

Appendix III: Bibliographical, v.2, p.441-448.

Articles of association and constitution and by-laws of the Indianapolis Bar Association and list of members and officers, May 15, 1916

Mode of access: Internet.

The life and explorations of David Livingstone, LL.D.

Mode of access: Internet.

Bibliography of Herman Goodman, M. D. Books, articles,

Mode of access: Internet.

Directory of Federal R and D Installations

Mode of access: Internet.

The Roman empire: essays on the constitutional history from the accession of Domitian (81 A. D.) to the retirement of Nicephorus III (1081 A.D.).

Mode of access: Internet.

The life of Samuel Johnson, LL.D and the journal of his tour to the Hebrides.

Mode of access: Internet.

Memoir of John Griscom, LL.D., late professor of chemistry and natural philosophy; ...Comp. from an autobiography and other sources

Mode of access: Internet.

The life and letters of Lady Sarah Lennox, 1745-1826, daughter of Charles, 2nd Duke of Richmond, and successively the wife of Sir Thomas Charles Bunbury, Bart., and of the Hon. George Napier; also a short political sketch of the years 1760 to 1763,

Mode of access: Internet.

The works of William E. Channing, D. D.

Includes bibliographical references.

Isolation and characterisation of conomap-Vt, a D-amino acid containing excitatory peptide from the venom of a vermivorous cone snail

Cone snail venom is a rich source of bioactives, in particular small disulfide rich peptides that disrupt synaptic transmission. Here, we report the discovery of conomap-Vt (Conp-Vt), an unusual linear tetradecapeptide isolated from Conus vitulinus venom. The sequence displays no homology to known conopeptides, but displays significant homology to peptides of the MATP (myoactive tetradecapeptide) family, which are important endogenous neuromodulators in molluscs, annelids and insects. Conp-Vt showed potent excitatory activity in several snail isolated tissue preparations. Similar to ACh, repeated doses of Conp-Vt were tachyphylactic. Since nicotinic and muscarinic antagonists failed to block its effect and Conp-Vt desensitised tissue remained responsive to ACh, it appears that Conp-Vt contractions were non-cholinergic in origin. Finally, biochemical studies revealed that Conp-Vt is the first member of the MATP family with a D-amino acid. Interestingly, the isomerization of L-Phe to D-Phe enhanced biological activity, suggesting that this post-translational modified conopeptide may have evolved for prey capture. (c) 2006 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.

Molecular dynamics characterization of n-octyl-beta-D-glucopyranoside micelle structure in aqueous solution

n-Octyl-beta-D-glueopyranoside (OG) is a non-ionic glycolipid, which is used widely in biotechnical and biochemical applications. All-atom molecular dynamics simulations from two different initial coordinates and velocities in explicit solvent have been performed to characterize the structural behaviour of an OG aggregate at equilibrium conditions. Geometric packing properties determined from the simulations and small angle neutron scattering experiment state that OG micelles are more likely to exist in a non-spherical shape, even at the concentration range near to the critical micelle concentration (0.025 M). Despite few large deviations in the principal moment of inertia ratios, the average micelle shape calculated from both simulations is a prolate ellipsoid. The deviations at these time scales are presumably the temporary shape change of a micelle. However, the size of the micelle and the accessible surface areas were constant during the simulations with the micelle surface being rough and partially elongated. Radial distribution functions computed for the hydroxyl oxygen atoms of an OG show sharper peaks at a minimum van der Waals contact distance than the acetal oxygen, ring oxygen, and anomeric carbon atoms. This result indicates that these atoms are pointed outwards at the hydrophilic/hydrophobic interface, form hydrogen bonds with the water molecules, and thus hydrate the micelle surface effectively. (c) 2005 Elsevier Inc. All rights reserved.