Agri-News, October 9, 2009, Vol. 9, no. 16

Crop and livestock summaries for the state of Iowa, produced by the Iowa Department of Agriculture.

Agri-News, October 16, 2009, Vol. 9, no. 17

Crop and livestock summaries for the state of Iowa, produced by the Iowa Department of Agriculture.

Agri-News, October 17, 2008, Vol. 8, no. 16

Crop and livestock summaries for the state of Iowa, produced by the Iowa Department of Agriculture.

Agri-News, October 18, 2007, Vol. 7, no. 16

Crop and livestock summaries for the state of Iowa, produced by the Iowa Department of Agriculture.

Agri-News, November 16, 2007, Vol. 7, no. 18

Crop and livestock summaries for the state of Iowa, produced by the Iowa Department of Agriculture.

Iowa Department of Transportation Major Items - Preliminary Quantity Report, August 16, 2011; With Addendums

Weekly letting report.

List of Bid Proposal Holders, August 16, 2011

List of Bid Proposal Holders

Vendor Ranking, August 16, 2011

Vendor Ranking for letting reports from the Iowa Department of Transportation.

Report of the Workshop on Intelligent Construction for Earthworks, April 14-16, 2008

This document summarizes the discussion and findings of a workshop on intelligent technologies for earthwork construction held in West Des Moines, Iowa, on April 14–16, 2009. This meeting follows a similar workshop conducted in 2008. The objective of the meeting was to provide a focused discussion on identifying research and implementation needs/strategies to advance intelligent compaction and automated machine guidance technologies. Technical presentations, interactive working breakout sessions, and a panel discussion comprised the workshop. About 100 attendees representing state departments of transportation, Federal Highway Administration, contractors, equipment manufacturers, and researchers participated in the workshop.

Report on a review of selected general and application controls over the Iowa Public Employees’ Retirement System (IPERS) Legacy and I-Que Pension Administration Systems for the period May 16, 2011 through June 16, 2011

Report on a review of selected general and application controls over the Iowa Public Employees’ Retirement System (IPERS) Legacy and I-Que Pension Administration Systems for the period May 16, 2011 through June 16, 2011

Systemic in vivo lentiviral delivery of miR-15a/16 reduces malignancy in the NZB de novo mouse model of chronic lymphocytic leukemia.

Similar to human chronic lymphocytic leukemia (CLL), the de novo New Zealand Black (NZB) mouse model has a genetically determined age-associated increase in malignant B-1 clones and decreased expression of microRNAs miR-15a and miR-16 in B-1 cells. In the present study, lentiviral vectors were employed in vivo to restore miR-15a/16, and both the short-term single injection and long-term multiple injection effects of this delivery were observed in NZB. Control lentivirus without the mir-15a/16 sequence was used for comparison. We found that in vivo lentiviral delivery of mir-15a/16 increased miR-15a/16 expression in cells that were transduced (detected by GFP expression) and in sera when compared with control lentivirus treatment. More importantly, mice treated with the miR-expressing lentivirus had decreased disease. The lentivirus had little systemic toxicity while preferentially targeting B-1 cells. Short-term effects on B-1 cells were direct effects, and only malignant B-1 cells transduced with miR-15a/16 lentivirus had decreased viability. In contrast, long-term studies suggested both direct and indirect effects resulting from miR-15a/16 lentivirus treatment. A decrease in B-1 cells was found in both the transduced and non-transduced populations. Our data support the potential use of systemic lentiviral delivery of miR-15a/16 to ameliorate disease manifestations of CLL.

Friday Facts, September 16, 2011, Vol. 114

Bureau of Nutrition and Health Promotion part of the Iowa Department of Public Health produces of weekly newsletter about the Iowa WIC Program for the State of Iowa citizen.