L'amour maternel chez les animaux / par Ernest Menault... ; ouvrage ill. de 78 vignettes sur bois par A. Mesnel

Collection : Bibliothèque des merveilles

Marseille. Collection de copies et de documents originaux concernant l'histoire de Marseille. Collection Mortreuil sur Marseille vol. 33 : Pièces originales I (13 janvier 1218-1324).

Le manuscrit est composé de différents documents originaux datant de 1217 à 1324. La date est signalée au crayon (XIXe s.)

Marseille. Collection de copies et de documents originaux concernant l'histoire de Marseille. collection Mortreuil sur Marseille vol. 37 : Pièces originales V (11 août 1391- 31 janvier 1711). Pièces provençales (1221-1476).

Le manuscrit est composé de différents documents originaux du XIIIe au XVIIIe siècle . La date est signalée au crayon (XIXe s.)F. 1 -70. 11 août 1391- 31 janvier 1711; F. 71-108. Pièces provençales 1221-1476.

Missale ad usum monasterii Sancti Cornelii Compendiensis.

Les ff. 1-20, en papier, ont été ajoutés aux XVIIe-XVIIIe s. Ils renferment une série d'évangiles.

VOLUMES RELIES du Cabinet des titres : recherches de noblesse, armoriaux, preuves, histoires généalogiques. « État des gentilhommes et de leur filiation.. dans la Généralité de la haute Normandie, faite par Mr de Barin, seigneur de La Galisonnière, lors intendant de Rouen, en l'année 1666 ».

Il y a une table alphabétique des noms à la page 921.

O Desporto Nos Países Africanos: Entre as Práticas Coloniais e os Projectos De Modernidade

Nos anos 60, o mundo mudava. No arquipélago, em 1960, tiveram lugar as comemorações do centenário da morte do Infante D. Henrique. Em 1970, celebrou-se o quinto centenário da sua descoberta. Dir-se-ia que ambas as comemorações selavam um aparente imobilismo. Porém, também no arquipélago, o quotidiano a pouco e pouco deixava de ser hegemonizado pelo ideário nacionalista justificativo da situação colonial. Um dos indícios dessa mudança foi o incremento do desporto. No dia 11 de Junho de 1960, dia seguinte ao da Raça, teve lugar a inauguração da sede do Sport S. Tomé e Benfica, a que compareceu o governador e o respectivo séquito. Na sua alocução, aquele incitou os dirigentes do clube a prosseguirem na “Cruzada do Desportivismo a que tinham metido ombros, explanando o Significado Patriótico da prática dos Desportos a que o Governo não podia alhear-se”. Tratava-se de um discurso já coçado. Sem embargo da constância dos referentes ideológicos e dos motes políticos, os anos 60 iriam trazer mudanças em matéria de política social e de desporto. Continuando embora como um elo do vínculo emocional e político à metrópole, o desporto conheceria novas facetas, ocupando, progressivamente, maior espaço no quotidiano local.

Cis-configured aziridines are new pseudo-irreversible dual-mode inhibitors of Candida albicans secreted aspartic protease 2

A series of cis-configured epoxides and aziridines containing hydrophobic moieties and amino acid esters,were synthesized as new potential inhibitors of the secreted aspartic protease 2 (SAP2) of Candida albicans. Enzyme assays revealed the N- benzyl-3-phenyl-substituted aziridines 11 and 17 as the most potent inhibitors, with second-order inhibition, rate constants (k(2)) between 56000 and 12-1000 M-1 min(-1). The compounds were shown to be pseudo-irreversible dual-mode, inhibitors: the interm ediate esterified enzyme resulting from nucleophilic ring opening was hydrolyzed and yielded amino alcohols as transition state-mimetic reversible inhibitors. The results of docking studies with the ring-closed aziridine forms of the inhibitors suggest binding modes mainly dominated by hydrophobic interactions with the S1, S1' S2, and S2' subsites of the protease, and docking studies with the processed amino alcohol forms predict additional hydrogen bonds of the new hydroxy group to the active site Asp residues. C. albicans growth assays showed the compounds to decrease SAP2-dependent growth while not affecting SAP2-independent growth.

Myocardial infarct size and mortality depend on the time of day-a large multicenter study.

BACKGROUND: Different studies have shown circadian variation of ischemic burden among patients with ST-Elevation Myocardial Infarction (STEMI), but with controversial results. The aim of this study was to analyze circadian variation of myocardial infarction size and in-hospital mortality in a large multicenter registry. METHODS: This retrospective, registry-based study was based on data from AMIS Plus, a large multicenter Swiss registry of patients who suffered myocardial infarction between 1999 and 2013. Peak creatine kinase (CK) was used as a proxy measure for myocardial infarction size. Associations between peak CK, in-hospital mortality, and the time of day at symptom onset were modelled using polynomial-harmonic regression methods. RESULTS: 6,223 STEMI patients were admitted to 82 acute-care hospitals in Switzerland and treated with primary angioplasty within six hours of symptom onset. Only the 24-hour harmonic was significantly associated with peak CK (p = 0.0001). The maximum average peak CK value (2,315 U/L) was for patients with symptom onset at 23:00, whereas the minimum average (2,017 U/L) was for onset at 11:00. The amplitude of variation was 298 U/L. In addition, no correlation was observed between ischemic time and circadian peak CK variation. Of the 6,223 patients, 223 (3.58%) died during index hospitalization. Remarkably, only the 24-hour harmonic was significantly associated with in-hospital mortality. The risk of death from STEMI was highest for patients with symptom onset at 00:00 and lowest for those with onset at 12:00. DISCUSSION: As a part of this first large study of STEMI patients treated with primary angioplasty in Swiss hospitals, investigations confirmed a circadian pattern to both peak CK and in-hospital mortality which were independent of total ischemic time. Accordingly, this study proposes that symptom onset time be incorporated as a prognosis factor in patients with myocardial infarction.