Tenascin-W is found in malignant mammary tumors, promotes alpha8 integrin-dependent motility and requires p38MAPK activity for BMP-2 and TNF-alpha induced expression in vitro

Tenascins represent a family of extracellular matrix glycoproteins with distinctive expression patterns. Here we have analyzed the most recently described member, tenascin-W, in breast cancer. Mammary tumors isolated from transgenic mice expressing hormone-induced oncogenes reveal tenascin-W in the stroma around lesions with a high likelihood of metastasis. The presence of tenascin-W was correlated with the expression of its putative receptor, alpha8 integrin. HC11 cells derived from normal mammary epithelium do not express alpha8 integrin and fail to cross tenascin-W-coated filters. However, 4T1 mammary carcinoma cells do express alpha8 integrin and their migration is stimulated by tenascin-W. The expression of tenascin-W is induced by BMP-2 but not by TGF-beta1, though the latter is a potent inducer of tenascin-C. The expression of tenascin-W is dependent on p38MAPK and JNK signaling pathways. Since preinflammatory cytokines also act through p38MAPK and JNK signaling pathways, the possible role of TNF-alpha in tenascin-W expression was also examined. TNF-alpha induced the expression of both tenascin-W and tenascin-C, and this induction was p38MAPK- and cyclooxygenase-dependent. Our results show that tenascin-W may be a useful diagnostic marker for breast malignancies, and that the induction of tenascin-W in the tumor stroma may contribute to the invasive behavior of tumor cells.

Dilution and redistribution effects of rapid 2-litre infusions of 0.9% (w/v) saline and 5% (w/v) dextrose on haematological parameters and serum biochemistry in normal subjects: a double-blind crossover study

Although hypoalbuminaemia after injury may result from increased vascular permeability, dilution secondary to crystalloid infusions may contribute significantly. In this double-blind crossover study, the effects of bolus infusions of crystalloids on serum albumin, haematocrit, serum and urinary biochemistry and bioelectrical impedance analysis were measured in healthy subjects. Ten male volunteers received 2-litre infusions of 0.9% (w/v) saline or 5% (w/v) dextrose over 1 h; infusions were carried out on separate occasions, in random order. Weight, haemoglobin, serum albumin, serum and urinary biochemistry and bioelectrical impedance were measured pre-infusion and hourly for 6 h. The serum albumin concentration fell in all subjects (20% after saline; 16% after dextrose) by more than could be explained by dilution alone. This fall lasted more than 6 h after saline infusion, but values had returned to baseline 1 h after the end of the dextrose infusion. Changes in haematocrit and haemoglobin were less pronounced (7.5% after saline; 6.5% after dextrose). Whereas all the water from dextrose was excreted by 2 h after completion of the infusion, only one-third of the sodium and water from the saline had been excreted by 6 h, explaining its persistent diluting effect. Impedances rose after dextrose and fell after saline (P<0.001). Subjects voided more urine (means 1663 and 563 ml respectively) of lower osmolality (means 129 and 630 mOsm/kg respectively) and sodium content (means 26 and 95 mmol respectively) after dextrose than after saline (P<0.001). While an excess water load is excreted rapidly, an excess sodium load is excreted very slowly, even in normal subjects, and causes persistent dilution of haematocrit and serum albumin. The greater than expected change in serum albumin concentration when compared with that of haemoglobin suggests that, while dilution is responsible for the latter, redistribution also has a role in the former. Changes in bioelectrical impedance may reflect the electrolyte content rather than the volume of the infusate, and may be unreliable for clinical purposes.

Measurement of hard double-parton interactions in W→lv+ 2 jet events at sqrt(s)=7 TeV with the ATLAS detector

The production of W bosons in association with two jets in proton-proton collisions at a centre-of-mass energy of root s = 7 TeV has been analysed for the presence of double-parton interactions using data corresponding to an integrated luminosity of 36 pb(-1), collected with the ATLAS detector at the Large Hadron Collider. The fraction of events arising from double-parton interactions, f(DP)((D)), has been measured through the p(T) balance between the two jets and amounts to f(DP)((D)) = 0.08 +/- 0.01 (stat.) +/- 0.02 (sys.) for jets with transverse momentum p(T) > 20 GeV and rapidity vertical bar y vertical bar < 2.8. This corresponds to a measurement of the effective area parameter for hard double-parton interactions of sigma(eff) = 15 +/- 3 (stat.)(-3)(+5) (sys.) mb.

Ediacaran 2,500-km-long synchronous deep continental subduction in the West Gondwana Orogen

The deeply eroded West Gondwana Orogen is a major continental collision zone that exposes numerous occurrences of deeply subducted rocks, such as eclogites. The position of these eclogites marks the suture zone between colliding cratons, and the age of metamorphism constrains the transition from subduction-dominated tectonics to continental collision and mountain building. Here we investigate the metamorphic conditions and age of high-pressure and ultrahigh-pressure eclogites from Mali, Togo and NE-Brazil and demonstrate that continental subduction occurred within 20 million years over at least a 2,500-km-long section of the orogen during the Ediacaran. We consider this to be the earliest evidence of large-scale deep-continental subduction and consequent appearance of Himalayan-scale mountains in the geological record. The rise and subsequent erosion of such mountains in the Late Ediacaran is perfectly timed to deliver sediments and nutrients that are thought to have been necessary for the subsequent evolution of sustainable life on Earth.

[Signatur: W 1153 Nr. 2]

In Fraktur

Na 1 Nachlass Max Horkheimer, 510 - Korrespondenzen mit Theodor W. Adono (p. VI 2, 1 - 212)

Briefwechsel zwischen Theodor W. Adono, Gretel Adorno und Max Horkheimer, 1955-1957; 1 Brief der Gesellschaft für soziale Betriebspraxis an Theodor W. Adorno und Max Horkheimer, 30.08.1955; 1 Brief der Gesellschaft für soziale Betriebspraxis mbH in Düsseldorf an das Rationalisierungs-Kuratorium der Deutschen Wirtschaft RG Mensch und Arbeit in Frankfurt; 1 Brief von Theodor W. Adorno an Elisabeth Calvelli-Adorno, 19.08.1955; 5 Briefe zwischen Alice Maier und Theodor W. Adorno, 1955-1956; 2 Briefe von Theodor W. Adorno an Frederick Polock, 1955; 1 Brief von Theodor W. Adorno an Herrn Ritter, Dekan der Philosphischen Fakultät der Johann Wolfgang Goethe-Universität Frankfurt am Main, 24.05.1955; 1 Brief von Marianne Regensburger an Theodor W. Adorno, 1955; 1 Brief von Marianne Regensburger an Walter Abendroth, Berlin-Schöneberg, 11.05.1955; 1 Brief von Theodor W. Adorno an Herrn von Staa, 24.03.1955; 1 Brief von Theodor W. Adorno an Herrn Kux, 08.03.1955; 1 Briefentwurf von Theodor W. Adorno an Gottfried Weber, Dekan der Philosophischen Fakultät der Johann Wolfgang Goethe-Universität Frankfurt am Main, 1956; 1 Brief von Theodor W. Adorno an Renato Solmi, 04.09.1956; 1 Brief von Theodor W. Adorno an das Kuratorium der Johann Wolfgang Goethe-Universität in Frankfurt am Main, 27.03.1956;

Na 1 Nachlass Max Horkheimer, 511 - Korrespondenzen mit Theodor W. Adorno (p. VI 2, 213 - 379)

Briefwechsel zwischen Theodor W. Adorno, Gretel Adorno und Max Horkheimer, 1955-1957; Briefwechsel zwischen Alice Maier und Gertrud Straulino, 1957; 3 Briefe von Theodor W. Adorno und dem Soziologen Kurt H. Wolff, 1957; 1 Brief von Theodor W. Adorno und Herrn Hesse, 29.07.1957; 1 Brief von Theodor W. Adorno an Herbert Marcuse, 16.07.1957; 1 Brief von Theodor W. Adorno und dem Deutschen Institut für Talentstudien Köln, 03.07.1957; 1 Brief von Franz Ollig an Max Horkheimer, 10.04.1957; 1 Brief von H. Schelsky von der Deutschen Gesellschaft für Soziologie in Hamburg an Friedrich Bülow, 19.02.1957; 1 Rundbrief der Deutschen Gesellschaft für Soziologie in Hamburg; 1 Brief von Max Horkheimer und Theodor W. Adorno an Julius Ebbinghaus, 07.01.1957;

Sammlung der, die neue Organisation des Judenwesens im Großherzogthum Posen betreffenden Gesetze, Instruktionen, Rescripte u.s.w. : in deutscher u. zugleich hebr. Schrift hrsg. u. mit Einl., Anm. u. 2 alphabet. Sachreg. vers.

von W. J. Eichborn

Eröffnungs-Vorstellung : Fest-Ouverture componirt von Herrn Kapellmeister Goltermann ; Festspiel von Wilhelm Jordan … ; hierauf Don Juan ; Oper in 2 Akten von W. A. Mozart ; 20. October 1880 ; [Theaterzettel]

Opernhaus [Frankfurt]. Musik-Dirigent: Herr Kapellmeister Dessoff. Regie Herr F. Schwemer