Vastaus ed. K. Anderssonin kysymykseen, joka koskee toimenpiteitä 4 päivänä heinäkuuta 1944 sotaväen rikoslain muuttamisesta annetun lain kumoamiseksi

Puhe 4.7.1944

Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma.

We performed exome sequencing to detect somatic mutations in protein-coding regions in seven melanoma cell lines and donor-matched germline cells. All melanoma samples had high numbers of somatic mutations, which showed the hallmark of UV-induced DNA repair. Such a hallmark was absent in tumor sample-specific mutations in two metastases derived from the same individual. Two melanomas with non-canonical BRAF mutations harbored gain-of-function MAP2K1 and MAP2K2 (MEK1 and MEK2, respectively) mutations, resulting in constitutive ERK phosphorylation and higher resistance to MEK inhibitors. Screening a larger cohort of individuals with melanoma revealed the presence of recurring somatic MAP2K1 and MAP2K2 mutations, which occurred at an overall frequency of 8%. Furthermore, missense and nonsense somatic mutations were frequently found in three candidate melanoma genes, FAT4, LRP1B and DSC1.

Valtioneuvos K.-A.Fagerholm 8/6 1970

Kirje 8.6.1970

Statsrådet K.-A. Fagerholm 8.6.1970

Kirje