Neutrophil death induced by a triathlon competition in elite athletes

Introduction/Purpose: The effect of a triathlon competition on death of neutrophils from elite athletes was investigated. Methods: Blood was collected from 11 sedentary volunteers and 12 triathletes under rest and after a Half Ironman triathlon competition (2-km swimming, 80-km cycling, and 20-km running). Results: The triathlon competition increased DNA fragmentation, phosphatidylserine externalization, and reactive oxygen species production in neutrophils when compared to the results at rest. The proportion of neutrophils with mitochondrial transmembrane depolarization was increased in the triathletes at rest and after competition as compared with sedentary volunteers. Plasma levels of thiobarbituric acid reactive substances were increased in triathletes after competition. Expression of bcl-xL (antiapoptotic) was decreased and that of bax (proapoptotic) was increased, whereas intracellular neutral lipid content was lowered in neutrophils after the triathlon. A positive correlation was found between the proportion of neutrophils with DNA fragmentation and the plasma free fatty acid levels (r = 0.688, P < 0.05), which was elevated by threefold after competition. Plasma levels of oleic, linoleic, and stearic acids were increased in triathletes after the competition when compared with sedentary volunteers. The plasma concentration of these three fatty acids, measured after the triathlon competition, was toxic for 3-h cultured neutrophils obtained from sedentary volunteers. The maximal tolerable (nontoxic) concentration of the fatty acids by 3-h cultured neutrophils was 100 mu mol.L-1 for oleic and linoleic acids and 200 mu mol.L-1 for stearic acid. Conclusion: The triathlon competition induced neutrophil death possibly by apoptosis as indicated by DNA fragmentation and phosphatidylserine externalization. The increase in plasma levels of oleic, linoleic, and stearic acids induced by the competition may be involved in the neutrophil death observed possibly by increasing the production of reactive oxygen species and by decreasing the accumulation of intracellular neutral lipid.

Creatine supplementation reduces plasma levels of pro-inflammatory cytokines and PGE(2) after a half-ironman competition

Objective. The effect of creatine supplementation upon plasma levels of pro-inflammatory cytokines: Interleukin (IL) 1 beta and IL-6, Tumor Necrosis Factor alpha (TNF alpha), and Interferon alpha (INF alpha) and Prostaglandin E(2) (PGE(2)) after a half-ironman competition were investigated. Methods. Eleven triathletes, each with at least three years experience of participation in this sport were randomly divided between the control and experimental groups. During 5 days prior to competition, the control group (n = 6) was supplemented with carbohydrate (20g center dot d(-1)) whereas the experimental group (n = 5) received creatine (20 center dot d(-1)) in a double-blind trial. Blood samples were collected 48h before and 24 and 48h after competition and were used for the measurement of cytokines and PGE(2). Results. Forty-eight hours prior to competition there was no difference between groups in the plasma concentrations (pg center dot ml(-1), mean +/- SEM) of IL-6 (7.08 +/- 0.63), TNF alpha (76.50 +/- 5.60), INF alpha (18.32 +/- 1.20), IL-1 beta (23.42 +/- 5.52), and PGE(2) (39.71 +/- 3.8). Twenty-four and 48h after competition plasma levels of TNF alpha, INF alpha, IL-1 beta and PGE(2) were significantly increased (P < 0.05) in both groups. However, the increases in these were markedly reduced following creatine supplementation. An increase in plasma IL-6 was observed only after 24h and, in this case, there was no difference between the two groups. Conclusion. Creatine supplementation before a long distance triathlon competition may reduce the inflammatory response induced by this form of strenuous of exercise.

Pricing and competition in the Swedish retail market for electricity

Sweden, together with Norway, Finland and Denmark, have created a multi-national electricity market called NordPool. In this market, producers and retailers of electricity can buy and sell electricity, and the retailers then offers this electricity to end consumers such as households and industries. Previous studies have shown that pricing at the NordPool market is functioning quite well, but no other study has to my knowledge studied if pricing in the retail market to consumers in Sweden is well functioning. If the market is well functioning, with competition and low transaction costs when changing electricity retailer, we would expect that a homogeneous good such as electricity would be sold at the approximately same price, and that price changes would be highly correlated, in this market. Thus, the aim of this study is to test whether the price of Vattenfall, the largest energy firm in the Swedish market, is highly correlated to the price of other firms in the Swedish retail market for electricity. Descriptive statistics indicate that the price offered by Vattenfall is quite similar to the price of other firms in the market. In addition, regression analysis show that the correlation between the price of Vattenfall and other firms is as high as 0.98.

Competition of sicklepod, cassia obtusifolia l., densities on soybean, glycine max (l.) merr., at variable row distance

Competition studies with soybeans, Glycine max (L.) Merr. "Bragg." and sicklepod, Cassia obtusifolia L., were conducted at the Agricultural Research and Education Center of the University of Florida in Quincy, Florida. Two field experiments were established, one on May 22, 1975. and the other four weeks later, on June 19, 1975, to determine the competitive effects of various sicklepod densities and the influences of soybean row distances on weed dry matter, soybear plant characteristics, yield components and seed yield, and on soil nutrient content. Control, low, medium, and high sicklepod densities in the first experiment were O, 25,000, 53,000, and 77,000 p1ants/ha, respectively; while the second experiment presented control, low, medium, and high sicklepod densities of O, 36,000, 68,000, and 122,000 plants/ha, respectively. Three soybean row distance treatments were tested using a constant pattern of 90-, 60-, and 45-cm widths throughout the growing season. Three other treatments, evaluated in a variable patern, were initially seeded in 30-cm row widths. Five weeks after planting, an appropriate number of soybean rows were harvested from the 30"cm pattern to establish row distances of 90, 60, and 30-60 cm for the remainder of the season. ln the greenhouse a test was conducted to evaluate the effects af those variables on seed germination and seedling vigor for the next soybean generation. As a result of full-season sicklepod competition, soybean plants were less branched, set fewer leaves, and presented thinner stems as compared to the control. However, height of soybean plants was not affected by the presence of sicklepod. ln one of the two experiments, number of nodes decreased for soybeans under weed campetition. The yield components--number of pods; number of seeds, and seed yield per soybean plant--were all similarly reduced due to weed competition. Seeds per pod were decreased to a lesser extent. Soybean seed yields per unit area were significantly diminished by increasing levels af sicklepod ínfestation. While the control produced 3120 kg/ha, the sicklepod densities of 25,000, 53,000, and 77,000 plants/ha reduced seed yíelds 47, 65, and 73%, respectively. As soybean row distances decreased, number of branches, number of leaves, and stem diameter of soybeans decreased. However, the height of soybean plants increased with narrwing of row width. The components of seed yield--number of pods, number of seeds, and seed yield per soybean plant--diminished as row spacing was reduced. Maximum difference between row distances for these attributes was attained for soybean plants under weed-free conditions. Generally, as row width decreased, soybean seed yield per unit area increased. Specifically, soybear.s in 90-cm rows, either in constant or variable row pattern, yielded less than soybeans in 60- and 30-60-cm rows in the variable pattern. Soil contents of phosphorus, potassium, calcium, and magnesium were not affected by the various levels of sicklepod and soybean populalions. Neither the sicklepod densities nor the soybean row distances influenced seed germination and seedling vigor in the next soybean generation. Sicklepod was a strong competitor with soybeans at all density ranges investigated. Because sicklepod grows taller than soybeans during the reproductive stages of the crop, limited success can be reached by varying row spacing alone. However, this practice is considered an integral measure to complement other methods of sicklepod control. Compared to constant rows, the soybean cropping system using variable row spacings presents the choice of planting soybeans at close row spacings to provide early competition with weeds and the possibility of obtaining a forage crop after the first month of growth, without any decreases on the final seed yields.

Antecedentes e conseqüências da confiança do consumidor final em trocas relacionadas com empresas de serviço : um estudo com o usuário de Internet Banking no Brasil

Este trabalho analisa um dos setores econômicos mais desenvolvidos do Brasil, a indústria financeira. Mais especificamente, as situações de trocas relacionais com os clientes finais (pessoas-físicas), tanto através dos contatos tradicionais (com empregados do banco) quanto através do comércio eletrônico (via internet). São descritos aspectos dos comportamentos dos clientes bancários em seus relacionamentos comerciais, notadamente como a confiança desses clientes em relação à empresa é construída e quais as suas conseqüências para o relacionamento com o Banco. Através de uma survey com 611 clientes usuários de Internet Banking do Banco do Brasil de todo o País, confirmou-se a hipótese de que os clientes realizam avaliações do serviço através de facetas múltiplas: o Web Site, os Empregados de Fronteira e as Políticas e Práticas Gerenciais. De maneira geral, a competência operacional e a benevolência de cada uma das facetas foram confirmadas como antecedentes (ou formadores) da confiança. Ratificou-se, também, que os clientes avaliam os serviços em dois contextos distintos: situações rotineiras e quando ocorrem problemas (a chamada recuperação de serviços). A hipótese central do trabalho de que, em situações de trocas relacionais, a confiança que os clientes têm em cada uma das facetas gera o comportamento de lealdade foi confirmada. A mediação dessa relação pelo valor que o cliente percebe na relação de troca também mostrou-se consistente. A maioria dos resultados obtidos apresentou-se conforme o esperado e de acordo com a revisão de literatura realizada, sendo que muitos deles foram similares, em termos de magnitude e significância estatística, a trabalhos anteriores sobre tema semelhante em outros países. A partir desses resultados, são apresentadas limitações do trabalho e sugestões para pesquisas futuras em relação aos aspectos teóricos, metodológicos e práticos abordados.

Identificação das causas da não utilização do Sistema de Internet Banking da Caixa Econômica Federal em Porto Alegre

Os anos noventa representaram, para a sociedade brasileira, o início de uma era de mudanças contínuas. Na esfera econômica, as empresas passaram a ter um ambiente competitivo como nunca visto antes. Os bancos têm investido, desde então, recursos vultosos em sistemas de informação. A popularização da Internet para as empresas e o cidadão comum, ocorrida também neste período, criou um novo ambiente competitivo de marketing, levando os bancos a investirem pesadamente neste novo canal de distribuição. A Caixa Econômica Federal, um dos maiores bancos brasileiros, fez elevados investimentos na área de Internet, permitindo a seus clientes realizarem a maioria de suas operações domésticas a partir de qualquer computador. Apesar de ser uma forma rápida e barata de resolver os problemas de serviços bancários, muitos clientes não o utilizam, e, entre os que utilizam, muitos não o fazem com freqüência. Para entender melhor este problema, foi realizado uma pesquisa de cunho exploratório para analisar o comportamento dos usuários de Internet Banking da Caixa Econômica Federal, identificando quais atributos podem ser utilizados pela empresa para aumentar a utilização deste tipo de serviço. Este trabalho foi realizado com clientes de três agências de Porto Alegre (São João, Mont Serrat e Shopping Iguatemi), ao longo de 2.001. As principais conclusões deste trabalho são de que, para aumentar o acesso é necessário resolver dois problemas: primeiro, é necessário maior estímulo da mídia para persuadir os clientes a se habituarem com o novo sistema. Segundo, é necessário treinar os clientes, para que tenham mais facilidade no uso da Internet, ainda complicada para muitos.

O internet banking e os hábitos de uso entre os clientes pessoa física : atributos e resistências

A tecnologia vem alterando significativamente o modo de se atender o cliente bancário. Se antes os clientes obrigatoriamente percebiam os bancos como sinônimo de filas e, consequentemente, perda de tempo, hoje, estes mesmos bancos podem ser alcançados a partir de casa. Essa migração, no entanto, da forma de atendimento tradicional para o auto atendimento eletrônico traz algumas considerações relacionadas ao cliente usuário dos novos canais criados. Cabe saber se este cliente conhece os serviços oferecidos pelos novos canais, se enxerga atributos nestes e se detecta algum ponto de restrição ao seu uso. Este estudo teve por objetivo responder a algumas dessas questões, e para isso foram entrevistados duzentos e oitenta e um usuários do Internet Banking oferecido pelo Banco do Brasil, conhecido como BB Personal Banking Internet, em Brasília, Distrito Federal.

Effects of the real plan of the Brazilian banking system

The aim of this paper is to assess the progress of the banking sector before and shortly after the Real Plan. We began by assessing the drop in the inflation revenues (negative real interest rates paid by the excess of demand deposits over total reserve requirements) as a result of the change in inflation from 40% a month for the pre-Real Plan period to a monthly average of 3.65% (IGP-DI), between July 1994 and May 1995. Then, using the financial statement data of a group of 90 banks, we attempt to estimate the net losses due to the inflation drop analyzing the profitability and other parameters of the banking industry. The calculations are made separately for private, state and federal banks. A later analysis on performance using information given to CVM (Securities Exchange Commission) by the six major private banks in the country is also discussed herein.

Oligopolistic competition under knightian uncertainty

This artic/e applies a theorem of Nash equilibrium under uncertainty (Dow & Werlang, 1994) to the classic Coumot model of oligopolistic competition. It shows, in particular, how one can map all Coumot equilibrium (which includes the monopoly and the null solutions) with only a function of uncertainty aversion coefficients of producers. The effect of variations in these parameters over the equilibrium quantities are studied, also assuming exogenous increases in the number of matching firms in the game. The Cournot solutions under uncertainty are compared with the monopolistic one. It shows principally that there is an uncertainty aversion level in the industry such that every aversion coefficient beyond it induces firms to produce an aggregate output smaller than the monopoly output. At the end of the artic/e equilibrium solutions are specialized for Linear Demand and for Coumot duopoly. Equilibrium analysis in the symmetric case allows to identify the uncertainty aversion coefficient for the whole industry as a proportional lack of information cost which would be conveyed by market price in the perfect competition case (Lerner Index).

Relations between regulation, competition policy and consumer protection in telecommunications, electricity and water supply

The purpose of this article is to discuss the relations between regulation, competition policy and consumer protection these relations in three key sectors of Brazil’s infrastructure: telecommunications, electricity and water supply. A study of the literature points to two general principles. First, the need for consumer protection depends on the “degree of sovereignty” enjoyed by consumers, defined in terms of the cost of consumer organization, consumers’ ability to evaluate services, and the level of competition in each sector. Second, the less sovereignty consumers enjoy the more consumer protection institutions are involved with regulation agencies. The evidence for the Brazilian case apparently corroborates these points. In addition, it is important to stress that consumer complaints in regulated sectors seem to have increased more intensely than in others. The article is divided into three sections. Section 1 presents theoretical elements and aspects of the relations between regulation, competition policy and consumer protection evidenced by international experience. Section 2 analyzes the Brazilian experience and in particular the available statistics on consumer complaints about telecommunications, electricity and water supply, submitted to Fundação Procon-SP during the nineties. The last section points to possible configurations of the institutional relations between competition policy, regulation and consumer protection, showing how the existing configuration of these areas in the three infrastructure sectors discussed confirms that the theoretical framework proposed has reasonable predictive power.

Aspects of Brazilian competition policy

Este Trabalho Discute a Evolução da Defesa da Concorrência no Brasil a Partir de uma Perspectiva Histórica e Comparada. para Tanto, Primeiramente são Apresentadas as Transformações Estruturais da Economia Brasileira Assim como as Circunstâncias Internacionais que Fizeram com que a Defesa da Concorrência se Tornasse Relevante, o que Permite Fazer um Contraste com a Evolução de Outros Regimes de Concorrência. em Segundo Lugar, são Apresentados os Desafios e as Peculiaridades da Implementação da Defesa da Concorrência em uma Economia em Desenvolvimento e como Tais Desafios Foram Tratados no Caso Brasileiro. a Principal Conclusão é que as Melhores Práticas dos Países do Ocde não Podem ser Automaticamente Importadas sem a Devida Atenção Às Peculiaridades de uma Economia em Desenvolvimento.

Intellectual property and competition as complementary policies: a test using an ordered probit model

Este Artigo Testa a Proposição da Teoria Econômica de que Propriedade Intelectual e Defesa da Concorrência são Políticas Complementares. um Modelo Probit Ordenado é Utilizado para Estimar os Efeitos Marginais do Uso e Qualidade do Enforcement dos Direitos de Propriedade Intelectual em uma Medida da Gravidade dos Problemas Relacionados À Concorrência. os Resultados Obtidos Reforçam a Noção de que as Políticas de Concorrência e Propriedade Intelectual não são Contraditórias.