Audit report on the Taylor County Early Childhood Iowa Area for the year ended June 30, 2012

Audit report on the Taylor County Early Childhood Iowa Area for the year ended June 30, 2012

Audit report on Taylor County, Iowa for the year ended June 30, 2013

Audit report on Taylor County, Iowa for the year ended June 30, 2013

Common variants near MC4R are associated with fat mass, weight and risk of obesity.

To identify common variants influencing body mass index (BMI), we analyzed genome-wide association data from 16,876 individuals of European descent. After previously reported variants in FTO, the strongest association signal (rs17782313, P = 2.9 x 10(-6)) mapped 188 kb downstream of MC4R (melanocortin-4 receptor), mutations of which are the leading cause of monogenic severe childhood-onset obesity. We confirmed the BMI association in 60,352 adults (per-allele effect = 0.05 Z-score units; P = 2.8 x 10(-15)) and 5,988 children aged 7-11 (0.13 Z-score units; P = 1.5 x 10(-8)). In case-control analyses (n = 10,583), the odds for severe childhood obesity reached 1.30 (P = 8.0 x 10(-11)). Furthermore, we observed overtransmission of the risk allele to obese offspring in 660 families (P (pedigree disequilibrium test average; PDT-avg) = 2.4 x 10(-4)). The SNP location and patterns of phenotypic associations are consistent with effects mediated through altered MC4R function. Our findings establish that common variants near MC4R influence fat mass, weight and obesity risk at the population level and reinforce the need for large-scale data integration to identify variants influencing continuous biomedical traits.

Audit report on the Taylor County Early Childhood Iowa Area for the year ended June 30, 2013

Audit report on the Taylor County Early Childhood Iowa Area for the year ended June 30, 2013

University of Iowa John Pappajohn Entrepreneurial Center annual report, FY 2011.

Annual report of the John Pappajohn Entrepreneurial Center at the University of Iowa.

University of Iowa John Pappajohn Entrepreneurial Center annual report, FY 2012.

Annual report of the John Pappajohn Entrepreneurial Center at the University of Iowa.

University of Iowa John Pappajohn Entrepreneurial Center annual report, FY 2013.

Annual report of the John Pappajohn Entrepreneurial Center at the University of Iowa.

Audit report on Taylor County, Iowa for the year ended June 30, 2014

Audit report on Taylor County, Iowa for the year ended June 30, 2014

John Deweyn idealismista

Vastine Sami Pihlströmin kirjoitukseen Tieteessä tapahtuu-lehden numerossa 4/2000

Enquête sur la mode féminine : [plaquette de prestige] / High-Life Taylor ; [texte signé J.R.] ; [ill. de Bernard B. de Monvel, Maurice Leloir, L. Sabattier,...]

Mécénat texte imprimé : Cet ouvrage a été numérisé grâce à Myriam Lenourry