Studio portrait of Joseph Molling and business partner Ernst Joachim (?); Hannover, Germany.

Digital Image

New genetic loci link adipose and insulin biology to body fat distribution

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10−8). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.

Studio portrait of Hermann (Lazar Hirsch) Judey, his father Joseph (Mitskun) Judey, and Hermann's cousin Vladimir (Valodya) Barosin seated around a chess table; Riga Portraits Family

Hermann (Lazar Hirsch) Judey, born 1878 Riga and died 1959 New York; Joseph (Mitskun) Judey, born 1854 Vilna and died 1931 Berlin

Reproduction of photograph of Kaufman and Rosenberg family portrait on the occasion of the wedding of Ludwig Rosenberg and Paula Rosenberg nee Joseph (left); Hamburg.

Includes Ludwig Rosenberg and Paula Rosenberg nee Joseph (left), Thekla (Tekie) Joseph (standing center), Karl Kaufman and Else Kaufman (right)

Reproduction of wedding portrait of Ludwig Rosenberg and Paula Rosenberg nee Joseph; Hamburg.

Digital Image

Reproduction of portrait of Paula Rosenberg nee Joseph; Tel Aviv.

Digital Image

Studio portrait of Joseph and Meta Gruenstein Portraits Couples

Digital Image

Window display; Joseph? Marcus storefront; Gilgenburg Business Establishments

Digital Image

Joseph Molling with wife Margarete "Gretchen" nee Benjamin and son Peter on a walk.

Digital Image

Portrait of Hedwig and Ludwig Heinemann and Margarete nee Benjamin and Joseph Molling.

Elderly couple Hedwig and Ludwig Heinemann envolved with Adolph Molling Business. Younger couple is Margarete "Gretchen" Molling geb. Benjamin and Joseph Molling.