¿Anarquistas, ambientalistas o revolucionarios? La conflictividad rural en Chalco. San Francisco Acuautla contra Zoquiapa, 1850-1868

Resumen El artículo pretende determinar el peso de lo material y lo cultural como factores fundamentales del levantamiento rural en la región de Chalco, México. Entre 1760 y 1920 se producen una serie de cambios en la estructura económica y social de esa región que revelan la ofensiva de la hacienda comercial en detrimento de los recursos comunales de los pueblos. Esto genera una serie de conflictos agrarios de los cuales este artículo analiza uno, el de 1868, ya que su análisis permite considerar y discutir la naturaleza esencial del movimiento social, ponderando el componente anarquista con la dimensión ambientalista del mismo. El autor se encuentra un discurso reivindicativo de los recursos naturales que considera ?ambientalista? por ser una defensa del modo de vida de los pueblos y no sólo de un recurso ?ambiental?, mismo que inserta en la reflexión global sobre la encrucijada entre conflicto y negociación en la región de Chalco. Abstract This essay analyzes material and cultural explanations of rural rebellions in Chalco, Mexico between 1760 and 1920. In that period, several social and economic changes took place which reveal the consolidation of the commercial hacienda against pueblos communal resources. This situation produced several agrarian conflicts; this paper analyses one of those conflicts: that of 1868. The study of that conflict discloses the composition of the rural movement in its anarchist and environmental dimensions. This paper argues that the pueblos defended their natural resources and consequently their way of life by using an ?environmentalist? discourse. Such a discourse was inserted at a crossroads of conflict and negotiation in Chalco.

Differential Persistence of Transmitted HIV-1 Drug Resistance Mutation Classes

Methods. We studied participants with acute and/or early HIV infection and TDR in 2 cohorts (San Francisco, California, and Sao Paulo, Brazil). We followed baseline mutations longitudinally and compared replacement rates between mutation classes with use of a parametric proportional hazards model. Results. Among 75 individuals with 195 TDR mutations, M184V/I became undetectable markedly faster than did nonnucleoside reverse-transcriptase inhibitor (NNRTI) mutations (hazard ratio, 77.5; 95% confidence interval [CI], 14.7-408.2; P < .0001), while protease inhibitor and NNRTI replacement rates were similar. Higher plasma HIV-1 RNA level predicted faster mutation replacement, but this was not statistically significant (hazard ratio, 1.71 log(10) copies/mL; 95% CI, .90-3.25 log(10) copies/mL; P = .11). We found substantial person-to-person variability in mutation replacement rates not accounted for by viral load or mutation class (P < .0001). Conclusions. The rapid replacement of M184V/I mutations is consistent with known fitness costs. The long-term persistence of NNRTI and protease inhibitor mutations suggests a risk for person-to-person propagation. Host and/or viral factors not accounted for by viral load or mutation class are likely influencing mutation replacement and warrant further study.

Gene Expression in Brain: A Window on Ethanol Dependence, Neuroadaptation, and Preference

This article represents the proceedings of a symposium at the 2002 joint RSA/ISBRA Conference in San Francisco, California. The organizer was Paula L. Hoffman and the co-chairs were Paula L. Hoffman and Michael Miles. The presentations were (1) Introduction and overview of the use of DNA microarrays, by Michael Miles; (2) DNA microarray analysis of gene expression in brains of P and NP rats, by Howard J. Edenberg; (3) Gene expression patterns in brain regions of AA and ANA rats, by Wolfgang Sommer; (4) Patterns of gene expression in brains of selected lines of mice that differ in ethanol tolerance, by Boris Tabakoff; (5) Gene expression profiling related to initial sensitivity and tolerance in gamma-protein kinase C mutants, by Jeanne Wehner; and (6) Gene expression patterns in human alcoholic brain: from microarrays to protein profiles, by Joanne Lewohl.

El joc del TERCETI : una unitat didàctica multimèdia sobre GNU/LINUX amb suport DVB-MHP i SCORM.

Fent ús del programari lliure s'ha generat la unitat didàctica del joc del terceti per a la televisió digital interactiva i s'ha desada en format SCORM. La facilitat d'ús del comandament a distància fa possible practicar un tipus de t-learning fonamentat en l'edutainment (education+entertaiment) i provoca que el teleespectador passiu passi a ser un "teleusuari" més actiu.

Línia : Desenvolupament de projectes de programari lliure

Aquest projecte s'emmarca dins l'activitat docent dels centres de la Comunitat Valenciana que imparteixen cicles formatius de Formació Professional. En concret, totes les titulacions han d¿incloure pràctiques formatives en empreses o altres entitats com a part del seu currículum. El projecte intenta facilitar el màxim possible tot el procés de gestió d'aquestes pràctiques.

Meeting highlights of the 8th Annual Scientific Sessions of the Society For Cardiovascular Magnetic Resonance, January 21 to 23, 2005.

Parallel tracks for clinical scientists, basic scientists, and pediatric imagers was the novel approach taken for the highly successful 8th Annual Scientific Sessions of the Society for Cardiovascular Magnetic Resonance, held in San Francisco, California, January 21 to 23, 2005. Attendees were immersed in information on the latest scientific advances in cardiovascular magnetic resonance (CMR) from mice to man and technological advances from systems with field strengths from 0.5 T to 11.7 T. State-of-the-art applications were reviewed, spanning a wide range from molecular imaging to predicting outcome with CMR in large patient populations.

Taxonomy and morphology of Apsil Malloch (Diptera, Muscidae, Coenosiinae, Coenosiini) with new records, description of a new species and a key to identification

Taxonomy and morphology of Apsil Malloch (Diptera, Muscidae, Coenosiinae, Coenosiini) with new records, description of a new species and a key to identification. Apsil Malloch (Diptera, Muscidae, Coenosiinae, Coenosiini) includes 10 species, most of them described from Chile, but some also from Argentina. Five of them and one new species were found at the California Academy of Sciences collection (San Francisco, California) during the course of a project developed in that institution. Almost all material studied was collected in Chile, mainly by M. E. Irwin, during the year of 1966. Brief diagnosis of the known studied species (A. apicata Malloch, A. atripes Malloch, A. dilata Malloch, A. maculiventris Malloch (female described for the first time) and A. spatulata, Malloch), the description of A. mallochi, sp. nov. and a key for the identification of all known species are given. Color illustrations of some morphological characters make easier the recognition of the species. New geographic records were assigned.

Assessment of human skin penetration of two irritant herbicides

Two common herbicides; isoproturon and bentazon, are strong skin irritants and cross the skin barrier easily. Assessment of percutaneous absorption of these substances is a very important step in the evaluation of any dermal or transdermal dose, especially among agricultural workers who frequently have dermal exposures during crop treatment. The aims of the study were to determine the permeation rate of human skin for both herbicides in vitro, and histologically evaluate skin damage due to irritation at different concentrations. Skin penetration was assessed using a dynamic flow-through in vitro penetration system and analysis were performed with ion trap LC-MS (acidified water: acetronitile, C18 column). Two concentrations of bentazon (75 and 150 μg/mL) and isoproturon (125 and 250 μg/mL) in saline solution were applied on excised human skin from several donors. Saline water was used as receptor fluid. Collection times were: 4, 8, and 24 hours. After the experiments, the skin was removed and examined by histopathology for apoptosis, acanthosis, acantholysis and epidermolysis. The skin permeation rate, J, was calculated from the slope of the cumulative amount permeated as a function of time. The lag time, tL, was assigned from the time-axis intercept of the extrapolation of this linearity. Our results showed that tL for bentazon and isoproturon for both concentrations tested were similar; 2, 1.5 hours, respectively. Bentazon had a lowerer J compared to isoproturon; 350, 600 ng/cm2/h, respectively. Some acanthosis was observed after 8 hours of exposure to either of the two substances. In conclusion, our in vitro experiments demonstrate that bentazon and isoproturon cross the skin barrier within 2 hours even at very low concentrations, and showed some signs of skin damage. Future tests involve concentrations found in commercial products.

Effect of age toxicokinetics among human volunteers exposed to propylene glycol monomethyl ether (PGME)

Rationale: Aging adults represent the fastest growing population segment in many countries. Physiological and metabolic changes in the aging process may alter how aging adults respond to exposures compared to younger workers. Current preventive workplace exposure measures may therefore not be sufficiently protective for the aging workforce. In a controlled human toxicokinetic study (exposure chamber; 12m3), the volunteers (n=11) were men and women over the age of 58 years and exposed to a commonly used, low neurotoxic glycol ether; PGME (CAS no. 107-98- 2) (50 ppm, 6 hours). Oxidative metabolism (Michaelis-Menten) is the major pathway and conjugation the minor in humans. Metabolites, conjugated and free PGME are eliminated through the kidneys, and the elimination kinetics is dose-dependent (0 order). Scope: (1) compare the toxicokinetic profile of PGME obtained in the aging volunteers (58- 62 years) to young volunteers (20-25 years) from a previous study; (2) Test the predictive power of an existing PGME toxicokinetic compartment model for aging persons against urinary PGME concentrations found in volunteers from our experimental study. Experimental procedure: Urine samples were collected before, every 2-hour during exposures for six hours, and ad-lib for additional 20 hours. Urinary analysis of free and total PGME was performed using capillary GC/FID. The toxicokinetic model (Berkley Madonna software) was ageadjusted. Results. Urinary free and total PGME concentration rose rapidly, and did not reach an apparent plateau level during exposure. Less conjugation was observed in the older group. The predictive model developed for the young group predicted well total PGME in the aging group but not free PGME. The age adjusted toxicokinetic model's Vmax1 had to be changed for the aging group, implying slower enzymatic pathway. Conclusion: The toxicokinetic model did not predict well if only the physiological parameters were adjusted for aging adults (existing model); a substance specific metabolic rate parameter was also needed.

Article - Chardonnay

An article published by the Wine Advisory Board in California, that discusses the history, culture and process of making Chardonnay.

The Wine and Food Society Presents: Le diner de Noel Des Pape Clement V

A menu from the event "le Diner de Noel Des Pape Clement V to be held at St. Francis Hotel in San Francisco, California. The menu includes several varieties of wine, all highlighted in red ink.

PTPN22 Association in Systemic Lupus Erythematosus (SLE) with Respect to Individual Ancestry and Clinical Sub-Phenotypes

Protein tyrosine phosphatase non-receptor type 22 (PTPN22) is a negative regulator of T-cell activation associated with several autoimmune diseases, including systemic lupus erythematosus (SLE). Missense rs2476601 is associated with SLE in individuals with European ancestry. Since the rs2476601 risk allele frequency differs dramatically across ethnicities, we assessed robustness of PTPN22 association with SLE and its clinical subphenotypes across four ethnically diverse populations. Ten SNPs were genotyped in 8220 SLE cases and 7369 controls from in European-Americans (EA), African-Americans (AA), Asians (AS), and Hispanics (HS). We performed imputation-based association followed by conditional analysis to identify independent associations. Significantly associated SNPs were tested for association with SLE clinical sub-phenotypes, including autoantibody profiles. Multiple testing was accounted for by using false discovery rate. We successfully imputed and tested allelic association for 107 SNPs within the PTPN22 region and detected evidence of ethnic-specific associations from EA and HS. In EA, the strongest association was at rs2476601 (P = 4.761029, OR = 1.40 (95% CI = 1.25–1.56)). Independent association with rs1217414 was also observed in EA, and both SNPs are correlated with increased European ancestry. For HS imputed intronic SNP, rs3765598, predicted to be a cis-eQTL, was associated (P = 0.007, OR = 0.79 and 95% CI = 0.67–0.94). No significant associations were observed in AA or AS. Case-only analysis using lupus-related clinical criteria revealed differences between EA SLE patients positive for moderate to high titers of IgG anti-cardiolipin (aCL IgG .20) versus negative aCL IgG at rs2476601 (P = 0.012, OR = 1.65). Association was reinforced when these cases were compared to controls (P = 2.761025, OR = 2.11). Our results validate that rs2476601 is the most significantly associated SNP in individuals with European ancestry. Additionally, rs1217414 and rs3765598 may be associated with SLE. Further studies are required to confirm the involvement of rs2476601 with aCL IgG.

Relación entre la política de internacionalización de la economía colombiana y el desarrollo de la competitividad

La década de los noventa Colombia decide romper con el esquema tradicional de su política económica y comienza a desarrollar un proceso llamado apertura económica tendiente a la inserción de la economía en la nueva dinámica mundial del comercio

Caracterización de la cultura organizacional y lineamientos de intervención para la implementación de procesos de cambio en las organizaciones. Caso empresa sector financiero

El presente Trabajo de Grado busca caracterizar la cultura organizacional de una empresa del sector Financiero en Colombia y realizar orientaciones de acciones para el cambio organizacional de acuerdo con la estrategia de perdurabilidad establecida por la Alta Dirección de dicha empresa. Para este fin, se realiza una cuidadosa revisión y actualización del estado del arte de los conceptos clave ¨Cultura Organizacional¨ y ¨Cambio Organizacional¨. Es de resaltar que para el primero de ellos, se toma como punto de partida el estado del arte sobre Cultura Organizacional realizado por el profesor Carlos Eduardo Méndez Álvarez y cuyo marco temporal abarca desde los orígenes del concepto en el siglo XIX hasta el año 2006. Asimismo, luego de una cuidadosa revisión de los Modelos de Cambio Organizacional existentes y de la realidad de la empresa objeto de estudio, se adopta el Modelo ADKAR que consta de cinco fases: Conciencia del Cambio, Deseo, Conocimiento, Capacidad – Habilidad y Refuerzo. Asimismo, a partir de la construcción de un fundamento teórico sólido y a través de la aplicación de la metodología para describir la Cultura Organizacional en Colombia MEDECO se busca una aproximación a la Cultura Organizacional de la empresa objeto de estudio con el fin de describir e identificar los rasgos predominantes de su cultura organizacional y entregar una propuesta final con los rasgos necesarios que alientan la consecución exitosa de los procesos de cambio.

Coco Chanel. El éxito y la perdurabilidad de su marca, en relación con el liderazgo

Este trabajo de investigación consiste en establecer si Coco Chanel puede ser considerada un líder, y de ser así se determinarán las características de su liderazgo. Coco Chanel además de ser una diseñadora exitosa que marcó tendencias entre 1901 y 1971, también fue una administradora que posicionó una marca y un estilo a nivel mundial. Lo anterior es particularmente relevante en una sociedad y en un tiempo en el que la gran mayoría de empresarios eran hombres. Para lograr el objetivo, se describirán diferentes momentos y situaciones de la vida de Chanel, las cuales le dejaron enseñanzas y experiencias que contribuyeron a su desarrollo como persona, a marcar una época con tendencias revolucionarias y a posicionar su marca, la cuales a pesar del tiempo siguen intactas. Para caracterizar a Chanel, se analizarán sus decisiones y la repercusión tanto a nivel personal como empresarial, su entorno, documentos académicos, documentales, biografías, páginas web oficiales y videos que permitirán establecer el tipo de discurso y lenguaje utilizado por ella para la toma de decisiones en su vida y en su marca, las características de su empresa y del contexto que influyó en el éxito de su marca y en qué medida tal éxito se debió a procesos de liderazgo; de igual forma se establecerá si ella utilizó comprensión descriptiva, (lenguaje que sigue a la realidad) o comprensión generativa (la realidad que sigue al lenguaje) (Barbosa, 2009). A lo largo de esta investigación, se podrá reflexionar en torno a las habilidades que resultan esenciales en un líder y si estas podrían utilizarse en el entorno cambiante al que nos enfrentamos hoy en día.