Zur Geschichte der jüdischen Cultusgemeinde Belovar (Kroatien) : (Festschrift zur Einweihung d. neuerbauten Synagoge am 19. Sept. 1881)

von M. Grünwald

Prolog zur Feier des 200jährigen Bestehens der israelitischen Gemeinde zu Rendsburg und der vor 50 Jahren erfolgten Einweihung des neuerbauten Gotteshauses Rendsburg 1895

Enth. außerdem: Meyer, Frau Martin: Prolog zur Feier des 200jährigen Bestehens der israelitischen Gemeinde zu Rendsburg und der vor 50 Jahren erfolgten Einweihung des neuerbauten Gotteshauses Rendsburg 1895

Zur Geschichte der jüdischen Gemeinden Pisek und Mirotitz

von M. Grünwald

Jungbunzlauer Rabbiner

von M. Grünwald

Sitten und Bräuche der Juden im Orient

von M. Grünwald

Fünf Wochen in Brody unter jüdisch-russischen Emigranten : ein Beitr. zur Gesch. d. russ. Judenverfolgung

von M. Friedländer

Rezeption und Orthodoxie : gegenwärtiges Stadium dieser Angelegenheit. Nebst Beleuchtung antijüd. Agitationen Itzig Reichs ...; ein Beitr. z. Gesch. d. jüd. Partei-Streitigkeiten in Ungarn-Siebenbürgen

von M. Ehrentheil

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Using a genome-wide association and replication study in up to 100,000 individuals, we identified 35 common variant loci associated with QT interval that collectively explain ∼8-10% of QT-interval variation and highlight the importance of calcium regulation in myocardial repolarization. Rare variant analysis of 6 new QT interval-associated loci in 298 unrelated probands with LQTS identified coding variants not found in controls but of uncertain causality and therefore requiring validation. Several newly identified loci encode proteins that physically interact with other recognized repolarization proteins. Our integration of common variant association, expression and orthogonal protein-protein interaction screens provides new insights into cardiac electrophysiology and identifies new candidate genes for ventricular arrhythmias, LQTS and SCD.

Beiträge zur Geschichte der jüdischen Gemeinde Eisenstadt : nach archivarischen Quellen

bearb. von Moritz Markbreiter

Semi-dwarfism and lodging tolerance in tef (Eragrostis tef) is linked to a mutation in the α-Tubulin 1 gene

Genetic improvement of native crops is a new and promising strategy to combat hunger in the developing world. Tef is the major staple food crop for approximately 50 million people in Ethiopia. As an indigenous cereal, it is well adapted to diverse climatic and soil conditions; however, its productivity is extremely low mainly due to susceptibility to lodging. Tef has a tall and weak stem, liable to lodge (or fall over), which is aggravated by wind, rain, or application of nitrogen fertilizer. To circumvent this problem, the first semi-dwarf lodging-tolerant tef line, called kegne, was developed from an ethyl methanesulphonate (EMS)-mutagenized population. The response of kegne to microtubule-depolymerizing and -stabilizing drugs, as well as subsequent gene sequencing and segregation analysis, suggests that a defect in the α-Tubulin gene is functionally and genetically tightly linked to the kegne phenotype. In diploid species such as rice, homozygous mutations in α-Tubulin genes result in extreme dwarfism and weak stems. In the allotetraploid tef, only one homeologue is mutated, and the presence of the second intact α-Tubulin gene copy confers the agriculturally beneficial semi-dwarf and lodging-tolerant phenotype. Introgression of kegne into locally adapted and popular tef cultivars in Ethiopia will increase the lodging tolerance in the tef germplasm and, as a result, will improve the productivity of this valuable crop.