981 resultados para Lee, Benjamin, 1765-1828.
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von Max Freudenthal
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[Hs. vervielfältigt]
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Fibromuscular dysplasia (FMD) is a rare, nonatherosclerotic arterial disease for which the molecular basis is unknown. We comprehensively studied 47 subjects with FMD, including physical examination, spine magnetic resonance imaging, bone densitometry, and brain magnetic resonance angiography. Inflammatory biomarkers in plasma and transforming growth factor β (TGF-β) cytokines in patient-derived dermal fibroblasts were measured by ELISA. Arterial pathology other than medial fibrodysplasia with multifocal stenosis included cerebral aneurysm, found in 12.8% of subjects. Extra-arterial pathology included low bone density (P<0.001); early onset degenerative spine disease (95.7%); increased incidence of Chiari I malformation (6.4%) and dural ectasia (42.6%); and physical examination findings of a mild connective tissue dysplasia (95.7%). Screening for mutations causing known genetically mediated arteriopathies was unrevealing. We found elevated plasma TGF-β1 (P=0.009), TGF-β2 (P=0.004) and additional inflammatory markers, and increased TGF-β1 (P=0.0009) and TGF-β2 (P=0.0001) secretion in dermal fibroblast cell lines from subjects with FMD compared to age- and gender-matched controls. Detailed phenotyping of patients with FMD allowed us to demonstrate that FMD is a systemic disease with alterations in common with the spectrum of genetic syndromes that involve altered TGF-β signaling and offers TGF-β as a marker of FMD.
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Con este trabajo sobre la nobleza de la ciudad de Quito, Christian Büschges amplía el campo de los estudios socio-económicos y políticos sobre las así llamadas élites coloniales, con un análisis que se enfoca de manera especial en las mentalidades y representaciones estamentales, que tan fuertemente marcaron las relaciones sociales del antiguo régimen colonial.
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par E. Carmoly
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Text in 3 Sp. unter d. Abb.
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Text in 3 Sp. unter d. Abb.
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von Moses Fried
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par Armand Lipman
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Digitalisat der Ausg. Pest, 1859
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[Aharon Ben-Benjamin Porges] ...