Clinicopathological analysis of head and neck chondrosarcoma: three case reports and literature review

Chondrosarcoma (CHS) is a malignant neoplasm characterized by the formation of cartilaginous matrix by neoplastic cells, with a high propensity for local recurrences. Head and neck CHS is rare, accounting for less than 12% of all cases of CHS, usually affecting the maxilla. The majority of affected patients are in the fourth decade of life, with a slight predilection for male patients. A painless swelling is commonly the most frequent complaint. Surgery with wide en-bloc resection is the preferred treatment for CHS; radiotherapy and chemotherapy are usually palliative options. Owing to its rarity, there are few clinical series evaluating the biological behaviour of head and neck CHS. The aim of this study is to analyse the clinicopathological characteristics of head and neck CHS by reporting 3 new cases of this neoplasia affecting the jaw bones and reviewing the clinical series previously published in the English literature.

Built to Bite: Feeding Kinematics, Bite Forces, and Head Shape of a Specialized Durophagous Lizard, Dracaena Guianensis (Teiidae)

Most lizards feed on a variety of food items that may differ dramatically in their physical and behavioral characteristics. Several lizard families are known to feed upon hard-shelled prey (durophagy). Yet, specializations toward true molluscivory have been documented for only a few species. As snails are hard and brittle food items, it has been suggested that a specialized cranial morphology, high bite forces, and an adapted feeding strategy are important for such lizards. Here we compare head and skull morphology, bite forces, and feeding kinematics of a snail-crushing teiid lizard (Dracaena guianensis) with those in a closely related omnivorous species (Tupinambis merianae). Our data show that juvenile D. guianensis differ from T. merianae in having bigger heads and greater bite forces. Adults, however, do not differ in bite force. A comparison of feeding kinematics in adult Dracaena and Tupinambis revealed that Dracaena typically use more transport cycles, yet are more agile in manipulating snails. During transport, the tongue plays an important role in manipulating and expelling shell fragments before swallowing. Although Dracaena is slow, these animals are very effective in crushing and processing hard-shelled prey. J. Exp. Zool. 317A:371381, 2012. (c) 2012 Wiley Periodicals, Inc.

Second Primary Tumors in Patients with Head and Neck Cancer

This is a review on second primary tumors in patients with head and neck cancer. These patients have a high risk of developing other cancers simultaneously or subsequently. The incidence of multiple primary tumors in this population can be as high as 27%. Recurrences are the most common cause of treatment failure within the first 2 years of follow-up. After the third year the diagnosis of a second primary tumor becomes the most important cause of morbimortality in head and neck cancer patients, especially in those treated for cancers early diagnosed. Most second primary tumors occur in the upper aerodigestive tract (40%-59%), lung (31%-37.5%), and esophagus (9%-44%). Patients who develop second primary tumor have a significant reduction of survival expectancy.

Analysis of the TAX1BP1 gene in head and neck cancer patients

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Invertebrates from the Low Head Member (Polonez Cove Formation, Oligocene) at Vaureal Peak, King George Island, West Antarctica

Eight taxa of marine invertebrates, including two new bivalve species, are described from the Low Head Member of the Polonez Cove Formation (latest early Oligocene) cropping out in the Vaureal Peak area, King George Island, West Antarctica. The fossil assemblage includes representatives of Brachiopoda (genera Neothyris sp. and Liothyrella sp.), Bivalvia (Adamussium auristriatum sp. nov., ?Adamussium cf. A. alanbeui Jonkers, and Limatula (Antarctolima) ferraziana sp. nov.), Bryozoa, Polychaeta (serpulid tubes) and Echinodermata. Specimens occur in debris flows deposits of the Low Head Member, as part of a fan delta setting in a high energy, shallow marine environment. Liothyrella sp., Adamussium auristriatum sp. nov. and Limatula ferraziana sp. nov. are among the oldest records for these genera in King George Island. In spite of their restrict number and diversification, bivalves and brachiopods from this study display an overall dispersal pattern that roughly fits in the clockwise circulation of marine currents around Antarctica accomplished in two steps. The first followed the opening of the Tasmanian Gateway at the Eocene/Oligocene boundary, along the eastern margin of Antarctica, and the second took place in post-Palaeogene time, following the Drake Passage opening between Antarctic Peninsula and South America, along the western margin of Antarctica.

Analysis of the workers head transcriptome of the Asian subterranean termite, Coptotermes gestroi

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Electromyographic study of the trapezius (pars media) and rhomboideus major muscles in free movements of the head

The authors studied the trapezius (pars media) and rhomboideus major muscles in movements of flexion, extension, inclination and rotation of the head. The electromyographic records demonstrated that referred muscles are inactive in these different movements.

Electromyographic study of the trapezius (pars superior) and levator scapulae muscles in the movements of the head

The electromyographic study of the trapezius (pars superior) and levator scapulae mm. in the head movements was carried out in 30 young, adult male volunteers of both sexes and with no antecedent muscular or articular problems. The analysis was carried out with a two-channel TECA TE4 electromyograph and with single coaxial needle electrodes. Inactivity of the trapezius (pars superior) and levator scapulae mm. was noticed in all cases, in flexion and extension movements, whereas in homolateral and heterolateral rotation movements, these muscles showed to be inactive in most cases.

Distinct regions of loss of heterozygosity on 22q at different sites of head and neck squamous cell carcinomas

Background: Frequent loss of heterozygosity (LOH) has been reported in many types of cancer, including head and neck carcinomas. Somatic deletions involving specific chromosomal regions are strongly associated with inactivation of the allele of a tumor suppressor gene located within the deleted region. In most studies concerning LOH in head and neck squamous cell carcinomas (HNSCC) the different anatomical sites are not distinguished. The behavior of tumors arising at various sites differs significantly, however, suggesting different intrinsic tumor properties. In this study we compared the LOH on 22q and its relationship to clinicopathological parameters at the three major sites of HNSCC: oral cavity, larynx and pharynx. Material/Methods: LOH and microsatellite instability (MSI) were studied using seven polymorphic microsatellite markers mapped to the 22q11-q13.3 region in 37 oral, 32 laryngeal, and 31 pharyngeal carcinomas. Results: Two separate regions of LOH were identified in the laryngeal (22q11.2-12.1) and oral cavity (22q13.1-13.31) tumors. When the different anatomical sites were compared, a statistically significant difference was found between the presence of LOH at D22S421 (p<0.001), D22S315 (p=0.014) and D22S929 (p=0.026) in the laryngeal tumors. Conclusions: These data suggest that distinct regions on 22q are involved in LOH in oral cavity and laryngeal tumorigenesis but do not support a similar association between the development of pharyngeal tumors and genes located on 22q. These findings implicate the presence of different tumor suppressor genes mapping to distinct regions on chromosome 22q in oral and laryngeal carcinomas.

Efeito do bálsamo de copaíba (Copaitéra reticulata ducke) sobre a Germinação de esporos de Fusarium

The germinative capacity of spores of Fusarium was studied in the presence of copahiba balsam (5 to 100%). The culture was carried out in Erlenmeyer flasks with 50ml of ICI medium and 1 ml of the pre-inoculated fungus. In some specific cases, 1 ml of copahiba balsam was added to the medium. The development of spores was significantly reduced in the presence of copahiba balsam. Sensibility to copahiba balsam varied with the different strains of Fusarium.

Mango cultivars behavior in relation to fusarium subglutinans

The mango malformation, caused by the fungus Fusarium subglutinans Wollenweb & Reinking, is probably one of the diseases that causes more damages in the mangoes production in Brazil and other producing countries. This fungus was isolated of a Tommy Atkins plant with advanced symptoms of malformation, purified and prepared to be inoculated in 15 cultivars of national and imported mangoes. Initially, 10 cultivars had been inoculated in July/2000: Bourbon IAC - 100, Coração de Boi, Keitt, Parvin, Primor de Amoreira, Sensation, Smith, Surpresa, Tommy Atkins and Van Dyke. Another group was inoculated in December/2000, on the cultivars: Adams, Bhadauran, Palmer, Princesa and Zill, and with others cultivars Primor de Amoreira, Sensation and Tommy Atkins, that were inoculated in the first time, with the purpose to compare the two times of inoculation. Throughout the evaluated data at the two times of inoculation, after 11 months of evaluation, were maden the analysis of the variance in function of the involved sources of variation and the test of Duncan to compare the averages of inoculated cultivars. With the results obtained, the cultivars Bhadauran, Palmer, Parvin, Sensation, Van Dyke and Zill presents less percentage of plants with malformation symptoms or less progression of symptoms in relation to the others inoculated cultivars, under protected environmental conditions, where the assays were carried out.

Insertion of the superior head of the lateral pterigoid muscle in the human fetuses

The lateral pterygoid muscle, more specifically its superior head, as we know, is closely related to the temporomandibular joint (TMJ). Particularly in children, in contrast with what was observed in adults, these joints have been rarely studied, by the anatomic functional aspect, little knowing about its functions in the embryonic and fetal periods. We used, in this work, 12 fetuses ranging in age from 16 to 39 weeks of intrauterine life, where we observed that the superior head of the lateral pterygoid muscle is inserted in the disc and in the articular capsule, in all age groups studied, and also, that the fibers and the thickness of the articular disc is, as well as the articular capsule suffer modifications in accordance with the period of development. © 2007 Sociedad Chilena de Anatom•br>.

Influence of preventive dental treatment on mutans streptococci counts in patients undergoing head and neck radiotherapy

The aim of this study was to evaluate the influence of chlorhexidine gluconate, sodium fluoride and sodium iodine on mutans streptococci counts in saliva of irradiated patients. Forty-five patients were separated into three experimental groups and received chlorhexidine (0.12%), sodium fluoride (0.5%) or sodium iodine (2%), which were used daily during radiotherapy and for 6 months after the conclusion of the treatment. In addition, a fourth group, composed by 15 additional oncologic patients, who did not receive the mouthwash or initial dental treatment, constituted the control group. Clinical evaluations were performed in the first visit to dental clinic, after initial dental treatment, immediately before radiotherapy, after radiotherapy and 30, 60, 90 days and 6 months after the conclusion of radiotherapy. After clinical examinations, samples of saliva were inoculated on SB20 selective agar and incubated under anaerobiosis, at 37oC for 48 h. Total mutans streptococci counts were also evaluated by using real-time PCR, through TaqMan system, with specific primers and probes for S. mutans and S. sobrinus. All preventive protocols were able to reduce significantly mutans streptococci counts, but chlorhexidine gluconate was the most effective, and induced a significant amelioration of radiotherapy side effects, such as mucositis and candidosis. These results highlights the importance of the initial dental treatment for patients who will be subjected to radiotherapy for head and neck cancer treatment.

Head and neck carcinogenesis: Impact of MTHFD1 G1958A polymorphism

Objective: To investigate the MTHFD1 G1958A polymorphism involved in the folate metabolism as a risk for head and neck cancer, and to find the association of the polymorphism with the risk factors and clinical and histopathological characteristics. Methods: Retrospective study investigating MTHFD1 G1958A polymorphism in 694 subjects (240 patients in the Case Group and 454 in the Control Group) by Restriction Fragment Length Polymorphism (RFLP) Analysis. Multiple logistic regression and chi-square tests were used in the statistical analysis. Results: Multivariable analysis showed that smoking and age over 42 years were disease predictors (p < 0.05). MTHFD1 1958GA or AA genotypes were associated with smoking (p = 0.04) and alcoholism (p = 0.03) and were more ofen found in more advanced stage tumors (p = 0.04) and in patients with a shorter survival (p = 0.03). Conclusion: Te presence of MTHFD1 G1948A polymorphism associated with smoking and alcoholism raises the head and neck cancer risk.