Titres faux de SOUVIGNY. — Mélanges de GENEALOGIE et d'HISTOIRE ECCLESIASTIQUE.

Contient : Pièces relatives aux titres faux de Souvigny (sur ces titres, cf. M.-A. Chazaud, Étude sur la chronologie des sires de Bourbon, Moulins, 1866, in-8°, p. 33-80) : ; Notes sur les chartes de Souvigny envoyées à M. de Barville (Chazaud, op. cit., p. 47) ; Note de Mabillon sur la charte de Childebrand II (ibid., p. 44) ; Testaments d'Aimon et d'Aimar de Bourbon, prétendus originaux en parchemin ; Note, de la main de Baluze, attribuant la fabrication de ces pièces au duc d'Epernon (ibid., p. 38) ; Rapport de Mabillon et de Baluze sur les titres de Souvigny (ibid., p. 36) ; Minute, de la main de Baluze, du procès-verbal d'examen du cartulaire de Sauxillange, par Baluze, Mabillon, Ruinart et Ch. d'Hozier (19 août 1696) ; Note, de la main de Baluze, sur P. de Bar ; Procès-verbal d'examen des titres fournis par P. de Bar au duc de Bouillon, signé de Baluze, Mabillon et Ruinart ; Lettres d'érection du marquisat de Montausier en duché et pairie (août 1664) ; Mémoires sur les droits de la terre de Chevreuse du titre de duché ; Note sur l'état de la seigneurie de Vitry-sur-Seine ; Mémoires concernant les ducs d'Atrie (Atri) et princes de Melfe (Melfi) et les maisons d'Acquaviva et « Diaceto », parmi lesquels une Remonstrance à Monseigneur le chancellier par Anne et Charlotte de Melphe d'Aquin, impr. s. d. de 4 p. in-4° (f. 44), une Descendance de Messire Scipion d'Aquavive, duc d'Atrye, placard impr. s. d. (f. 48), une Lettre envoyée et présentée au Roy de la part du comte de Chasteauvillain, impr. de 12 p. in-4°, Cambrai, 1624 (f. 49), une lettre de M. de Cadenet, lieutenant d'une compagnie de M. de Montmorency, d'Aire, 20 mai 1579 (f. 60) ; Notice généalogique sur la maison d'Albert ; Contrat de mariage d'Honoré d'Albert de Luynes et d'Anne de Rodulph (6 mars 1573) ; Lettres originales, des XVIe et XVIIe siècles, relatives à la famille de Luynes, écrites par divers personnages : ; [Richelieu], évêque de Luçon, au connétable de Luynes, s. d. ; minute ; Le même au même, s. d. ; minute originale ; La reine mère [Marie de Médicis] à M. de Luynes ; minute ; La même au même, minute ; Le cardinal G[eorges] d'Armagnac à la reine (Avignon, 13 septembre 1570) ; M. de Clermont-Lodève au roi (Toulouse, 2 septembre 1570) ; Le même au duc d'Anjou (même date) ; Instructions données par le maréchal de Montmorency d'Anville à M. de Luynes (1570) ; Lettre du même au duc d'Anjou (Nîmes, 12 septembre 1570) ; Le même à la reine (même date) ; Pièces relatives au conflit de juridiction entre François, évêque de Verdun, et Jean Gillet, lieutenant-général en la justice royale de la dite ville (31 décembre 1626-13 février 1627) ; Extraits des registres du Conseil d'État (22 juin-15 juillet 1670) relatifs à l'assemblée du clergé, avec une lettre de Du Mez à Baluze lui annonçant l'envoi desdits extraits (f. 101) ; Requête adressée au roi par le comte de Coligny ; « Relation du conclave où le pape Alexandre VII a esté esleu, composée à ce qu'on croit par M. l'abbé Charrier » [1655] ; Lettres d'Alexandre VII relatives à l'insulte faite au duc de Créquy (28 août 1662) ; « Oratio habita a... Clemente IX in concilio habito ad cardinales circa nuncium pacis inter reges Christianum, et Catholicum » ; Lettre de Clément X à l'amiral d'Estrées (22 août 1672) ; Lettres d'Innocent XI adressées à Louis XIV (27 décembre 1679), à Henri [Cauchon], évêque d'Evreux, du 21 janvier 1680 (f. 146), à Joseph [de Montpezat], archevêque de Toulouse, du 2 octobre 1680 (f. 147), aux religieuses de Charonne, du 7 août 1680 et du 15 octobre 1680 (f. 148 et 149) ; Mémoire de [C.-M. Le Tellier], coadjuteur de Reims, sur les conciles provinciaux (1670) ; Mémoire sur la régale (en italien), et documents divers, en italien, sur le même sujet, à propos de l'affaire de l'évêché de Pamiers ; Mémoire de l'ambassadeur de France au collège des cardinaux (s. d.) ; Historique des événements survenus à l'occasion de la régale de Pamiers, de 1673 à 1680 ; « Lettera d'un curiale di Roma a un suo amico in Parigi » (11 novembre 1680) ; Autre lettre d'un « curiale di Roma » (s. d.) ; « Lettera di monsieur N. scritta al sig. cardinale N., a di 16 febr. 1681. »

Pharmacogenetic Study on Risperidone Long-Acting Injection: Influence of Cytochrome P450 2D6 and Pregnane X Receptor on Risperidone Exposure and Drug-Induced Side-Effects.

Risperidone is metabolized by polymorphic enzymes, and a large variability in plasma concentration and therapeutic response is observed. Risperidone long-acting injection (RLAI) avoids the first-pass effect, and little is known about the influence of gene polymorphisms involved in its pharmacokinetics. The influence on plasma concentrations of risperidone (RIS), its metabolite 9-hydroxy-risperidone, and on adverse effects were investigated for polymorphisms of cytochrome P450 2D6 (CYP2D6) (*3, *4, *5, *6), CYP3A (CYP3A4*1B, CYP3A4 rs4646437, CYP3A5*3, CYP3A7*1C), ABCB1 (1236C>T, 2677G>T, 3435C>T), NR1/2 coding for pregnane X receptor (rs1523130, rs2472677, rs7643645), and for CYP3A activity measured by a phenotyping test. Forty-two patients with at least 4 consecutive unchanged doses of RLAI were included in a multicenter cross-sectional study. A 55% lower dose-adjusted plasma levels of RIS were observed for CYP2D6 ultrarapid metabolizers (n = 5) as compared with CYP2D6 intermediate metabolizers (P < 0.007). NR1/2 polymorphism (rs7643645A>G) influenced RIS exposure with a 2.8-fold lower active moiety (P = 0.031) in GG compared with the AA genotype. This was confirmed in a second independent cohort (n = 16). Furthermore, high-density lipoprotein cholesterol was positively correlated with CYP3A activity (P = 0.01), and the NR1/2 (rs2472677) polymorphism was associated with different adverse effects including prolactin plasma levels adjusted for age and sex. In conclusion, our results confirmed the influence of CYP2D6 genotype on plasma levels of RIS. This is the first report on the influence of NR1/2 polymorphisms on RLAI exposure and on drug-induced adverse effects. These results should be validated in larger cohorts.

Exploring the high frequency emission of radio loud X-ray binaries

We report millimetre-wave continuum observations of the X-ray binaries Cygnus X-3, SS 433, LSI+61 303, Cygnus X-1 and GRS 1915+105. The observations were carried out with the IRAM 30 m-antenna at 250 GHz (1.25 mm) from 1998 March 14 to March 20. These millimetre measurements are complemented with centimetre observations from the Ryle Telescope, at 15 GHz (2.0 cm) and from the Green Bank Interferometer at 2.25 and 8.3 GHz (13 and 3.6 cm). Both Cygnus X-3 and SS 433 underwent moderate flaring events during our observations, whose main spectral evolution properties are described and interpreted. A significant spectral steepening was observed in both sources during the flare decay, that is likely to be caused by adiabatic expansion, inverse Compton and synchrotron losses. Finally, we also report 250 GHz upper limits for three additional undetected X-ray binary stars: LSI+65 010, LSI+61 235 and X Per.

Projet de dispositions pour les troupes de Bourgogne pour s'oposer aux contrebandiers de quelque coté qu'ils veuillent pénétrer dans le duché de Bourgogne

Ancien possesseur : Argenson, Antoine-René de Voyer (1722-1787 ; marquis de Paulmy d')

Faint arc-minute extended radio emission around Cygnus X-3

Aims.We revisit the vicinity of the microquasar Cygnus X-3 at radio wavelengths. We aim to improve our previous search for possible associated extended radio features/hot spots in the position angle of the Cygnus X-3 relativistic jets focusing on shorter angular scales than previously explored. Methods.Our work is mostly based on analyzing modern survey and archive radio data, mainly including observations carried out with the Very Large Array and the Ryle Telescopes. We also used deep near-infrared images that we obtained in 2005. Results.We present new radio maps of the Cygnus X-3 field computed after combining multi-configuration Very Large Array archive data at 6 cm and different observing runs at 2 cm with the Ryle Telescope. These are probably among the deepest radio images of Cygnus X-3 reported to date at cm wavelengths. Both interferometers reveal an extended radio feature within a few arc-minutes of the microquasar position, thus making our detection more credible. Moreover, this extended emission is possibly non-thermal, although this point still needs confirmation. Its physical connection with the microquasar is tentatively considered under different physical scenarios. We also report on the serendipitous discovery of a likely Fanaroff-Riley type II radio galaxy only away from Cygnus X-3.

Possible hot spots excited by the relativistic jets of Cygnus X-3

We present the results of a deep search for associated radio features in the vicinity of the microquasar Cygnus X-3. The motivation behind is to find out evidence for interaction between its relativistic jets and the surrounding interstellar medium, which could eventually allow us to perform calorimetry of the total energy released by this microquasar during its flaring lifetime. Remarkably, two radio sources with mJy emission level at centimeter wavelengths have been detected in excellent alignment with the position angle of the inner radio jets. We propose that these objects could be the hot spots where the relativitic outflow collides with the ambient gas in analogy with Fanaroff-Riley II radio galaxies. These candidate hot spots are within a few arc-minutes of Cygnus X-3 and, if physically related, the full linear extent of the jet would reach tens of parsecs. We discuss here the evidence currently available to support this hypothesis based on both archival data and our own observations.

Informe sobre les X Jornades d'Arxivística de Catalunya: "Els arxivers com (ens) comuniquem?" (Terrassa, 19, 20 i 21 de maig de 2005)

Com ja és costum des de fa vint anys (1985-2005), pel maig l'Associació d'Arxivers de Catalunya (AAC) convoca els seus associats i la comunitat arxivística en general a les Jornades d'Arxivística de Catalunya. Enguany han estat les desenes i amb el títol "Els arxivers com (ens) comuniquem?" s'han dut a terme els dies 19, 20 i 21 de maig a la ciutat de Terrassa. L'objectiu de les X Jornades ha estat doble: en primer lloc, s'ha volgut reflexionar sobre les estratègies de què disposen els arxivers per fer difusió de la seva activitat professional ("com comuniquem") i a continuació s'ha produït el debat sobre la comunicació intraprofessional dels arxivers ("com ens comuniquem").

DNA methylation profiles of human active and inactive X chromosomes.

X-chromosome inactivation (XCI) is a dosage compensation mechanism that silences the majority of genes on one X chromosome in each female cell. To characterize epigenetic changes that accompany this process, we measured DNA methylation levels in 45,X patients carrying a single active X chromosome (X(a)), and in normal females, who carry one X(a) and one inactive X (X(i)). Methylated DNA was immunoprecipitated and hybridized to high-density oligonucleotide arrays covering the X chromosome, generating epigenetic profiles of active and inactive X chromosomes. We observed that XCI is accompanied by changes in DNA methylation specifically at CpG islands (CGIs). While the majority of CGIs show increased methylation levels on the X(i), XCI actually results in significant reductions in methylation at 7% of CGIs. Both intra- and inter-genic CGIs undergo epigenetic modification, with the biggest increase in methylation occurring at the promoters of genes silenced by XCI. In contrast, genes escaping XCI generally have low levels of promoter methylation, while genes that show inter-individual variation in silencing show intermediate increases in methylation. Thus, promoter methylation and susceptibility to XCI are correlated. We also observed a global correlation between CGI methylation and the evolutionary age of X-chromosome strata, and that genes escaping XCI show increased methylation within gene bodies. We used our epigenetic map to predict 26 novel genes escaping XCI, and searched for parent-of-origin-specific methylation differences, but found no evidence to support imprinting on the human X chromosome. Our study provides a detailed analysis of the epigenetic profile of active and inactive X chromosomes.

Correlations between trabecular bone score, measured using anteroposterior dual-energy x-ray absorptiometry acquisition, and 3-dimensional parameters of bone microarchitecture: an experimental study on human cadaver vertebrae.

Developing a novel technique for the efficient, noninvasive clinical evaluation of bone microarchitecture remains both crucial and challenging. The trabecular bone score (TBS) is a new gray-level texture measurement that is applicable to dual-energy X-ray absorptiometry (DXA) images. Significant correlations between TBS and standard 3-dimensional (3D) parameters of bone microarchitecture have been obtained using a numerical simulation approach. The main objective of this study was to empirically evaluate such correlations in anteroposterior spine DXA images. Thirty dried human cadaver vertebrae were evaluated. Micro-computed tomography acquisitions of the bone pieces were obtained at an isotropic resolution of 93μm. Standard parameters of bone microarchitecture were evaluated in a defined region within the vertebral body, excluding cortical bone. The bone pieces were measured on a Prodigy DXA system (GE Medical-Lunar, Madison, WI), using a custom-made positioning device and experimental setup. Significant correlations were detected between TBS and 3D parameters of bone microarchitecture, mostly independent of any correlation between TBS and bone mineral density (BMD). The greatest correlation was between TBS and connectivity density, with TBS explaining roughly 67.2% of the variance. Based on multivariate linear regression modeling, we have established a model to allow for the interpretation of the relationship between TBS and 3D bone microarchitecture parameters. This model indicates that TBS adds greater value and power of differentiation between samples with similar BMDs but different bone microarchitectures. It has been shown that it is possible to estimate bone microarchitecture status derived from DXA imaging using TBS.

Reliure de : Georgii Agricolae de Ortu et causis subterraneorum lib. V. De natura eorum quae effluunt ex terra lib. IIII. De natura fossilium lib. X. De veteribus et novis metallis lib. II. Bermannus, sive de re metallica dialogus. Interpretatio germanica vocum rei metallicae...

Numérisation partielle de reliure