Unexpected role of surface transglutaminase type II in celiac disease

Background & Aims: In celiac disease (CD), transglutaminase type II (TG2) has 2 fundamental roles: (1) as the autoantigen recognized by highly specific autoantibodies and (2) the modifier of pathogenic gliadin T-cell epitopes. It follows that inhibition of TG2 might represent an attractive strategy to curb the toxic action of gliadin. Here we studied the validity of this strategy using the organ culture approach. Methods: Duodenal biopsy specimens from 30 treated patients with CD, 33 untreated patients with CD, and 24 controls were cultured with or without gliadin peptides p31-43, pα-9, and deamidated pα-9 for 20 minutes, 3 hours, and 24 hours. In 31 patients with CD and 16 controls, TG2 inhibitor R283 or anti-TG CUB 7402 or anti-surface TG2 (6B9) mAbs were used in cultures. T84 cells were also cultured with or without peptides with or without TG inhibitors. Mucosal modifications after culture were assessed by immunofluorescence, in situ detection of TG activity, confocal microscopy, and fluorescence-activated cell sorter analysis. Results: The enzymatic inhibition of TG2 only controlled gliadin-specific T-cell activation. The binding of surface TG2 contained gliadin-specific T-cell activation and p31-43-induced actin rearrangement, epithelial phosphorylation, and apoptosis, both in organ cultures and T84 cells. Conclusions: These data indicate a novel and unexpected biological role for surface TG2 in the pathogenesis of CD suggesting a third role for TG2 in CD. These results have a specific impact for celiac disease, with wider implications indicating a novel biologic function of TG2 with possible repercussions in other diseases. © 2005 by the American Gastroenterological Association.

A beszerzés fogalmi kerete a kis - és középvállalatok gyakorlatában (The characteristics of the purchasing practice of SMEs)

A kis- és középvállalatok számottevő gazdasági tényezőt jelentenek. A cikk a szakirodalom azon egyre szélesedő részéhez szeretne hozzátenni, amely az ő gyakorlatuk, sajátosságaik megismerésével foglalkozik: a KKV-k beszerzési sajátosságainak megismerését és rendező modellben való bemutatását célozza meg. A modell felépítéséhez a nemzetközi szakirodalomban elérhető empirikus eredményeket és a versenyképesség-kutatás kérdőíves adatbázisának válaszait dolgozza fel. A javasolt modell a nagyvállalati beszerzés és a fogyasztói vásárlás jellemző sajátosságait egészíti ki a KKV-k gyakorlatának leírásával. ________________ Small and medium sized enterprises play an important role in every economy. This article aims to contribute to the growing number of literature focusing on SMEs management practice. Based on a review of literature and the analysis of the survey database of Competitiveness Research of CUB it develops a model to describe the characteristics of the purchasing practice of SMEs. The suggested model will describe the main attributes of SMEs purchasing as compared to large companies practice and buying habits of individuals.

A beszerzés helye és szerepe a kis és középvállalatok gyakorlatában = The role of purchasing in small and medium sized companies

A tanulmány a szakirodalom azon egyre szélesedő részéhez járul hozzá, amely a kis és középvállalatok gyakorlatával, sajátosságaik vizsgálatával foglalkozik. Egy speciális aspektust emel ki, mely a hazai nagyvállalati működésben jelentős fejlődésen ment keresztül azzal, hogy a KKV-k beszerzési sajátosságainak megismerését célozza meg. Az áttekintő kép kialakításához a nemzetközi szakirodalomban elérhető empirikus eredményeket és a BCE-n folyó Versenyképesség Kutatás kérdőíves adatbázisának válaszait dolgozza fel. Olyan kérdéseket emel ki, mint a beszerzés szerepe a KKV-k működésében és az azt befolyásoló tényezők illetve a beszerzési gyakorlat sajátosságai. _________ Small and medium sized enterprises play an important role in every economy. This article aims to contribute to the growing number of literature focusing on SMEs management practice. It highlights a management field, which has gone through a significant development in large companies’ practice as it investigates the purchasing and supplier management related issues. The overview is based on a review of literature and the analysis of the survey database of Competitiveness Research of CUB. It highlights such topics as the role of purchasing in SMEs, factors influencing the perceived importance and the purchasing practice of SME-s.

Beszállítók és a beszerzés a vállalati innovációban = Role of purchasing in innovation management

A dolgozat a beszállítónak az innovációban játszott szerepével kapcsolatos irodalmat rendszerezi, egy olyan kutatási keret kialakítása érdekében, amely túltekint a beszállítók innovációban szűken értelmezett szerepén. A szakirodalom elsősorban a beszállítók termékinnovációban játszott szerepével foglalkozik, ugyanakkor a beszerzési feladatok között számos más beszállítói kapcsolat menedzsmentje is szerepel, amelyek indirekt módon, de jelentős hatással lehetnek a vállalati versenyképesség alakulására. Célunk, építve az irodalom elemzés eredményeire és a Versenyképesség Kutatás adatainak elemzésére egy olyan keret kialakítása, melynek során ez a szerep és az ehhez alkalmazható eszközrendszer feltárható. _______________ This paper provides a literature review in order to build a theoretic framework which describes a broadened role of purchasing in innovation management. Literature deals in detail with the role of suppliers in new product development, however the role of purchasing in this process seldom is in focus. Our paper highlights those supplier relationships, which in an indirect way, but also support innovation, and through new solutions promote competitiveness. Built on literature results and survey data of Competitiveness Research Program of CUB, our aim was to initiate a research framework, in which it is possible to describe purchasing role in innovation and which may support identifying the appropriate means to be used.

Follow-up of the sponge and asteroid populations at the station Larsen A south (PS69/724-1 and PS77/253-1), Antarctic Peninsula, between 2007 and 2011

Over 30% of the Antarctic continental shelf is permanently covered by floating ice shelves, providing aphotic conditions for a depauperate fauna sustained by laterally advected food. In much of the remaining Antarctic shallows (<300 m depth), seasonal sea-ice melting allows a patchy primary production supporting rich megabenthic communities dominated by glass sponges (Porifera, Hexactinellida). The catastrophic collapse of ice shelves due to rapid regional warming along the Antarctic Peninsula in recent decades has exposed over 23,000 km**2 of seafloor to local primary production. The response of the benthos to this unprecedented flux of food is, however, still unknown. In 2007, 12 years after disintegration of the Larsen A ice shelf, a first biological survey interpreted the presence of hexactinellids as remnants of a former under-ice fauna with deep-sea characteristics. Four years later, we revisited the original transect, finding 2- and 3-fold increases in glass sponge biomass and abundance, respectively, after only two favorable growth periods. Our findings, along with other long-term studies, suggest that Antarctic hexactinellids, locked in arrested growth for decades, may undergo boom-and-bust cycles, allowing them to quickly colonize new habitats. The cues triggering growth and reproduction in Antarctic glass sponges remain enigmatic.

Global proliferation of cephalopods

Acknowledgments We thank Nancy Barahona (IFOP), Rosemary Hurst (NIWA), Timothy Emery, FelipeBriceño and Jeremy Lyle (UTAS), Patricia Hobsbawn (ABARES), John Bower (HU), Mitsuo Sakai (TNFRI), Blue Ventures, SHOALS (Rodrigues), and the Fisheries Research and Training Unit (Rodrigues) for their assistance in sourcing time-series and providing catch and effort data, as well as Felipe Briceño and Eriko Hoshino (UTAS) for Spanish- and Japanese-to-English translation, respectively. This paper resulted from a workshop funded by The Environment Institute, University of Adelaide.

International Women's day march in support of ERA

General note: Title and date provided by Bettye Lane.

Body measurements and blood plasma lipid, PCB and OH-PCB content of polar bear (U. maritimus) mothers and cubs, Svalbard

The aim of this study was to examine the plasma concentrations and prevalence of polychlorinated biphenyls (PCBs) and hydroxylated PCB-metabolites (OH-PCBs) in polar bear (Ursus maritimus) mothers (n = 26) and their 4 months old cubs-of-the-year (n = 38) from Svalbard to gain insight into the mother-cub transfer, biotransformation and to evaluate the health risk associated with the exposure to these contaminants. As samplings were performed in 1997/1998 and 2008, we further investigated the differences in levels and pattern of PCBs between the two sampling years. The plasma concentrations of Sum(21)PCBs (1997/1998: 5710 ± 3090 ng/g lipid weight [lw], 2008: 2560±1500 ng/g lw) and Sum(6)OH-PCBs (1997/1998: 228 ± 60 ng/g wet weight [ww], 2008: 80 ± 38 ng/g ww) in mothers were significantly lower in 2008 compared to in 1997/1998. In cubs, the plasma concentrations of Sum(21)PCBs (1997/1998: 14680 ± 5350 ng/g lw, 2008: 6070 ± 2590 ng/g lw) and Sum(6)OH-PCBs (1997/1998: 98 ± 23 ng/g ww, 2008: 49 ± 21 ng/g ww) were also significantly lower in 2008 than in 1997/1998. Sum(21)PCBs in cubs was 2.7 ± 0.7 times higher than in their mothers. This is due to a significant maternal transfer of these contaminants. In contrast, Sum(6)OH-PCBs in cubs were approximately 0.53 ± 0.16 times the concentration in their mothers. This indicates a lower maternal transfer of OH-PCBs compared to PCBs. The majority of the metabolite/precursor-ratios were lower in cubs compared to mothers. This may indicate that cubs have a lower endogenous capacity to biotransform PCBs to OH-PCBs than polar bear mothers. Exposure to PCBs and OH-PCBs is a potential health risk for polar bears, and the levels of PCBs and OH-PCBs in cubs from 2008 were still above levels associated with health effects in humans and wildlife.

Forest typology of broadleaf forests from Sierra Maestra, Eastern Cuba

A phytosociological study of the forests from Sierra Maestra is conducted, following the methodology of the Zurich- Montpelier School. They are transformed into a forest typology using the standards of the Institute of Agro-Forestry Research. In general, 35 types and/or subtypes are presented. From this group, the most abundant ones belong to semi-deciduous microphyll forest, followed by those from mangroves and mountain rainforest, respectively. Silvicultural treatments are needed; among them, the protection forests are those found above 800 m asl and mangroves. 

La popularización del fútbol en España. Análisis del fenómeno a través de la literatura especializada del fútbol (1920-1936)

La consolidación del fútbol en España se produjo a partir de los años veinte del siglo pasado. Entre 1920 a 1936 el fútbol adquirió todos los rasgos personales que hoy le caracterizan. En esta época surgió una literatura técnica y periodística especializada que se configuró como uno de los pilares más importantes para el desarrollo técnico deportivo y del espectáculo de masas. En torno a esta cuestión, el presente artículo busca un doble objetivo: recopilar la literatura técnica y periodística especializada publicada durante el período de 1920 a 1936, y reconocer el alcance social, técnico e ideológico de esta literatura futbolística en el proceso de configuración del fútbol en España. Para abordar este propósito hemos utilizado una metodología heurística y de análisis documental de las fuentes originales. Apreciamos que a través de estas obras podemos conocer mejor el contexto del espacio socio-deportivo del fútbol en España y, también, despertar nuevas líneas potenciales de investigación.

Phenotypically linked dichotomy in sea turtle foraging requires multiple conservation approaches

[EN] Marine turtles undergo dramatic ontogenic changes in body size and behavior, with the loggerhead sea turtle, Caretta caretta, typically switching from an initial oceanic juvenile stage to one in the neritic, where maturation is reached and breeding migrations are subsequently undertaken every 2-3 years [1-3]. Using satellite tracking, we investigated the migratory movements of adult females from one of the world's largest nesting aggregations at Cape Verde, West Africa. In direct contrast with the accepted life-history model for this species [4], results reveal two distinct adult foraging strategies that appear to be linked to body size. The larger turtles (n = 3) foraged in coastal waters, whereas smaller individuals (n = 7) foraged oceanically.

How the Pershore Plum Won the Great War

The First World War was won not just on the battlefields but on the Home Front, by the men, women and children left behind. This book explores the lives of the people of Pershore and the surrounding district in wartime, drawing on their memories, letters, postcards, photographs, leaflets and recipes to demonstrate how their hard work in cultivating and preserving fruit and vegetables helped to win the Great War. Pershore plums were used to make jam for the troops; but ensuring these and other fruits and vegetables were grown and harvested required the labour of land girls, Boy Scouts, schoolchildren, Irish labourers and Belgian refugees. When submarine warfare intensified, food shortages occurred and it became vital for Britain to grow more and eat less food. Housewives faced many challenges in feeding their families and so in 1916 the Pershore Women’s Institute was formed, providing many women with practical help and companionship during some of Britain’s darkest hours in history.

Nonprofit brand heritage its ability to influence volunteer retention, engagement, and satisfaction

Volunteer organizations operate in a challenging environment and their management practices toward volunteers have become increasingly influenced by the private sector. This case study explores the impact of brand heritage on the experience of volunteering in such managed environments. We use data from the U.K. Scouts to show that brand heritage has a positive bearing on the level of engagement volunteers experience and on their reported attitude to the way(s) in which they are managed within the volunteer organization. We then use these findings to establish the salience of brand heritage to both long established and recently formed organizations, extending current volunteer management theory; consequently, we suggest volunteer managers utilize the power of brand heritage through unlocking its ability to retain engaged and satisfied volunteers.

Unexpected Levels of Biological Activity during the Polar Night Offer New Perspectives on a Warming Arctic

The current understanding of Arctic ecosystems is deeply rooted in the classical view of a bottom-up controlled system with strong physical forcing and seasonality in primary-production regimes. Consequently, the Arctic polar night is commonly disregarded as a time of year when biological activities are reduced to a minimum due to a reduced food supply. Here, based upon a multidisciplinary ecosystem-scale study from the polar night at 79 degrees N, we present an entirely different view. Instead of an ecosystem that has entered a resting state, we document a system with high activity levels and biological interactions across most trophic levels. In some habitats, biological diversity and presence of juvenile stages were elevated in winter months compared to the more productive and sunlit periods. Ultimately, our results suggest a different perspective regarding ecosystem function that will be of importance for future environmental management and decision making, especially at a time when Arctic regions are experiencing accelerated environmental change [1].

Statistical forecasting of the Australian macadamia crop

Three types of forecasts of the total Australian production of macadamia nuts (t nut-in-shell) have been produced early each year since 2001. The first is a long-term forecast, based on the expected production from the tree census data held by the Australian Macadamia Society, suitably scaled up for missing data and assumed new plantings each year. These long-term forecasts range out to 10 years in the future, and form a basis for industry and market planning. Secondly, a statistical adjustment (termed the climate-adjusted forecast) is made annually for the coming crop. As the name suggests, climatic influences are the dominant factors in this adjustment process, however, other terms such as bienniality of bearing, prices and orchard aging are also incorporated. Thirdly, industry personnel are surveyed early each year, with their estimates integrated into a growers and pest-scouts forecast. Initially conducted on a 'whole-country' basis, these models are now constructed separately for the six main production regions of Australia, with these being combined for national totals. Ensembles or suites of step-forward regression models using biologically-relevant variables have been the major statistical method adopted, however, developing methodologies such as nearest-neighbour techniques, general additive models and random forests are continually being evaluated in parallel. The overall error rates average 14% for the climate forecasts, and 12% for the growers' forecasts. These compare with 7.8% for USDA almond forecasts (based on extensive early-crop sampling) and 6.8% for coconut forecasts in Sri Lanka. However, our somewhatdisappointing results were mainly due to a series of poor crops attributed to human reasons, which have now been factored into the models. Notably, the 2012 and 2013 forecasts averaged 7.8 and 4.9% errors, respectively. Future models should also show continuing improvement, as more data-years become available.