Steric sea level variability (1993-2010) in an ensemble of ocean reanalyses and objective analyses

Quantifying the effect of the seawater density changes on sea level variability is of crucial importance for climate change studies, as the sea level cumulative rise can be regarded as both an important climate change indicator and a possible danger for human activities in coastal areas. In this work, as part of the Ocean Reanalysis Intercomparison Project, the global and regional steric sea level changes are estimated and compared from an ensemble of 16 ocean reanalyses and 4 objective analyses. These estimates are initially compared with a satellite-derived (altimetry minus gravimetry) dataset for a short period (2003–2010). The ensemble mean exhibits a significant high correlation at both global and regional scale, and the ensemble of ocean reanalyses outperforms that of objective analyses, in particular in the Southern Ocean. The reanalysis ensemble mean thus represents a valuable tool for further analyses, although large uncertainties remain for the inter-annual trends. Within the extended intercomparison period that spans the altimetry era (1993–2010), we find that the ensemble of reanalyses and objective analyses are in good agreement, and both detect a trend of the global steric sea level of 1.0 and 1.1 ± 0.05 mm/year, respectively. However, the spread among the products of the halosteric component trend exceeds the mean trend itself, questioning the reliability of its estimate. This is related to the scarcity of salinity observations before the Argo era. Furthermore, the impact of deep ocean layers is non-negligible on the steric sea level variability (22 and 12 % for the layers below 700 and 1500 m of depth, respectively), although the small deep ocean trends are not significant with respect to the products spread.

Commentary: not just genes - reclaiming a role for environmental influences on aetiology and outcome in autism. A commentary on Mandy and Lai (2016)

Mandy and Lai (2015) do the field a service in 'reclaiming' the role of pre- and postnatal environmental influences on the aetiology and course of autism spectrum conditions (ASC). This follows several decades where now discredited theories about putative psychogenic and biological disease models held sway, not least in the public mind. We discuss issues that arise from their review; including the need to identify how large the environmental influences on ASC are likely to be; the specificity of these environmental influences to ASC as opposed to a broader range of neurodevelopmental conditions and outcomes; how best to study complex interactions between genetic and environmental influences; and the promise of novel insights into their mechanisms of action. The review highlights current research that aims to better our understanding of the role of environmental factors in the aetiology and course of ASC and, in the near future, may offer the potential for personalised medicine approaches to intervention based on these discoveries.

Cambium non est mutuum: exchange and interest rates in medieval Europe

A major gap in our understanding of the medieval economy concerns interest rates, especially relating to commercial credit. Although direct evidence about interest rates is scattered and anecdotal, there is much more surviving information about exchange rates. Since both contemporaries and historians have suggested that exchange and rechange transactions could be used to disguise the charging of interest in order to circumvent the usury prohibition, it should be possible to back out the interest rates from exchange rates. The following analysis is based on a new dataset of medieval exchange rates collected from commercial correspondence in the archive of Francesco di Marco Datini of Prato, c.1383-1411. It demonstrates that the time value of money was consistently incorporated into market exchange rates. Moreover, these implicit interest rates are broadly comparable to those received from other types of commercial loan and investment. Although on average profitable, the return on any individual exchange and rechange transaction did involve a degree of uncertainty that may have justified their non-usurious nature. However, there were also practical reasons why medieval merchants may have used foreign exchange transactions as a means of extending credit.

Production of bioactive diterpenoids in the Euphorbiaceae depends on evolutionarily conserved gene clusters

The Euphorbiaceae produce a diverse range of diterpenoids, many of which have pharmacological activities. These diterpenoids include ingenol mebutate, which is licensed for the treatment of a precancerous skin condition (actinic keratosis), and phorbol derivatives such as resiniferatoxin and prostratin, which are undergoing investigation for the treatment of severe pain and HIV, respectively. Despite the interest in these diterpenoids, their biosynthesis is poorly understood at present, with the only characterized step being the conversion of geranylgeranyl pyrophosphate into casbene. Here, we report a physical cluster of diterpenoid biosynthetic genes from castor (Ricinus communis), including casbene synthases and cytochrome P450s from the CYP726A subfamily. CYP726A14, CYP726A17, and CYP726A18 were able to catalyze 5-oxidation of casbene, a conserved oxidation step in the biosynthesis of this family of medicinally important diterpenoids. CYP726A16 catalyzed 7,8-epoxidation of 5-keto-casbene and CYP726A15 catalyzed 5-oxidation of neocembrene. Evidence of similar gene clustering was also found in two other Euphorbiaceae, including Euphorbia peplus, the source organism of ingenol mebutate. These results demonstrate conservation of gene clusters at the higher taxonomic level of the plant family and that this phenomenon could prove useful in further elucidating diterpenoid biosynthetic pathways.

Reducing defects through organizational learning within a Housing Association environment

Housing Associations (HAs) contribute circa 20% of the UK’s housing supply. HAs are however under increasing pressure as a result of funding cuts and rent reductions. Due to the increased pressure, a number of processes are currently being reviewed by HAs, especially how they manage and learn from defects. Learning from defects is considered a useful approach to achieving defect reduction within the UK housebuilding industry. This paper contributes to our understanding of how HAs learn from defects by undertaking an initial round table discussion with key HA stakeholders as part of an ongoing collaborative research project with the National House Building Council (NHBC) to better understand how house builders and HAs learn from defects to reduce their prevalence. The initial discussion shows that defect information runs through a number of groups, both internal and external of a HA during both the defects management process and organizational learning (OL) process. Furthermore, HAs are reliant on capturing and recording defect data as the foundation for the OL process. During the OL process defect data analysis is the primary enabler to recognizing a need for a change to organizational routines. When a need for change has been recognized, new options are typically pursued to design out defects via updates to a HAs Employer’s Requirements. Proposed solutions are selected by a review board and committed to organizational routine. After implementing a change, both structured and unstructured feedback is sought to establish the change’s success. The findings from the HA discussion demonstrates that OL can achieve defect reduction within the house building sector in the UK. The paper concludes by outlining a potential ‘learning from defects model’ for the housebuilding industry as well as describing future work.

Detecting defects in the UK new-build housing sector: a learning perspective

Rapid growth in the production of new homes in the UK is putting build quality under pressure as evidenced by an increase in the number of defects. Housing associations (HAs) contribute approximately 20% of the UK’s new housing supply. HAs are currently experiencing central government funding cuts and rental revenue reductions. As part of HAs’ quest to ramp up supply despite tight budget conditions, they are reviewing how they learn from defects. Learning from defects is argued as a means of reducing the persistent defect problem within the UK housebuilding industry, yet how HAs learn from defects is under-researched. The aim of this research is to better understand how HAs, in practice, learn from past defects to reduce the prevalence of defects in future new homes. The theoretical lens for this research is organizational learning. The results drawn from 12 HA case studies indicate that effective organizational learning has the potential to reduce defects within the housing sector. The results further identify that HAs are restricting their learning to focus primarily on reducing defects through product and system adaptations. Focusing on product and system adaptations alone suppresses HAs’ abilities to reduce defects in the future.

The CATH Hierarchy Revisited-Structural Divergence in Domain Superfamilies and the Continuity of Fold Space

This paper explores the structural continuum in CATH and the extent to which superfamilies adopt distinct folds. Although most superfamilies are structurally conserved, in some of the most highly populated superfamilies (4% of all superfamilies) there is considerable structural divergence. While relatives share a similar fold in the evolutionary conserved core, diverse elaborations to this core can result in significant differences in the global structures. Applying similar protocols to examine the extent to which structural overlaps occur between different fold groups, it appears this effect is confined to just a few architectures and is largely due to small, recurring super-secondary motifs (e.g., alpha beta-motifs, alpha-hairpins). Although 24% of superfamilies overlap with superfamilies having different folds, only 14% of nonredundant structures in CATH are involved in overlaps. Nevertheless, the existence of these overlaps suggests that, in some regions of structure space, the fold universe should be seen as more continuous.

The CATH classification revisited-architectures reviewed and new ways to characterize structural divergence in superfamilies

The latest version of CATH (class, architecture, topology, homology) (version 3.2), released in July 2008 (http://www.cathdb.info), contains 1 14215 domains, 2178 Homologous superfamilies and 1110 fold groups. We have assigned 20 330 new domains, 87 new homologous superfamilies and 26 new folds since CATH release version 3.1. A total of 28 064 new domains have been assigned since our NAR 2007 database publication (CATH version 3.0). The CATH website has been completely redesigned and includes more comprehensive documentation. We have revisited the CATH architecture level as part of the development of a `Protein Chart` and present information on the population of each architecture. The CATHEDRAL structure comparison algorithm has been improved and used to characterize structural diversity in CATH superfamilies and structural overlaps between superfamilies. Although the majority of superfamilies in CATH are not structurally diverse and do not overlap significantly with other superfamilies, similar to 4% of superfamilies are very diverse and these are the superfamilies that are most highly populated in both the PDB and in the genomes. Information on the degree of structural diversity in each superfamily and structural overlaps between superfamilies can now be downloaded from the CATH website.

Obfuscation and Strict Online Anonymity

I consider the case for genuinely anonymous web searching. Big data seems to have it in for privacy. The story is well known, particularly since the dawn of the web. Vastly more personal information, monumental and quotidian, is gathered than in the pre-digital days. Once gathered it can be aggregated and analyzed to produce rich portraits, which in turn permit unnerving prediction of our future behavior. The new information can then be shared widely, limiting prospects and threatening autonomy. How should we respond? Following Nissenbaum (2011) and Brunton and Nissenbaum (2011 and 2013), I will argue that the proposed solutions—consent, anonymity as conventionally practiced, corporate best practices, and law—fail to protect us against routine surveillance of our online behavior. Brunton and Nissenbaum rightly maintain that, given the power imbalance between data holders and data subjects, obfuscation of one’s online activities is justified. Obfuscation works by generating “misleading, false, or ambiguous data with the intention of confusing an adversary or simply adding to the time or cost of separating good data from bad,” thus decreasing the value of the data collected (Brunton and Nissenbaum, 2011). The phenomenon is as old as the hills. Natural selection evidently blundered upon the tactic long ago. Take a savory butterfly whose markings mimic those of a toxic cousin. From the point of view of a would-be predator the data conveyed by the pattern is ambiguous. Is the bug lunch or potential last meal? In the light of the steep costs of a mistake, the savvy predator goes hungry. Online obfuscation works similarly, attempting for instance to disguise the surfer’s identity (Tor) or the nature of her queries (Howe and Nissenbaum 2009). Yet online obfuscation comes with significant social costs. First, it implies free riding. If I’ve installed an effective obfuscating program, I’m enjoying the benefits of an apparently free internet without paying the costs of surveillance, which are shifted entirely onto non-obfuscators. Second, it permits sketchy actors, from child pornographers to fraudsters, to operate with near impunity. Third, online merchants could plausibly claim that, when we shop online, surveillance is the price we pay for convenience. If we don’t like it, we should take our business to the local brick-and-mortar and pay with cash. Brunton and Nissenbaum have not fully addressed the last two costs. Nevertheless, I think the strict defender of online anonymity can meet these objections. Regarding the third, the future doesn’t bode well for offline shopping. Consider music and books. Intrepid shoppers can still find most of what they want in a book or record store. Soon, though, this will probably not be the case. And then there are those who, for perfectly good reasons, are sensitive about doing some of their shopping in person, perhaps because of their weight or sexual tastes. I argue that consumers should not have to pay the price of surveillance every time they want to buy that catchy new hit, that New York Times bestseller, or a sex toy.

Skolans demokratiska fostrande roll : Undersökning om gymnasieelevers uppfattning av skolans demokratiska fostrande roll samt om elevernas egna roll i skoldemokratin.

Syftet med denna uppsats är att undersöka hur gymnasieelever uppfattar skolans demokratiska fostrande roll samt hur den lokala skolan har lyckats i sin roll som demokratiska fostrare. För att svara på syftet har vi ställt följande frågeställningar: Hur medvetna är eleverna egentligen om skolans demokratiska fostrande roll? Vilken typ av regler anser eleverna vara de viktigaste? Stämmer de demokratiska mål som presenteras i den undersökta skolans arbetsplan och skolplan väl överens med de mål som finns i läroplanen Lpf 94 och skollagen?Det använda källmaterialet består av enkätundersökningar gjorda med elever som går årskurs 3 på gymnasiet samt även arbetsplan och skolplan från den undersökta skolan. Resultaten visar på att eleverna är medvetna om skolans demokratiska fostrande roll i de flesta aspekterna. Däremot visar undersökningen på att det praktiska arbetet kring skolans demokratiska fostran är bristfällig. Enligt resultaten är det regler som rör moraliska värderingar viktigast i skolan. Undersökningen visar även på att de demokratiska mål som presenteras i den undersökta skolans arbetsplan samt skolplan stämmer väl överens med de mål som finns i Lpf 94 samt skollagen. Generellt kan man säga att eleverna uppfattar skolans demokratiska fostrande roll positivt. Den undersökta skolan lyckas med att förmedla de demokratiska idéerna till eleverna men inte ge dem de rätta verktygen för att uppnå målen.

Utveckling av System för att Kartlägga Cykelbanor

Cykeln har på senare år fått en allt större roll inom transportpolitiska sammanhang. Det finns ettintresse att öka användningen av cykel, framförallt av miljö- och hälsoskäl. Därmed finns detockså ett intresse för att kartlägga cykelvägar på samma sätt bilvägar är kartlagda. Om Sverigescykelvägar fanns samlade i en databas skulle utveckling och underhåll förenklas. Det skulle ävenvara möjligt att ta fram informationstjänster som t.ex. ruttplanering för cykelvägnätet.Målet med det här arbetet var att utveckla en applikation för att kartlägga cykelbanor.Applikationen skulle kunna köras på en PC under Windows XP. Koordinater skulle hämtas frånen GPS-enhet ansluten till datorn och plottas på en karta. Insamlade koordinater skulle ävenkunna omvandlas till noder och länkar för att beskriva vägnätets utsträckning och logiskakopplingar. Projektet genomfördes i samarbete med WM-data.WM-data tillhandahöll ett antal färdiga moduler för uppritning av karta samt hantering avdatabas och GPS-enhet. Problemet kunde grovt delas i tre sektioner; utveckla användargränssnittför applikationen, integrera tillhandahållna moduler i applikationen och utveckla den internalogiken för hantering av länkar och noder. Uppgifterna löstes mer parallellt än sekventiellt.Resultat blev ett program där de tre huvudfunktionerna från användarperspektivet är starta/stoppakartläggning samt upprätta kopplingspunkt (nod). Den applikation som utvecklades under det härprojektets gång har möjliggjort kartläggning av cykelbanor, och det finns ett flertal alternativ förvidareutveckling.

Flexibelt lärande? : En intervjustudie med lärare och rektorer angående deras uppfattningar, möjliggöranden och förverkliganden av flexibelt lärande samt dess påverkan på elevers lärande

Syftet med detta examensarbete är att undersöka hur lärare och rektorer på ett specifikt utbildningscentrum uppfattar, möjliggör och förverkligar flexibelt lärande samt få deras insikt i vad flexibelt lärande bidrar till när det gäller elevers lärande. För att uppnå syftet med denna undersökning har följande frågeställnings ställts: Hur uppfattas flexibelt lärande av lärare och rektorer, vad uppfattar rektorer och lärare som positivt samt negativt med flexibelt lärande, hur möjliggörs och förverkligas utbildningscentrumets vision om flexibelt lärande av lärare och rektorer samt hur ser lärare och rektorer på det flexibla lärandets funktion när det gäller elevers lärande?Det använda källmaterialet består av intervjuer gjorda med 2 rektorer och 4 lärare som arbetar med flexibelt lärande på ungdomsgymnasiet och vuxenutbildning på ett utbildningscentrum i mellersta Sverige. Resultaten visar på att den generella uppfattningen om flexibelt lärande hos rektorerna och lärarna är positiv. Man kan se utifrån intervjuerna att de positiva sakerna med flexibelt lärande ofta cirkulerar kring relationen mellan lärare och eleven, medan de negativa sakerna ofta berör mer praktiska saker som angår både lärare och elev. Möjliggörandet och förverkligandet kan man säga består till största del att tillgodose elevers önskemål och behov. Detta innebär att man inte begränsar sig på något sätt, eleverna erbjuds alla möjligheter till studier. Utifrån intervjuerna kan man dra slutsatsen att flexibelt lärande bidrar till elevers lärande på ett sådant sätt att kunskapen fördjupas och eleverna får en annan förståelse för den kunskap som dom skapar. Den problematik vi kan se när det gäller det flexibla lärandet utifrån intervjuerna är att det saknas en allmän rådande definition av begreppet flexibelt lärande och att den socialkonstruktivistiska teorin inte är tillräckligt förankrad. Detta är nödvändigt för att projektet Flexibelt lärande ska lyckas.

Implementing Policy Management through BDI

The requirement for Grid middleware to be largely transparent to individual users and at the same time act in accordance with their personal needs is a difficult challenge. In e-science scenarios, users cannot be repeatedly interrogated for each operational decision made when enacting experiments on the Grid. It is thus important to specify and enforce policies that enable the environment to be configured to take user preferences into account automatically. In particular, we need to consider the context in which these policies are applied, because decisions are based not only on the rules of the policy but also on the current state of the system. Consideration of context is explicitly addressed, in the agent perspective, when deciding how to balance the achievement of goals and reaction to the environment. One commonly-applied abstraction that balances reaction to multiple events with context-based reasoning in the way suggested by our requirements is the belief-desire-intention (BDI) architecture, which has proven successful in many applications. In this paper, we argue that BDI is an appropriate model for policy enforcement, and describe the application of BDI to policy enforcement in personalising Grid service discovery. We show how this has been implemented in the myGrid registry to provide bioinformaticians with control over the services returned to them by the service discovery process.