602 resultados para BIM 4D
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Mode of access: Internet.
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Index, v. 4, p. [375-424].
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Signatures:)(⁴ 2)(⁴ A-4D⁴ 4E².
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Mode of access: Internet.
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Mode of access: Internet.
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"PM 400-4D."
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[architectural rendering showing the new addition to the Bentley Library. Prepared by Studio 4d for Jickling, Lyman, Powell Assoc., architects.
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Head- and tail-pieces; initials.
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Thesis (Master's)--University of Washington, 2016-06
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Thesis (Ph.D.)--University of Washington, 2016-06
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A benzothiazole-derived compound (4a) designed to mimic the C-alpha-C-beta bond vectors and terminal functionalities of Lys2, TyrI3 and Arg17 in omega-conotoxin GVIA was synthesised, together with analogues (4b-d), which had each side-chain mimic systematically truncated or eliminated. The affinity of these compounds for rat brain N-type and P/Q-type voltage gated calcium channels (VGCCs) was determined. In terms of N-type channel affinity and selectivity, two of these compounds (4a and 4d) were found to be highly promising, first generation mimetics of omega-conotoxin. The fully functionalised mimetic (4a) showed low PM binding affinity to N-type VGCCs (IC50 = 1.9 muM) and greater than 20-fold selectivity for this channel sub-type over P/Q-type VGCCs, whereas the mimetic in which the guanidine-type side chain was truncated back to an amine (4d, IC50 = 4.1 muM) showed a greater than 25-fold selectivity for the N-type channel. (C) 2004 Elsevier Ltd. All rights reserved.
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Basic structure studies of the biosynthetic machinery of the cell by electron microscopy (EM) have underpinned much of our fundamental knowledge in the areas of molecular cell biology and membrane traffic. Driven by our collective desire to understand how changes in the complex and dynamic structure of this enigmatic organelle relate to its pivotal roles in the cell, the comparatively high-resolution glimpses of the Golgi and other compartments of the secretory pathway offered to us through EM have helped to inspire the development and application of some of our most informative, complimentary (molecular, biochemical and genetic) approaches. Even so, no one has yet even come close to relating the basic molecular mechanisms of transport, through and from the Golgi, to its ultrastructure, to everybody's satisfaction. Over the past decade, EM tomography has afforded new insights into structure -function relationships of the Golgi and provoked a re-evaluation of older paradigms. By providing a set of tools for structurally dissecting cells at high-resolution in three-dimensions (3D), EM tomography has emerged as a method for studying molecular cell biology in situ. As we move rapidly toward the establishment of molecular atlases of organelles through advances in proteomics and genomics, tomographic studies of the Golgi offer the tantalizing possibility that one day, we will be able to map the spatio-temporal coordinates of Golgi-related proteins and lipids accurately in the context of 4D cellular space. (c) 2005 Elsevier B.V. All rights reserved.
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Single-phase Ba(Cd1/3Ta2/3)O-3 powder was produced using conventional solid state reaction methods. Ba(Cd1/3Ta2/3)O-3 ceramics with 2 wt % ZnO as sintering additive sintered at 1550 degreesC exhibited a dielectric constant of similar to32 and loss tangent of 5x10(-5) at 2 GHz. X-ray diffraction and thermogravimetric measurements were used to characterize the structural and thermodynamic properties of the material. Ab initio electronic structure calculations were used to give insight into the unusual properties of Ba(Cd1/3Ta2/3)O-3, as well as a similar and more widely used material Ba(Zn1/3Ta2/3)O-3. While both compounds have a hexagonal Bravais lattice, the P321 space group of Ba(Cd1/3Ta2/3)O-3 is reduced from P (3) under bar m1 of Ba(Zn1/3Ta2/3)O-3 as a result of a distortion of oxygen away from the symmetric position between the Ta and Cd ions. Both of the compounds have a conduction band minimum and valence band maximum composed of mostly weakly itinerant Ta 5d and Zn 3d/Cd 4d levels, respectively. The covalent nature of the directional d-electron bonding in these high-Z oxides plays an important role in producing a more rigid lattice with higher melting points and enhanced phonon energies, and is suggested to play an important role in producing materials with a high dielectric constant and low microwave loss. (C) 2005 American Institute of Physics.
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The relative length of the second and fourth fingers (the 2D:4D ratio) has been taken to be an indicator of prenatal exposure to testosterone, and hence possibly relevant to sexual orientation and other sex-differentiated behaviors. Studies have reported a difference in this ratio between Caucasian males in Britain and in the U.S.: higher average 2D:4D ratios were obtained in Britain. This raises the question of whether differences among different Caucasian gene pools were responsible or whether some environmental variable associated with latitude might be involved (e.g., exposure to sunlight or different day-length patterns). This question was explored by examining 2D:4D ratios for an Australian adolescent sample. The Australians were predominantly of British ancestry, but lived at distances from the equator more like those of the U.S. studies. The Australian 2D:4D ratios resembled those in Britain rather than those in the U.S., tending to exclude hypotheses related to latitude and making differences in gene pools a plausible explanation.
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Este estudo tem como finalidade primeira contribuir com o debate especializado que enfrenta o desafio de apontar caminhos que auxiliem as empresas familiares a garantirem a própria continuidade a partir da segunda geração de dirigentes. Embora imprecisas e desatualizadas, as estatísticas mostram que 70% dos negócios familiares sucumbem ao alcançarem a segunda geração e, em média, apenas 15% conseguem sobreviver até a terceira geração. A sucessão constitui o tema de maior atenção dos especialistas. Entretanto, há indicações de que, embora as pesquisas se multipliquem a cada ano, existe uma relativa estagnação teórica do campo. Nos últimos anos observa-se um discreto aumento de participação de mulheres em cargos de presidência das empresas familiares que, historicamente,influenciadas pela cultura patriarcal,elegem seus filhos herdeiros como sucessores. Este estudo, portanto, foi orientado pelo objetivo geral de identificar elementos do processo sucessório que permitam o aprofundamento da aparente mudança que está ocorrendo nas empresas familiares, evidenciada pelo discreto aumento do repasse do comando às mulheres, o que, a princípio, contraria a tradição patriarcal. De modo específico, este estudo foi orientado pelos seguintes objetivos: i) analisar a práxis de determinada família empresária que, tendo inaugurado o processo sucessório em sua empresa, encontra-se em fase de preparação de uma filha para assumir o comando do negócio no lugar do pai/fundador; ii) à luz do conhecimento teórico acumulado e da práxis da família empresária investigada reunir um conhecimento que permita a formulação de hipóteses que contribuam com o aprofundamento da problemática tratada neste estudo. Trata-se de uma pesquisa de caráter exploratório que emprega os seguintes métodos: qualitativo, monográfico/estudo de caso e dialético. A unidade de análise é a família proprietária de uma empresa sediada na região do ABC Paulista há 30 anosque se encontra em fase de preparação de uma filha (herdeira) para assumir o comando no lugar do pai/fundador. Existem evidências de que a decisão sucessória foi tomada estrategicamente com afinalidade de garantir que o patrimônio familiar continue sendo controlado pelo fundador, conforme preconiza o modelo de patrimonialismo patriarcal que se faz presente na sociedade brasileira.