Propuesta metodol??gica para la ense??anza de la Lucha Canaria en la educaci??n b??sica

Se presenta una propuesta metodol??gica para introducir la ense??anza de la Lucha Canaria en los curr??culos de Educaci??n F??sica, en las etapas de Educaci??n Infantil, Primaria, Secundaria y Bachillerato, describiendo la relaci??n entre los elementos prescriptivos y los contenidos propios del deporte m??s identificativo de las Islas Canarias. Se ha adaptado esta propuesta a las nuevas corrientes metodol??gicas, para el desarrollo de las capacidades b??sicas del alumnado, incorpor??ndose las investigaciones desarrolladas en el ??mbito universitario de la Comunidad, as?? como la literatura y otras publicaciones relacionadas.

Enterprising personality profile in youth : components and assessment

Resumen tomado de la publicaci??n

Compartiendo lecturas : orientaciones y gu??a de lecturas para ni??os y ni??as de 0-3 a??os

Peque??a gu??a que surge a ra??z de las reflexiones de las integrantes de un grupo de trabajo del CPR de Avil??s (Asturias), en calidad de su actividad profesional como educadoras y mediadoras con las familias en el uso de la Literatura en el primer ciclo de Educaci??n Infantil, que pretende reivindicar una nueva mirada al uso de la literatura infantil en las escuelas y en casa: la lectura como puente afectivo

Evaluaci??n de diagn??stico : Asturias 2009 : 2?? curso de Educaci??n Secundaria Obligatoria

La evaluaci??n de diagn??stico de las competencias b??sicas es uno de los pilares de la evaluaci??n general del sistema educativo, y se orienta a una doble finalidad: sustentar mejoras mediante la aportaci??n de datos contrastados a los centros, a las familias y a la propia Administraci??n educativa, y rendir cuentas a la comunidad escolar mediante informaci??n transparente acerca del uso que se hace de los medios y recursos puestos a su disposici??n, valorando los resultados que con ellos se alcanzan. Este informe de la evaluaci??n realizada al alumnado de segundo curso de Educaci??n secundaria obligatoria del Principado de Asturias, que tuvo lugar en el a??o 2009, presenta los resultados, la descripci??n de los niveles de rendimiento en los que se encuadra al alumnado asturiano y, por ??ltimo, la identificaci??n y an??lisis de los factores asociados a esos rendimientos

Biodiversidad : el mosaico de la vida

Resumen basado en la publicaci??n

Glycan alterations of serum proteins as tumour markers. Prostate-specific antigen in prostate cancer and acute-phase proteins in pancreatic cancer

Els pacients amb càncer presenten una taxa de supervivència superior si es diagnostiquen a estadis inicials, per la qual cosa és indispensable disposar de marcadors tumorals adequats. Glicoformes de proteïnes específiques es podrian utilizar com marcadors tumorals. S’han investigat les subformes i glicosilació de l’Antígen Prostàtic Específic (PSA) per millorar la seva capacitat de diagnosis de pacients amb càncer de pròstata vs aquells amb hiperplàsia benigna prostàtica. També s’han avaluat glicoproteïnes sèriques amb alteracions glucídiques en pacients de càncer de pàncrees, comparat amb pacients amb pancreatitis crònica i controls. S’ha observat una disminució de la fucosilació core i sialilació del PSA en càncer de pròstata i un augment de la fucosilació core i Sialyl-Lewis X en algunes Proteïnes de fase Aguda en càncer de pàncrees. Aquest canvis s’haurien d’avaluar en un cohort de pacients més gran per determinar el seu paper en el cribratge, diagnòstic o monitorització dels cancers estudiats.

Mecanismos para conservar el equilibrio económico en los contratos de obra pública

Todo contrato celebrado es ley para los contratantes. Este principio enseña que todas las personas y órganos del poder público están sometidos al ordenamiento jurídico del Estado. Otros principios bajo los cuales se puede contratar son el de la reciprocidad de las prestaciones y buena fe de los contratantes, porque si cada una de las partes no se obliga para con la otra a dar, hacer o no hacer, no puede haber contrato; y bajo este supuesto las dos partes lo hacen de buena fe. Ahora bien, durante la ejecución del contrato de obra pública se podrían generar factores que obstaculizan el equilibrio económico del mismo y producen contraposición en los principios jurídicos, haciendo insuficientes los mecanismos previstos en la ley y la doctrina. Con estos antecedentes, pretendo mediante el presente trabajo determinar los factores que producen el desequilibrio económico en la contratación de obra, identificar los principios jurídicos que se contraponen al darse el desequilibrio económico en los contratos y finalmente después del análisis de los mecanismos previstos en la ley o en la doctrina para conservar el equilibrio económico proponer unos nuevos. En definitiva académicamente se pretende contribuir de forma científica a generar nuevos mecanismos que produzcan de manera efectiva un equilibrio económico en el contrato de obra pública.

«Dios, patria y libertad»: artesanos quiteños y política 1929-1933

Entre los años 1929 y 1933, los maestros, los operarios y los aprendices de los talleres artesanales quiteños ingresaron en la política nacional en medio de la multitud que ocupaba los espacios públicos. Construyeron una agenda política con demandas específicas y generales para expresar su identidad y sus aspiraciones. Utilizaron diversas formas de lucha, como asambleas, peticiones y demandas a las autoridades; y participaron en elecciones locales y nacionales, movilizaciones, huelgas parciales, huelgas generales y la acción armada para interpelar a las élites y enfrentarse al Estado. Así contribuyeron al proceso de formación histórica de la clase obrera ecuatoriana. Aquí unas páginas sobre esta historia, escritas en diálogo con periódicos de la época, hojas volantes y otros documentos, contestimonios de testigos y con los aportes realizados por quienes se han ocupado del tema, desde la historia y otras ciencias sociales.

Effect of plasma insulin and branched-chain amino acids on skeletal muscle protein synthesis in fasted lambs

The increase in fractional rate of protein synthesis (K-s) in the skeletal muscle of growing rats during the transition from fasted to fed state has been explained by the synergistic action of a rise in plasma insulin and branched-chain amino acids (BCAA). Since growing lambs Also exhibit an increase in K-s with level of feed intake, the objective of the present study was to determine if this synergistic relationship between insulin and BCAA also occurs in ruminant animals. Six 30 kg fasted (72 h) lambs (8 months of age) received each of four treatments, which were based on continuous infusion into the jugular vein for 6 h of: (1) saline (155 mmol NaCl/l); (2) a mixture of BCAA (0.778 mumol leucine, 0.640 mumol isoleucine and 0.693 mumol valine/min.kg); (3) 18.7 mumol glucose/min.kg (to induce endogenous insulin secretion): (4) co-infusion of BCAA and glucose. Within each period all animals received the same isotope of phenylalanine, (Phe) as follows: (1) L-[1-C-13]Phe; (2) L-phenyl-[ring H-2(5)]-alanine; (3) L-[N-15]Phe; (4) L-[ring 2,6-H-3]Phe. Blood was sampled serially during infusions to measure plasma concentrations of insulin, glucose and amino acids, and plasma free Phe isotopic activity; biopsies were taken 6 h after the beginning of infusions to determine K-s in in. longissimus dorsi and vastus muscle. Compared with control (saline-infused) lambs, K-s was increased by an average of 40% at the end of glucose infusion, but this effect was not statistically significant in either of the muscles sampled. BCAA infusion, alone or in combination with glucose, also had no significant effect on K-s compared with control sheep. K-s was approximately 60% greater for vastus muscle than for m. longissimus dorsi (P<0.01), regardless of treatment. It is concluded that there are signals other than insulin and BCAA that are responsible for the feed-induced increase in K-s in muscle of growing ruminant animals.

Pre-B-cell transcription factor 1 and steroidogenic factor 1 synergistically regulate adrenocortical growth and steroidogenesis

variety of transcription factors including Wilms tumor gene (Wt-1), steroidogenic factor 1 (Sf-1), dosage-sensitive sex reversal, adrenal hypoplasia congenita on the X-chromosome, Gene 1 (Dax-1), and pre-B-cell transcription factor 1 (Pbx1) have been defined as necessary for regular adrenocortical development. However, the role of Pbx1 for adrenal growth and function in the adult organism together with the molecular relationship between Pbx1 and these other transcription factors have not been characterized. We demonstrate that Pbx haploinsufficiency (Pbx1(+/-)) in mice is accompanied by a significant lower adrenal weight in adult animals compared with wild-type controls. Accordingly, baseline proliferating cell nuclear antigen levels are lower in Pbx1(+/-) mice, and unilateral adrenalectomy results in impaired contralateral compensatory adrenal growth, indicating a lower proliferative potential in the context of Pbx1 haploinsufficiency. In accordance with the key role of IGFs in adrenocortical proliferation and development, real-time RT-PCR demonstrates significant lower expression levels of the IGF-I receptor, and up-regulation of IGF binding protein-2. Functionally, Pbx1(+/-) mice display a blunted corticosterone response after ACTH stimulation coincident with lower adrenal expression of the ACTH receptor (melanocortin 2 receptor, Mc2-r). Mechanistically, in vitro studies reveal that Pbx1 and Sf-1 synergistically stimulates Mc2-r promoter activity. Moreover, Sf-1 directly activates the Pbx1 promoter activity in vitro and in vivo. Taken together, these studies provide evidence for a role of Pbx1 in the maintenance of a functional adrenal cortex mediated by synergistic actions of Pbx1 and Sf-1 in the transcriptional regulation of the critical effector of adrenocortical differentiation, the ACTH receptor.

Liquid matrix deposition on conductive hydrophobic surfaces for tuning and quantitation in UV-MALDI mass spectrometry

With its highly fluctuating ion production matrix-assisted laser desorption/ionization (MALDI) poses many practical challenges for its application in mass spectrometry. Instrument tuning and quantitative ion abundance measurements using ion signal alone depend on a stable ion beam. Liquid MALDI matrices have been shown to be a promising alternative to the commonly used solid matrices. Their application in areas where a stable ion current is essential has been discussed but only limited data have been provided to demonstrate their practical use and advantages in the formation of stable MALDI ion beams. In this article we present experimental data showing high MALDI ion beam stability over more than two orders of magnitude at high analytical sensitivity (low femtomole amount prepared) for quantitative peptide abundance measurements and instrument tuning in a MALDI Q-TOF mass spectrometer. Samples were deposited on an inexpensive conductive hydrophobic surface and shrunk to droplets <10 nL in size. By using a sample droplet <10 nL it was possible to acquire data from a single irradiated spot for roughly 10,000 shots with little variation in ion signal intensity at a laser repetition rate of 5-20 Hz.

On the structural differences between markers and genomic AC microsatellites

AC microsatellites have proved particularly useful as genetic markers. For some purposes, such as in population biology, the inferences drawn depend on the quantitative values of their mutation rates. This, together with intrinsic biological interest, has led to widespread study of microsatellite mutational mechanisms. Now, however, inconsistencies are appearing in the results of marker-based versus non-marker-based studies of mutational mechanisms. The reasons for this have not been investigated, but one possibility, pursued here, is that the differences result from structural differences between markers and genomic microsatellites. Here we report a comparison between the CEPH AC marker microsatellites and the global population of AC microsatellites in the human genome. AC marker microsatellites are longer than the global average. Controlling for length, marker microsatellites contain on average fewer interruptions, and have longer segments, than their genomic counterparts. Related to this, marker microsatellites show a greater tendency to concentrate the majority of their repeats into one segment. These differences plausibly result from scientists selecting markers for their high polymorphism. In addition to the structural differences, there are differences in the base composition of flanking sequences, marker flanking regions being richer in C and G and poorer in A and T. Our results indicate that there are profound differences between marker and genomic microsatellites that almost certainly affect their mutation rates. There is a need for a unified model of mutational mechanisms that accounts for both marker-derived and genomic observations. A suggestion is made as to how this might be done.

Identification of lipophilic flavones and flavonols by comparative HPLC, TLC and UV spectral analysis

The identification of lipophilic flavones and flavonols using a combination of high performance liquid chromatography, thin layer chromatography and UV spectral analysis is discussed. Data are provided for the flavones, apigenin, luteolin and tricetin and twelve of their methyl ethers, 8-hydroxyluteolin, 6-hydroxyluteolin and scutellarein and fourteen of their methyl ethers, and some 6,8-dihydroxyapigenin and 6,8-dihydroxyluteolin derivatives. Data for some forty two flavonols with extra 6- and/or 8-hydroxylation, mostly 6-hydroxykaempferol and quercetagetin derivatives, are also presented. The remaining compounds analysed include fourteen 5-deoxyflavones, four 5-methoxyflavones and five 5-deoxyflavonols plus further 5-hydroxylated flavones and flavonols without B-ring oxidation or with 2-, 5- or 6-hydroxylation. Copyright © 2003 John Wiley & Sons, Ltd.

Nitrogen donor ligands bearing N-H groups: Effect on catalytic and cytotoxic activity of molybdenum eta(3)-allyldicarbonyl complexes

Reactions of [Mo(eta(3)-C3H5)Br(CO)(2)(NCMe)(2)] with the bidentate nitrogen ligands 2-(2'-pyridyl)imidazole (L1), 2-(2'-pyridyl)benzimidazole (L2), N,N'-bis(2'-pyridinecarboxamido)-1,2-ethane (L3), and 2,2'-bisimidazole (L4) led to the new complexes [Mo(eta(3)-C3H5)Br(CO)(2)(L)] (L = L1, 1; L2, 2; L4, 4) and [{Mo(eta(3)-C3H5) Br(CO)(2)}(2)(mu-L-3)] (3). The reaction of complexes 2 and 3 with Tl[CF3SO3] afforded [Mo(eta(3)-C3H5)(CF3SO3)(CO)(2)(L2)] (2T) and [{Mo(eta(3)-C3H5)(CF3SO3)(CO)(2)}(2)(mu-L-3)] (3T). Complexes 3 and 2T were structurally characterized by single crystal X-ray diffraction, showing the facial allyl/carbonyls arrangement and the formation of the axial isomer. In 2T, two molecules are assembled in a hydrogen bond dimer. The four complexes 1-4 were tested as precursors in the catalytic epoxidation of cyclooctene and styrene, in the presence of t-butylhydroperoxide (TBHP), with moderate conversions and turnover frequencies for complexes 1-3 and very low ones for 4. The increasing number of N-H groups in the complexes seems to be responsible for the loss of catalytic activity, compared with other related systems. The cytotoxic activities of all the complexes were evaluated against HeLa cells. The results showed that compounds 1,2,4, and 2T exhibited significant activity, complexes 2 and 2T being particularly promising. (C) 2008 Elsevier B.V. All rights reserved.