31/12/19, [crue de la Seine], le [square du] Vert-Galant : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57416

29/12/19, crue de la Seine quais de Bercy [Paris, 12e arrondissement] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57379

22/12/19, réouverture du musée du Rhin à la maison de Victor Hugo, [6] place des Vosges [à Paris] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57302

25-12-19, Coupe de Noël, les concurrents au départ [compétition de natation dans la Seine, deux nageuses et dix neuf nageurs] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57323

25-12-19, stade Bergeyre, rugby, équipe du Stadoceste tarbais [qui va jouer contre l'équipe de l'Olympique] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57320

25-12-19, stade Bergeyre, rugby, équipe de l'Olympique : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57322

16/12/19, conseil suprême, rue Franklin [domicile de M. Clemenceau], sortie de M. [Giacomo] de Martino : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57247

13-12-19, stade Jean-Bouin, équipe des Probables [hockey sur gazon] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57222

13-12-19, cardinal Mercier [de Malines, arrivé à Paris le 11 décembre 1919] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57211

Cross-cultural adaptations of the Oxford-12 HIP score to the French speaking population.

BACKGROUND: An objective measurement of surgical procedures outcomes is inherent to professional practices quality control; this especially applies in orthopaedics to joint replacement outcomes. A self-administered questionnaire offers an attractive alternative to surgeon's judgement but is infrequently used in France for these purposes. The British questionnaire, the 12-item Oxford Hip Score (OHS) was selected for this study because of its ease of use. HYPOTHESIS: The objective of this study was to validate the French translation of the self-assessment 12-item Oxford Hip Score and compare its results with those of the reference functional scores: the Harris Hip Score (HHS) and the Postel-Merle d'Aubigné (PMA) score. MATERIALS AND METHODS: Based on a clinical series of 242 patients who were candidates for total hip arthroplasty, the French translation of this questionnaire was validated. Its coherence was also validated by comparing the preoperative data with the data obtained from the two other reference clinical scores. RESULTS: The translation was validated using the forward-backward translation procedure from French to English, with correction of all differences or mistranslations after systematized comparison with the original questionnaire in English. The mean overall OHS score was 43.8 points (range, 22-60 points) with similarly good distribution of the overall value of the three scores compared. The correlation was excellent between the OHS and the HHS, but an identical correlation between the OHS and the PMA was only obtained for the association of the pain and function parameters, after excluding the mobility criterion, relatively over-represented in the PMA score. DISCUSSION AND CONCLUSION: Subjective questionnaires that contribute a personal appreciation of the results of arthroplasty by the patient can easily be applied on a large scale. This study made a translated and validated version of an internationally recognized, reliable self-assessment score available to French orthopaedic surgeons. The results obtained encourage us to use this questionnaire as a complement to the classical evaluation scores and methods.

Colombes, 28/12/19, rugby, Union sportive dacquoise : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57346

28/12/19, voyage présidentiel à Arras [la foule devant la tribune présidentielle] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57357

Colombes, 28/12/19, rugby, Union sportive dacquoise : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57345

Prospective analysis of KRAS, BRAF, and PIK3CA mutations and EGFR copy number in patients (pts) with locally advanced rectal cancer: A translational substudy of a clinical trial (SAKK 41/07) evaluating the effect of neoadjuvant chemoradiation (CRT) with or without panitumumab

Background: Prognostic and predictive markers are of great importance for future study designs and essential for the interpretation of clinical trials incorporating an EGFR-inhibitor. The current study prospectively assessed and validated KRAS, BRAF and PIK3CA mutations in rectal cancer patients screened for the trial SAKK41/07 of concomitant preoperative radio-chemotherapy with or without panitumumab.Methods: Macrodissection was performed on pretreatment formalin fixed paraffin embedded biopsy tissue sections to arrive at a minimum of 50% of tumor cells. DNA was extracted with the Maxwell 16 FFPE Tissue LEV DNA purification kit. After PCR amplification, mutations were identified by pyrosequencing. We prospectively analysed pretreatment biopsy material from 149 rectal cancer pts biopsies for KRAS (exon 2 codon 12 [2-12] and 13 [2-13], exon 3 codon 59 [3-59]) and 61 [3-61], exon 4 codon 117 [4-117] and 146 [4-146]). Sixty-eight pts (KRASwt exon 2, 3 only) were further analysed for BRAF (exon 15 codon 600) and PIK3CA (exon 9 codon 542, 545 and 546, exon 20 codon 1043 [20-1043] and 1047 [20-1047]) mutations, and EGFR copy number by qPCR. For the calculation of the EGFR copy number, we used KRAS copy number as internal reference standard. The calculation was done on the basis of the two standard curves relative quantification method.Results: In 149 screened pts with rectal cancer, the prevalence of KRAS mutations was 36%. Among the 68 pts enrolled in SAKK 41/07 based on initially presumed KRASwt status (exon 2/codons 12+13), 18 pts (26%) had a total of 23 mutations in the RAS/PIK3CA-pathways upon validation analysis. Twelve pts had a KRAS mutation, 7 pts had a PIK3CA mutation, 3 pts had a NRAS mutation, 1 patient a BRAF mutation. Surprisingly, five of these pts had double- mutations, including 4 pts with KRAS plus PIK3CA mutations, and 1 pt with NRAS plus PIK3CA mutations. The median normalized EGFR copy number was 1. Neither mutations of KRAS, BRAF, and PIK3CA, nor EGFR copy number were statistically associated with the primary study endpoint pCR (pathological complete regression).Conclusions: The prevalence of KRAS mutations in rectal and in colon cancer appears to be similar. BRAF mutations are rare; PIK3CA mutations are more common (10%). EGFR copy number is not increased in rectal cancer. A considerable number or KRAS exon 2 wt tumors harbored KRAS exon 3+4 mutations. Further study is needed to determine if KRAS testing should include exons 2-4.

19/12/19, MM. Pannetier, Pericaud, Aubignac faisant partie de la délégation des comités de défense des intérêts des étudiants français qui sont reçus aujourd'hui par le ministre [Léon] Bérard de l'Instruction publique : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57267