Mosul Region, Iraq, 1855 (Image 1 of 3) (Raster Image)

This layer is a georeferenced raster image of the historic paper map set entitled: Vestiges of Assyria, by Felix Jones ; aided in the field operations by J.M. Hyslop ; engraved by J. & C. Walker. Map 1 entitled: Ichnographic sketch of the remains of ancient Nineveh with the enceinte of modern Mosul of Arab M.S.S. and the [Mespila] of the Anabasis. It was published by John Walker in 1855. Scale [ca. 1:12,000]. This layer is image 1 of 3 total images of the six sheet source map, representing the Mosul region Iraq. Map chiefly in English. Some place names given also in Arabic. This datalayer is compiled from two images of the six sheet source map that have been stitched together using image editing software to create a single image.The image inside the map neatline is georeferenced to the surface of the earth and fit to the European Datum 1950 TM42 (Transverse Mercator, Central Meridian 42) coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as ancient city ruins, drainage, canals, cities, villages, and other human settlements, roads, fortifications, selected buildings, and more. Relief shown by hachures.This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

Maldives, 1902 (Image 1 of 3) (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Trigonometrical survey of the Maldive Islands, by Commander R. Moresby, assisted by Lieut. F.T. Powell, Indian Navy ; additions and corrections by Professor A. Agassiz, Mr. Stanley Gardiner and Mr. L. A. Molony, 1902 ; eng. by J. & C. Walker. Sheet 1. It was published by Hydrographic Office, 1904. Scale [ca. 1:310,000]. This layer is image 1 of 3 total images of the three sheet source map representing the northern portion of the map. The image inside the map neatline is georeferenced to the surface of the earth and fit to the 'Mercator' projection. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, human settlements, ground cover, shoreline features, inlets, lagoons, shoals, sand banks, atolls, islands and islets, points, rocks, bottom types, and more. Relief shown by spot heights. Depths shown by soundings. Includes notes on navigation and locations of potable water. This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection and the Harvard University Library as part of the Open Collections Program at Harvard University project: Organizing Our World: Sponsored Exploration and Scientific Discovery in the Modern Age. Maps selected for the project correspond to various expeditions and represent a range of regions, originators, ground condition dates, scales, and purposes.

Amsterdam Region, the Netherlands, 1749 (Image 1 of 3) (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Kaarte van alle de dykpligtige en eenige waalpligtige landen behorende onder het Hoogreemraadschap van den Zeeburg en Diemerdyk, J. Wandelaar, delin. et sculpsit. It was published in 1749. Scale [ca. 1:6,000]. This layer is image 1 of 3 total images of the three sheet source map, representing the northern portion of the map. Covers the region east of Amsterdam, the Netherlands including portions of Gemeente Amsterdam, Gemeente Diemen, Gemeente Muiden, and Gemeente Weesp. Map in Dutch.The image inside the map neatline is georeferenced to the surface of the earth and fit to the RD_New (Rijksdriehoekstelsel), GCS Amersfoort coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, canals, cities and other human settlements, administrative boundaries, roads, propery boundaries with names of landowners, selected buildings and built-up areas, fortification, dikes, dams, windmills, shoreline features, and more. Relief shown by hachures. Depths shown by soundings.This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

North Carolina, 1808 (Image 1 of 3) (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: To David Stone and Peter Brown, Esq. : this first actual survey of the state of North Carolina taken by the subscribers is respectfully dedicated by their humble servants, Jona. Price and John Strother ; engraved by W. H. Harrison. It was printed by C.P. Harrison in 1808. Scale [ca. 1:506,880]. This layer is image 1 of 3 total images of the three sheet source map, representing the western portion of the map.The image inside the map neatline is georeferenced to the surface of the earth and fit to the North Carolina State Plane NAD 1983 coordinate system (in Feet) (Fipszone 3200). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, drainage, canals, cities and towns, selected public buildings (churches, inns), industry locations (e.g. mills, mines, etc.), selected private buildings with names of property owners, state and county boundaries, shoreline features, and more. Relief shown pictorially and by hachures.This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

Synthesis of xanthone-1,2,3-triazole dyads

Xanthones and 1,2,3-triazoles are known to exhibit several biological, pharmacological and biocidal properties[1]. The potential applications of these two classes of heterocycles led us to develop new strategies to synthesize xanthone-1,2,3-triazole dyads, aiming to get potentially improved therapeutic agents[2]. With this rational in mind we designed and synthesized novel chromone derivatives 1a-d to be used as building motifs and to explore the reactivity of the two unsaturated systems (the diene and the alkyne). In the present communication we will present a new synthetic route towards the synthesis of xanthone-1,2,3-triazole dyads 7a-d using consecutively the azide-alkyne Huisgen 1,3-dipolar cycloaddition and Diels-Alder reaction. Our approach involves the synthesis chromone-triazole derivatives 2a-d using the reaction of 1a-d with sodium azide, followed by the methylation of the NH of the triazole moiety. The methylation afforded three isomers 3a-d, 4a-d and 5a-d, as expected. The major isomers 3a-d were used in the Diels-Alder reaction with N-methylmaleimide, and the adducts obtained 6a-d were oxidized to afford the xanthone-1,2,3-triazole dyads 7a-d. All the synthetic details as well as the structural characterization (by 1D and 2D NMR studies) of the new synthesised compounds will be presented and discussed.

Recent developments in the synthesis of novel xanthone-1,2,3-triazole dyads

The development of multi-target drugs for treating complex multifactorial diseases constitutes an active research ield. This kind of drugs has gained much importance as alternative strategy to combination therapy (“cocktail drugs”).1 A common way to design them brings together two different pharmacophores in one single molecule (so-called dyads). Following this idea and being aware that xanthones2 and 1,2,3-triazoles3 possess important pharmacological properties, we combined these two heterocycles in one molecule to create new dyads with improved therapeutic potential. In this work, new xanthone-1,2,3-triazole dyads were prepared from novel (E)-2-(4-arylbut-1-en-3-yn-1-yl)chromones by two different approaches to evaluate their eficiency and sustainability. Both methodologies involved Diels-Alder reactions to build the xanthone core, which were optimized using microwave irradiation as alternative heating method, and 1,3-dipolar cycloadditions to insert the 1,2,3-triazole moiety (Figure 1).4 All final and intermediate compounds were fully characterized by 1D and 2D NMR techniques.