UML 1.4 versus UML 2.0 as Languages to Describe Software Architectures.

ML 1.4 is widely accepted as the standard for representing the various software artifacts generated by a development process. For this reason, there have been attempts to use this language to represent the software architec- ture of systems as well. Unfortunately, these attempts have ended in representa- tions (boxes and lines) already criticized by the software architecture commu- nity. Recently, OMG has published a draft that will constitute the future UML 2.0 specification. In this paper we compare the capacities of UML 1.4 and UML 2.0 to describe software architectures. In particular, we study extensions of both UML versions to describe the static view of the C3 architectural style (a simplification of the C2 style). One of the results of this study is the difficulties found when using the UML 2.0 metamodel to describe the concept of connector in a software architecture.

Antisense oligonucleotides against α1E reduce R-type calcium currents in cerebellar granule cells

Many neurons of the central nervous system display multiple high voltage-activated Ca2+ currents, pharmacologically classified as L-, N-, P-, Q-, and R-type. Of these current types, the R-type is the least understood. The leading candidate for the molecular correlate of R-type currents in cerebellar granule cells is the α1E subunit, which yields Ca2+ currents very similar to the R-type when expressed in heterologous systems. As a complementary approach, we tested whether antisense oligonucleotides against α1E could decrease the expression of R-type current in rat cerebellar granule neurons in culture. Cells were supplemented with either antisense or sense oligonucleotides and whole-cell patch clamp recordings were obtained after 6–8 days in vitro. Incubation with α1E antisense oligonucleotide caused a 52.5% decrease in the peak R-type current density, from −10 ± 0.6 picoamperes/picofarad (pA/pF) (n = 6) in the untreated controls to −4.8 ± 0.8 pA/pF (n = 11) (P < 0.01). In contrast, no significant changes in the current expression were seen in sense oligonucleotide-treated cells (−11.3 ± 3.2 pA/pF). The specificity of the α1E antisense oligonucleotides was supported by the lack of change in estimates of the P/Q current amplitude. Furthermore, antisense and sense oligonucleotides against α1A did not affect R-type current expression (−11.5 ± 1.7 and −11.7 ± 1.7 pA/pF, respectively), whereas the α1A antisense oligonucleotide significantly reduced whole cell currents under conditions in which P/Q current is dominant. Our results support the hypothesis that members of the E class of α1 subunits support the high voltage-activated R-type current in cerebellar granule cells.

Tema 3, parte 4: El API DOM

En esta presentación se describe el API DOM1 para JavaScript, que permite manipular dinámicamente documentos HTML y XML.

Cas pràctic 4. Psicologia Evolutiva de 3 a 6 anys

a) Detectar aspectes o variables personals i contextuals que afecten el desenvolupament integral del xiquet/a. b) Conèixer l’impacte que determinades situacions personals o ambientals produeixen en els diferents àmbits del desenvolupament. c) Analitzar les relacions que hi ha entre els diferents agents i com afecten el desenvolupament del xiquet/a. d) Debatre propostes i actuacions per a minimitzar o potenciar l’impacte de determinats agents en el desenvolupament del xiquet/a.

Sedimentology of core PS2564-3 and GeoB2110-4

In the South Atlantic and adjoining Southern Ocean the kaolinite/chlorite-ratio in Late Quaternary sediments are an alternative deep water proxy to benthic foraminiferal proxies and carbonate preservation indices that is even suitable in regions with poor carbonate preservation. This paper shows the relationship between modern abyssal circulation and the kaolinite/chloriteratio and presents reconstructions of deep and bottom water advection based on the kaolinite/ chlorite proxy. We also discuss the limitations and future perspectives of the kaolinite/chlorite proxy. Latitudinal and water depth-related patterns of the kaolinite/chlorite-ratio in surface sediments correspond to the modern deep and bottom water mass distribution. Kaolinite originates from lowlatitudes and traces North Atlantic Deep Water (northern-source deep water) advection to the south. Chlorite from the southern high-latitudes is exported via northward advecting Antarctic Bottom Water and Circumpolar Deep Water (southern-source deep and bottom water). Deep-sea sedimentation in regions underlying the Antarctic Circumpolar Current was current-dominated throughout the Late Quaternary. Temporal variations of the kaolinite/chlorite-ratio in response to glacial-interglacial cycles reflect changing deep water mass configurations, suggesting a shallowing and northward retreat of northern-source deep water and accordingly wider expansion of southernsource deep and bottom water masses during glacial times relative to interglacial times. Submarine topography influenced the spatial and temporal patterns of deep water mass distribution.