Incidence of breast cancer in first-degree female relatives of men with newly diagnosed prostate cancer

Prostate cancer is the most common incident cancer and the second leading cause of death in men in the United States. Although numerous attempts have been made to identify risk factors associated with prostate cancer, the results have been inconsistent and conflicting. The only established risk factors are age and ethnicity. A positive family history of prostate cancer has also been shown to increase the risk two- to three-fold among close relatives.^ There are several similarities between breast and prostate cancer that make the relationship between the two of interest. (1) Histologically, both cancers are predominantly adenocarcinomas, (2) both organs have a sexual and/or reproductive role, (3) both cancers occur in hormone-responsive tissue, (4) therapy often consists of hormonal manipulation, (5) worldwide distribution patterns of prostate and breast cancer are positively correlated.^ A family history study was conducted to evaluate the aggregation of prostate cancer and co-aggregation of breast cancer in 149 patients referred to The University of Texas, M.D. Anderson Cancer Center with newly diagnosed prostate cancer. All patients were white, less than 75 years of age at diagnosis and permanent residents of the United States. Through a personal interview with the proband, family histories were collected on 1,128 first-degree relatives. Cancer diagnoses were verified through medical records or death certificate. Standardized incidence ratios were calculated using a computer program by Monson incorporating data from Connecticut Tumor Registry.^ In this study, familial aggregation of prostate cancer was verified only among the brothers, not among fathers. Although a statistically significant excess of breast cancer was not found, the increased point estimates in mothers, sisters and daughters are consistent with a co-aggregation hypothesis. Rather surprising was the finding of a seven-fold increased risk of prostate cancer and a three-fold increased risk of breast cancer among siblings in the presence of a maternal history of any cancer. Larger family history studies including high risk (African-Americans) and lower-risk groups (Hispanics) and incorporating molecular genetic evaluations should be conducted to determine if genetic differences play a role in the differential incidence rates across ethnic groups. ^

CIGARETTE SMOKING AMONG HIGH SCHOOL STUDENTS IN RURAL AREAS OF THAILAND

The purpose of this study was to identify the smoking prevalence among high school students in rural areas of Thailand and the factors associated with their smoking habits. The sample population was comprised of 946 volunteer students of both sexes enrolled in the twelfth grade classes of the 1981-82 school year in randomly chosen regional public high schools throughout the country. Data were obtained from a formal self-administered questionnaire survey. The comparisons were treated by classified smoking habits as "non-smoker," "trier," "ex-smoker," and "smoker."^ The study presented the low rate of cigarette smoking habits among female students, compared to male students. Significant differences of smoking-related habits were found among those who had exemplar models for smoking habits; fathers, siblings and peers were their reference groups. Parental approval was found to be a significant factor associated with students' smoking habits. The awareness of health hazards, the perceptions of the influence of cigarette advertisement, and the attitudes toward the concerns of government in cigarette manufacturing were also factors associated with cigarette smoking habits of high school subjects. ^

MARITAL STATUS AND CARDIOVASCULAR RISK (SERUM, CHOLESTEROL, CIGARETTE, SMOKING, BLOOD, PRESSURE, SYSTOLIC)

There were three purposes of this study. The first was to describe the association between stable marital status and serum cholesterol, systolic blood pressure and cigarette smoking. The second purpose was to determine whether individuals who were married at one point and became widowed or divorced/separated had higher serum cholesterol, higher systolic blood pressure or were more likely to smoke prior to the change in marital status compared with individuals who did not change marital status. The third purpose was to determine whether the changes in marital status described above were related to increases in serum cholesterol or in cigarette smoking behavior. The rationale for the study was to determine whether previously reported associations between marital status categories and cardiovascular mortality may be mediated through higher values of risk correlates for cardiovascular disease among unmarried individuals.^ The study group selected for this dissertation was a sample from the Hypertension Detection and Follow-up Program (HDFP) population. The HDFP population was aged 30-69 years at the initial visit and included blacks and whites, males and females. The population was followed five years after the initial visit and periodic measurements of serum cholesterol, blood pressure and cigarette smoking behavior were obtained.^ Serum cholesterol was not associated with stable marital status category or with marital status prior to change. Changes in serum cholesterol were associated with marital status categories after change but the serum cholesterol values deceased rather than increased. Married individuals were shown to have higher serum cholesterol values compared with unmarried. Selection of the HDFP population may have influenced an ability to detect a significant association between marital status and serum cholesterol but it is doubtful that use of a general population would alter the direction of the association.^ Systolic blood pressure was significantly higher at the initial visit among unmarried white males and females compared with their married counterparts. No association between systolic blood pressure was found among black males or females. Those individuals who were married at the initial visit who experienced a change in marital status were found to have higher systolic blood pressure prior to the change in marital status. . . . (Author's abstract exceeds stipulated maximum length. Discontinued here with permission of author.) UMI ^

RELATIONSHIP OF ANTISOCIAL PERSONALITY SYNDROME IN BOYS TO PARENTAL ALCOHOL/DRUG DEPENDENCY

The study focused on the relationship between antisocial personality syndrome in boys ages 8-15 and parental alcohol/drug dependency. The population studied was case records of 101 boys coming to a private psychiatrist from 1966 through 1979. The boys were predominantly white and from middle to upper income families.^ A boy was determined to have antisocial personality syndrome if he exhibited antisocial behaviors in four or five major categories, did not exhibit a brain syndrome, and did not exhibit a thought disorder. The five major behavior categories were: (1) self-control (i.e., temper tantrums or hyperactivity), (2) behavior at home (i.e., disobedience or lying), (3) behavior at school (i.e., truancy or cheating), (4) behavior toward peers (i.e., bullying, fighting, or tattling), and (5) behavior against property (i.e., destructiveness or stealing). A boy was determined to be a control if he exhibited antisocial behaviors in two or less behavior categories.^ A parent was determined to have alcohol/drug dependency if s/he exhibited a score above the established threshold (1) for the MacAndrew Alcoholism Scale (28 or above), and (2) for the Holmes Alcoholism Scale (35 or above) which are used with the MMPI. A parent was classified not alcohol/drug dependent if s/he had scores below set thresholds (22 on the MacAndrew Alcoholism Scale and 28 on the Holmes Alcoholism Scale).^ For the final sample (N = 10), there was no reason to believe a relationship exists between antisocial personality syndrome in boys ages 8-15 and parental alcohol/drug dependency (Fisher's Exact Test {FET} P = 1.0). The small sample size primarily occurred as a result of 88.12% of the parents being classified in a questionable category in terms of alcohol/drug dependency.^ The sample was suggestive of a relationship between the fathers' Psychopathic Deviate (Pd) Scale scores as a measure of antisocial tendencies and the boy having antisocial personality syndrome (N = 75; P = .12). There was no evidence of such a relationship for mothers (N = 75; P = .97). ^

Trastuzumab use and risk of congestive heart failure in older breast cancer patients

Trastuzumab is a humanized-monoclonal antibody, developed specifically for HER2-neu over-expressed breast cancer patients. Although highly effective and well tolerated, it was reported associated with Congestive Heart Failure (CHF) in clinical trial settings (up to 27%). This leaves a gap where, Trastuzumab-related CHF rate in general population, especially older breast cancer patients with long term treatment of Trastuzumab remains unknown. This thesis examined the rates and risk factors associated with Trastuzumab-related CHF in a large population of older breast cancer patients. A retrospective cohort study using the existing Surveillance, Epidemiology and End Results (SEER) and Medicare linked de-identified database was performed. Breast cancer patients ≥ 66 years old, stage I-IV, diagnosed in 1998-2007, fully covered by Medicare but no HMO within 1-year before and after first diagnosis month, received 1st chemotherapy no earlier than 30 days prior to diagnosis were selected as study cohort. The primary outcome of this study is a diagnosis of CHF after starting chemotherapy but none CHF claims on or before cancer diagnosis date. ICD-9 and HCPCS codes were used to pool the claims for Trastuzumab use, chemotherapy, comorbidities and CHF claims. Statistical analysis including comparison of characteristics, Kaplan-Meier survival estimates of CHF rates for long term follow up, and Multivariable Cox regression model using Trastuzumab as a time-dependent variable were performed. Out of 17,684 selected cohort, 2,037 (12%) received Trastuzumab. Among them, 35% (714 out of 2037) were diagnosed with CHF, compared to 31% (4784 of 15647) of CHF rate in other chemotherapy recipients (p<.0001). After 10 years of follow-up, 65% of Trastuzumab users developed CHF, compared to 47% in their counterparts. After adjusting for patient demographic, tumor and clinical characteristics, older breast cancer patients who used Trastuzumab showed a significantly higher risk in developing CHF than other chemotherapy recipients (HR 1.69, 95% CI 1.54 - 1.85). And this risk is increased along with the increment of age (p-value < .0001). Among Trastuzumab users, these covariates also significantly increased the risk of CHF: older age, stage IV, Non-Hispanic black race, unmarried, comorbidities, Anthracyclin use, Taxane use, and lower educational level. It is concluded that, Trastuzumab users in older breast cancer patients had 69% higher risk in developing CHF than non-Trastuzumab users, much higher than the 27% increase reported in younger clinical trial patients. Older age, Non-Hispanic black race, unmarried, comorbidity, combined use with Anthracycline or Taxane also significantly increase the risk of CHF development in older patients treated with Trastuzumab. ^

Fathering Behavior within the Context of Role Expectations and Marital Satisfaction: Framework for Studying Fathering Behavior

A father’s participation in a child’s life has been regarded as a significant factor in the enhancement of a couple’s relationship. Although the investigations between paternal behavior and marital satisfaction come with mixed results, they clearly link the concepts of maternal and paternal role expectations to paternal behavior, which can be also moderated by earner status, child’s gender, and traditional versus contemporary role expectations. Research needs to focus on examining how individuals’ perceptions of role expectations relate to fathers’ actual parenting behavior. Therefore, a framework that outlines the interaction between and among these variables is developed, as supported by recent literature as a guide for future research directives.

Family Structure and Obesity Among U.S. Children

Child obesity in the U.S. is a significant public health issue, particularly among children from disadvantaged backgrounds. Thus, the roles of parents’ human and financial capital and racial and ethnic background have become important topics of social science and public health research on child obesity. Less often discussed, however, is the role of family structure, which is an important predictor of child well-being and indicator of family socioeconomic status. The goal of this study, therefore, is to investigate how preschool aged children’s risk of obesity varies across a diverse set of family structures and whether these differences in obesity are moderated by family poverty status and the mothers’ education. Using a large nationally representative sample of children from the Early Childhood Longitudinal Study – Birth Cohort, we find that preschoolers raised by two biological cohabiting parents or a relative caregiver (generally the grandparent) have greater odds of being obese than children raised by married biological parents. Also, poor children in married biological parent households and non-poor children in married step parent households have greater obesity risks, while poor children in father only, unmarried step, and married step parent families actually have lower odds of obesity than children in non-poor intact households. The implications of these findings for policy and future research linking family structure to children’s weight status are discussed.

An investigation of pertussis cases in a Texas county from 2008 through 2012

Background: Once thought to be eradicated, pertussis is now making a steady comeback throughout Texas and the United States. Pertussis can have an effect on all demographics, but infants have the greatest health concern as they suffer the highest case-fatality rate. The objective of this study was to create and report a comprehensive summary of confirmed or probable pertussis cases in a Texas County during the 2008 through 2012 time period.^ Methods: A cross-sectional study design was used to show at risk populations in a Texas county using descriptive statistics of data from probable and confirmed pertussis cases in this Texas County from 2008-2012. Data was collected during routine pertussis investigations conducted by the local health department of this Texas County.^ Results: There was a sharp increase in pertussis cases seen in this county in 2012. Hispanics made up the majority of cases (74.9%) as compared to 12.8% of cases among Whites, 3.1% of cases among Blacks and 9.2% of cases among unknown/other. The population of Hispanics within this county was 58.9%. Almost a quarter of cases (24.2%) in this study were hospitalized. There was no difference identified in the proportion of male sources of exposure (48.9%) as compared to female (51.1%). Household contacts were the main sources of exposure: siblings (29.2%), fathers (14.5%), children (14.6%), and mothers (12.5%).^ Conclusion: Prevention intervention needs to be designed to target vulnerable populations and reduce the effect of this sometimes fatal disease. These results show pertussis proportionally has a greater effect on Hispanics. Additional research needs to be conducted on risk factors such as household crowding and immunization status among Hispanics to identify if ethnicity plays a role in risk of transmission of pertussis. The results were limited due to the large amount of missing data in vaccination history and identification of source of exposure.^

La configuración alegórica del espacio en William Faulkner : Absalom, Absalom!, Go Down Moses y The Sound and the Fury

El artículo analiza la configuración del espacio en tres novelas de William Faulkner como parte de un continuum iniciado en el período colonial: la idea del Nuevo Mundo generada por los puritanos y la adaptación de esa idea y de su manifestación retórica a las circunstancias inauguran la tópica que caracteriza a la literatura norteamericana y que Faulkner, echando mano de un imaginario autorreferencial, resignifica y enriquece con connotaciones innovadoras.

La persona en Pedro Lombardo y sus antecedentes en Alcuino

Las Sententiae de Pedro Lombardo es, en la Edad Media, el libro más comentado luego de la Biblia. Se trata de una “colección" de las doctrinas teológicas vigentes a partir de la contribución de los Padres y de otros maestros más cercanos en el tiempo. En este trabajo se buscará identificar el estado de la cuestión acerca del concepto de persona en la obra de Alcuino de York como antecedente del desarrollo que esta misma noción tendrá en Pedro Lombardo. En primer lugar se determinará la presencia del concepto boeciano de persona en la obra de Alcuino y, luego, el desarrollo que este mismo maestro realiza de este concepto motivado por la necesidad de establecer las características de la persona de Cristo. En tercer lugar se analizará la aplicación que efectúa de lo ya definido al caso de la persona humana. Finalmente, se estudiará la aplicación de estas nociones a un caso concreto pero particularmente significativo para el desarrollo de la metafísica altomedieval: el poder político.

La asthéneia en la antropología cristiana primitiva

La Patrística cristiana recibió la noción veterotestamentaria de asthéneia de la versión griega de los LXX. Entendida como “debilidad" y “falta de fuerza", se la asoció con “enfermedad" o “estado general de debilidad", significado que se conservó tanto en los libros históricos como en los poéticos. El término aparece con frecuencia también en los Evangelios y en los escritos de Pablo, posibilitando así una comprensión de la enfermedad en clave filosófico-teológica por parte de los Padres, entre los que se destaca el Patriarca de Constantinopla San Juan Crisóstomo, quien recurriendo a una exégesis literal de la Escritura según los principios de la escuela antioquena, analiza el concepto en sus comentarios a las Epístolas llamadas “Mayores" de San Pablo y, particularmente, a la Segunda Carta a los Corintios. De esta lectura se desprende la necesidad de considerar la asthéneia de manera inseparable de la antropología cristiana. En los orígenes del cristianismo la concepción de hombre resultaba extremadamente compleja, oscilando desde la antropología tripartita de San Pablo (I Tes. 5, 23) a la quíntuple presentada por ciertos textos gnósticos (Carta esotérica de Santiago 11, 36-12, 17; 14, 24-36) y a la década de Clemente de Alejandría (Strómata VI, 16, 135, 1-2). El estudio de la aplicación del concepto de asthéneia a los distintos componentes del hombre en la polifacética literatura cristiana primitiva, permite comprender la importancia asignada a cada uno de ellos según las distintas corrientes interpretativas.

La psicología en el saber carolingio : el tema de la mente en Alcuino de York

In this paper the author analyses the concept of the mind in the Alcuin’s treatise De ratione animae. Following the teaching of the Fathers, specially Augustine and Isidore of Sevilla, Alcuin of York comprehends the mind as a nominal part of the soul and as its highest peak, the way in which the man is a God’s image. Finally is presented an sketch of the Alcuin’s knowledge theory as exposed in this treatise.

La recepción del concepto de acedia en la obra de Alberto Magno

La acedia ocupó un importante lugar dentro de la teología espiritual de los Padres del Desierto y el concepto por ellos acuñado pasó al mundo latino a través de Casiano aunque con un significado ya levemente diverso. San Gregorio Magno la desplaza de su listado de los siete pecados capitales y, es por eso, que en los siglos siguientes la acedia será considerada una especie de pereza concerniente a las actividades piadosas propias de la vida religiosa. La escolástica del siglo XIII, sin embargo, produce una renovación del estudio de la acedia, la que encontrará un lugar más o menos importante dentro de los tratados que escribirán pensadores como Guillermo de Auxerre, Alejandro de Hales, Alberto Magno o Tomás de Aquino. En este trabajo deseo puntualizar los aspectos más destacados de la doctrina sobre la acedia que elabora Alberto Magno a lo largo de varias de sus obras, buscando señalar los aspectos más destacados y que evidencia una clara evolución de su pensamiento al respecto.

El trabajo de derribar antinomias : los intentos de Helmut Plessner y Talcott Parsons

La relación entre comunidad y sociedad puede rastrearse de los orígenes de la sociología hasta la actualidad. Fue un punto central en el pensamiento de la segunda generación de padres fundadores -Durkheim, Tönnies, Weber-, lo fue luego en la sociología de Talcott Parsons, y es aún un fuerte centro de debate entre las diversas corrientes contemporáneas, tanto dentro de la sociología como en las ciencias políticas y la filosofía. En este sentido, la relación comunidad-sociedad continúa hasta el día de hoy suscitando polémicas e inspirando numerosos y sugerentes trabajos. No obstante, si bien en sus diferentes tratamientos presenta incontables diferencias, un elemento común es analizar la relación como dos polos excluyentes y antitéticos. Este trabajo se propone describir cómo dos pensadores provenientes de corrientes diferentes como Talcott Parsons y Helmut Plessner buscaron pensar ambos conceptos -comunidad y sociedad- no cómo elementos excluyentes, sino como dimensiones necesarias y presentes en todo nivel de la vida humana. Así, la intención es demostrar cómo dichos autores lograron integrar ambas dimensiones, a la vez que advertir sobre las consecuencias y dificultades de los intentos de superación o eliminación de esta relación.

Religión y política entre los primeros cristianos : proyecciones de la nueva mentalidad en la patrística temprana

El artículo se compone de una introducción que examina el pasaje evangélico de Mc 12, 13-17 en relación con el pago de los impuestos, como la fuente sustancial de la arcaica problemática religioso-política cristiana. El tema de religión y política de intrínseca complejidad incluye el estudio de un documento gnóstico directo, el Tratado Tripartito (NHC I, 5), porque él encierra el vocabulario filosófico político usado por los primeros cristianos. El estudio del testimonio investigado es, además, de utilidad, porque permite analizar con superior tecnicismo la concepción político-religiosa de Pablo de Tarso y sus posibles aplicaciones a la cultura política cristiana en formación. Teniendo en cuenta este contexto es posible ir más a fondo en la captación del sentido del kath’ ékhon que aparece en la epístola deutero-paulina a los tesalonicenses (2 Tes. 2, 1-12) y la relación de este conjunto de conceptos político-religiosos con las ideas paralelas, aunque ambivalentes, acuñadas por los autores de las generaciones inmediatas, es decir, los Padres Apostólicos. Las conclusiones abordan las consecuencias que se pueden extraer de estos planteamientos antiguos que se han mantenido en el Medioevo, y su posible efectividad para el mejoramiento de la concepción cristiana actual de la política.