1000 resultados para Ruotsi - 1809


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Urheiluliiton asiallisessa ja rauhallisessa kokouksessa purettiin yksimielisesti toukokuun päätös ja annettiin liiton johdolle luottamuslause; kokouksessa läsnä 313 edustajaa 210 seurasta; Kekkonen: Suomen urheiluliikkeen päämääränä tulee olla Suomen urheilun todellisten voimanlähteiden etsiminen ja kehittäminen

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Intracellular membrane fusion proceeds via distinct stages of membrane docking, hemifusion and fusion pore opening and depends on interacting families of Rab, SNARE and SM proteins. Trans-SNARE complexes dock the membranes in close apposition. Efficient fusion requires further SNARE-associated proteins. They might increase the number of trans-SNARE complexes or the fusogenic potential of a single SNARE complex. We investigated the contributions of the SM protein Vps33 to hemifusion and pore opening between yeast vacuoles. Mutations in Vps33 that weaken its interactions with the SNARE complex allowed normal trans-SNARE pairing and lipid mixing but retarded content mixing. Deleting the H(abc) domain of the vacuolar t-SNARE Vam3, which interacts with Vps33, had the same effect. This suggests that SM proteins promote fusion pore opening by enhancing the fusogenic activity of a SNARE complex. They should thus be considered integral parts of the fusion machinery.

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Urho Kekkosen haast.

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