Rehabilitation Services for Older People Regional Report (PDF 397 KB)

March 2004 - main findings, key recommendations and the way forward

Acute Hospital Portfolio - Day Surgery in Northern Ireland Regional Summary (PDF 80 KB)

October 2003 - main findings arising from the study and the key conclusions

Mental Health Services for Older People Regional Summary (PDF 217 KB)

June 2004 - study to examine service provision, early identification, information and support, co-ordination of services and strategic planning

Mental Health Services Follow Up Regional Summary (PDF 186 KB)

June 2004 - main findings on progress arising from follow-up, emerging issues, key conclusions

Mental Health Services in NI VFM Review Regional Summary (PDF 1650 KB)

June 2000 - to review whether the strategy for mental health services is based on clearly defined needs

Flexible employment and cross- regional adjustment

Employment flexibility is commonly associated to greater labour mobility and thus faster cross-regional adjustments. The literature however offers very little hard evidence on this and quite limited theoretical guidance. This paper examines empirically the relationship between employment flexibility and cross-regional adjustment (migration) at the regional and local levels in the UK. Employment flexibility is associated to higher labour mobility (but only at a rather localised scale) and at the same time seems to reduce the responsiveness of migration to unemployment. This suggest that rising flexibility may be linked to higher persistence in spatial disparities, as intra-regional adjustments are strengthened while extraregional adjustments weakened. Keywords: Employment flexibility, regional migration, labour market adjustment JEL Codes: R11, R23, J08, J61

Radiology Services in NI Follow Up Regional Summary (PDF 1243 KB)

Report Published June 2001 - Contains key recommendations and the way forward

District Nursing Services in Northern Ireland Follow Up Regional Report (PDF 1080 KB)

District Nursing Services in Northern Ireland Follow Up Regional Report

Regional Redesign of Community Nursing Project (PDF 447 KB)

Report describing the regional redesign of community nursing project commissioned by DHSSPS Nursing and Advisory Group in 2004

Regional Redesign of Community Nursing Project Final Report (PDF 467 KB)

Report on the regional redesign of community nursing project by Deloitte

District Nursing Services in Northern Ireland Regional Summary (PDF 1.92mb)

District Nursing Services in Northern Ireland Regional Summary Health Services Audit

Draft Regional Transport Services Strategy - March 2005 (PDF 232 KB)

A Consultation Paper

Characterization of the Aspergillus nidulans biotin biosynthetic gene cluster and use of the bioDA gene as a new transformation marker.

The genes involved in the biosynthesis of biotin were identified in the hyphal fungus Aspergillus nidulans through homology searches and complementation of Escherichia coli biotin-auxotrophic mutants. Whereas the 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase are encoded by distinct genes in bacteria and the yeast Saccharomyces cerevisiae, both activities are performed in A. nidulans by a single enzyme, encoded by the bifunctional gene bioDA. Such a bifunctional bioDA gene is a genetic feature common to numerous members of the ascomycete filamentous fungi and basidiomycetes, as well as in plants and oömycota. However, unlike in other eukaryota, the three bio genes contributing to the four enzymatic steps from pimeloyl-CoA to biotin are organized in a gene cluster in pezizomycotina. The A. nidulans auxotrophic mutants biA1, biA2 and biA3 were all found to have mutations in the 7,8-diaminopelargonic acid synthase domain of the bioDA gene. Although biotin auxotrophy is an inconvenient marker in classical genetic manipulations due to cross-feeding of biotin, transformation of the biA1 mutant with the bioDA gene from either A. nidulans or Aspergillus fumigatus led to the recovery of well-defined biotin-prototrophic colonies. The usefulness of bioDA gene as a novel and robust transformation marker was demonstrated in co-transformation experiments with a green fluorescent protein reporter, and in the efficient deletion of the laccase (yA) gene via homologous recombination in a mutant lacking non-homologous end-joining activity.