Multi-responsiveness of single anterior pituitary cells to hypothalamic-releasing hormones: A cellular basis for paradoxical secretion

The classic view for hypothalamic regulation of anterior pituitary (AP) hormone secretion holds that release of each AP hormone is controlled specifically by a corresponding hypothalamic-releasing hormone (HRH). In this scenario, binding of a given HRH (thyrotropin-, growth hormone-, corticotropin-, and luteinizing hormone-releasing hormones) to specific receptors in its target cell increases the concentration of cytosolic Ca2+ ([Ca2+]i), thereby selectively stimulating the release of the appropriate hormone. However, “paradoxical” responses of AP cells to the four well-established HRHs have been observed repeatedly with both in vivo and in vitro systems, raising the possibility of functional overlap between the different AP cell types. To explore this possibility, we evaluated the effects of HRHs on [Ca2+]i in single AP cells identified immunocytochemically by the hormone they stored. We found that each of the five major AP cell types contained discrete subpopulations that were able to respond to several HRHs. The relative abundance of these multi-responsive cells was 59% for lactotropes, 33% for thyrotropes, and in the range of 47–55% for gonadotropes, corticotropes, and somatotropes. Analysis of prolactin release from single living cells revealed that each of the four HRHs tested were able to induce hormone release from a discrete lactotrope subpopulation, the size of which corresponded closely to that in which [Ca2+]i changes were induced by the same secretagogues. When viewed as a whole, our diverse functional measurements of multi-responsiveness suggest that hypothalamic control of pituitary function is more complicated than previously envisioned. Moreover, they provide a cellular basis for the so-called “paradoxical” behavior of pituitary cells to hypothalamic hypophysiotropic agents.

Notebook on geometry, geography, astronomy, and navigation, ca. 1714-1718

This heavily illustrated notebook contains entries on the following topics: geometrical definitions and axioms, geographical and astronomical definitions, compasses, plain sailing, parallel sailing, and Mercator's sailing. It also contains pages designated for notes on "Currents, Lee Way, & Variation," but these pages have been left blank. The back cover contains calculations which appear to relate to charting a course from Jamaica to "Lizzard."

Elements of geometry : manuscript, 1798

Contains work on geometry, trigonometry, surveying, mensuration of heights and distances, and navigation. The graphs and diagrams illustate story problems and navigational examples.

The bear watches the dragon. The Russian debate on China. OSW Point of View Number 31, February 2013

Most participants in the Russian public debate seem to agree in their evaluation of the present condition of Russian-Chinese relations. There is awareness of increasing inequality between these two powers and Russia’s weakening position as compared to China.Those who share the optimistic view see co-operation with China as an opportunity for the Russian economy and a key element of Russia’s multi-directional foreign policy, an opportunity for Russia to avoid unilateral dependence on the West. The pessimists view the deepening co-operation with China through the prism of threats resulting from the increasing imbalance in bilateral relations. The greatest source of concern is the model of economic relations, which is often referred to as neo-colonial, where Russia’s role is reduced to that of a supplier of raw materials to China. The possible consequences are evaluated in different ways, ranging from the political subordination of Russian interests the Chinese ones to real loss of control over the Russian Far East. Those who share such views believe that Moscow should slow down its rapprochement with China and search for other partners in Eastern Asia, relations with whom could counterbalance the Chinese influence.

WINDOWS 10 IoT SU RASPBERRY PI 2: MULTI-PARADIGM PROGRAMMING TRA JAVA E C#

Questa tesi ha come obiettivo la sperimentazione del nuovo sistema operativo Windows 10 IoT Core su tecnologia Raspberry Pi 2, verificandone la compatibilita con alcuni sensori in commercio. Tale studio viene poi applicato in un contesto di Home Intelligence al fine di creare un agente per la gestione di luci LED, in prospettiva della sua integrazione nel sistema prototipale Home Manager.

Cooperative research and development agreement with Frandon Enterprises : development and evaluation of multi-media test kits for lead and other trace metals.

Mode of access: Internet.

GAO questions key aspects of FAA's plans to acquire the multi-billion dollar advanced automation system and related programs.

"B-206887."

The geometry of selected U.S. tidal inlets /

"May 1980."

Topics in differential geometry.

Based on lectures given in the spring of 1949; a few of the latest results of work done since that time have been included.

Definition of the requirements in plane geometry, solid geometry, plane and solid geometry, major requirement, plane and solid geometry minor requirement /

Wm. F. Osgood, chairman.

The basic concepts of mathematics; a companion to current textbooks on algebra and analytic geometry.

pt.1. Algebra.

Analytic geometry,

"Answers to odd-numbered problems": p. 375-393.

Selected topics in algebraic geometry; report of the Committee on rational transformations:

Bibliography at end of each chapter.

Selected topics in algebraic geometry

Cover-title.

Lectures on classical differential geometry.

Bibliography: p. vii-viii.