Problems and potentialities of e-Learning for regular undergraduate courses in emergency medicine

BACKGROUND: E-learning techniques are spreading at great speed in medicine, raising concerns about the impact of adopting them. Websites especially designed to host courses are becoming more common. There is a lack of evidence that these systems could enhance student knowledge acquisition. GOAL: To evaluate the impact of using dedicated-website tools over cognition of medical students exposed to a first-aid course. METHODS: Prospective study of 184 medical students exposed to a twenty-hour first-aid course. We generated a dedicated-website with several sections (lectures, additional reading material, video and multiple choice exercises). We constructed variables expressing the student's access to each section. The evaluation was composed of fifty multiple-choice tests, based on clinical problems. We used multiple linear regression to adjust for potential confounders. RESULTS: There was no association of website intensity of exposure and the outcome - beta-coeficient 0.27 (95%CI - 0.454 - 1.004). These findings were not altered after adjustment for potential confounders - 0.165 (95%CI -0.628 - 0.960). CONCLUSION: A dedicated website with passive and active capabilities for aiding in person learning had not shown association with a better outcome.

Theorica Pantegni . Facsimile and Transcription of the Helsinki manuscript (Codex EÖ.II.14)

The Theorica Pantegni is a medieval medical textbook written in Latin. The author was Constantine the African (Constantinus Africanus), a monk of Tunisian origin. He compiled the work in the latter half of the eleventh century at the Benedictine monastery of Monte Cassino in Italy. - Manuscript Eö.II.14, containing the Theorica Pantegni published here, belongs today to the National Library of Finland. It can be dated to the third quarter of the twelfth century, which makes it one of the earliest surviving exemplars of the Theorica Pantegni: over seventy manuscripts of the work survive, of which about fifteen can be dated to the twelfth century. Manuscript Eö.II.14 is written in black ink on 210 parchment leaves (recto and verso), amounting to 420 pages, in pre-Gothic script. - The present text is a transcription of Ms Eö.II.14. The goal is to provide the reader with an accessible text that is faithful to the original.

Distributed Repositories of Medieval Calendars and Crowd-Sourcing of Transcription

Presentation at Open Repositories 2014, Helsinki, Finland, June 9-13, 2014

Protein folding: a perspective for biology, medicine and biotechnology

At the present time, protein folding is an extremely active field of research including aspects of biology, chemistry, biochemistry, computer science and physics. The fundamental principles have practical applications in the exploitation of the advances in genome research, in the understanding of different pathologies and in the design of novel proteins with special functions. Although the detailed mechanisms of folding are not completely known, significant advances have been made in the understanding of this complex process through both experimental and theoretical approaches. In this review, the evolution of concepts from Anfinsen's postulate to the "new view" emphasizing the concept of the energy landscape of folding is presented. The main rules of protein folding have been established from in vitro experiments. It has been long accepted that the in vitro refolding process is a good model for understanding the mechanisms by which a nascent polypeptide chain reaches its native conformation in the cellular environment. Indeed, many denatured proteins, even those whose disulfide bridges have been disrupted, are able to refold spontaneously. Although this assumption was challenged by the discovery of molecular chaperones, from the amount of both structural and functional information now available, it has been clearly established that the main rules of protein folding deduced from in vitro experiments are also valid in the cellular environment. This modern view of protein folding permits a better understanding of the aggregation processes that play a role in several pathologies, including those induced by prions and Alzheimer's disease. Drug design and de novo protein design with the aim of creating proteins with novel functions by application of protein folding rules are making significant progress and offer perspectives for practical applications in the development of pharmaceuticals and medical diagnostics.

Antioxidant properties of natural compounds used in popular medicine for gastric ulcers

There is evidence concerning the participation of reactive oxygen species in the etiology and physiopathology of human diseases, such as neurodegenerative disorders, inflammation, viral infections, autoimmune pathologies, and digestive system disorders such as gastrointestinal inflammation and gastric ulcer. The role of these reactive oxygen species in several diseases and the potential antioxidant protective effect of natural compounds on affected tissues are topics of high current interest. To consider a natural compound or a drug as an antioxidant substance it is necessary to investigate its antioxidant properties in vitro and then to evaluate its antioxidant functions in biological systems. In this review article, we shall consider the role of natural antioxidants derived from popular plants to reduce or prevent the oxidative stress in gastric ulcer induced by ethanol.

Repercussions of a sleep medicine outreach program

Despite the high prevalence of sleep disorders, many healthcare professionals and lay people have little knowledge of Sleep Medicine. Mindful of such a reality, in 2001 the Sleep Institute of the Associação Fundo de Incentivo à Psicofarmacologia launched a campaign to increase Sleep Medicine awareness. Media features, exhibitions, inserts, and classes were used to reach 2,000,000 people and 55,000 healthcare professionals during the period from 2001 to 2004. To evaluate this program, we compared data for polysomnography referrals to the Institute in 2000 and in 2004. A total of 8805 referrals were evaluated (2000: 2164; 2004: 6641). Over the 4 years of the program, the number of beds increased by 43%; more women were referred (31 vs 37%; P < 0.001), mainly with a diagnostic hypothesis of sleep-disorder breathing (SDB). SDB was the most frequent diagnostic hypothesis in 2000 and 2004. In 2004 there were fewer referrals without a diagnostic hypothesis (27 vs 21%; P < 0.001) and for controlling surgically treated SDB (2.3 vs 1.6%; P < 0.05), and an increase in the following diagnostic hypotheses: non-invasive treatment of SDB (8.3 vs 12.3%; P < 0.001) and insomnia (3.5 vs 6.5%; P < 0.001). Insomnia diagnostic hypothesis was better correlated with SDB on referral documents in 2004 and less with a diagnostic hypothesis of limb movement disturbance. The program helped increase polysomnography referrals, particularly among women. Healthcare professionals appear to have a more developed understanding of sleep disorders.

Evaluation of cardiovascular toxicity of carbon nanotubes functionalized with sodium hyaluronate in oral regenerative medicine

It has been demonstrated that carbon nanotubes (CNTs) associated with sodium hyaluronate (HY-CNTs) accelerate bone repair in the tooth sockets of rats. Before clinical application of HY-CNTs, it is important to assess their biocompatibility. Moreover, cardiac toxicity may be caused by the translocation of these particles to the blood stream. The aim of this study was to evaluate possible changes in cardiovascular function in male Wistar rats whose tooth sockets were treated with either CNTs or HY-CNTs (100 μg/mL, 0.1 mL). Blood pressure and heart rate were monitored in conscious rats 7 days after treatment. Cardiac function was evaluated using the Langendorff perfusion technique. The data showed no changes in blood pressure or heart rate in rats treated with either CNTs or HY-CNTs, and no significant changes in cardiac function were found in any of the groups. To confirm these findings, experiments were conducted in rats injected intraperitoneally with a high concentration of either CNTs or HY-CNTs (0.75 mg/kg). The same parameters were analyzed and similar results were observed. The results obtained 7 days following injection indicate that the administration of low concentrations of CNTs or HY-CNTs directly into tooth sockets did not cause any significant change in cardiovascular function in the rats. The present findings support the possibility of using these biocomposites in humans.

Understanding outlawry in medieval Iceland

Lectio praecursoria Helsingin yliopistossa 24.5.2014.

Sobre as origens do vocabulário político medieval

O fenômeno da incorporação do corpo lexical político aristotélico transliterado do grego ao contexto latino do século XIII nos remete a problemas sobre as presenças e ausências terminológicas, não somente na tradução da Política, feita por Guilherme de Moerbeke, e nos comentários de Alberto Magno e Tomás de Aquino ao texto latino de Aristóteles, mas também à possível reverberação desses vocábulos políticos moerbekianos em alguns leitores da Política, no século XIV. Não se trata apenas de verificação de quem usou ou não usou tais ou quais termos, nem mesmo da elaboração de juízos sobre esses usos, como que para rotular pensadores; antes, trata-se de tentar individuar, a partir dos usos terminológicos, o surgimento de um novo modo de pensar e compreender a esfera da vida humana que é a dimensão pública, ou melhor, política. Tentaremos compreender, neste artigo, especificamente como emerge, a partir dessa tradução latina da Política, um novo quadro conceitual, a saber: a esfera política. Constataremos que a tradução da Política de Moerbeke consolida um novo vocabulário e um novo quadro conceitual que será, doravante, um dos fundamentos do pensamento político.

Hermenêutica medieval: a compreensão espiritual de Joaquim de Fiore

O estudo trata a hermenêutica medieval sob o prisma da compreensão espiritual (intelectio spiritualis) de Joaquim de Fiore (1135-1202). Mostra que a noção de Trindade serve de base para retomar o método alegórico e o tipológico da tradição. Além disso, serve para propor o novo método por concórdia que, a nosso ver, culminará na maior inovação da leitura da história medieval. Entre os resultados, destacamos a continuidade imediata dessa hermenêutica com os franciscanos espirituais do século XIII e sua influência direta na cultura luso-brasileira. Avaliamos também os estudos que tentam encontrar em Joaquim a gênese da filosofia da história hegeliana. Por fim, analisamos sumariamente a proposta de Gianni Vattimo, que encontra o novo sentido do cristianismo no legado joaquimita.

A Destruktion heideggeriana da ontologia medieval em Die Grundprobleme Der Phänomenologie (§§ 10-12)

Em primeiro lugar, (1) examinarei a chamada Destruktion fenomenológica da ontologia medieval, componente básico do método a partir da história da ontologia. Nessa seção, coloco algumas questões sobre a apropriação da Idade Média com base na escolástica tardia, como se esta fosse o "cume" das reflexões precedentes! Em segundo lugar, (2) apresento a reflexão de próprio Heidegger sobre a ontologia medieval tal como se expõe no curso de semestre de verão de 1927 ("Os problemas fundamentais da fenomenologia"), ministrado na Universidade de Marburg. Igualmente nessa parte, faço algumas reflexões críticas sobre a leitura heideggeriana dos medievais, que se presta muito mais para conhecer o próprio modo de pensar de Heidegger do que os medievais em si mesmos, ou seja, pela leitura cursiva dos textos em seu contexto histórico e cultural: sem o élan espiritual, consubstancial aos escritos de Tomás de Aquino, por exemplo, a organização conceitual deste último não pareceria um sistema assaz grandioso e seco? Esta não terá sido a compreensão de Heidegger, fruto da separação metodológica feita entre mística medieval e filosofia escolástica desde o curso não proferido intitulado "Fundamentos filosóficos da Mística Medieval" (1918-1919)?

Seria o Sujeito uma Criação Medieval? Temas de Arqueologia Filosófica

O artigo visa analisar, em linhas gerais, a arqueologia do sujeito operada por Alain de Libera, o que será feito pela concentração no estudo de duas teses fundamentais: (a) Descartes chegou ao sujeito menos por reflexão e mais por refração, em seu debate com Hobbes e Regius, ao tentar escapar da redução do indivíduo à vida corporal e, portanto, à passividade; (b) Tomás de Aquino e Pedro de João Olivi teriam sido os responsáveis por dar certo acabamento a uma temática elaborada desde a Patrística, eminentemente por Agostinho de Hipona, que teria formulado um esquema compreensivo do eu como suporte e como agente.

LE || TIERS LIVRE || Des Faicts et Dicts || Heroïques du bon Pantagruel : || Composé par M. Fran. || Rabelais docteur || en Medi- || cine. || Reueu, & corrigé par l'Autheur, sus || la censure antique. || L'Autheur susdict || supplie les Lecteurs beneuoles, soy || reseruer a rire au soixante || & dixhuytiesme || Liure. || A Paris, || De l'imprimerie de Michel Fezandat, au mont || S. Hilaire, a l'hostel d'Albret. || 1552. Il Auec priuilege du Roy. In-8 de 160 f. inexactement chiffr. (le dernier coté 170), 3 f. non chiffr. et 1 f. blanc. — LE || QVART LIVRE || des faicts et || dicts Heroiques du bon || Pantagruel. || Composé par M. François Rabelais || docteur en Medicine. || A Paris, || De l'imprimerie de Michel Fezandat, au mont || S. Hilaire, a l'hostel d'Albret. || 1552. || Auec priuilege du Roy. — [A la fin de la Table :] Acheué d'imprimer le XXVIII. de || Ianuier M.D.LII [1552]. In-8 de 19 f. non chiffr., 144 f. chiffr. et 14 f. non chiffr. — Ensemble 2 vol. in-8, mar. citr., fil., dos ornés, tr. dor. (Anc. rel.). Rothschild 1514 (2)

Rabelais (François). Tiers Livre (1552)