1000 resultados para Manuel Torres Aguilar


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Para los futuros docentes es primordial en su formación inicial conocer de primera mano experienciasinnovadoras que impliquen a toda la comunidad educativa y que se desarrollen anivel competencial. Es tarea de la institución universitaria, y en última instancia del profesor,mostrar la realidad del día a día de los centros de enseñanza primaria y secundaria para complementarsu labor y enseñar a ser docentes en un mundo cada vez más exigente y complejo.Gracias a la ejemplificación de actividades reales que deriven en la práctica reflexiva y el espíritucrítico se puede alcanzar el objetivo principal del formador de cualquier ámbito: transmitirpasión por la docencia. El secreto de enseñar, a parte de transmitir los conocimientos, esla motivación (“las ganas”), ya que el profesor de manera inevitable contagia a los alumnos emociones, conocimientos y sensaciones, según Vaello (Ortiz, 2011).

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Para los futuros docentes es primordial en su formación inicial conocer de primera mano experienciasinnovadoras que impliquen a toda la comunidad educativa y que se desarrollen anivel competencial. Es tarea de la institución universitaria, y en última instancia del profesor,mostrar la realidad del día a día de los centros de enseñanza primaria y secundaria para complementarsu labor y enseñar a ser docentes en un mundo cada vez más exigente y complejo.Gracias a la ejemplificación de actividades reales que deriven en la práctica reflexiva y el espíritucrítico se puede alcanzar el objetivo principal del formador de cualquier ámbito: transmitirpasión por la docencia. El secreto de enseñar, a parte de transmitir los conocimientos, esla motivación (“las ganas”), ya que el profesor de manera inevitable contagia a los alumnos emociones, conocimientos y sensaciones, según Vaello (Ortiz, 2011).

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Collection : Archives de la linguistique française ; 40

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En el present projecte s'avalua l'impacte acústic causat pel trànsit ferroviari dels dos trams de via d'alta velocitat i del tram de via única de tren convencional al seu pas per la partida de les Torres de Sanui de Lleida, tot realitzant un estudi de millora de les pantalles acústiques instal·lades per tal de disminuir aquest impacte sota criteris legals i medioambientals. Es demostra, per mitjà de mètodes de previsió basats en teories d'emissió i propagació del so combinats amb la presa de mesures directes realitzades in situ, que amb la col·locació de pantalles acústiques, com a mesura correctora d'ADIF per reduir l'impacte acústic, no sempre s'obtenen els resultats esperats.

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S’ha estudiat l’eficiència energètica del sector “D” de la Comunitat de Regants de Carrassumada, amb l’objectiu de trobar els punts crítics de funcionament de les instal·lacions per tal de poder plantejar diferents alternatives com per exemple el dur a terme torns amb la mateixa demanda energètica, recalcular les pressions de consigna per les necessitats actuals o introduir una pressió de consigna variable en funció de la demanda, aquest diagnosi és realitza mitjançant una sèrie d’indicadors. D’altra banda, s’ha estudiat l’impacte que aquestes mesures suposarien, així com la seva viabilitat econòmica i tècnica per a dur-les a terme.

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Background: The 22q11.2 deletion syndrome is the most frequent genomic disorder with an estimated frequency of 1/4000 live births. The majority of patients (90%) have the same deletion of 3 Mb (Typically Deleted Region, TDR) that results from aberrant recombination at meiosis between region specific low-copy repeats (LCRs). Methods: As a first step towards the characterization of recombination rates and breakpoints within the 22q11.2 region we have constructed a high resolution recombination breakpoint map based on pedigree analysis and a population-based historical recombination map based on LD analysis. Results: Our pedigree map allows the location of recombination breakpoints with a high resolution (potential recombination hotspots), and this approach has led to the identification of 5 breakpoint segments of 50 kb or less (8.6 kb the smallest), that coincide with historical hotspots. It has been suggested that aberrant recombination leading to deletion (and duplication) is caused by low rates of Allelic Homologous Recombination (AHR) within the affected region. However, recombination rate estimates for 22q11.2 region show that neither average recombination rates in the 22q11.2 region or within LCR22-2 (the LCR implicated in most deletions and duplications), are significantly below chromosome 22 averages. Furthermore, LCR22-2, the repeat most frequently implicated in rearrangements, is also the LCR22 with the highest levels of AHR. In addition, we find recombination events in the 22q11.2 region to cluster within families. Within this context, the same chromosome recombines twice in one family; first by AHR and in the next generation by NAHR resulting in an individual affected with the del22q11.2 syndrome. Conclusion: We show in the context of a first high resolution pedigree map of the 22q11.2 region that NAHR within LCR22 leading to duplications and deletions cannot be explained exclusively under a hypothesis of low AHR rates. In addition, we find that AHR recombination events cluster within families. If normal and aberrant recombination are mechanistically related, the fact that LCR22s undergo frequent AHR and that we find familial differences in recombination rates within the 22q11.2 region would have obvious health-related implications.

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En el presente estudio se analiza la eficiencia energética de una estación de bombeo que abastece una superficie de 205 ha. Mediante el uso de una serie de indicadores se han identificado los puntos críticos y planteado las medidas de mejora oportunas, se ha estudiado el impacto que supondría su implantación así como su viabilidad técnica y económica para llevarlas a cabo. Los resultados reflejan que las mejoras más importantes se dan cuando se establecen turnos que agrupen las parcelas con demandas energéticas similares, consiguiendo un ahorro energético y económico del 21 %. Las otras medidas analizadas son: Evitar caudales bajos, Cambiar el punto de transición entre una a dos bombas en paralelo, Fijar la presión de consigna en función de los hidrantes abiertos, Ajustar la presión de consigna a las necesidades reales. Las cuales combinadas permitirían un ahorro del 22%.

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There are numerous studies describing the signaling mechanisms that mediate oligodendrocyte precursor cell (OPC) proliferation and differentiation, although the contribution of the cellular prion protein (PrPc) to this process remains unclear. PrPc is a glycosyl-phosphatidylinositol (GPI)-anchored glycoprotein involved in diverse cellular processes during the development and maturation of the mammalian central nervous system (CNS). Here we describe how PrPc influences oligodendrocyte proliferation in the developing and adult CNS. OPCs that lack PrPc proliferate more vigorously at the expense of a delay in differentiation, which correlates with changes in the expression of oligodendrocyte lineage markers. In addition, numerous NG2-positive cells were observed in cortical regions of adult PrPc knockout mice, although no significant changes in myelination can be seen, probably due to the death of surplus cells.

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Randomized, controlled trials have demonstrated efficacy for second-generation antipsychotics in the treatment of acute mania in bipolar disorder. Despite depression being considered the hallmark of bipolar disorder, there are no published systematic reviews or meta-analyses to evaluate the efficacy of modern atypical antipsychotics in bipolar depression. We systematically reviewed published or registered randomized, double-blind, placebo-controlled trials (RCTs) of modern antipsychotics in adult bipolar I and/or II depressive patients (DSM-IV criteria). Efficacy outcomes were assessed based on changes in the Montgomery-Asberg Depression Rating Scale (MADRS) during an 8-wk period. Data were combined through meta-analysis using risk ratio as an effect size with a 95% confidence interval (95% CI) and with a level of statistical significance of 5% (p<0.05). We identified five RCTs; four involved antipsychotic monotherapy and one addressed both monotherapy and combination with an antidepressant. The two quetiapine trials analysed the safety and efficacy of two doses: 300 and 600 mg/d. The only olanzapine trial assessed olanzapine monotherapy within a range of 5-20 mg/d and olanzapine-fluoxetine combination within a range of 5-20 mg/d and 6-12 mg/d, respectively. The two aripiprazole placebo-controlled trials assessed doses of 5-30 mg/d. Quetiapine and olanzapine trials (3/5, 60%) demonstrated superiority over placebo (p<0.001). Only 2/5 (40%) (both aripiprazole trials) failed in the primary efficacy measure after the first 6 wk. Some modern antipsychotics (quetiapine and olanzapine) have demonstrated efficacy in bipolar depressive patients from week 1 onwards. Rapid onset of action seems to be a common feature of atypical antipsychotics in bipolar depression. Comment in The following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlEfficacy of modern antipsychotics in placebo-controlled trials in bipolar depression: a meta-analysis--results to be interpreted with caution.

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[cat] En els anys 2003 i 2004 una intervenció arqueològica preventiva en el terme de Salàs de Pallars va permetre documentar seixanta estructures excavades al subsòl. La majoria de les estructures foren identificades com a sitges, però també es documentaren cubetes i fosses de diversa funció, algunes utilitzades com a sepultures. L"estudi dels materials recuperats, complementats per datacions radiocarbòniques, indiquen dos períodes cronològics: el bronze inicial i l"etapa ibèrica plena, als quals s"ha d"afegir una única estructura que pertany a començaments de l"Imperi romà. Les dades obtingudes informen sobre les pràctiques de les comunitats agrícoles assentades en el sector meridional de la comarca del Pallars Jussà en tres moments històrics diferents. [eng]In 2003 and 2004 a Preventive Archaeological Excavation was done in the locality of Salàs de Pallars. This allowed to catalogue the sixty structures found in the subsoil. Most of the structures were identified as silos, but we also documented basins and pits with different functions, some used as graves. The study of the recovered materials, supported by a radiocarbon analysis technique, ages this around two chronological periods: the Early Bronze Age and Iberian Period. We must add a third period to classify a single structure that belongs to the Early Roman Empire. The obtained results provide us information about the farming methods used by the communities placed in the southern Region of the Pallars Jussà during the three different historical moments.