Obras poeticas de don Eugenio Gerardo Lobo ...

Según Palau t. 7, p. 597-139449 el año de imp. es problablemente 1724 y según Gutiérrez del Caño, Jerónimo Peralta imprime entre 1725 y 1736.

Obras poeticas del ... Señor Don Eugenio Gerardo Lobo ... : Tomo Primero.

Mode of access: Internet.

Varias poesías y entre ellas muchas del... señor... Eugenio Gerardo Lobo... : Tomo II.

Mode of access: Internet.

Analysis of some cloud and frontal events : recorded during the Boulder Upslope Cloud Observation Experiment (BUCOE) of 1982 /

"March 1984."

Un lobo y una raposa : juguete cómico en un acto y en verso /

"Representado con aceptación en el teatro del Príncipe" -port.-

El Lobo blanco /

Contiene: Los fanfarrones del rey, p. [339]-700, con port. propia.

On the functions of the cerebrum; the frontal lobes.

Mode of access: Internet.

Hernán el lobo (canto primero).

Hernán el lobo, fragmento -- Luz y tinieblas -- La novicia -- A Lesbia -- A mi madre -- El Cristo de mi hogar.

Chase S. Osborn, frontal portrait ca. 1898

see inscriptions and label on portrait from same studio session, na18169

En la boca del lobo : juguete cómico en un acto y en prosa /

Mode of access: Internet.

Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics

The molecular processes underlying alcohol dependence are not fully understood. Many characteristic behaviours result from neuroadaptations in the mesocorticolimbic system. In addition, alcoholism is associated with a distinct neuropathology. To elucidate the molecular basis of these features, we compared the RNA expression profile of the nucleus accumbens and prefrontal cortex of human brain from matched individual alcoholic and control cases using cDNA microarrays. Approximately 6% of genes with a marked alcohol response were common to the two brain regions. Alcohol-responsive genes were grouped into 11 functional categories. Predominant alcohol-responsive genes in the prefrontal cortex were those encoding DNA-binding proteins including transcription factors and repair proteins. There was also a down-regulation of genes encoding mitochondrial proteins, which could result in disrupted mitochondrial function and energy production leading to oxidative stress. Other alcohol-responsive genes in the prefrontal cortex were associated with neuroprotection/apoptosis. In contrast, in the nucleus accumbens, alcohol-responsive genes were associated with vesicle formation and regulation of cell architecture, which suggests a neuroadaptation to chronic alcohol exposure at the level of synaptic structure and function. Our data are in keeping with the previously reported alcoholism-related pathology characteristic of the prefrontal cortex, but suggest a persistent decrease in neurotransmission and changes in plasticity in the nucleus accumbens of the alcoholic.

Patterns of gene expression in the frontal cortex discriminate alcoholic from non-alcoholic individuals

Alcohol dependence is characterized by tolerance, physical dependence, and craving. The neuroadaptations underlying these effects of chronic alcohol abuse are likely due to altered gene expression. Previous gene expression studies using human post-mortem brain demonstrated that several gene families were altered by alcohol abuse. However, most of these changes in gene expression were small. It is not clear if gene expression profiles have sufficient power to discriminate control from alcoholic individuals and how consistent gene expression changes are when a relatively large sample size is examined. In the present study, microarray analysis (similar to 47 000 elements) was performed on the superior frontal cortex of 27 individual human cases ( 14 well characterized alcoholics and 13 matched controls). A partial least squares statistical procedure was applied to identify genes with altered expression levels in alcoholics. We found that genes involved in myelination, ubiquitination, apoptosis, cell adhesion, neurogenesis, and neural disease showed altered expression levels. Importantly, genes involved in neurodegenerative diseases such as Alzheimer's disease were significantly altered suggesting a link between alcoholism and other neurodegenerative conditions. A total of 27 genes identified in this study were previously shown to be changed by alcohol abuse in previous studies of human post-mortem brain. These results revealed a consistent re-programming of gene expression in alcohol abusers that reliably discriminates alcoholic from non-alcoholic individuals.