Lead selection and characterization of antitubercular compounds using the Nested Chemical Library

Discovering new drugs to treat tuberculosis more efficiently and to overcome multidrug resistance is a world health priority. To find novel antitubercular agents several approaches have been used in various institutions worldwide, including target-based approaches against several validated mycobacterial enzymes and phenotypic screens. We screened more than 17,000 compounds from Vichem's Nested Chemical Library(TM) using an integrated strategy involving whole cell-based assays with Corynebacterium glutamicum and Mycobacterium tuberculosis, and target-based assays with protein kinases PknA, PknB and PknG as well as other targets such as PimA and bacterial topoisomerases simultaneously. With the help of the target-based approach we have found very potent hits inhibiting the selected target enzymes, but good minimal inhibitory concentrations (MIC) against M. tuberculosis were not achieved. Focussing on the whole cell-based approach several potent hits were found which displayed minimal inhibitory concentrations (MIC) against M. tuberculosis below 10 mu M and were non-mutagenic, non-cytotoxic and the targets of some of the hits were also identified. The most active hits represented various scaffolds. Medicinal chemistry-based lead optimization was performed applying various strategies and, as a consequence, a series of novel potent compounds were synthesized. These efforts resulted in some effective potential antitubercular lead compounds which were confirmed in phenotypic assays. (C) 2015 Elsevier Ltd. All rights reserved.

An examination of the Community Fisheries Sub-Decree in Cambodia: changes and developments during the drafting process

This study examines the development of the Community Fisheries Sub-Decree. From its promulgation in late 2000 through its draft form in June 20021, this sub-decree has gone through over 25 drafts. Initially, the writing process involved the public intimately: community meetings were conducted, NGOs contributed their knowledge and expertise, and then, with these consultations in mind, the newly-formed Community Fisheries Development Office (CFDO) in the Department of Fisheries (DoF) drafted the sub-decree. Over the following year and a half, the sub-decree went through numerous changes, some of which fundamentally alter the tenor of the legislation. This includes the deletion of some of the primary issues of rural communities, such as what fishing gears they can use and whether they can participate in patrolling the fishing area. While the final form is still pending, there are many questions as to the positive effects that the sub-decree will ultimately have on people’s livelihoods when it is finally approved. This research was undertaken to track the development of the sub-decree to gain a better understanding of how the Cambodian policy-making system functions. Consultations were undertaken with the DoF and CFDO before the research began, both of which agreed to the study. It is hoped that this report will help not only those interested in community fisheries issues, but also those who want to advocate on other Cambodian development issues as well. Due to the sensitive nature of the subject material, and the fact that the sub-decree is still pending, the author has conducted interviews with the express purpose of keeping them confidential. Therefore, no individual will be quoted directly in this study. In addition, many of the English versions of the drafts examined were unofficial translations. The author has made no effort to correct the English in the drafts. Moreover, there are also questions regarding the drafts and their sequence, as no government records were kept of the process or the changes that were made along the way. These have been compiled after the fact. (33 p.)

Blackburn College: DIY! College departments catalogue their own technologies on Library Management System for loan

Blackburn College is making use of its Heritage Library Management System (LMS) for a wide variety of loans beyond that of books; this has enabled them to better manage the growing numbers and types of technologies that are being used in teaching and learning. In an additional pilot development, they have taken the bold step of training college departments in cataloguing their own technologies to add to the LMS for loan. This has enabled the departments to keep track of their own equipment easily, and provided a more consistent approach to equipment loan within the College.

Information legislation and management survey 2014

The 10th annual Jisc, GuildHE and Universities UK information legislation and management survey shows a rise in the number of Freedom of Information (FOI) requests for the tenth consecutive year. In contrast Environmental Information Regulations (EIR) requests appear to have levelled off to a fairly consistent rate, while Data Protection Act (DPA) requests have declined back to levels last seen in 2008. The average monthly number of FOI requests received by UK universities has risen by 19% since 2013 and by almost seven times over the last decade since our survey began. The average across the 46 participating institutions was 219 FOI requests with the highest of 454 reported by one participant.

Information legislation and management survey 2014

The 10th annual Jisc, GuildHE and Universities UK information legislation and management survey shows a rise in the number of Freedom of Information (FOI) requests for the tenth consecutive year. In contrast Environmental Information Regulations (EIR) requests appear to have levelled off to a fairly consistent rate, while Data Protection Act (DPA) requests have declined back to levels last seen in 2008. The average monthly number of FOI requests received by UK universities has risen by 19% since 2013 and by almost seven times over the last decade since our survey began. The average across the 47 participating institutions was 218 FOI requests with the highest of 454 reported by one participant.

Good practice guidance for library and information professionals - moving towards accessible e-book platforms

Good practice guidance for publishers and procurers of e-book platforms based on the benefits and barriers identified by robust testing using real people with disabilities

Authority files: Breaking out of the library silo to become signposts for research information

Authority files serve to uniquely identify real world ‘things’ or entities like documents, persons, organisations, and their properties, like relations and features. Already important in the classical library world, authority files are indispensable for adequate information retrieval and analysis in the computer age. This is because, even more than humans, computers are poor at handling ambiguity. Through authority files, people tell computers which terms, names or numbers refer to the same thing or have the same meaning by giving equivalent notions the same identifier. Thus, authority files signpost the internet where these identifiers are interlinked on the basis of relevance. When executing a query, computers are able to navigate from identifier to identifier by following these links and collect the queried information on these so-called ‘crosswalks’. In this context, identifiers also go under the name controlled access points. Identifiers become even more crucial now massive data collections like library catalogues or research datasets are releasing their till-now contained data directly to the internet. This development is coined Open Linked Data. The concatenating name for the internet is Web of Data instead of the classical Web of Documents.