Multimodal Imaging and Choroidal Volumetric Changes After Half-fluence PDT in Central Serous Chorioretinopathy.

PURPOSE The purpose of this study was to identify SD-OCT changes that correspond to leakage on fluorescein (FA) and indocyanine angiography (ICGA) and evaluate effect of half-fluence photodynamic therapy (PDT) on choroidal volume in chronic central serous choroidoretinopathy (CSC). METHODS Retrospective analysis of patients with chronic CSC who had undergone PDT. Baseline FA and ICGA images were overlaid on SD-OCT to identify OCT correlates of FA or ICGA hyperfluorescence. Choroidal volume was evaluated in a subgroup of eyes before and after PDT. RESULTS Twenty eyes were evaluated at baseline, of which seven eyes had choroidal volume evaluations at baseline and 3 months following PDT. SD-OCT changes corresponding to FA hyperfluorescence were subretinal fluid (73%), RPE microrip (50%), RPE double-layer sign (31%), RPE detachment (15%), and RPE thickening (8%). ICGA hyperfluoresence was correlated in 93% with hyperreflective spots in the superficial choroid. Choroidal volume decreased from 9.35 ± 1.99 to 8.52 ± 1.92 and 8.04 ± 1.7 mm(3) (at 1 and 3 months post PDT, respectively, p ≤ 0.001). CONCLUSIONS We identified specific OCT findings that correlate with FA and ICGA leakage sites. SD-OCT is a valuable tool to localize CSC lesions and may be useful to guide PDT treatment. Generalized choroidal volume decrease occurs following PDT and extends beyond PDT treatment site.

Half hours with a naturalist: rambles near the shore.

Mode of access: Internet.

North half the city of Ann Arbor published by Everts and Stewart [plat] [west one-half]

Scale 400 ft. per inch; drawn & compiled by F. Krause, C.E. Ann Arbor, Mich.Publication information: Chicago, Ill. : Everts & Stewart, 1874.

North half the city of Ann Arbor published by Everts and Stewart [plat] [east one-half]

Publication information: Chicago, Ill. : Everts & Stewart, 1874.

Professors' Houses. North University Ave. East Residence

Built 1840. Professors' Houses (East Residence) 1840-1868. University Hospital 1868-1891. Additions in 1877 and after in the form of two parallel wings built out from back of house and several additions onto them. Dental College 1891-1908. Building removed 1908. Replaced by new Chemistry Building 1910On verso in two hands: (1) Looking at 2 prof. houses at this time both converted into a) Univ. Hosp. & b) Homeo. [Homeopathic] School (2) R.C. Smith.

South half the city of Ann Arbor published by Everts and Stewart [plat] [Wards 2, 1, and 6]

Publication information: Chicago, Ill. : Everts & Stewart, 1874. [pages 110 and 111 of the original volume were scanned separately and edited intoa single image file.]