Identification of novel functional TBP-binding sites and general factor repertoires.

Our current knowledge of the general factor requirement in transcription by the three mammalian RNA polymerases is based on a small number of model promoters. Here, we present a comprehensive chromatin immunoprecipitation (ChIP)-on-chip analysis for 28 transcription factors on a large set of known and novel TATA-binding protein (TBP)-binding sites experimentally identified via ChIP cloning. A large fraction of identified TBP-binding sites is located in introns or lacks a gene/mRNA annotation and is found to direct transcription. Integrated analysis of the ChIP-on-chip data and functional studies revealed that TAF12 hitherto regarded as RNA polymerase II (RNAP II)-specific was found to be also involved in RNAP I transcription. Distinct profiles for general transcription factors and TAF-containing complexes were uncovered for RNAP II promoters located in CpG and non-CpG islands suggesting distinct transcription initiation pathways. Our study broadens the spectrum of general transcription factor function and uncovers a plethora of novel, functional TBP-binding sites in the human genome.

2007 Streamlined Sales Tax Annual Report to the Iowa General Assembly

Calendar-year annual report to the Iowa Legislature on the Iowa Streamlined Sales Tax Advisory Council members, meetings, significant developments, issues, pending issues, and statutory responsibilities discharged.

2008 Streamlined Sales Tax Annual Report to the Iowa General Assembly

Calendar-year annual report to the Iowa Legislature on the Iowa Streamlined Sales Tax Advisory Council members, meetings, significant developments, issues, pending issues, and statutory responsibilities discharged.

2009 Streamlined Sales Tax Annual Report to the Iowa General Assembly

Calendar-year annual report to the Iowa Legislature on the Iowa Streamlined Sales Tax Advisory Council members, meetings, significant developments, issues, pending issues, and statutory responsibilities discharged.

Report on a review of selected general and application controls over the Iowa Department of Human Services’ Issuance Verification System for the period March 19, 2009 through April 17, 2009

Report on a review of selected general and application controls over the Iowa Department of Human Services’ Issuance Verification System for the period March 19, 2009 through April 17, 2009

Accessibilitat al web: panoràmica general

Es presenta el concepte d'accessibilitat al web com a sistema per a facilitar el treball a la xarxa per part de les persones discapacitades i millorar la usabilitat dels continguts. A partir de la Iniciativa per a l'Accessibilitat al Web (WAI) del World-Wide Web Consortium (W3C), aquest ha elaborat unes directrius que actualment estan en procés d'adopció pels diferents governs i empreses. Finalment es presenten diverses eines informàtiques i entitats de contacte que donen suport a aquestes actuacions.

Le médecin face aux inégalités sociales de santé: quel pouvoir d'action [General practitioners facing social inequalities in health: which power to act?].

The link between social inequalities and health has been known for many years, as attested by Villermé's work on the "mental and physical status of the working class" (1840). We have more and more insight into the nature of this relationship, which embraces not only material deprivation, but also psychological mechanisms related to social and interpersonal problems. Defining our possible role as physicians to fight against these inequalities has become a public health priority. Instruments and leads, which are now available to help us in our daily practice, are presented here.