Latina Super-heroines: Hot Tamales in Tights vs. Women Warriors, Wrestlers and Guerrilla Fighters of La Raza

The year 1977 saw the making of the first Latino superhero by a Latino artist. From the 1980s onwards it is also possible to find Latina super-heroines, whose number and complexity has kept increasing ever since. Yet, the representations of spandexed Latinas are still few. For that reason, the goal of this paper is, firstly, to gather a great number of Latina super-heroines and, secondly, to analyze the role that they have played in the history of American literature and art. More specifically, it aims at comparing the spandexed Latinas created by non-Latino/a artists and mainstream comic enterprises with the Latina super-heroines devised by Latino/a artists. The conclusion is that whereas the former tend to conceive heroines within the constraints of the logic of Girl Power, the latter choose to imbue their works with a more daring political content and to align their heroines with the ideologies of Feminism and Postcolonialism.

Frequency of mutations and polymorphisms in borderline ovarian tumors of known cancer genes.

Borderline ovarian tumors represent an understudied subset of ovarian tumors. Most studies investigating aberrations in borderline tumors have focused on KRAS/BRAF mutations. In this study, we conducted an extensive analysis of mutations and single-nucleotide polymorphisms (SNPs) in borderline ovarian tumors. Using the Sequenom MassArray platform, we investigated 160 mutations/polymorphisms in 33 genes involved in cell signaling, apoptosis, angiogenesis, cell cycle regulation and cellular senescence. Of 52 tumors analyzed, 33 were serous, 18 mucinous and 1 endometrioid. KRAS c.35G>A p.Gly12Asp mutations were detected in eight tumors (six serous and two mucinous), BRAF V600E mutations in two serous tumors, and PIK3CA H1047Y and PIK3CA E542K mutations in a serous and an endometrioid BOT, respectively. CTNNB1 mutation was detected in a serous tumor. Potentially functional polymorphisms were found in vascular endothelial growth factor (VEGF), ABCB1, FGFR2 and PHLPP2. VEGF polymorphisms were the most common and detected at four loci. PHLPP2 polymorphisms were more frequent in mucinous as compared with serous tumors (P=0.04), with allelic imbalance in one case. This study represents the largest and most comprehensive analysis of mutations and functional SNPs in borderline ovarian tumors to date. At least 25% of borderline ovarian tumors harbor somatic mutations associated with potential response to targeted therapeutics.

IGF-1R inhibition sensitizes breast cancer cells to ATM-Related Kinase (ATR) inhibitor and cisplatin

The complexity of the IGF-1 signalling axis is clearly a roadblock in targeting this receptor in cancer therapy. Here, we sought to identify mediators of resistance, and potential co-targets for IGF-1R inhibition. By using an siRNA functional screen with the IGF-1R tyrosine kinase inhibitor (TKI) BMS-754807 in MCF-7 cells we identified several genes encoding components of the DNA damage response (DDR) pathways as mediators of resistance to IGF-1R kinase inhibition. These included ATM and Ataxia Telangiectasia and RAD3-related kinase (ATR). We also observed a clear induction of DDR in cells that were exposed to IGF-1R TKIs (BMS-754807 and OSI-906) as indicated by accumulation of γ-H2AX, and phosphorylated Chk1. Combination of the IGF-1R/IR TKIs with an ATR kinase inhibitor VE-821 resulted in additive to synergistic cytotoxicity compared to either drug alone. In MCF-7 cells with stably acquired resistance to the IGF-1R TKI (MCF-7-R), DNA damage was also observed, and again, dual inhibition of the ATR kinase and IGF-1R/IR kinase resulted in synergistic cytotoxicity. Interestingly, dual inhibition of ATR and IGF-1R was more effective in MCF-7-R cells than parental cells. IGF-1R TKIs also potentiated the effects of cisplatin in a panel of breast cancer cell lines. Overall, our findings identify induction of DDR by IGF-1R kinase inhibition as a rationale for co-targeting the IGF-1R with ATR kinase inhibitors or cisplatin, particularly in cells with acquired resistance to TKIs.

En intresseväckande teknikundervisning : Kvantitativ studie gällande hur tekniklärare undervisar för att skapa ett teknikintresse hos elever i årskurs 4-6

Tidigare forskning samt den systematiska litteraturstudie (Flanagan, 2016) som legat till grund för detta arbete framhåller hur teknikintresset hos grundskoleelever minskar och hur detta delvis påverkas av undervisningens utformning och lärares teknikdidaktiska kompetens. Syftet med denna studie var att berika den tidigare genomförda litteraturstudien genom att studera hur lärare skapar en intressant och engagerande teknikundervisning i praktiken. För att nå ut till så många av landets tekniklärare som möjligt valdes en kvantitativ ansats i form av en nätbaserad enkätundersökning, vilken vidare spreds via flera olika kontaktnät. Lärarna som besvarade enkäten framhöll att teknikundervisningen genomfördes på ett samstämmigt vis beträffande vad tidigare forskning ansett vara en intresseväckande och måluppfyllande teknikundervisning, där ämnesintegrering, studiebesök samt elevinflytande var vanliga inslag. Studiens respondenter ansåg sig ej ha svårigheter med att skapa ett teknikintresse hos sina elever, däremot så framkom i studien att lärarnas personliga intresse för undervisningsämnet teknik påverkade undervisningens utformning. Studiens resultat visar även att de mer organisatoriska delarna av teknikundervisningen så som tidsbrist samt tillgång till lämpliga materiella resurser påverkade hur lärarna hade

An Exploration of the Data Collection Methods Utilised with Children, Teenagers and Young People (CTYPs)

Background: The impact of cancer upon children, teenagers and young people can be profound. Research has been undertaken to explore the impacts upon children, teenagers and young people with cancer, but little is known about how researchers can ‘best’ engage with this group to explore their experiences. This review paper provides an overview of the utility of data collection methods employed when undertaking research with children, teenagers and young people. A systematic review of relevant databases was undertaken utilising the search terms ‘young people’, ‘young adult’, ‘adolescent’ and ‘data collection methods’. The full-text of the papers that were deemed eligible from the title and abstract were accessed and following discussion within the research team, thirty papers were included. Findings: Due to the heterogeneity in terms of the scope of the papers identified the following data collections methods were included in the results section. Three of the papers identified provided an overview of data collection methods utilised with this population and the remaining twenty seven papers covered the following data collection methods: Digital technologies; art based research; comparing the use of ‘paper and pencil’ research with web-based technologies, the use of games; the use of a specific communication tool; questionnaires and interviews; focus groups and telephone interviews/questionnaires. The strengths and limitations of the range of data collection methods included are discussed drawing upon such issues as of the appropriateness of particular methods for particular age groups, or the most appropriate method to employ when exploring a particularly sensitive topic area. Conclusions: There are a number of data collection methods utilised to undertaken research with children, teenagers and young adults. This review provides a summary of the current available evidence and an overview of the strengths and limitations of data collection methods employed.

Plant Migrations Impact on Potential Vegetation and Carbon Redistribution in Northern North America from Climate Change

Forests have a prominent role in carbon storage and sequestration. Anthropogenic forcing has the potential to accelerate climate change and alter the distribution of forests. How forests redistribute spatially and temporally in response to climate change can alter their carbon sequestration potential. The driving question for this research was: How does plant migration from climate change impact vegetation distribution and carbon sequestration potential over continental scales? Large-scale simulation of the equilibrium response of vegetation and carbon from future climate change has shown relatively modest net gains in sequestration potential, but studies of the transient response has been limited to the sub-continent or landscape scale. The transient response depends on fine scale processes such as competition, disturbance, landscape characteristics, dispersal, and other factors, which makes it computational prohibitive at large domain sizes. To address this, this research used an advanced mechanistic model (Ecosystem Demography Model, ED) that is individually based, but pseudo-spatial, that reduces computational intensity while maintaining the fine scale processes that drive the transient response. First, the model was validated against remote sensing data for current plant functional type distribution in northern North America with a current climatology, and then a future climatology was used to predict the potential equilibrium redistribution of vegetation and carbon from future climate change. Next, to enable transient calculations, a method was developed to simulate the spatially explicit process of dispersal in pseudo-spatial modeling frameworks. Finally, the new dispersal sub-model was implemented in the mechanistic ecosystem model, and a model experimental design was designed and completed to estimate the transient response of vegetation and carbon to climate change. The potential equilibrium forest response to future climate change was found to be large, with large gross changes in distribution of plant functional types and comparatively smaller changes in net carbon sequestration potential for the region. However, the transient response was found to be on the order of centuries, and to depend strongly on disturbance rates and dispersal distances. Future work should explore the impact of species-specific disturbance and dispersal rates, landscape fragmentation, and other processes that influence migration rates and have been simulated at the sub-continent scale, but now at continental scales, and explore a range of alternative future climate scenarios as they continue to be developed.

Determinación de puntuaciones cuantitativas para la entrevista conducta estructurada en selección personas

La toma de decisiones de selección en organizaciones públicas se debe regir por procedimientos que garanticen la fiabilidad y validez de las herramientas utilizadas, así como se debe aplicar metodologías que permitan determinar la diferencia ente los diferentes candidatos de una manera objetiva (Salgado, Moscoso y Gorriti, 2004)) Esta investigación tiene dos objetivos relacionados. En primer lugar, identificar y ponderar aquellos comportamientos significativos del perfil de enfermería incluidos en 5 competencias básicas, consideradas imprescindibles para trabajar en un ambiente sanitario. En segundo lugar establecer, con base en los comportamientos anteriores, anclajes conductuales asociados a calificaciones cuantitativas que proporcione una puntuación numérica y objetiva en la entrevista de selección. Para la consecución de estos objetivos se han llevado a cabo distintas metodologías. En la primera fase se utilizó el panel de expertos para identificar las conductas y competencias claves del perfil de enfermería asociadas a los valores, la misión y las líneas estratégicas de la organización (ASCS). En segundo lugar se elaboró un cuestionario que siguiendo la metodología de Pereda y Berrocal (2005) fue valorado por 217 profesionales, conocedores del puesto y con más de 4 años de antigüedad en el mismo. Por último, en el diseño de la entrevista conductual estructurada se emplea la técnica de incidentes críticos (Flanagan, 1954)y además se aplica el porcentaje de puntuación obtenido por cada comportamiento en el proceso anterior a una escala de valoración con anclajes conductuales (EVAS)(Smith y Kendall, 1963; Quijano, 1992). Así. puede obtenerse un calificación numérica diferente para cada candidato/a. Utilidad. La utilización de metodologías que permitan discriminar a los candidatos de manera cuantitativa, posiciona la labor del psicólogo, profesionaliza la evaluación, facilita la toma de decisiones y nos permite abordar la selección con base en criterios de fiabilidad y validez.

A qualidade de vida dos enfermeiros: O impacto da mudança de 35 para 40 horas no horário de trabalho

Desde os primórdios da sociedade que o trabalho é encarado como um elemento-chave na vida do Homem, uma vez que lhe permite garantir a sua sobrevivência. Com a globalização de mercados foram surgindo novos métodos e modalidades de trabalho, nomeadamente o trabalho por turnos. Com a presente dissertação pretende-se compreender o impacto resultante da mudança de 35 para 40 horas laborais na qualidade de vida dos enfermeiros. Para o efeito foi realizada uma pesquisa exploratória, descritiva e quantitativa sobre a temática da qualidade de vida no período antes e após a mudança de horário das 35 para as 40 horas laborais. O instrumento de recolha de dados utilizado foi o inquérito por questionário da escala de qualidade de vida de Flanagan (EQVF), o qual foi aplicado aos enfermeiros do CHMT, a exercer funções no serviço de medicina 1, que sofreram alterações no seu horário de trabalho (das 35 para 40 horas). Os resultados obtidos demonstraram que o género feminino se identifica mais com o horário das 35 horas de trabalho do que com o horário das 40 horas de trabalho, assim como a variável que sofreu maior impacto na passagem das 35 para as 40 horas laborais foi o Bem-estar Físico e Material

Rural change south of the river Bride in counties Cork and Waterford: the surveyors' evidence 1716–1851

Estate studies in Irish historical geography have been often designed to confirm or contrast local trends of development with those previously identified at the regional or sub-regional level. To date, little attention has been awarded to estate maps in studies of rural landscape change. It is a theme of this paper that the results yielded from a careful study of such estate maps can throw light on the results of the activities of the majority of estate residents. In this regard, it is fortunate that at Lismore surveys of the estate in 1716–17 and 1773–4 have survived, and a nineteenth century dimension is added by an analysis of the Valuation Office maps for 1851. This work is focused on a study of critical indicators of change, notably leasing arrangements, farm size, rate and type of enclosure, infrastructural development and settlement growth. These changes are reviewed within the framework of the dialectic that developed between landlord or landlord-inspired management policies and the forces released locally by the vast bulk of the population. Broadly this analysis indicates some of the potential rewards which may be secured by detailed scrutiny of estate maps in conjunction with other estate records.