Avaliação gastroprotetora da epicatequina e verificação de seus mecanismos de ação

The stomach is an exceptional organ, which functions are sterilize food ingested, form the primitive bolus, digest lipids and proteins, and to store food temporarily in the gastrointestinal tract. Its capacity of digesting food without digesting itself is amazing. This fact occurs due to innumerous protective substances adjacent to the gastric mucosa. When aggressive factors overwhelm the protective factors, a lesion in the gastric mucosa is formed. Lesions that reach the lamina propria are called gastric ulcers, which are classified macroscopically as openings on the gastric wall and; microscopically, as a gastric injury characterized with epithelial desquamation, mucosal hemorrhage, glandular damage and eosinophilic infiltration. The current therapy available is effective, although it causes collateral effects, therefore researching new drugs is necessary. This work aim to evaluate the gastroprotective effect of epicatechin against gastric lesions induced by absolute ethanol and non steroidal anti-inflammatory drugs which are the main causes of this disease currently, yet we aim to study the main mechanisms of action responsible for the gastroprotective effect. The results show that epicatechin has a significant macroscopic and microscopic gastroprotective effect against gastric injuries induced by ethanol and indomethacin, acting locally by augmenting gastric mucus secretion and it also acts via antioxidant system by holding total glutathione levels. Epicatechin’s gastroprotective mechanisms depend on the activation of sulfhydryl compounds and doesn’t depend on the NO-synthase enzyme

Variabilidade entre materiais genéticos de eucalyptus spp quanto à distribuição de raízes finas em latossolos profundos

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

A gênese e a distribuição socioespacial das chuvas no município de Ubatuba-SP

This monograph aims to contribute to the understanding and analysis of extreme events and its correlation with anthropogenic actions, in order to understand the levels of human interference in the environment and to identify potential social and environmental damage that such events may result in Ubatuba, located on the northern coast of São Paulo state. Therefore, two strategies were established, on one hand, episodic analysis of extreme weather events, and on the other, the analysis of the impact of atmospheric phenomena in everyday society. In this case we gave greater emphasis to analysis years that had higher total rainfall. In this sense, the research was based on the standard deviation technique and percentages, which supported to characterize the exceptional rainy years, in addition, use of rhythm analysis technique that has helped to identify the active atmospheric systems. From a qualitative point of view, field works were carried out in order to make use of news by the local press and civil defense for years considered extreme (positive standard deviation). From this, it was analyzed how the extreme episodes of rainfall trigger repercussions in geographic space. Also the spatial distribution of rainfall were carried out by means of quantitative analysis of six rain gauges. It was found that the highest occurrences of impacts, are located in the central areas of the city, as well as the highest rainfall totals. In fact, Ubatuba/SP suffers from very high rainfall totals and has a singularity on the climate...

Patrimônio geológico no Parque Estadual Turístico do Alto Ribeira - SP: inventariação e quantificação de geossítios

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Matizes do pensamento político norte-americano na virada conservadora de 1970

This paper examines how the reinvigoration of the exceptional American historical experience appears as a solution to some of the leading neoconservatives, considering Nathan Glazer and Irving Kristol as emblematic, regarding the fall of the American empire, beginning in the 1960s and 1970s, after its rise during the Cold War, the so-called 25 glorious years. We note that the arguments of these authors is rooted in the revival of reactionary rhetoric as an antidote to the decadence of American virtue supposedly caused by Communism, by the counterculture movement and the alleged perverse effect of the welfare state.

Paleometry: a brand new area in brazilian science

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Blood oxygen affinity increases during digestion in the South American rattlesnake, Crotalus durissus terrificus

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

The role of qualea multiflora on mammary tumour cells and immune system

Species of the genus Qualea are used by the Brazilian public as a natural anti-inflammatory. Based on this evidence, we evaluated the effects of terpene fractions (βF and TF) obtained from Qualea multiflora on nitric oxide production (Griess assay), cytokines (IL-1, IL-10, IL-12, and TNF-a) and the transcription factor NF-κB by peritoneal macrophages. Since there is a relationship between inflammation and cancer, the cytotoxicity of βF and TF against mammary tumoural cell lineage, and macrophages was evaluated. Inhibition levels close to 90% of the production of NO, IL-1, IL-12 and TNF-a; about 32% of NF-κB; and a large stimulation of IL-10 production (close to the positive control) by peritoneal macrophages were observed in response to βF and TF which are correlated with anti-inflammatory activity. Additionally, the samples showed exceptional cytotoxic activity against tumoural cells but not against macrophages. Since anti-inflammatory activity is important in tumour inhibition, further examination of potential anti-cancerous activity of Qualea multiflora is warranted.

Women from the point of view of the Bukowskian narrator: the representation of the feminine universe in Erections, Ejaculations, Exhibitions and General Tales of Ordinary Madness

Pós-graduação em Letras - IBILCE

Concepção de um dispositivo fisioterápico: parapodium mecanizado

This paper presents a proposal to redesign a physical therapy device for patients with quadriplegia, called parapodium. With the help of the Association of Parents and Exceptional Friends of Guaratinguetá, it was possible to know the currently used device and from this it was conceived changes, allowing the increase of freedom of its central portion, in the down and across positions with mechanical drive . This adaptation is to introduce improvements in the routine of physical therapy professionals and reduce ergonomic problems resulting from repetitive strain during the transfer of patients to the parapodium. In addition to providing greater security for patients who require the use of this equipment. The proposed device comprises: wheel, gearbox and brake systems used for actuation, allowing a degree of turning of the rear post, along an axis which is fixed to the gearbox and the rear structure that permits posterior movement. The mechanism allows the rear post rotate from 0 ° to 90 °. The estimated cost to make the proposal is lower than the marketed parapodiuns, reaching the device's functional expectations

Estratigrafia do Andar Alagoas na sub-bacia do Tucano Norte, Bahia

Pós-graduação em Geociências e Meio Ambiente - IGCE

BOOK REVIEW of Oceans of Kansas: A Natural History of the Western Interior Sea by Michael J. Everhart

Just as there are seashells on Mt. Everest, there is an exceptional wealth of fossil remains of marine organisms preserved in the chalk of western Kansas. This Cretaceous-aged rock, and the fossils therein, were deposited at a time when a great sea cut northward across the interior of the continent around 85 million years ago, inspiring the provocative title of Everhart's book. The title is true to its subject: documentation of the Cretaceous fossils of western Kansas, their geographic and stratigraphic occurrences, and the inferences that paleontologists can make about how the organisms represented by these fossils may have once lived and interacted with one another.

Dr. Edward (Ted) Elliot Eulogy

Kathy and Susie, members of the faculty, and staff of the School of Natural Resource Sciences, ladies and gentlemen. There are some things in this world that, try as we may, just cannot be adequately accomplished. One of those things, for me at least, is to express adequately what I feel about the passing of Dr. Edward (Ted) Elliot. Ted came to this University of Nebraska a few months before I arrived, and it was my distinct honor to count him among my friends at this great University. Ted was a man of exceptional scientific standing and wisdom, and his loss leaves a void in all of our lives that will not be readily filled.

Towards a Model of Information Systems User Competency

The ability to utilize information systems (IS) effectively is becoming a necessity for business professionals. However, individuals differ in their abilities to use IS effectively, with some achieving exceptional performance in IS use and others being unable to do so. Therefore, developing a set of skills and attributes to achieve IS user competency, or the ability to realize the fullest potential and the greatest performance from IS use, is important. Various constructs have been identified in the literature to describe IS users with regard to their intentions to use IS and their frequency of IS usage, but studies to describe the relevant characteristics associated with highly competent IS users, or those who have achieved IS user competency, are lacking. This research develops a model of IS user competency by using the Repertory Grid Technique to identify a broad set of characteristics of highly competent IS users. A qualitative analysis was carried out to identify categories and sub-categories of these characteristics. Then, based on the findings, a subset of the model of IS user competency focusing on the IS-specific factors – domain knowledge of and skills in IS, willingness to try and to explore IS, and perception of IS value – was developed and validated using the survey approach. The survey findings suggest that all three factors are relevant and important to IS user competency, with willingness to try and to explore IS being the most significant factor. This research generates a rich set of factors explaining IS user competency, such as perception of IS value. The results not only highlight characteristics that can be fostered in IS users to improve their performance with IS use, but also present research opportunities for IS training and potential hiring criteria for IS users in organizations.

Concepção de um dispositivo fisioterápico: parapodium mecanizado

This paper presents a proposal to redesign a physical therapy device for patients with quadriplegia, called parapodium. With the help of the Association of Parents and Exceptional Friends of Guaratinguetá, it was possible to know the currently used device and from this it was conceived changes, allowing the increase of freedom of its central portion, in the down and across positions with mechanical drive . This adaptation is to introduce improvements in the routine of physical therapy professionals and reduce ergonomic problems resulting from repetitive strain during the transfer of patients to the parapodium. In addition to providing greater security for patients who require the use of this equipment. The proposed device comprises: wheel, gearbox and brake systems used for actuation, allowing a degree of turning of the rear post, along an axis which is fixed to the gearbox and the rear structure that permits posterior movement. The mechanism allows the rear post rotate from 0 ° to 90 °. The estimated cost to make the proposal is lower than the marketed parapodiuns, reaching the device's functional expectations