Basic ingredients for mathematical modeling of tumor growth in vitro: Cooperative effects and search for space

Based on the literature data from HT-29 cell monolayers, we develop a model for its growth, analogous to an epidemic model, mixing local and global interactions. First, we propose and solve a deterministic equation for the progress of these colonies. Thus, we add a stochastic (local) interaction and simulate the evolution of an Eden-like aggregate by using dynamical Monte Carlo methods. The growth curves of both deterministic and stochastic models are in excellent agreement with the experimental observations. The waiting times distributions, generated via our stochastic model, allowed us to analyze the role of mesoscopic events. We obtain log-normal distributions in the initial stages of the growth and Gaussians at long times. We interpret these outcomes in the light of cellular division events: in the early stages, the phenomena are dependent each other in a multiplicative geometric-based process, and they are independent at long times. We conclude that the main ingredients for a good minimalist model of tumor growth, at mesoscopic level, are intrinsic cooperative mechanisms and competitive search for space. © 2013 Elsevier Ltd.

Infant and child mortality in the Third World: background information and proposals for cooperative studies among demographic centers

Includes bibliography

Project proposal for the establishment of a Caribbean Cooperative Agricultural Research Network

Presenta una propuesta para establecer una red de investigación agrícola cooperativa en el Caribe para servir a los países del CDCC

IX Meeting of the Steering Committee for Cooperative Action on the International Drinking Water Supply and Sanitation Decade (IDWSSD), 15-16 April, 1982

Comenta aspectos principales sobre los cuales se centro el debate en la reunion.

Gestão escolar, trabalho associado e participação no âmbito da Cooperativa Educacional de Marília

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Cooperativa Agrícola Santo Antônio: uma ação coletiva bem sucedida no Município de Marituba-PA

Esta pesquisa trata de um estudo de caso realizado na Cooperativa Agrícola Santo Antônio (COOPSANT) no Município de Marituba-PA. A cooperativa é uma referência no Estado do Pará e a nível nacional como empreendimento coletivo no ramo da produção da alface hidropônica, plantas ornamentais e hortaliças orgânicas. O objetivo da pesquisa é estudar o processo de autogestão da cooperativa. Para isso, utilizaram-se as abordagens qualitativas e quantitativas baseadas em entrevistas informais e semi-estruturadas (aplicação de questionário) com os cooperados, bem como observação in loco. O trabalho enfoca, principalmente, a abordagem teórica da Escola Francesa de Sociologia das Organizações de Crozier e Friedberg que trata de temas como poder, organização e autogestão. Conclui-se que mesmo enfrentando problemas, como conflitos, dificuldades de mobilizar a cooperação, dentre outros, os sócios contribuem para a gestão da organização. A COOPSANT tem uma autogestão equilibrada com a participação ativa de seus sócios, mas destaca-se o papel predominante do presidente na condução dos processos decisórios na assembleia geral, coordenação das ações e criação e modificação das regras de funcionamento da cooperativa. O poder pode ser considerado uma força estruturante na organização. A pesquisa identifica, além do presidente, outras pessoas estratégicas na cooperativa. A família participa de forma ativa no trabalho individual e coletivo, assim, fortalecendo o caráter familiar do empreendimento associativo. Por isto os cooperados, mesmo os que não têm familiares envolvidos, dizem que a cooperativa é um empreendimento familiar. Os cooperados se identificam, tanto como agricultor, quanto como cooperado. A identidade dos membros cria um vínculo entre eles e a organização a qual pertencem.

Novel technique for locating an intruder in 3D environments by using a cooperative system of multistatic radars

The aim of this work is to present a new methodology, based on vector and geometrical techniques, for determining the position of an intruder in a residence (3D problem). Initially, modifications in the electromagnetic responses of the environment, caused by movements of the trespasser, are detected. It is worth mentioning that slight movements are detected by high frequency components of the used pulse. The differences between the signals (before and after any movement) are used to define a sphere and ellipsoids, which are used for estimating the position of the invader. In this work, multiple radars are used in a cooperative manner. The multiple estimates obtained are used to determine a mean position and its standard deviation, introducing the concept of sphere of estimates. The electromagnetic simulations were performed by using the FDTD method. Results were obtained for single and double floor residences.

Multicollinearity and financial constraint in investment decisions: a bayesian generalized ridge regression

This paper addresses the investment decisions considering the presence of financial constraints of 373 large Brazilian firms from 1997 to 2004, using panel data. A Bayesian econometric model was used considering ridge regression for multicollinearity problems among the variables in the model. Prior distributions are assumed for the parameters, classifying the model into random or fixed effects. We used a Bayesian approach to estimate the parameters, considering normal and Student t distributions for the error and assumed that the initial values for the lagged dependent variable are not fixed, but generated by a random process. The recursive predictive density criterion was used for model comparisons. Twenty models were tested and the results indicated that multicollinearity does influence the value of the estimated parameters. Controlling for capital intensity, financial constraints are found to be more important for capital-intensive firms, probably due to their lower profitability indexes, higher fixed costs and higher degree of property diversification.

Cooperative effects of H+ and H- hydrido carbonyl ruthenium derivatives; role of homogeneous and heterogeneous protonic and lewis acids in catalytic hydrocarbonylation reactions

The role played by H+ hydrido iodocarbonyl and H- hydrido carbonyl ruthenium catalysts in the different catalytic steps of hydroformylation and hydroesterification of olefins, and in the homologation of alcohols has been investigated. The H- hydrido carbonyl species are mainly involved in the activation of olefins and in the hydrogenation of the acyl intermediates to aldehydes and alcohols, whereas the H+ hydrido iodocarbonyl derivatives are involved in the activation of alcohols and other oxygenated substrates, and in their carbonylation to esters. The cooperation between the two species, possible under particular reaction conditions, results in an improvement of the selectivity towards homologation (carbonylation plus hydrogenation) products. Heterogeneous Lewis acid promoters, easily recyclable from the reaction mixture, have also been successfully used in the hydrocarbonylation of alcohols, resulting in an increase of the carbonylation and homologation products. A reaction pathway in agreement with the experimental results is discussed. © 1989.

Discourse and Cooperative Learning in the Math Classroom

In this action research study of my 6th grade math classroom I investigated the effects of increased student discourse and cooperative learning on the students’ ability to explain and understand math concepts and problem solving, as well as its effects on their use of vocabulary and written explanations. I also investigated how it affected students’ attitudes. I discovered that increased student discourse and cooperative learning resulted in positive changes in students’ attitudes about their ability to explain and understand math, as well as their actual ability to explain and understand math concepts. Evidence in regard to use of vocabulary and written explanations generally showed little change, but this may have been related to insufficient data. As a result of this research, I plan to continue to use cooperative learning groups and increased student discourse as a teaching practice in all of my math classes. I also plan to include training on cooperative learning strategies as well as more emphasis on vocabulary and writing in my math classroom.

Cooperative Learning Groups in the Eighth Grade Math Classroom

In this action research study of my classroom of 8th grade mathematics students, I investigated whether cooperative learning would lead to a better understanding of the mathematical concepts and thus more success for the students. I used my three eighth grade classes with two using cooperative groups and the third not. I discovered that the students who wanted to work in cooperative groups were more successful than they had been. I also discovered that the grouping itself has a great effect on how the group works together. The wrong grouping of students can lead to disaster and many headaches for the teacher. Overall the two classes that used cooperative groups did better grade wise than the one class that was taught using the traditional way of not using cooperative groups. As a result of this research, I plan to continue using cooperative groups but will be more aware of the students who are grouped together.

An Uphill Battle: Incorporating cooperative learning using a largely individualized curriculum

In this action research study of my classroom of 8th grade mathematics, I investigated if cooperative learning could be an effective teaching method with the Saxon curriculum. Saxon curriculum is largely individualized in that most lessons could be completed without much group interaction. I discovered that cooperative learning was very successful with the curriculum as long as it was structured. Ninety-five percent of the students in the study preferred to work in groups, and I observed mathematical communication grow with most of the students. As a result of this research, I plan to continue to incorporate cooperative learning into my mathematics classroom. I will use cooperative learning with all of my mathematics classes, even the ones that do not use the Saxon curriculum. I believe in the power of working together.