Creació d'un Sistema d'Informació Geogràfica de Carreteres amb GEOMEDIA PROFESSIONAL 5.2

Aquest document detalla, desglossant la informació en diferents capítols, les tasques que s'han fet per a construir un sistema d'informació geogràfica (SIG) de carreteres emprant el producte Geomedia Professional 5.2 d'Intergraph: què és un SIG, per a què serveix, quins usos pot tenir i què el diferencia d'altres productes semblants com ara un programari de disseny assistit per ordinador (CAD) o un sistema de teledetecció, nocions de cartografia, formats d'intercanvi d'informació geogràfica, etc.

Interfície de control de una línia industrial automatitzada

Estudi seriós sobre les interfícies gràfiques destinades al sector industrial. En aquest sentit, s'analitza el perfil d'usuari o usuaris més freqüent en aquest sector (les seves característiques i les seves necessitats), es presenten i es descriuen diverses pautes de disseny i diversos elements gràfics que compleixen una sèrie de requisits predefinits, es procedeix a fer un muntatge d'exemple presentant una sèrie de pantalles (se n'explica i justifica el funcionament) i, per acabar, es proposa un mètode per a fer la validació del disseny, mètode que pot comportar modificacions sobre el disseny inicial.

Web Scraping : extracció i anàlisi de dades

L'àrea de treball en la qual se centra aquest projecte final de carrera (d'ara endavant PFC), es l'àrea de Compiladors. Aquesta àrea és present, es desenvolupa, a les assignatures "Compiladors I" i "Compiladors II" del pla d'estudis d'Enginyeria Informàtica ofert per la UOC. Òbviament, a un treball de síntesi com aquest no és suficient amb el coneixement assolit a aquestes dues assignatures i es posen en pràctica coneixements teòrics i pràctics assolits en altres assignatures com ara "Metodologia i gestió de projectes informàtics", "Enginyeria del programari orientat a l'objecte" o "Enginyeria del programari de components i sistemes distribuïts".

Basket manager: administració web i comerç electrònic en entorns de programari lliure

Joc en línia senzill de gestió esportiva basat en bàsquet.

Automatic classification of breast density

A recent trend in digital mammography is computer-aided diagnosis systems, which are computerised tools designed to assist radiologists. Most of these systems are used for the automatic detection of abnormalities. However, recent studies have shown that their sensitivity is significantly decreased as the density of the breast increases. This dependence is method specific. In this paper we propose a new approach to the classification of mammographic images according to their breast parenchymal density. Our classification uses information extracted from segmentation results and is based on the underlying breast tissue texture. Classification performance was based on a large set of digitised mammograms. Evaluation involves different classifiers and uses a leave-one-out methodology. Results demonstrate the feasibility of estimating breast density using image processing and analysis techniques

The molecular signature of the stroma response in prostate cancer-induced osteoblastic bone metastasis highlights expansion of hematopoietic and prostate epithelial stem cell niches.

The reciprocal interaction between cancer cells and the tissue-specific stroma is critical for primary and metastatic tumor growth progression. Prostate cancer cells colonize preferentially bone (osteotropism), where they alter the physiological balance between osteoblast-mediated bone formation and osteoclast-mediated bone resorption, and elicit prevalently an osteoblastic response (osteoinduction). The molecular cues provided by osteoblasts for the survival and growth of bone metastatic prostate cancer cells are largely unknown. We exploited the sufficient divergence between human and mouse RNA sequences together with redefinition of highly species-specific gene arrays by computer-aided and experimental exclusion of cross-hybridizing oligonucleotide probes. This strategy allowed the dissection of the stroma (mouse) from the cancer cell (human) transcriptome in bone metastasis xenograft models of human osteoinductive prostate cancer cells (VCaP and C4-2B). As a result, we generated the osteoblastic bone metastasis-associated stroma transcriptome (OB-BMST). Subtraction of genes shared by inflammation, wound healing and desmoplastic responses, and by the tissue type-independent stroma responses to a variety of non-osteotropic and osteotropic primary cancers generated a curated gene signature ("Core" OB-BMST) putatively representing the bone marrow/bone-specific stroma response to prostate cancer-induced, osteoblastic bone metastasis. The expression pattern of three representative Core OB-BMST genes (PTN, EPHA3 and FSCN1) seems to confirm the bone specificity of this response. A robust induction of genes involved in osteogenesis and angiogenesis dominates both the OB-BMST and Core OB-BMST. This translates in an amplification of hematopoietic and, remarkably, prostate epithelial stem cell niche components that may function as a self-reinforcing bone metastatic niche providing a growth support specific for osteoinductive prostate cancer cells. The induction of this combinatorial stem cell niche is a novel mechanism that may also explain cancer cell osteotropism and local interference with hematopoiesis (myelophthisis). Accordingly, these stem cell niche components may represent innovative therapeutic targets and/or serum biomarkers in osteoblastic bone metastasis.

Desarrollo de una aplicación para la gestión de documentos internos de ámbito empresarial

La asesoría de empresas Ribas Álvarez tiene, actualmente, un problema con la gestión de documentos internos, que se realiza mediante correo interno y una aplicación sencilla de indexación de archivos (HTML); sin ningún tipo de supervisión ni restricción. Esta empresa dispone de un cierto número de trabajadores, los cuales pertenecen a diferentes secciones (privadas o públicas) dentro de la empresa. La información que circula dentro de la empresa, no tiene ningún tipo de seguridad pudiendo cualquier trabajador, disponer de ella aunque no le sea de utilidad. Se quiere crear una aplicación que cumpla con las necesidades que la empresa desea para la administración y gestión de documentos internos, con un control de usuarios y seguridad de acceso a esta aplicación. El objetivo básico de la aplicación seria la creación y gestión de una intranet de control y seguimiento de documentos para una asesoría de empresas

Effective diagnosis of Alzheimer's disease by means of large margin-based methodology.

BACKGROUND Functional brain images such as Single-Photon Emission Computed Tomography (SPECT) and Positron Emission Tomography (PET) have been widely used to guide the clinicians in the Alzheimer's Disease (AD) diagnosis. However, the subjectivity involved in their evaluation has favoured the development of Computer Aided Diagnosis (CAD) Systems. METHODS It is proposed a novel combination of feature extraction techniques to improve the diagnosis of AD. Firstly, Regions of Interest (ROIs) are selected by means of a t-test carried out on 3D Normalised Mean Square Error (NMSE) features restricted to be located within a predefined brain activation mask. In order to address the small sample-size problem, the dimension of the feature space was further reduced by: Large Margin Nearest Neighbours using a rectangular matrix (LMNN-RECT), Principal Component Analysis (PCA) or Partial Least Squares (PLS) (the two latter also analysed with a LMNN transformation). Regarding the classifiers, kernel Support Vector Machines (SVMs) and LMNN using Euclidean, Mahalanobis and Energy-based metrics were compared. RESULTS Several experiments were conducted in order to evaluate the proposed LMNN-based feature extraction algorithms and its benefits as: i) linear transformation of the PLS or PCA reduced data, ii) feature reduction technique, and iii) classifier (with Euclidean, Mahalanobis or Energy-based methodology). The system was evaluated by means of k-fold cross-validation yielding accuracy, sensitivity and specificity values of 92.78%, 91.07% and 95.12% (for SPECT) and 90.67%, 88% and 93.33% (for PET), respectively, when a NMSE-PLS-LMNN feature extraction method was used in combination with a SVM classifier, thus outperforming recently reported baseline methods. CONCLUSIONS All the proposed methods turned out to be a valid solution for the presented problem. One of the advances is the robustness of the LMNN algorithm that not only provides higher separation rate between the classes but it also makes (in combination with NMSE and PLS) this rate variation more stable. In addition, their generalization ability is another advance since several experiments were performed on two image modalities (SPECT and PET).

Sexual dimorphism of the human mandible: demonstration by elliptical Fourier analysis.

A new quantitative approach of the mandibular sexual dimorphism, based on computer-aided image analysis and elliptical Fourier analysis of the mandibular outline in lateral view is presented. This method was applied to a series of 117 dentulous mandibles from 69 male and 48 female individuals native of Rhenish countries. Statistical discriminant analysis of the elliptical Fourier harmonics allowed the demonstration of a significant sexual dimorphism in 97.1% of males and 91.7% of females, i.e. in a higher proportion than in previous studies using classical metrical approaches. This original method opens interesting perspectives for increasing the accuracy of sex identification in current anthropological practice and in forensic procedures.

A dramatic lung cancer course in a patient with a rare EGFR germline mutation exon 21 V843I: Is EGFR TKI resistance predictable?

We report on the medical history of a Caucasian smoker woman diagnosed with a stage IV NSCLC adenocarcinoma, characterized by a rare epidermal growth factor receptor (EGFR) point mutation in exon 21 codon 843 (p.V843I/c.2527G>A/COSMIC ID 85894). This genetic alteration revealed to be germline, after its presence was demonstrated in chondroblasts from the bone biopsy. While it is the first description of germline V843I mutation without concomitant additional known EGFR activating mutation, we modeled the EGFR ATP catalytic domain in complex with ATP, gefitinib and erlotinib using computer-aided approaches to estimate possible changes in affinity upon the V843I mutation.

Guiding students through competence-based educational material

Student guidance is an always desired characteristic in any educational system, butit represents special difficulty if it has to be deployed in an automated way to fulfilsuch needs in a computer supported educational tool. In this paper we explorepossible avenues relying on machine learning techniques, to be included in a nearfuture -in the form of a tutoring navigational tool- in a teleeducation platform -InterMediActor- currently under development. Since no data from that platform isavailable yet, the preliminary experiments presented in this paper are builtinterpreting every subject in the Telecommunications Degree at Universidad CarlosIII de Madrid as an aggregated macro-competence (following the methodologicalconsiderations in InterMediActor), such that marks achieved by students can beused as data for the models, to be replaced in a near future by real data directlymeasured inside InterMediActor. We evaluate the predictability of students qualifications, and we deploy a preventive early detection system -failure alert-, toidentify those students more prone to fail a certain subject such that correctivemeans can be deployed with sufficient anticipation.

An Automatic Approach for Learning and Tuning Gaussian Interval Type-2 Fuzzy Membership Functions Applied to Lung CAD Classification System

The potential of type-2 fuzzy sets for managing high levels of uncertainty in the subjective knowledge of experts or of numerical information has focused on control and pattern classification systems in recent years. One of the main challenges in designing a type-2 fuzzy logic system is how to estimate the parameters of type-2 fuzzy membership function (T2MF) and the Footprint of Uncertainty (FOU) from imperfect and noisy datasets. This paper presents an automatic approach for learning and tuning Gaussian interval type-2 membership functions (IT2MFs) with application to multi-dimensional pattern classification problems. T2MFs and their FOUs are tuned according to the uncertainties in the training dataset by a combination of genetic algorithm (GA) and crossvalidation techniques. In our GA-based approach, the structure of the chromosome has fewer genes than other GA methods and chromosome initialization is more precise. The proposed approach addresses the application of the interval type-2 fuzzy logic system (IT2FLS) for the problem of nodule classification in a lung Computer Aided Detection (CAD) system. The designed IT2FLS is compared with its type-1 fuzzy logic system (T1FLS) counterpart. The results demonstrate that the IT2FLS outperforms the T1FLS by more than 30% in terms of classification accuracy.

Tietokoneavusteinen opetus koulun oppimisympäristöjen muutoksessa

Summary: Computer-aided instruction in the changing learning environments

Iowa ABC Connections, RB06-013, 2015

For several years the Iowa Department of Transportation (DOT), Iowa State University, the Federal Highway Administration, and several Iowa counties have been working to develop accelerated bridge construction (ABC) concepts, details, and processes. Throughout this development, much has been learned and has resulted in Iowa being viewed as a national leader in the area of ABC. However, at this time, the Office of Bridges and Structures does not have a complete set of working standards nor design examples to accompany ABC portions of the bridge design manual (now called the Load and Resistance Factor Design/LRFD Bridge Design Manual). During the fall of 2013, the Iowa DOT constructed a bridge on IA 92 in Cass County using an ABC technique known as slide-in bridge construction. During the design of the Cass County Bridge, several questions were raised about the performance of critical design and construction details: the pile-to-pile cap connection and the polytetrafluoroethylene (PTFE) coated bearing pads on which the bridge would slide. The timing of this specific need and the initiation of this project offered a unique opportunity to provide significant short- and long-term value to the Office of Bridges and Structures. Several full-scale laboratory tests, which included several variations of the pile-to-pile cap connection and bearing pad slides, were completed. These tests proved that the connection was capable of achieving the desired capacity and that the expected coefficient of friction of the bearing pads was reasonably low. Finally, a design tool was developed for the Office of Bridges and Structures to be used on future projects that might benefit from a precast pile cap.