Motor Vehicle Crash Fatalities for Week Ending, December 24, 2010,

Motor Vehicle Crash Fatalities

Motor Vehicle Crash Fatalities for Week Ending, December 30, 2010,

Motor Vehicle Crash Fatalities

Motor Vehicle Crash Fatalities Year End Report, January 7, 2011

Motor Vehicle Crash Fatalities

Motor Vehicle Crash Fatalities, January 21, 2011

Motor Vehicle Crash Fatalities

Motor Vehicle Crash Fatalities, January 21, 2011, Part II

Motor Vehicle Crash Fatalities

Motor Vehicle Crash Fatalities, January 28, 2011

Motor Vehicle Crash Fatalities

Motor Vehicle Crash Fatalities, February 4, 2011

Motor Vehicle Crash Fatalities

Extracellular histones in tissue injury and inflammation.

Neutrophil NETosis is an important element of host defense as it catapults chromatin out of the cell to trap bacteria, which then are killed, e.g., by the chromatin's histone component. Also, during sterile inflammation TNF-alpha and other mediators trigger NETosis, which elicits cytotoxic effects on host cells. The same mechanism should apply to other forms of regulated necrosis including pyroptosis, necroptosis, ferroptosis, and cyclophilin D-mediated regulated necrosis. Beyond these toxic effects, extracellular histones also trigger thrombus formation and innate immunity by activating Toll-like receptors and the NLRP3 inflammasome. Thereby, extracellular histones contribute to the microvascular complications of sepsis, major trauma, small vessel vasculitis as well as acute liver, kidney, brain, and lung injury. Finally, histones prevent the degradation of extracellular DNA, which promotes autoimmunization, anti-nuclear antibody formation, and autoimmunity in susceptible individuals. Here, we review the current evidence on the pathogenic role of extracellular histones in disease and discuss how to target extracellular histones to improve disease outcomes.

Motor Vehicle Crash Fatalities, February 11, 2011

Motor Vehicle Crash Fatalities

Motor Vehicle Crash Fatalities, February 18, 2011

Motor Vehicle Crash Fatalities

Motor Vehicle Crash Fatalities, February 25, 2011

Motor Vehicle Crash Fatalities

Motor Vehicle Crash Fatalities, March 4, 2011

Motor Vehicle Crash Fatalities

Motor Vehicle Crash Fatalities, March 4, 2011, Part II

Motor Vehicle Crash Fatalities

Motor Vehicle Crash Fatalities, March 11, 2011

Motor Vehicle Crash Fatalities