A guide to the Mental deficiency act, 1913 : containing a legal and general exposition of the act, with suggestions to local authorities, managers and others for the organization and administration of the work dealing with the mental defective /

Mode of access: Internet.

The 1990 Farm Act and the 1990 Budget Reconciliation Act : how U.S. farm policy mechanisms will work under the new legislation : includes description of target prices, loan rates, deficiency payments, and new planting flexibility provisions.

Mode of access: Internet.

American journal of mental deficiency.

Includes the association's conference proceedings and addresses.

Six books of Proclus : On the theology of Plato, trans. from the Greek; to which a seventh book is added, in order to supply the deficiency of another book on this subject, which was written by Proclus, but since lost.

"Also, a trans. of [his] Elements of theology ... Providence and fate ... extracts from ... Ten doubts concerning providence, and trans. of extracts from ... Subsistence of evil ; by Thomas Taylor."

Acquired immune deficiency syndrome (AIDS).

"June 13, 1984."

Report of the committee, appointed to inquire into and report the amount of the deficiency in the account of the late treasurer Skinner ... June 11, 1812.

Mode of access: Internet.

"Construction bustbuster's notebook" : repetitive constructive deficiency checklist /

Mode of access: Internet.

Intelligence and social valuation, a practical method for the diagnosis of mental deficiency and other forms of social inefficiency,

Mode of access: Internet.

Mental deficiency (amentia)

Mode of access: Internet.

Prothrombin deficiency.

Includes bibliography.

Experimental studies in mental deficiency. Three cases of imbeciltiy (Mongolian) and six cases of feeble-mindedness,

"Appendix and bibliography": p. 52-56.

Urgent supplemental appropriations for 1935 : hearing before the subcommittee of House Committee on Appropriations in charge of deficiency appropriations. Seventy-fourth Congress, first session. Federal Communications Commission, National Mediation Board, National Railroad Adjustment Board, Securities and Exchange Commission.

Mode of access: Internet.

Thiamine Deficiency Results in Downregulation of the GLAST Glutamate Transporter in Cultured Astrocytes

Pyrithiamine-induced thiamine deficiency (TD) is a well-established model of Wernicke's encephalopathy in which a glutamate-mediated excitotoxic mechanism may play an important role in determining selective vulnerability. In order to examine this possibility, cultured astrocytes were exposed to TD and effects on glutamate transport and metabolic function were studied. TD led to decreases in cellular levels of thiamine and thiamine diphosphate (TDP) after 24 h of treatment and decreased activities of the TDP-dependent enzymes alpha-ketoglutarate dehydrogenase and transketolase after 4 and 7 days, respectively. TD treatment for 10 days led to a reversible decrease in the uptake of [H-3]-D-aspartate, a nonmetabolizable analogue of glutamate. Kinetic analysis revealed that the uptake inhibition was caused by a 47% decrease in the V-max for uptake of [H-3]-D-aspartate, with no change in the K-m value. Immunoblotting showed that this decrease in uptake was due to an 81% downregulation of the astrocyte-specific GLAST glutamate transporter. Loss of uptake activity and GLAST protein were blocked by treatment with the protein kinase C inhibitor H7, while exposure to DCG IV, a group II metabotropic glutamate receptor (mGluR) agonist, resulted in improvement of [H-3]-D-aspartate uptake and a partial reversal of transporter downregulation. These results are consistent with our recent in vivo findings of a loss of astrocytic glutamate transporters in TD and provide evidence that TD conditions may increase phosphorylation. of GLAST, contributing to its downregulation. In addition, manipulation of group II mGluR activity may provide an important strategy in the treatment of this disorder. (C) 2003 Wiley-Liss, Inc.