Meta-analysis of studies analyzing the role of human papillomavirus in the development of bladder carcinoma

PURPOSE We aimed to ascertain the degree of association between bladder cancer and human papillomavirus (HPV) infection. MATERIALS AND METHODS We performed a meta-analysis of observational studies with cases and controls with publication dates up to January 2011. The PubMed electronic database was searched by using the key words "bladder cancer and virus." Twenty-one articles were selected that met the required methodological criteria. We implemented an internal quality control system to verify the selected search method. We analyzed the pooled effect of all the studies and also analyzed the techniques used as follows: 1) studies with DNA-based techniques, among which we found studies with polymerase chain reaction (PCR)-based techniques and 2) studies with non-PCR-based techniques, and studies with non-DNA-based techniques. RESULTS Taking into account the 21 studies that were included in the meta-analysis, we obtained a heterogeneity chi-squared value of Q(exp)=26.45 (p=0.383). The pooled odds ratio (OR) was 2.13 (95% confidence interval [CI], 1.54 to 2.95), which points to a significant effect between HPV and bladder cancer. Twenty studies assessed the presence of DNA. The overall effect showed a significant relationship between virus presence and bladder cancer, with a pooled OR of 2.19 (95% CI, 1.40 to 3.43). Of the other six studies, four examined the virus's capsid antigen and two detected antibodies in serum by Western blot. The estimated pooled OR in this group was 2.11 (95% CI, 1.27 to 3.51), which confirmed the relationship between the presence of virus and cancer. CONCLUSIONS The pooled OR value showed a moderate relationship between viral infection and bladder tumors.

Sistema d'informació d'esdeveniments locals per a dispositius Android

Sistema d'informació per al registre d'entitats i esdeveniments locals geolocalitzables a través de dispositius mòbils Android.

Genetic diversity and antimicrobial resistance in Streptococcus agalactiae strains recovered from female carriers in the Bucharest area

For the first time, we used multilocus sequence typing (MLST) to understand how Romanian group B streptococcus (GBS) strains fit into the global GBS population structure. Colonising isolates recovered from adult human females were tested for antibiotic resistance, were molecularly serotyped based on the capsular polysaccharide synthesis (cps) gene cluster and further characterised using a set of molecular markers (surface protein genes, pilus-encoded islands and mobile genetic elements inserted in the scpB-lmb intergenic region). Pulsed-field gel electrophoresis was used to complement the MLST clonal distribution pattern of selected strains. Among the 55 strains assigned to six cps types (Ia, Ib, II-V), 18 sequence types (STs) were identified by MLST. Five STs represented new entries to the MLST database. The prevalent STs were ST-1, ST-17, ST-19 and ST-28. Twenty molecular marker profiles were identified. The most common profiles (rib+GBSi1+PI-1, rib+GBSi1+PI-1, PI-2b and alp2/3+PI-1, PI-2a) were associated with the cps III/ST-17 and cps V/ST-1 strains. A cluster of fluoroquinolone-resistant strains was detected among the cps V/ST-19 members; these strains shared alp1 and IS1548 and carried PI-1, PI-2a or both. Our results support the usefulness of implementing an integrated genotyping system at the reference laboratory level to obtain the reliable data required to make comparisons between countries.

Análisis de incidentes químicos ocurridos en piscinas de España, 2008-2012.

Objective: Compared historical overview and systematic description of the distribution, features and public health implication of incidents occurred in swimming pools associated with exposure to chemicals, during the period 2008-2012 in Spain. Method: Retrospective observational design, using information reported to the digital mass media internetbased. Records of chemical incidents from a database of 5-year were analyzed to categorize main features. We examined the following variables: year, frequency and geographical location of incidents, class of swimming pool, settings lead to the event, causal factors, chemicals released, exposure ways, balance of victims, attending hospital and evacuated people. Results: 41 chemical incidents were identified in 5 years with a balance of 428 victims, 119 in-patient and 1750 people evacuated. Common profile of a chemical incident in a swimming pool was featured as a municipal setting where a release or hazardous chemical leak, mainly chlorine or mixed with acids occurred. An average of 10 exposed people per event, mostly children, exposed by respiratory airway, needed to be attended in hospital or community health center an annual average of 24 people, including bathers, employees or users. Conclusions: Swimming pools display scenarios with chemical risks that must be evaluated. Planning and implementing preventive measures are priority to mitigate a negative impact for public health. Our findings suggest the convenience of the regulation of a coordinated information system for ongoing surveillance of incidents in swimming pools to enable a safe management of chemical hazards.

Structure-based drug design studies of the interactions ofent-kaurane diterpenes derived from Wedelia paludosa with the Plasmodium falciparumsarco/endoplasmic reticulum Ca2+-ATPase PfATP6

Malaria is responsible for more deaths around the world than any other parasitic disease. Due to the emergence of strains that are resistant to the current chemotherapeutic antimalarial arsenal, the search for new antimalarial drugs remains urgent though hampered by a lack of knowledge regarding the molecular mechanisms of artemisinin resistance. Semisynthetic compounds derived from diterpenes from the medicinal plant Wedelia paludosawere tested in silico against the Plasmodium falciparumCa2+-ATPase, PfATP6. This protein was constructed by comparative modelling using the three-dimensional structure of a homologous protein, 1IWO, as a scaffold. Compound 21 showed the best docking scores, indicating a better interaction with PfATP6 than that of thapsigargin, the natural inhibitor. Inhibition of PfATP6 by diterpene compounds could promote a change in calcium homeostasis, leading to parasite death. These data suggest PfATP6 as a potential target for the antimalarial ent-kaurane diterpenes.

Computational drug design strategies applied to the modelling of human immunodeficiency virus-1 reverse transcriptase inhibitors

Reverse transcriptase (RT) is a multifunctional enzyme in the human immunodeficiency virus (HIV)-1 life cycle and represents a primary target for drug discovery efforts against HIV-1 infection. Two classes of RT inhibitors, the nucleoside RT inhibitors (NRTIs) and the nonnucleoside transcriptase inhibitors are prominently used in the highly active antiretroviral therapy in combination with other anti-HIV drugs. However, the rapid emergence of drug-resistant viral strains has limited the successful rate of the anti-HIV agents. Computational methods are a significant part of the drug design process and indispensable to study drug resistance. In this review, recent advances in computer-aided drug design for the rational design of new compounds against HIV-1 RT using methods such as molecular docking, molecular dynamics, free energy calculations, quantitative structure-activity relationships, pharmacophore modelling and absorption, distribution, metabolism, excretion and toxicity prediction are discussed. Successful applications of these methodologies are also highlighted.

MyFrameUOC : Disseny i implementació d'un framework de persistència

Disseny i implementació d'un framework de persistència anomenat MyFrameUOC que facilita i agilitza la implementació de la capa d'administració de dades de les aplicacions J2EE.

Desenvolupament de l'aplicació per a Android "Paga lo justo"

Aquest projecte desenvolupa una aplicació per a dispositius mòbils compatibles amb el sistema operatiu Android. El resultat és el programa "Paga lo justo", una calculadora per repartir el compte d'un restaurant.

Desenvolupament d'aplicacions per a dispositius mòbils : Aprèn amb Koki

Desenvolupament d'una aplicació per a dispositius mòbils basats en Android. L'aplicació és un joc multi-pantalla, multi-nivell.

Desenvolupament d'aplicacions per a dispositius mòbils Android : Curses

Desenvolupament d'una aplicació per a la plataforma Android que ofereix un calendari integrat de curses a peu.

Diseño e implantación de la base de datos de un sistema de descarga de aplicaciones para móviles inteligentes

Desarrollo de una base de datos para dar soporte a una plataforma de descarga de aplicaciones para móviles inteligentes.

Desarrollo de una aplicación educativa para Android

El proyecto consiste en la realización de una aplicación educativa para móviles con sistema operativo Android. La aplicación será supervisada por el director de un colegio y pretende atraer la atención de los alumnos para que puedan aprender en cualquier momento y lugar, poniendo a su disposición un contenido multimedia presentado de forma amena.

Diseño e implementación de la base de datos de un sistema de descargas de aplicaciones para móviles inteligentes

En este trabajo se nos encarga la implementación de un sistema de base de datos que sea capaz de dar respuesta a las necesidades de los desarrolladores de aplicaciones móviles a nivel mundial.

Software de adquisición de imágenes y reconocimiento óptico de caracteres para Android

El presente proyecto parte de la propuesta realizada por la empresa Tempos21 donde se recoge la necesidad de crear una librería de reconocimiento óptico de caracteres para la plataforma Android. Esta librería podrá ser utilizada por diferentes aplicaciones ejecutadas en terminales móviles que cuenten con este sistema operativo.

Diseño e implementación de un sistema de descarga de aplicaciones para móviles inteligentes

El proyecto detalla la planificación, diseño y creación de un sistema de base de datos que permita la gestión de una futura plataforma centralizada para la difusión de aplicaciones móviles a nivel mundial. Se tratarán los datos correspondientes a los usuarios y desarrolladores de aplicaciones así como los correspondientes a las propias aplicaciones y sus descargas.