657 resultados para Adjuvante de Freund


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Welsch (Projektbearbeiter): Voraussetzung für eine gedeihliche Entwicklung ist Ruhe und Gesetzlichkeit. Aufruf zur Wahl von Männern, welche auch früher schon Achtung und Vertrauen genossen. Warnung vor der Wahl solcher, welche der Bevölkerung allzuviel versprechen und vor 'Hetzern und Wühlern', die zu Unruhe und Widerstand gegen die Obrigkeit auffordern

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Welsch (Projektbearbeiter): Replik auf ein Rundschreiben des Wiener Fürsterzbischofs Vinzenz Eduard Milde in Form eines offenen Briefes, in dem Milde vorgeworfen wird, ein Freund Metternichs und ein Feind der neuen Ordnung zu sein

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Welsch (Projektbearbeiter): Appell an die Nationalgarde, die Grenze der von Kaiser Ferdinand bewilligten Volksfreiheiten nicht zu überschreiten, auf die Rückkehr des öffentlichen Friedens hinzuarbeiten und in Verfolgung dieses Zieles das Heer als Freund und Mitstreiter anzusehen

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Welsch (Projektbearbeiter): Antisemitisches Flugblatt: Nach Abschüttelung des "aristokratische[n], bureaukratische[n] und und Zensurs-Joch" droht nun das Joch der "israelitischen Herrschsucht"

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Welsch (Projektbearbeiter): Scharfe Kritik der Frankfurter Nationalversammlung und der politischen Geschehnisse in Deutschland aus entschieden linker, republikanischer Sicht: das Parlament sei schon halb " ... verwandelt in e groß Menascherie, do sieht mer Büffel, Labfrösch, Hund, Karnarienvögel, Hyäne und Löwe, Maulwörf und Jesuite. Wenns Rappeleplick gibt, mache mer e große Glaskaste darüber und lossese vor Geld seih." In Form einer Unterhaltung des 'Perlements-Schnell-Laafers' Itzik mit seinem Freund Schmul

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Welsch (Projektbearbeiter): Kritische Kommentierung einer von der Regierung Auerswald-Hansemann geplanten Zwangsanleihe. In der Form einer Unterhaltung des Berliner Nationalversammlungsabgeordneten Nante mit seinem Freund Brennecke (fiktiv)

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Ismar Freund

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Ismar Freund

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Contagious bovine pleuropneumonia (CBPP) is a serious respiratory disease of cattle caused by Mycoplasma mycoides subsp. mycoides. Current vaccines against CBPP induce short-lived immunity and can cause severe postvaccine reactions. Previous studies have identified the N terminus of the transmembrane lipoprotein Q (LppQ-N') of M. mycoides subsp. mycoides as the major antigen and a possible virulence factor. We therefore immunized cattle with purified recombinant LppQ-N' formulated in Freund's adjuvant and challenged them with M. mycoides subsp. mycoides. Vaccinated animals showed a strong seroconversion to LppQ, but they exhibited significantly enhanced postchallenge glomerulonephritis compared to the placebo group (P = 0.021). Glomerulonephritis was characterized by features that suggested the development of antigen-antibody immune complexes. Clinical signs and gross pathological scores did not significantly differ between vaccinated and placebo groups. These findings reveal for the first time the pathogenesis of enhanced disease as a result of antibodies against LppQ during challenge and also argue against inclusion of LppQ-N' in a future subunit vaccine for CBPP.

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PURPOSE: To evaluate and characterize multiple evanescent white dot syndrome abnormalities with modern multimodal imaging modalities. METHODS: This retrospective cohort study evaluated fundus photography, fluorescein angiography, indocyanine green angiography, optical coherence tomography, enhanced depth imaging optical coherence tomography, short-wavelength autofluorescence, and near-infrared autofluorescence. RESULTS: Thirty-four multiple evanescent white dot syndrome patients with mean age of 28.7 years were studied (range, 14-49 years). Twenty-six patients were women, and eight were men. Initial mean visual acuity was 0.41 logMAR. Final mean visual acuity was 0.03 logMAR. Fluorescein angiography shows a variable number of mid retinal early fluorescent dots distributed in a wreathlike pattern, which correlate to fundus photography, fundus autofluorescence, and indocyanine green angiography. Indocyanine green angiography imaging shows the dots and also hypofluorescent, deeper, and larger spots, which are occasionally confluent, demonstrating a large plaque of deep retinal hypofluorescence. Optical coherence tomography imaging shows multifocal debris centered at and around the ellipsoid layer, corresponding to the location of spots seen with photography, indocyanine green angiography, and fluorescein angiography. Protrusions of the hyperreflectant material from the ellipsoid layer toward the outer nuclear layer correspond to the location of dots seen with photography, indocyanine green angiography, and fluorescein angiography. CONCLUSION: Multimodal imaging analysis of the retina in patients with multiple evanescent white dot syndrome shows additional features that may help in the diagnosis of the disease and in further understanding its etiology. Multiple evanescent white dot syndrome is predominantly a disease of the outer retina, centered at the ellipsoid zone, but also involving the interdigitation zone and the outer nuclear layer.

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Ismar Freund